Kristen Page

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen
    Riad Lutfi
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati, OH, USA
    J Inflamm (Lond) 9:32. 2012
  2. doi request reprint Role of cockroach proteases in allergic disease
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave ML7006, Cincinnati, OH, USA
    Curr Allergy Asthma Rep 12:448-55. 2012
  3. pmc Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Respir Res 8:91. 2007
  4. ncbi request reprint TLR2-mediated activation of neutrophils in response to German cockroach frass
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 180:6317-24. 2008
  5. pmc Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen
    Carrie I Morgan
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Inflamm (Lond) 8:36. 2011
  6. pmc A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 183:3400-8. 2009
  7. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
  8. pmc Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Ohio 45229, USA
    J Innate Immun 3:167-79. 2011
  9. pmc German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment
    Scottie B Day
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA
    J Innate Immun 4:100-10. 2012
  10. pmc Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
    Ian P Lewkowich
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Respir Res 12:122. 2011

Research Grants

Collaborators

Detail Information

Publications25

  1. pmc The role of protease-activated receptor-2 on pulmonary neutrophils in the innate immune response to cockroach allergen
    Riad Lutfi
    Department of Pediatrics, Division of Critical Care Medicine, Cincinnati, OH, USA
    J Inflamm (Lond) 9:32. 2012
    ..abstract:..
  2. doi request reprint Role of cockroach proteases in allergic disease
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave ML7006, Cincinnati, OH, USA
    Curr Allergy Asthma Rep 12:448-55. 2012
    ..We will highlight recent data exploring the potential mechanisms involved in the biological effects of the allergen...
  3. pmc Differences in susceptibility to German cockroach frass and its associated proteases in induced allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Respir Res 8:91. 2007
    ..Cockroach exposure is a major risk factor for the development of asthma. Inhalation of fecal remnants (frass) is the likely sensitizing agent; however isolated frass has not been tested for its ability to induce experimental asthma in mice...
  4. ncbi request reprint TLR2-mediated activation of neutrophils in response to German cockroach frass
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Immunol 180:6317-24. 2008
    ....
  5. pmc Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen
    Carrie I Morgan
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Inflamm (Lond) 8:36. 2011
    ..abstract:..
  6. pmc A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 183:3400-8. 2009
    ..This suggests a protective role for TLR2 activation and MMP-9 release in the context of experimentally induced asthma in mice...
  7. pmc Mucosal sensitization to German cockroach involves protease-activated receptor-2
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Respir Res 11:62. 2010
    ..The role for PAR-2 in mediating allergic airway inflammation has not been assessed using a real world allergen...
  8. pmc Early immunological response to German cockroach frass exposure induces a Th2/Th17 environment
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Ohio 45229, USA
    J Innate Immun 3:167-79. 2011
    ..Together, our data show that GC frass activated the innate immune response to augment DC recruitment and activation of mDCs which promoted robust T cell-skewing cytokines and ultimately drive the development of airway inflammation...
  9. pmc German cockroach proteases and protease-activated receptor-2 regulate chemokine production and dendritic cell recruitment
    Scottie B Day
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, Ohio, USA
    J Innate Immun 4:100-10. 2012
    ..This leads to increased recruitment and/or differentiation of myeloid DC populations in the lungs and likely plays an important role in the initiation of allergic airway responses...
  10. pmc Protease-activated receptor 2 activation of myeloid dendritic cells regulates allergic airway inflammation
    Ian P Lewkowich
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Respir Res 12:122. 2011
    ..A common characteristic of allergens is that they contain proteases that can activate protease-activated receptor (PAR-2); however the mechanism by which PAR-2 regulates allergic airway inflammation is unclear...
  11. pmc Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism
    Margaret A Chase
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 179:6318-24. 2007
    ..Taken together, these data suggest that Hsp72 is released and biologically active in the BALF and can regulate airway epithelial cell cytokine expression in a TLR4 and NF-kappaB-dependent mechanism...
  12. pmc CpG DNA modulates interleukin 1beta-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells
    N William Parilla
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Respir Res 7:84. 2006
