JAMES MULLOY

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    James C Mulloy
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Mail Location 7013, Cincinnati, OH 45229, USA
    Blood 102:4369-76. 2003
  2. ncbi Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 7:3314-9. 2008
  3. ncbi Peripheral T cell lymphoma: new model + new insight
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 207:911-3. 2010
  4. ncbi The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
    James C Mulloy
    Laboratory of Molecular Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Blood 99:15-23. 2002
  5. ncbi Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells
    Jorg Cammenga
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    Blood 101:2206-14. 2003
  6. ncbi AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion
    James C Mulloy
    Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:4016-21. 2005
  7. ncbi Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
    Mark Wunderlich
    Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45226, USA
    Blood 108:1690-7. 2006
  8. ncbi p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
    Ondrej Krejci
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA
    Blood 111:2190-9. 2008
  9. ncbi Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
    Junping Wei
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Cell 13:483-95. 2008

Research Grants

  1. Role of AML1/ETO in Hematopoiesis and Leukemogenesis
    JAMES MULLOY; Fiscal Year: 2005
  2. The Role of CBFb-MYH11 in Acute Myeloid Leukemia
    JAMES MULLOY; Fiscal Year: 2007
  3. RUNX-fusion Target Genes in Normal and Leukemic Hematopoiesis
    JAMES MULLOY; Fiscal Year: 2007
  4. The Role of CBFb-MYH11 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010
  5. The Role of MLL-AF9 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010

Collaborators

Detail Information

Publications9

  1. ncbi Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element
    James C Mulloy
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Mail Location 7013, Cincinnati, OH 45229, USA
    Blood 102:4369-76. 2003
    ....
  2. ncbi Transforming human blood stem and progenitor cells: a new way forward in leukemia modeling
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 7:3314-9. 2008
    ..We focus specifically on the Rho family of small guanosine triphosphatases (GTPases) as potential therapeutic targets, which we have implicated in the pathogenesis of AML associated with MA9 expression...
  3. ncbi Peripheral T cell lymphoma: new model + new insight
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 207:911-3. 2010
    ..A newly developed model of peripheral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect the signaling cascades important for SYK-associated malignancy in the context of t(5;9) PTCL...
  4. ncbi The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells
    James C Mulloy
    Laboratory of Molecular Hematopoiesis, Sloan Kettering Institute, New York, NY, USA
    Blood 99:15-23. 2002
    ..Thus, AML1-ETO enhances the self-renewal of pluripotent stem cells, the physiological target of many acute myeloid leukemias...
  5. ncbi Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells
    Jorg Cammenga
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, Division of Hematologic Oncology, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    Blood 101:2206-14. 2003
    ..Given the known differences in murine and human promoter regulatory sequences, this inducible system allows the identification of transcription factor target genes in a physiologic, human hematopoietic progenitor cell background...
  6. ncbi AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion
    James C Mulloy
    Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:4016-21. 2005
    ....
  7. ncbi Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability
    Mark Wunderlich
    Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45226, USA
    Blood 108:1690-7. 2006
    ....
  8. ncbi p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
    Ondrej Krejci
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA
    Blood 111:2190-9. 2008
    ..It is possible that the superior outcome of t(8;21) patients is partly due to an activated p53 pathway, and that loss of the p53 response pathway is associated with disease progression...
  9. ncbi Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia
    Junping Wei
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Cell 13:483-95. 2008
    ..Targeting the Rac signaling pathway by pharmacologic or genetic means resulted in rapid and specific apoptosis of MLL-AF9 cells, suggesting that the Rac signaling pathway may be a valid therapeutic target in MLL-rearranged AML...

Research Grants9

  1. Role of AML1/ETO in Hematopoiesis and Leukemogenesis
    JAMES MULLOY; Fiscal Year: 2005
    ..The establishment of a small animal model of AML will greatly enhance our ability to develop and test treatment strategies and drugs that may be useful in the therapy of AML. ..
  2. The Role of CBFb-MYH11 in Acute Myeloid Leukemia
    JAMES MULLOY; Fiscal Year: 2007
    ..To identify specific signals that will cooperate in the transformation to acute leukemia, defined genetic elements and saturating retroviral mutagenesis will be used. ..
  3. RUNX-fusion Target Genes in Normal and Leukemic Hematopoiesis
    JAMES MULLOY; Fiscal Year: 2007
    ..Understanding the modulation of the self-renewal process by these fusion proteins could give insight into the normal mechanisms of self-renewal employed by the stem cell. ..
  4. The Role of CBFb-MYH11 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010
    ..To identify specific signals that will cooperate in the transformation to acute leukemia, defined eenetic elements and saturatine retroviral mutaeenesis will be used. ..
  5. The Role of MLL-AF9 in Acute Myeloid Leukemia
    James C Mulloy; Fiscal Year: 2010
    ..RELEVANCE (See instructions): We have recently shown that human blood stem cells can be induced to make leukemia upon introduction ..