Kasiani C Myers

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Veno-occlusive disease of the liver in the absence of elevation in bilirubin in pediatric patients after hematopoietic stem cell transplantation
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:379-81. 2015
  2. doi request reprint High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 19:500-3. 2013
  3. doi request reprint Clinical and molecular pathophysiology of Shwachman-Diamond syndrome: an update
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH 45229, USA
    Hematol Oncol Clin North Am 27:117-28, ix. 2013
  4. doi request reprint Impaired immune function in children with Fanconi anaemia
    Kasiani C Myers
    Divisions of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 154:234-40. 2011
  5. doi request reprint The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations
    Kasiani Myers
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Blood Cancer 58:462-5. 2012
  6. doi request reprint Endocrine evaluation of children with and without Shwachman-Bodian-Diamond syndrome gene mutations and Shwachman-Diamond syndrome
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
    J Pediatr 162:1235-40, 1240.e1. 2013
  7. doi request reprint Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage
    Timothy M Chlon
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7013, Cincinnati, OH 45229, USA
    Stem Cell Reports 6:44-54. 2016
  8. doi request reprint Histologic Features of Intestinal Thrombotic Microangiopathy in Pediatric and Young Adult Patients after Hematopoietic Stem Cell Transplantation
    Javier El-Bietar
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1994-2001. 2015
  9. doi request reprint Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveals Good Outcomes and That the Risk of Mixed Chimerism Depends on Underlying Disease, Stem
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1460-70. 2015
  10. doi request reprint Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:307-15. 2016

