Research Topics
Species | Mark M MitsnefesSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Cardiovascular disease in children with chronic kidney diseaseMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Am Soc Nephrol 23:578-85. 2012..Slowing the progression of CKD, avoiding long-term dialysis and, if possible, conducting preemptive transplantation may represent the best strategies to decrease the risk of premature cardiac disease and death in children with CKD...
Hypertension in pediatric patients on long-term dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)Mark Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Kidney Dis 45:309-15. 2005..Using the North American Pediatric Renal Transplantation Cooperative Study database, we determined the prevalence of hypertension and assessed risk factors for elevated BP during long-term dialysis therapy in children...- Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunctionMark Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Clin J Am Soc Nephrol 2:46-50. 2007..Despite overall elevated adiponectin, overweight patients display lower serum adiponectin levels and might be at risk for future cardiovascular complications... 
Cardiovascular complications of pediatric chronic kidney diseaseMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Pediatr Nephrol 23:27-39. 2008..Recent data indicate that cardiovascular complications are already present in children with CKD. This review summarizes the current literature on cardiac risk factors, mortality and morbidity in children with CKD...- Blood pressure and total peripheral resistance in children with chronic kidney diseaseMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Pediatr Nephrol 20:803-6. 2005.... - Progression of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up studyMark M Mitsnefes
Division of Nephrology and Hypertension and the Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Pediatr 149:671-5. 2006.... - Increasing incidence of post-kidney transplant anemia in childrenMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, OH, USA
Am J Transplant 5:1713-8. 2005.... - Cardiovascular morbidity and mortality in children with chronic kidney disease in North America: lessons from the USRDS and NAPRTCS databasesMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Perit Dial Int 25:S120-2. 2005.... - Cardiac and vascular adaptation in pediatric patients with chronic kidney disease: role of calcium-phosphorus metabolismMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Am Soc Nephrol 16:2796-803. 2005.... - Cardiovascular disease in children with chronic kidney diseaseMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Adv Chronic Kidney Dis 12:397-405. 2005..Early identification of modifiable risk factors and treatment of asymptomatic CVD might lead to decrease of cardiovascular morbidity and mortality in young adults who developed CKD during childhood... - Severe cardiac hypertrophy and long-term dialysis: the Midwest Pediatric Nephrology Consortium studyMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7021, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Pediatr Nephrol 21:1167-70. 2006..We conclude that children on maintenance dialysis are at high risk for future cardiovascular disease... - Hypertension in children and adolescentsMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Pediatr Clin North Am 53:493-512, viii. 2006..Hypertension in children also is viewed as a significant risk factor for the development of cardiovascular disease in adulthood... - Hypertension and end-organ damage in pediatric renal transplantationMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 9039, USA
Pediatr Transplant 8:394-9. 2004..Aggressive treatment of elevated BP is an essential part of Tx care with the goal to delay graft failure and prevent the development of symptomatic cardiovascular disease in young recipients of renal Tx... - Serum cystatin C and left ventricular diastolic dysfunction in children with chronic kidney diseaseMark Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
Pediatr Nephrol 21:1293-8. 2006..0173, P=0.01). We conclude that, in contrast to measured GFR or serum creatinine level, elevated serum cystatin C might be associated with diastolic dysfunction in children with CKD... - Abnormal carotid artery structure and function in children and adolescents with successful renal transplantationMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital, MLC 7022, 3333 Burnet Ave, Cincinnati, Ohio 45229 3039, USA
Circulation 110:97-101. 2004..However, little is known about the extent of these abnormalities in children after transplantation... - Impaired left ventricular diastolic function in children with chronic renal failureMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Kidney Int 65:1461-6. 2004..We compared diastolic function and assessed risk factors associated with diastolic dysfunction in children with CRI with those on dialysis... - Left ventricular mass and systolic performance in pediatric patients with chronic renal failureMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
Circulation 107:864-8. 2003..The aim of this study was to determine the association between LV mass, LV performance, and LV contractility in children with chronic renal insufficiency (CRI) and children undergoing chronic dialysis... - Masked hypertension associates with left ventricular hypertrophy in children with CKDMark Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Am Soc Nephrol 21:137-44. 2010..The high prevalence of masked hypertension and its association with LVH supports early echocardiography and ambulatory BP monitoring to evaluate cardiovascular risk in children with CKD... - Hypertension and progression of chronic renal insufficiency in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)Mark Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Am Soc Nephrol 14:2618-22. 2003..03), acquired cause of renal disease (P = 0.0001), and baseline eGFR <50 ml/min.1.73 m2 (P = 0.0001). Hypertension is a highly significant and independent predictor for progression of CRI in children... - Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney diseaseMark M Mitsnefes
Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
Pediatr Nephrol 22:101-8. 2007..62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR... 
