Michael L Mucenski

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Beta-catenin regulates differentiation of respiratory epithelial cells in vivo
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L971-9. 2005
  2. ncbi request reprint beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
  3. doi request reprint R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
  4. ncbi request reprint Midkine is regulated by hypoxia and causes pulmonary vascular remodeling
    Paul R Reynolds
    Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:37124-32. 2004
  5. pmc GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium
    Hiroshi Kida
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Pathol 172:1542-54. 2008
  6. ncbi request reprint Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis
    Paul R Reynolds
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 227:227-37. 2003
  7. pmc Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung
    Yutaka Maeda
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 122:4388-400. 2012
  8. pmc Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
    Xueni Chen
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 103:11724-9. 2006
  9. pmc Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression
    Hiromi Yuasa
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    EMBO J 24:1976-87. 2005
  10. pmc The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:1615-25. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Beta-catenin regulates differentiation of respiratory epithelial cells in vivo
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L971-9. 2005
    ....
  2. ncbi request reprint beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  3. doi request reprint R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis
    Sheila M Bell
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Development 135:1049-58. 2008
    ..Interbreeding the Rspo2(Tg) and Lrp6(-) alleles resulted in more severe defects consisting of marked lung hypoplasia and absence of tracheal-bronchial rings, laryngeal structures and all limb skeletal elements...
  4. ncbi request reprint Midkine is regulated by hypoxia and causes pulmonary vascular remodeling
    Paul R Reynolds
    Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Biol Chem 279:37124-32. 2004
    ..These data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1alpha-dependent regulation of MK, enhancing myocardin expression to influence pulmonary vascular gene expression...
  5. pmc GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium
    Hiroshi Kida
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Pathol 172:1542-54. 2008
    ..In the present study, we show that GP130-STAT3 signaling functions in a cell-autonomous manner to restore cell shape and numbers required for repair of the bronchiolar epithelium following injury...
  6. ncbi request reprint Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis
    Paul R Reynolds
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 227:227-37. 2003
    ..TTF-1 regulates expression of MK in the lung. The temporal/spatial distribution of midkine is consistent with a potential role in paracrine signaling during lung morphogenesis...
  7. pmc Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung
    Yutaka Maeda
    Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 122:4388-400. 2012
    ..NKX2-1 inhibited both AP-1 activity and tumor colony formation in vitro. These data demonstrate that NKX2-1 functions in a context-dependent manner in lung tumorigenesis and inhibits Kras(G12D)-driven mucinous pulmonary adenocarcinoma...
  8. pmc Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
    Xueni Chen
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 103:11724-9. 2006
    ..We hypothesize that LPCAT plays a critical role in regulating surfactant phospholipid biosynthesis and suggest that understanding the regulation of LPCAT will offer important insight into surfactant phospholipid biosynthesis...
  9. pmc Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression
    Hiromi Yuasa
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    EMBO J 24:1976-87. 2005
    ..Our results reveal that GATA-2 is presumably one of critical targets for Evi1 and that transcription factors regulate the HSC pool hierarchically...
  10. pmc The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
    Hsi Hsien Lin
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:1615-25. 2005
    ..Peripheral tolerance was restored in F4/80(-/-) mice by adoptive transfer of F4/80(+) APCs in both peripheral tolerance models, indicating a central role for the F4/80 molecule in the generation of efferent CD8(+) T reg cells...