Collaborators

Detail Information

Publications21

  1. doi request reprint Veno-occlusive disease of the liver in the absence of elevation in bilirubin in pediatric patients after hematopoietic stem cell transplantation
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:379-81. 2015
    ..Early ultrasound evaluation in these patients may lead to more timely diagnosis and therapeutic interventions...
  2. doi request reprint High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 19:500-3. 2013
    ..We conclude that high-dose steroid therapy if initiated early may reverse VOD of the liver in pediatric HSCT patients, abrogating the need for defibrotide therapy with its associated toxicities and regulatory difficulties...
  3. doi request reprint Clinical and molecular pathophysiology of Shwachman-Diamond syndrome: an update
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, MLC 7015, Cincinnati, OH 45229, USA
    Hematol Oncol Clin North Am 27:117-28, ix. 2013
    ..This article summarizes the clinical phenotype of SDS, diagnostic and treatment approaches, and novel advances in our understanding of the molecular pathophysiology of this disease...
  4. doi request reprint Impaired immune function in children with Fanconi anaemia
    Kasiani C Myers
    Divisions of Bone Marrow Transplant and Immune Deficiency, Department of Pediatrics, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 154:234-40. 2011
    ..These findings may be especially relevant in this patient population with known predisposition to DNA damage and malignancy...
  5. doi request reprint The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations
    Kasiani Myers
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Blood Cancer 58:462-5. 2012
    ....
  6. doi request reprint Endocrine evaluation of children with and without Shwachman-Bodian-Diamond syndrome gene mutations and Shwachman-Diamond syndrome
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA
    J Pediatr 162:1235-40, 1240.e1. 2013
    ..To characterize the endocrine phenotype of patients with Shwachman-Diamond syndrome (SDS)...
  7. doi request reprint Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage
    Timothy M Chlon
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7013, Cincinnati, OH 45229, USA
    Stem Cell Reports 6:44-54. 2016
    ..These studies reveal that PSCs possess hyperactive CHK1 signaling that restricts their self-renewal in the absence of error-free DNA repair. ..
  8. doi request reprint Histologic Features of Intestinal Thrombotic Microangiopathy in Pediatric and Young Adult Patients after Hematopoietic Stem Cell Transplantation
    Javier El-Bietar
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1994-2001. 2015
    ..Recognition of these histologic signs in post-transplantation patients with significant gastrointestinal symptoms may guide clinical decisions. ..
  9. doi request reprint Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveals Good Outcomes and That the Risk of Mixed Chimerism Depends on Underlying Disease, Stem
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:1460-70. 2015
    ..We conclude that alemtuzumab, fludarabine, and melphalan RIC HCT offers good results for many patients and that the risk of developing mixed chimerism is influenced by underlying diagnosis, graft source, and alemtuzumab dosing...
  10. doi request reprint Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to Optimize Therapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 22:307-15. 2016
    ..This algorithm may guide eculizumab treatment and ensure that future efficacy studies use the most clinically appropriate and cost-efficient dosing schedules. ..
  11. pmc Variable clinical presentation of Shwachman-Diamond syndrome: update from the North American Shwachman-Diamond Syndrome Registry
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH
    J Pediatr 164:866-70. 2014
    ..To investigate the range of clinical presentations for Shwachman-Diamond syndrome (SDS) with the long-term goal of improving diagnosis...
  12. doi request reprint Clinical Utility of Computed Tomography and Magnetic Resonance Imaging for Diagnosis of Posterior Reversible Encephalopathy Syndrome after Stem Cell Transplantation in Children and Adolescents
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:2028-32. 2015
    ..Patients with clinical symptoms suggestive of PRES who have a negative CT should be treated appropriately for PRES and should undergo MRI of the brain as soon as clinically stable to confirm the diagnosis. ..
  13. pmc Oral human papillomavirus is common in individuals with Fanconi anemia
    Sharon L Sauter
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio
    Cancer Epidemiol Biomarkers Prev 24:864-72. 2015
    ..As individuals with Fanconi anemia respond poorly to chemotherapy and radiation, prevention of cancer is critical...
  14. doi request reprint Endocrine phenotype of children and adults with Fanconi anemia
    Susan R Rose
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 59:690-6. 2012
    ..We sought to further characterize the endocrine phenotype in children and adults with FA...
  15. doi request reprint A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury
    Sonata Jodele
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, USA Electronic address
    Blood Rev 29:191-204. 2015
    ....
  16. pmc An intermediate alemtuzumab schedule reduces the incidence of mixed chimerism following reduced-intensity conditioning hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 19:1625-31. 2013
    ..02). Our findings indicate that intermediate RIC reduces the incidence of mixed chimerism, is associated with a low incidence of upfront acute GVHD, and decreases the need for additional hematopoietic cell products after HCT. ..
  17. pmc High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells
    Timothy M Chlon
    Cincinnati Children s Hospital Medical Center, Cancer and Blood Diseases Institute, Cincinnati, Ohio, USA
    J Virol 88:11315-26. 2014
    ..Thus, we conclude that the FA pathway is required for the growth of iPSC beyond reprogramming and that p53-independent mechanisms are involved...
  18. doi request reprint Vitamin D Deficiency and Survival in Children after Hematopoietic Stem Cell Transplant
    Gregory Wallace
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Biol Blood Marrow Transplant 21:1627-31. 2015
    ..1%). We conclude that all pediatric transplant recipients should be screened for vitamin D deficiency before HSCT and at day 100 post-transplant and that aggressive supplementation is needed to maintain sufficient levels...
  19. doi request reprint Abnormal echocardiography 7 days after stem cell transplantation may be an early indicator of thrombotic microangiopathy
    Christopher E Dandoy
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Electronic address
    Biol Blood Marrow Transplant 21:113-8. 2015
    ..004) and may indicate early vascular injury in the lungs. These data suggest that echocardiography 7 days after HSCT can detect early cardiac complications of HSCT and may identify early vascular injury associated with TA-TMA...
  20. doi request reprint Hematopoietic stem cell transplantation for bone marrow failure syndromes in children
    Kasiani C Myers
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Biol Blood Marrow Transplant 15:279-92. 2009
    ....
  21. pmc The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
    Wei Du
    Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 119:4142-51. 2012
    ..In addition, oxidative stress-induced FANCD2 ubiquitination is required for the formation of a FA-BRG1-promoter complex. Taken together, these data identify a role for the FA pathway in cellular antioxidant defense...