Subclinical systolic dysfunction in pediatric patients with chronic kidney diseaseDonald J Weaver
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr 153:565-9. 2008..Midwall shortening (mwSF) is thought to be a more accurate measure of myocardial performance in the presence of left ventricular hypertrophy (LVH). We examined mwSF in pediatric patients with varying degrees of chronic kidney disease (CKD)...- Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort studyCatherine L Dent
Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
Crit Care 11:R127. 2007..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort... - Abnormal cardiac function in children after renal transplantationMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Am J Kidney Dis 43:721-6. 2004..In adults with a transplant, left ventricular (LV) mass (LVM) is associated with cardiac dysfunction. However, in children with a transplant, the relationship between LVM and LV function has not been evaluated... - Decreased maximal aerobic capacity in pediatric chronic kidney diseaseDonald J Weaver
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Am Soc Nephrol 19:624-30. 2008..These results suggest that aerobic capacity is decreased in the early stages of CKD in children and that lower VO(2) max can be predicted by the presence of diastolic dysfunction, even if systolic function is normal... - Early posttransplantation hypertension and poor long-term renal allograft survival in pediatric patientsMark M Mitsnefes
Division of Nephrology and Hypertension, Department of Pediatrics, University of Cincinnati College of Medicine and The Children s Hospital Research Foundation, Cincinnati, Ohio 45299 3039, USA
J Pediatr 143:98-103. 2003..To evaluate the effect of early hypertension on long-term allograft survival in children with kidney transplantation... - Cardiac output and associated left ventricular hypertrophy in pediatric chronic kidney diseaseDonald J Weaver
Division of Nephrology and Hypertension, Cincinnati Children s Medical Center, Cincinnati, OH 45229, USA
Pediatr Nephrol 24:565-70. 2009..25). The results of this study suggest that increased CO might predispose to increased LVMI in pediatric patients with CKD. Adaptations may be required to meet increased metabolic demand in these patients... - Blood pressure control in pediatric hemodialysis: the Midwest Pediatric Nephrology Consortium StudyGina M Barletta
Division of Pediatric Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Nephrol 22:547-53. 2007..Especially poor BP control was found in younger children; those patients who do not reach their posttreatment weight goals, perhaps reflecting their hypervolemic state; and those who have higher serum phosphorus levels... - Prevalence and correlates of multiple cardiovascular risk factors in children with chronic kidney diseaseAmy C Wilson
Division of Nephrology and Hypertension, J W Riley Hospital for Children, Indianapolis, IN 46202, USA
Clin J Am Soc Nephrol 6:2759-65. 2011..This study determined the prevalence and characteristics of multiple CVRF in children in the Chronic Kidney Disease in Children study... - Body mass index and allograft function in pediatric renal transplantationMark M Mitsnefes
Division of Nephrology, Department of Pediatrics, University of Cincinnati College of Medicine and The Children s Hospital Research Foundation TCHRF 5, Ohio 45229 3039, USA
Pediatr Nephrol 17:535-9. 2002..01) than children from other groups. We conclude that pre-Tx obesity is associated with decreased GFR in children at 1 year after Tx. The reason may be persistence or development of post-Tx hypertension in severely obese patients... - Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: roles of proteinuria and Fas-dependent pathwaysElif Erkan
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Am Soc Nephrol 16:398-407. 2005..The results indicate that an elevated tubule cell apoptosis rate at the time of initial biopsy represents an independent predictor of progression to ESRD in patients with early FSGS... - Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapyMai T Nguyen
Department of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Nephrol 23:1317-26. 2008..We concluded that urinary aprotinin levels 2 h after initiation of CPB predict the development of AKI and adverse clinical outcomes... - Management of blood pressure in childrenRossana Malatesta-Muncher