    ..We sought to investigate the role of CpG oligodeoxynucleotides (ODN) on a human bronchial epithelial cells...
  13. ncbi request reprint German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells
    Kristen Page
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, ML7006, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:225-31. 2005
    ..We conclude that proteases in German cockroach extract regulate PAR-2 and ERK to increase NF-IL6 activity and synergistically regulate TNF-alpha-induced IL-8 promoter activity in human airway epithelium...
  14. ncbi request reprint Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway
    Thomas K Shimotake
    Department of Pediatrics, University of Chicago, Illinois 60637, USA
    Pediatr Res 56:907-13. 2004
    ....
  15. pmc The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming
    Patricia A Abboud
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Shock 30:285-92. 2008
    ..These data demonstrate that endogenously produced and released extracellular Hsp72 has the ability to reprogram the in vitro response to endotoxin in cultured human mononuclear cells...
  16. pmc German cockroach frass proteases modulate the innate immune response via activation of protease-activated receptor-2
    Scottie B Day
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Innate Immun 2:495-504. 2010
    ..Understanding the potential role of protease-PAR-2 activation as a danger signal or adjuvant could yield attractive therapeutic targets...
  17. ncbi request reprint German cockroach frass proteases cleave pro-matrix metalloproteinase-9
    Valerie S Hughes
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229, USA
    Exp Lung Res 33:135-50. 2007
    ..These data suggest a mechanism by which inhalation of GC frass could regulate airway remodeling through the activation of pro-MMP-9...
  18. ncbi request reprint Heat shock-mediated regulation of MKP-1
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Cell Physiol 289:C1152-8. 2005
    ..These data demonstrate another potential mechanism by which heat shock can modulate inflammation-related signal transduction...
  19. pmc Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati Children s Research Foundation, Cincinnati, OH, USA
    Respir Res 10:31. 2009
    ..Heat shock proteins (HSPs) are generally regarded as intracellular proteins acting as molecular chaperones; however, HSP72 can also be released from cells, and the implications of this release are not fully understood...
  20. ncbi request reprint Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)-2 and extracellular-signal-regulated kinase
    Kristen Page
    Department of Pediatrics, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 112:1112-8. 2003
    ..The mechanism by which cockroach proteases regulate cytokine expression is unknown; however, protease-activated receptors (PARs) might play a role...
  21. pmc Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury
    Stephan W Glasser
    Cincinnati Children s Hospital Medical Center, Perinatal Institute, Division of Neonatology, Perinatal and Pulmonary Biology, MLC7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Respir Res 14:19. 2013
    ..SP-C gene targeted mice (Sftpc -/-) lack SP-C, develop an ILD-like disease and are susceptible to infection with RSV...
  22. ncbi request reprint Heat shock inhibition of lipopolysaccharide-mediated tumor necrosis factor expression is associated with nuclear induction of MKP-1 and inhibition of mitogen-activated protein kinase activation
    Lauren Sanlorenzo
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 32:2284-92. 2004
    ..We hypothesized that prior heat shock to monocytes would induce a phosphatase, MKP-1, that regulated mitogen-activated protein kinase activity and subsequently conferred cross-tolerance to lipopolysaccharide stimulation...
  23. ncbi request reprint Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta
    Kristen Page
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:5681-9. 2003
    ..Finally, PKC delta-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKC delta plays a key role in the regulation of airway epithelial cell NF-kappa B-dependent gene expression...
  24. ncbi request reprint Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta
    Kristen Page
    Department of Pediatrics and the Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 27:204-13. 2002
    ..These data suggest that PKCdelta attenuates cyclin D1 promoter activity via the regulation of three distinct cis-acting regulatory elements...
  25. ncbi request reprint Regulation of human airway epithelial cell IL-8 expression by MAP kinases
    Jing Li
    Am J Physiol Lung Cell Mol Physiol 283:L690-9. 2002
    ..We conclude that, in human airway epithelial cells, MAP kinases may regulate IL-8 promoter activity by NF-kappaB-dependent (in the case of JNK) and -independent (ERK) processes, as well as by posttranscriptional mechanisms (p38)...

Research Grants5

  1. Role of cockroach proteases in airway inflammation
    Kristen Page; Fiscal Year: 2009
    ..Finally, we will investigate the role of endogenous TNF alpha in the airways using a TNF alpha neutralizing antibody and TNF alpha knockout mice. ..