Research Topics
| Michael V MilesSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Coenzyme Q10 changes are associated with metabolic syndromeMichael V Miles
Division of Cardiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 344:173-9. 2004..The purpose of this study was to determine whether coenzyme Q10 (CoQ) concentrations and redox status are associated with components of the metabolic syndrome...- Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21Michael V Miles
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, Cincinnati, OH 45229 3039, USA
Pediatr Neurol 37:398-403. 2007..Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21... - Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trialMichael V Miles
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
Pediatr Neurol 35:30-7. 2006.... - The uptake and distribution of coenzyme Q10Michael V Miles
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Mitochondrion 7:S72-7. 2007..Improved CoQ10 dosing and drug level monitoring guidelines are suggested for adult and pediatric patient populations. Future CoQ10 research should consider uptake and distribution factors to determine cost-benefit relationships... - Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adultsMichael V Miles
Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 347:139-44. 2004.... 
Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficienciesMichael V Miles
Department of Pediatrics, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Mitochondrion 8:170-80. 2008..Determination of muscle coenzyme Q10 deficiency in children with suspected mitochondrial disease may facilitate diagnosis and encourage earlier supplementation of this agent...- Feasibility and limitations of oxcarbazepine monitoring using salivary monohydroxycarbamazepine (MHD)Michael V Miles
Department of Pediatrics, University of Cincinnati Medical Center, and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Ther Drug Monit 26:300-4. 2004..It is also recommended to avoid saliva collection within 8 hours after OXC dosing to allow complete absorption and transformation of the parent drug... - Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood plateletsMichael V Miles
Department of Pediatrics and Division of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Biomed Chromatogr 22:1403-8. 2008.... - Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergiesMichael V Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Mitochondrion 11:127-35. 2011..69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression... - Enzyme inducing antiepileptic drugs are associated with mitochondrial proliferation and increased cytochrome c oxidase activity in muscle of children with epilepsyMichael V Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, ML 1010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Epilepsy Res 98:76-87. 2012..To evaluate the effects of epilepsy-related factors associated with mitochondrial pathology and function in skeletal muscle of children with suspected mitochondrial disorders... - Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adultsMichael V Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3030, USA
Clin Chim Acta 332:123-32. 2003..The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q(10) for self-reported healthy adults... - Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stressLili Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, United States
Clin Chim Acta 360:87-96. 2005.... - Muscle coenzyme Q: a potential test for mitochondrial activity and redox statusLili Miles
Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Pediatr Neurol 32:318-24. 2005..This study suggests that total CoQ concentration provides a new method for estimating mitochondrial activity in biopsy muscle; and that the muscle CoQ test is feasible and potentially useful for diagnosing CoQ deficiency states... - Topiramate concentration in saliva: an alternative to serum monitoringMichael V Miles
Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Pediatr Neurol 29:143-7. 2003..8% +/- 12.1% (range 62.9% to 112.7%). The results of this study support the use of saliva as a viable alternative to serum for monitoring topiramate therapy. Topiramate concentration in saliva: an alternative to serum monitoring... - Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detectionPeter H Tang
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 341:173-84. 2004..However, previous methods are unreliable for estimating CoQ(10) redox status in tissue. We developed an accurate method for measuring tissue concentrations of reduced and oxidized coenzyme Q (CoQ)... - Importance of muscle light microscopic mitochondrial subsarcolemmal aggregates in the diagnosis of respiratory chain deficiencyLili Miles
Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, ML 1010, Cincinnati, OH 45229 3039, USA
Hum Pathol 43:1249-57. 2012.... - Measurement of oxidized and reduced coenzyme Q in biological fluids, cells, and tissues: an HPLC-EC methodPeter H Tang
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Methods Mol Biol 837:149-68. 2012.... - Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatographyPeter H Tang
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Biomed Chromatogr 20:1336-43. 2006..Coefficients of variations (CVs) for intra-day and inter-day assay precisions were less than 5%. A total of 194 breast milk samples were analyzed for the CoQ(10) concentration; the mean value was 0.32 +/- 0.21 micromol L(-1)... 
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitisRohit Kohli
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Hepatology 52:934-44. 2010....- Anticoagulant effects on plasma coenzyme Q(10) estimated by HPLC with coulometric detectionPeter H Tang
Division of Pediatric Neurology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Chim Acta 318:127-31. 2002..However, the ranges for Q(10)H(2):TQ(10) ratio from previous reports are quite variable. Sample handling and preparation appear to have a profound effect on the stability of Q(10)H(2)... - Feasibility and acceptance of salivary monitoring of antiepileptic drugs via the US Postal ServiceMichael Tennison
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Ther Drug Monit 26:295-9. 2004..Patients prefer and can successful collect saliva samples at home. Home monitoring of salivary antiepileptic drug levels is a cost-effective technique that deserves additional study... - Correlation of lamotrigine concentrations between serum and salivaMelody Ryan
University of Kentucky Chandler Medical Center, Lexington 40536-0293, USA
Pharmacotherapy 23:1550-7. 2003..However, there is wide interpatient variability in the saliva:serum ratio. The data suggest that salivary monitoring may play a role in the monitoring of lamotrigine for adult and pediatric patients... - Correlation of levetiracetam concentrations between serum and salivaShellee A Grim
University of Kentucky Chandler Medical Center, Lexington, USA
Ther Drug Monit 25:61-6. 2003..No published data exist for levetiracetam (LEV) to the authors' knowledge. This study's objective is to determine the correlation between LEV serum and saliva concentrations... - Stability of salivary concentrations of the newer antiepileptic drugs in the postal systemMikael D Jones
University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
Ther Drug Monit 27:576-9. 2005..90, and ZNS rs = 1). Saliva samples mailed by patients maintain stability and can be returned in a reasonable length of time. Further studies are needed to assess patient/caretaker capability of obtaining an adequate sample... - Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseasesPaul E Steele
Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center and University of Cincinnati 45229-3039, USA
Am J Clin Pathol 121:S113-20. 2004..Defining patient subpopulations and characteristics that predict benefit from exogenous Q10 and defining therapeutic ranges for those particular applications are major challenges in this field...