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Curr Opin Nephrol Hypertens 21:318-22. 2012.... - Office and ambulatory blood pressure elevation in children with chronic renal failureMark M Mitsnefes
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
Pediatr Nephrol 18:145-9. 2003..These results confirm a high prevalence of blood pressure abnormalities using ABPM criteria in children with CRI and suggest that ABP may better predict end-organ damage in these patients than casual BP... - Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgeryJaya Mishra
Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
Lancet 365:1231-8. 2005..00, and specificity was 0.98 for a cutoff value of 50 microg/L. INTERPRETATION: Concentrations in urine and serum of NGAL represent sensitive, specific, and highly predictive early biomarkers for acute renal injury after cardiac surgery... - High prevalence of the metabolic syndrome and associated left ventricular hypertrophy in pediatric renal transplant recipientsAmy C Wilson
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Pediatr Transplant 14:52-60. 2010..2-5.9). In conclusion: metabolic syndrome is common at time of pediatric kidney transplant, and prevalence rises sharply at one-yr post-transplant. The presence of metabolic syndrome is strongly associated with LVH in these patients... - Left ventricular hypertrophy in pediatric kidney transplant recipients: long-term follow-up studyNathan Bullington
Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Pediatr Transplant 10:811-5. 2006..The results of the study suggest that despite regression of LVM index overtime-pediatric patients post-kidney transplant are at continuous risk for developing cardiovascular disease... - Cardiovascular disease in CKD in children: update on risk factors, risk assessment, and managementAmy C Wilson
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Am J Kidney Dis 54:345-60. 2009..The purpose of this review is to provide an update of recent advances in the understanding and management of cardiovascular disease risks in this population... - Hypertension and CKDRene G Vandevoorde
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Adv Chronic Kidney Dis 18:355-61. 2011.... - Ambulatory blood pressure monitoring in pediatric renal transplantationMark M Mitsnefes
Department of Pediatrics, Division of Nephrology and Hypertension, University of Cincinnati College of Medicine and The Children's Hospital Research Foundation, Cincinnati, OH, USA
Pediatr Transplant 7:86-92. 2003..We will review the importance of hypertension in this patient subset, discuss the advantage of ABPM over CBP and focus on specific abnormalities and clinical significance of ABPM in renal transplant recipients... - Hyperinsulinemia in pediatric patients with chronic kidney disease: the role of tumor necrosis factor-alphaHsiao L Lai
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Pediatr Nephrol 22:1751-6. 2007..11, P = 0.01). We conclude that hyperinsulinemia and insulin resistance are frequent in pediatric CKD. In lean patients inflammation appears to be an important determinant of serum insulin level... - Flow-mediated vasodilatation of the brachial artery in children with chronic kidney diseaseAmy C Wilson
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Pediatr Nephrol 23:1297-302. 2008..In conclusion, children with CKD stage 2-4 appear to have increased prevalence of decreased FMD of the brachial artery. However, our study identified few significant factors associated with low FMD in children with CKD... - Serum adiponectin complexes and cardiovascular risk in children with chronic kidney diseaseMegan M Lo
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Pediatr Nephrol 26:2009-17. 2011..This imbalance may be an important biomarker for increased cardiovascular risk despite higher levels of total adiponectin in children with CKD... - Racial differences in graft survival: a report from the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)Abiodun Omoloja
Department of Pediatric Nephrology, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA
Clin J Am Soc Nephrol 2:524-8. 2007..65; 95% confidence interval 1.46 to 1.86). Significant racial differences in kidney transplant outcomes exist among pediatric patients even after controlling for confounding factors... - Advances in the pathogenesis and management of hypertensive crisisHiren P Patel
Department of Pediatrics, Children's Hospital, The Ohio State University School of Medicine and Public Health, Columbus, Ohio, USA
Curr Opin Pediatr 17:210-4. 2005.... - Evaluation of hypertension by the general pediatricianMai Nguyen
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Curr Opin Pediatr 19:165-9. 2007..To summarize the recommended work-up in a child who presents with elevated blood pressure as well as innovative evaluation techniques under development... - Racial differences in pediatric renal transplantation-24-year single center experienceAbiodun Omoloja
Department of Pediatrics, Wright State University School of Medicine, Dayton, OH, USA
J Natl Med Assoc 98:154-7. 2006..Significant racial differences were noted in number of pre-emptive transplants, type of graft received, height at transplant and causes of ESRD... - Kidney NGAL is a novel early marker of acute injury following transplantationJaya Mishra
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Nephrol 21:856-63. 2006..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation... - NGAL is an early predictive biomarker of contrast-induced nephropathy in childrenRussel Hirsch
Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Nephrol 22:2089-95. 2007..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN... - Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injuryJaya Mishra
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Am Soc Nephrol 14:2534-43. 2003..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury... - Neonatal renovascular hypertension due to prenatal traumatic retroperitoneal hematomaBradley P Dixon
Department of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Pediatr Nephrol 20:670-2. 2005..Likewise, attention must be drawn to the classic presentation of congestive heart failure in a child with severe hypertension... - Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injuryM Patricia Castaneda
Division of Nephrology, Children's Hospital at Montefiore, Bronx, New York, USA
Transplantation 76:50-4. 2003..CONCLUSIONS: Ischemia-reperfusion injury in CAD kidney transplants is associated with a duration-dependent increase in tubular cell apoptosis, mediated at least in part by activation of mitochondrial pathways... - Ambulatory blood pressure monitoring: a quest for truthMark M Mitsnefes
Pediatr Transplant 11:10-3. 2007 - Obesity and renal transplant outcome: a report of the North American Pediatric Renal Transplant Cooperative StudyCoral D Hanevold
Medical College of Georgia, Augusta, Georgia, USA
Pediatrics 115:352-6. 2005..CONCLUSIONS: Obesity is an increasing problem in children who present for transplantation and may have an adverse effect on allograft and patient survival... - Pediatric end-stage renal disease: heart as a targetMark M Mitsnefes
J Pediatr 141:162-4. 2002 - Understanding carotid artery intima-media thickness in childhood: lessons from studies in children with renal transplantsMark M Mitsnefes
Pediatr Transplant 12:377-80. 2008 - Hyperphosphatemia in children receiving peritoneal dialysis--an educational programRichard T Blaszak
Division of Nephrology, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital, 800 Marshall Street, Little Rock, AR 72202 3591, USA
Pediatr Nephrol 20:967-71. 2005.... - Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney And Cardiovascular Disease Council; the Councils on High Blood Pressure Research, CardiovascFrank C Brosius
Circulation 114:1083-7. 2006..All patients with cardiovascular disease should be screened for evidence of kidney disease with these two determinations...
Research Grants
- Cardiac disease in children with chronic renal failureMark Mitsnefes; Fiscal Year: 2006..Thus, the long-term goal will be to decrease the incidence and prevalence of cardiovascular disease in young adults who developed chronic renal disease during childhood. ..
- Adiponectin and Cardiovascular Disease in the CKiD ChildrenMark Mitsnefes; Fiscal Year: 2007....
- Adiponectin and Cardiovascular Disease in the CKiD ChildrenMark Mitsnefes; Fiscal Year: 2009....
- Adiponectin and Cardiovascular Disease in the CKiD ChildrenMark Mitsnefes; Fiscal Year: 2009....