ANNE KARINA THERESIA PERL

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar Fibroblasts during Realveolarization
    Leiling Chen
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
    Am J Respir Cell Mol Biol 47:517-27. 2012
  2. ncbi The a"MAZE"ing world of lung-specific transgenic mice
    Emma L Rawlins
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 46:269-82. 2012
  3. ncbi Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis
    Anne Karina T Perl
    Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 183:511-21. 2011
  4. ncbi FGF signaling is required for myofibroblast differentiation during alveolar regeneration
    Anne Karina T Perl
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 297:L299-308. 2009
  5. ncbi Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli
    Anne Karina T Perl
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 33:455-62. 2005
  6. ncbi Normal lung development and function after Sox9 inactivation in the respiratory epithelium
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Genesis 41:23-32. 2005
  7. ncbi Early restriction of peripheral and proximal cell lineages during formation of the lung
    Anne-Karina T Perl
    Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229-3039, USA
    Proc Natl Acad Sci U S A 99:10482-7. 2002
  8. ncbi Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema
    Isamu Hokuto
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:415-21. 2003
  9. ncbi Conditional gene expression in the respiratory epithelium of the mouse
    Anne-Karina T Perl
    Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Transgenic Res 11:21-9. 2002
  10. ncbi Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    Leigh Anne D Miller
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Dev Dyn 231:57-71. 2004

Research Grants

  1. FGF and PDGF regulate myofibroblast differentiation in alveolar regeneration
    ANNE KARINA THERESIA PERL; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi Dynamic Regulation of Platelet-Derived Growth Factor Receptor α Expression in Alveolar Fibroblasts during Realveolarization
    Leiling Chen
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039
    Am J Respir Cell Mol Biol 47:517-27. 2012
    ..Our data demonstrate for the first time that a comparable epithelial-mesenchymal crosstalk regulates fibroblast phenotypes during alveolar septation...
  2. ncbi The a"MAZE"ing world of lung-specific transgenic mice
    Emma L Rawlins
    Children s Hospital Medical Center, Divisions of Neonatology and Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Cell Mol Biol 46:269-82. 2012
    ..In addition, useful transgenic reporter mice for studying lineage relationships, promoter activity, and signaling pathways will complete our lung-specific conditional transgenic mouse shopping list...
  3. ncbi Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis
    Anne Karina T Perl
    Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 183:511-21. 2011
    ..Cellular processes underlying the repair and remodeling of the lung after chronic epithelial injury are poorly understood...
  4. ncbi FGF signaling is required for myofibroblast differentiation during alveolar regeneration
    Anne Karina T Perl
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Lung Cell Mol Physiol 297:L299-308. 2009
    ..Taken together, our data demonstrate that FGF signaling is required for the induction of alphaSMA in the PDGFRalpha-positive myofibroblast progenitor and the progression of alveolar regeneration...
  5. ncbi Conditional recombination reveals distinct subsets of epithelial cells in trachea, bronchi, and alveoli
    Anne Karina T Perl
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 33:455-62. 2005
    ..Conditional expression of Cre-recombinase in the respiratory epithelium provides a useful model for the study of gene expression and function in the mouse respiratory tract and in the lung...
  6. ncbi Normal lung development and function after Sox9 inactivation in the respiratory epithelium
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Genesis 41:23-32. 2005
    ..Although Sox9 is expressed at high levels throughout lung morphogenesis, inactivation of Sox9 from the respiratory epithelial cells does not alter lung structure, postnatal survival, or repair following oxygen injury...
  7. ncbi Early restriction of peripheral and proximal cell lineages during formation of the lung
    Anne-Karina T Perl
    Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229-3039, USA
    Proc Natl Acad Sci U S A 99:10482-7. 2002
    ....
  8. ncbi Prenatal, but not postnatal, inhibition of fibroblast growth factor receptor signaling causes emphysema
    Isamu Hokuto
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:415-21. 2003
    ..5 but did not alter alveolarization when expressed after birth. Although FGF signaling was required for branching morphogenesis early in lung development, postnatal alveolarization was not influenced by FGFR-HFc...
  9. ncbi Conditional gene expression in the respiratory epithelium of the mouse
    Anne-Karina T Perl
    Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Transgenic Res 11:21-9. 2002
    ..The SP-C-rtTA and CCSP-rtTA activator mice control the expression of transgenes in the developing and mature respiratory epithelium, and will be useful for the study of gene function in the lung...
  10. ncbi Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
    Leigh Anne D Miller
    Department of Pediatrics, Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Dev Dyn 231:57-71. 2004
    ..SHH regulates branching morphogenesis and influences differentiation of the peripheral lung mesenchyme required for formation of bronchial and vascular smooth muscle...
  11. ncbi Temporal effects of Sprouty on lung morphogenesis
    Anne Karina T Perl
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Dev Biol 258:154-68. 2003
    ..These findings demonstrate that the embryonic-pseudoglandular stage is a critical time period during which Spry-sensitive pathways are required for branching morphogenesis, lobulation, and formation of the peripheral lung parenchyma...
  12. ncbi FGF signaling is required for pulmonary homeostasis following hyperoxia
    Isamu Hokuto
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L580-7. 2004
    ..FGF signaling is required for maintenance of surfactant homeostasis and lung function during hyperoxia in vivo, mediated, at least in part, by its role in the maintenance of SP-B expression...
  13. ncbi Erm/thyroid transcription factor 1 interactions modulate surfactant protein C transcription
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 281:16716-26. 2006
    ..Taken together, these results demonstrate that Erm is involved in SP-C regulation, which results from an interaction with TTF-1...
  14. ncbi C/EBPalpha is required for lung maturation at birth
    Prithy C Martis
    Division of Pulmonary Biology and Neonatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 133:1155-64. 2006
    ..C/EBPalpha participates in a transcriptional network that is required for the regulation of genes mediating perinatal lung maturation and surfactant homeostasis that is necessary for adaptation to air breathing at birth...
  15. ncbi Fibroblast growth factor 18 influences proximal programming during lung morphogenesis
    Jeffrey A Whitsett
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:22743-9. 2002
    ..Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis...
  16. ncbi Stat-3 is required for pulmonary homeostasis during hyperoxia
    Isamu Hokuto
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:28-37. 2004
    ..Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury...
  17. ncbi Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4
    Fabienne Jäggi
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Basel, Switzerland
    Mol Cancer Res 6:468-82. 2008
    ..In contrast, transgenic expression of mSpry4 during beta-cell carcinogenesis does not significantly affect tumor outgrowth and progression to tumor malignancy. Rather, tumor cells seem to escape mSpry4 transgene expression...
  18. ncbi Conditional control of gene expression in the respiratory epithelium: A cautionary note
    Jeffrey A Whitsett
    Am J Respir Cell Mol Biol 34:519-20. 2006

Research Grants1

  1. FGF and PDGF regulate myofibroblast differentiation in alveolar regeneration
    ANNE KARINA THERESIA PERL; Fiscal Year: 2010
    ..Successful completion of the proposed studies will identify the myofibroblast progenitor cell and novel, potentially therapeutic agents to induce alveolar regeneration in an adult lung. ..