Michael V Miles

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Coenzyme Q10 changes are associated with metabolic syndrome
    Michael V Miles
    Division of Cardiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 344:173-9. 2004
  2. ncbi request reprint Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Neurol 37:398-403. 2007
  3. doi request reprint Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets
    Michael V Miles
    Department of Pediatrics and Division of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Biomed Chromatogr 22:1403-8. 2008
  4. doi request reprint Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies
    Michael V Miles
    Department of Pediatrics, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mitochondrion 8:170-80. 2008
  5. ncbi request reprint The uptake and distribution of coenzyme Q10
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mitochondrion 7:S72-7. 2007
  6. ncbi request reprint Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Pediatr Neurol 35:30-7. 2006
  7. ncbi request reprint Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults
    Michael V Miles
    Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 347:139-44. 2004
  8. doi request reprint Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Mitochondrion 11:127-35. 2011
  9. ncbi request reprint Feasibility and limitations of oxcarbazepine monitoring using salivary monohydroxycarbamazepine (MHD)
    Michael V Miles
    Department of Pediatrics, University of Cincinnati Medical Center, and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Ther Drug Monit 26:300-4. 2004
  10. doi request reprint Enzyme inducing antiepileptic drugs are associated with mitochondrial proliferation and increased cytochrome c oxidase activity in muscle of children with epilepsy
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, ML 1010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Epilepsy Res 98:76-87. 2012

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Coenzyme Q10 changes are associated with metabolic syndrome
    Michael V Miles
    Division of Cardiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 344:173-9. 2004
    ..The purpose of this study was to determine whether coenzyme Q10 (CoQ) concentrations and redox status are associated with components of the metabolic syndrome...
  2. ncbi request reprint Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Neurol 37:398-403. 2007
    ..Further studies are needed to determine whether correction of this oxidant imbalance improves clinical outcomes of children with trisomy 21...
  3. doi request reprint Validation and application of an HPLC-EC method for analysis of coenzyme Q10 in blood platelets
    Michael V Miles
    Department of Pediatrics and Division of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Biomed Chromatogr 22:1403-8. 2008
    ....
  4. doi request reprint Systematic evaluation of muscle coenzyme Q10 content in children with mitochondrial respiratory chain enzyme deficiencies
    Michael V Miles
    Department of Pediatrics, University of Cincinnati, College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mitochondrion 8:170-80. 2008
    ..Determination of muscle coenzyme Q10 deficiency in children with suspected mitochondrial disease may facilitate diagnosis and encourage earlier supplementation of this agent...
  5. ncbi request reprint The uptake and distribution of coenzyme Q10
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mitochondrion 7:S72-7. 2007
    ..Improved CoQ10 dosing and drug level monitoring guidelines are suggested for adult and pediatric patient populations. Future CoQ10 research should consider uptake and distribution factors to determine cost-benefit relationships...
  6. ncbi request reprint Coenzyme Q10 absorption and tolerance in children with Down syndrome: a dose-ranging trial
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Pediatr Neurol 35:30-7. 2006
    ....
  7. ncbi request reprint Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults
    Michael V Miles
    Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 347:139-44. 2004
    ....
  8. doi request reprint Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Mitochondrion 11:127-35. 2011
    ..69; p = 0.012; n = 23). Children with recurrent food intolerance and allergies may acquire CoQ10 deficiency with disease progression...
  9. ncbi request reprint Feasibility and limitations of oxcarbazepine monitoring using salivary monohydroxycarbamazepine (MHD)
    Michael V Miles
    Department of Pediatrics, University of Cincinnati Medical Center, and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Ther Drug Monit 26:300-4. 2004
    ..It is also recommended to avoid saliva collection within 8 hours after OXC dosing to allow complete absorption and transformation of the parent drug...
  10. doi request reprint Enzyme inducing antiepileptic drugs are associated with mitochondrial proliferation and increased cytochrome c oxidase activity in muscle of children with epilepsy
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, ML 1010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Epilepsy Res 98:76-87. 2012
    ..To evaluate the effects of epilepsy-related factors associated with mitochondrial pathology and function in skeletal muscle of children with suspected mitochondrial disorders...
