Anil Mishra

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Mechanism of eosinophilic esophagitis
    Anil Mishra
    Department of Pediatrics, Division of Allergy and Immunology, 3333 Burnnet Avenue, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Immunol Allergy Clin North Am 29:29-40, viii. 2009
  2. ncbi request reprint Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 31:257-65. 2004
  3. ncbi request reprint Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 293:L305-13. 2007
  4. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
  5. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
  6. ncbi request reprint Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
  7. ncbi request reprint Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice
    Anil Mishra
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
    J Leukoc Biol 81:916-24. 2007
  8. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
  9. ncbi request reprint Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 125:1419-27. 2003
  10. pmc Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1863-74. 2003

Collaborators

Detail Information

Publications22

  1. pmc Mechanism of eosinophilic esophagitis
    Anil Mishra
    Department of Pediatrics, Division of Allergy and Immunology, 3333 Burnnet Avenue, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Immunol Allergy Clin North Am 29:29-40, viii. 2009
    ....
  2. ncbi request reprint Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma
    Nina E King
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinatti College of Medicine, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 31:257-65. 2004
    ..Taken together with the role of ADAM33 in asthma, these results suggest that allergic lung responses involve the interplay of diverse members of the ADAM family...
  3. ncbi request reprint Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 293:L305-13. 2007
    ..In vitro experiments demonstrated that RELM-beta had fibroblast motogenic activity. These results identify RELM-beta as a Th2-associated cytokine with potent inflammatory and remodeling activity...
  4. ncbi request reprint Expression and regulation of small proline-rich protein 2 in allergic inflammation
    Nives Zimmermann
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 32:428-35. 2005
    ..Thus, SPRR2 is an allergen- and IL-13-induced gene in experimental allergic responses that may be involved in disease pathophysiology...
  5. pmc Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9)
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 101:1987-92. 2004
    ..The identification of a naturally occurring eosinophil inhibitory chemokine pathway in vivo provides a strategic basis for future therapeutic consideration...
  6. ncbi request reprint Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 172:1815-24. 2004
    ..These results provide unprecedented insight into the complex steps involved in the pathogenesis of allergic airway responses; as such, these results have significant therapeutic and clinical implications...
  7. ncbi request reprint Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice
    Anil Mishra
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, College of Medicine, OH 45229, USA
    J Leukoc Biol 81:916-24. 2007
    ..Taken together, these studies indicate a role for CD4+ and CD4- cell populations in EE pathogenesis and demonstrate that experimental allergen-induced EE is dependent on adaptive T cell immunity...
  8. pmc Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia
    Anil Mishra
    Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 134:204-14. 2008
    ..We hypothesized that the development of EE in patients and in an experimental murine model would be associated with eosinophil-mediated tissue remodeling...
  9. ncbi request reprint Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Gastroenterology 125:1419-27. 2003
    ..We aimed to determine whether delivery of a Th2 cytokine (interleukin [IL]-13) to the lung was sufficient for induction of EE...
  10. pmc Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1863-74. 2003
    ..Based on the ability of arginase to regulate generation of NO, polyamines, and collagen, these results provide a basis for pharmacologically targeting arginine metabolism in allergic disorders...
  11. ncbi request reprint IL-5 promotes eosinophil trafficking to the esophagus
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 168:2464-9. 2002
    ..In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus...
  12. ncbi request reprint Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses
    Hiroko Saito Akei
    Divisions of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:62-9. 2006
    ..The skin is often the first organ that manifests allergic disease and may provide an early entry point for antigen sensitization...
  13. ncbi request reprint Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice
    Xiang Zhu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:182-93.e7. 2010
    ....
  14. ncbi request reprint Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice
    Hiroko Saito Akei
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 129:985-94. 2005
    ..Data are emerging that atopic skin may provide an early entry point for antigen sensitization. We aimed to test the hypothesis that epicutaneous exposure to antigen primes for subsequent respiratory antigen-induced EE...
  15. pmc Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice
    Madhavi Rayapudi
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, 3333 Burnet Ave, MLC 7028, Cincinnati, OH 45229, USA
    J Leukoc Biol 88:337-46. 2010
    ..These experimental studies are in accordance with clinical data but may have some limitations inherent to animal models of human disease...
  16. pmc Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:536-47. 2006
    ..Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis...
  17. pmc An imbalance of esophageal effector and regulatory T cell subsets in experimental eosinophilic esophagitis in mice
    Xiang Zhu
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Am J Physiol Gastrointest Liver Physiol 297:G550-8. 2009
    ..In conclusion, our results suggest that local regulatory interaction of CD45RB(high) and CD45RB(low) CD4(+) T cells may be required for protective and pathogenic immunity in EE...
  18. pmc Significance of para-esophageal lymph nodes in food or aeroallergen-induced iNKT cell-mediated experimental eosinophilic esophagitis
    Priya Rajavelu
    Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Gastrointest Liver Physiol 302:G645-54. 2012
    ..Thus we provide evidence that para-esophageal lymph nodes are involved in food- or aeroallergen-induced eosinophilia and patchy EoE pathogenesis, likely a mechanism dependent on eotaxins and iNKT cells...
  19. pmc Esophageal functional impairments in experimental eosinophilic esophagitis
    Parm Mavi
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, OH 45229, USA
    Am J Physiol Gastrointest Liver Physiol 302:G1347-55. 2012
    ..Collectively, our present study directly implicates chronic eosinophilic inflammation in the development of the esophageal structural impairments of experimental EoE...
  20. ncbi request reprint Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung
    Nikolaos M Nikolaidis
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7028 Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 29:458-64. 2003
    ....
  21. pmc Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Allergy Clin Immunol 118:257-68. 2006
    ..Resistin-like molecule (RELM) beta is a cysteine-rich cytokine expressed in the gastrointestinal tract and implicated in insulin resistance and gastrointestinal nematode immunity; however, its function primarily remains an enigma...
  22. ncbi request reprint Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking
    Anil Mishra
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:4406-12. 2002
    ....

Research Grants7

  1. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2006
    ..This proposed study would provide new insight into eosinophil-induced esophageal inflammation, enabling us to develop novel approaches to treating eosinophil-associated esophageal diseases. ..
  2. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2007
    ..This proposed study would provide new insight into eosinophil-induced esophageal inflammation, enabling us to develop novel approaches to treating eosinophil-associated esophageal diseases. ..
  3. Role of IL-15 in the Pathogensis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2009
    ..The goal of our proposed study is to identify a target molecule for EE therapy by examining the role of IL-15 and iNKT cells in the pathogenesis of EE. ..
  4. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2009
    ..This proposed study would provide new insight into eosinophil-induced esophageal inflammation, enabling us to develop novel approaches to treating eosinophil-associated esophageal diseases. ..
  5. Mechanistic Analysis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2009
    ..This proposed study would provide new insight into eosinophil-induced esophageal inflammation, enabling us to develop novel approaches to treating eosinophil-associated esophageal diseases. ..
  6. Role of IL-15 in the Pathogensis of Eosinophilic Esophagitis
    Anil Mishra; Fiscal Year: 2010
    ..The goal of our proposed study is to identify a target molecule for EE therapy by examining the role of IL-15 and iNKT cells in the pathogenesis of EE. ..