  11. ncbi request reprint Ubiquinol: a potential biomarker for tissue energy requirements and oxidative stress
    Lili Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, United States
    Clin Chim Acta 360:87-96. 2005
    ....
  12. ncbi request reprint Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults
    Michael V Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3030, USA
    Clin Chim Acta 332:123-32. 2003
    ..The purpose of this study is to determine the reference intervals of plasma concentrations of ubiquinone-10, ubiquinol-10, and total coenzyme Q(10) for self-reported healthy adults...
  13. ncbi request reprint Muscle coenzyme Q: a potential test for mitochondrial activity and redox status
    Lili Miles
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Neurol 32:318-24. 2005
    ..This study suggests that total CoQ concentration provides a new method for estimating mitochondrial activity in biopsy muscle; and that the muscle CoQ test is feasible and potentially useful for diagnosing CoQ deficiency states...
  14. ncbi request reprint Topiramate concentration in saliva: an alternative to serum monitoring
    Michael V Miles
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Neurol 29:143-7. 2003
    ..8% +/- 12.1% (range 62.9% to 112.7%). The results of this study support the use of saliva as a viable alternative to serum for monitoring topiramate therapy. Topiramate concentration in saliva: an alternative to serum monitoring...
  15. ncbi request reprint Measurement of reduced and oxidized coenzyme Q9 and coenzyme Q10 levels in mouse tissues by HPLC with coulometric detection
    Peter H Tang
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 341:173-84. 2004
    ..However, previous methods are unreliable for estimating CoQ(10) redox status in tissue. We developed an accurate method for measuring tissue concentrations of reduced and oxidized coenzyme Q (CoQ)...
  16. doi request reprint Importance of muscle light microscopic mitochondrial subsarcolemmal aggregates in the diagnosis of respiratory chain deficiency
    Lili Miles
    Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, ML 1010, Cincinnati, OH 45229 3039, USA
    Hum Pathol 43:1249-57. 2012
    ....
  17. doi request reprint Measurement of oxidized and reduced coenzyme Q in biological fluids, cells, and tissues: an HPLC-EC method
    Peter H Tang
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Biol 837:149-68. 2012
    ....
  18. ncbi request reprint Determination of coenzyme Q10 in human breast milk by high-performance liquid chromatography
    Peter H Tang
    Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Biomed Chromatogr 20:1336-43. 2006
    ..Coefficients of variations (CVs) for intra-day and inter-day assay precisions were less than 5%. A total of 194 breast milk samples were analyzed for the CoQ(10) concentration; the mean value was 0.32 +/- 0.21 micromol L(-1)...
  19. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
    ..001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice...
  20. doi request reprint Interaction between akt1-positive neurons and age at surgery is associated with surgical outcome in children with isolated focal cortical dysplasia
    Lili Miles
    Divisions of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Neuropathol Exp Neurol 72:884-91. 2013
    ....
  21. ncbi request reprint Anticoagulant effects on plasma coenzyme Q(10) estimated by HPLC with coulometric detection
    Peter H Tang
    Division of Pediatric Neurology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Chim Acta 318:127-31. 2002
    ..However, the ranges for Q(10)H(2):TQ(10) ratio from previous reports are quite variable. Sample handling and preparation appear to have a profound effect on the stability of Q(10)H(2)...
  22. ncbi request reprint Feasibility and acceptance of salivary monitoring of antiepileptic drugs via the US Postal Service
    Michael Tennison
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Ther Drug Monit 26:295-9. 2004
    ..Patients prefer and can successful collect saliva samples at home. Home monitoring of salivary antiepileptic drug levels is a cost-effective technique that deserves additional study...
  23. ncbi request reprint Correlation of lamotrigine concentrations between serum and saliva
    Melody Ryan
    University of Kentucky Chandler Medical Center, Lexington 40536 0293, USA
    Pharmacotherapy 23:1550-7. 2003
    ..To compare the relationship between serum and salivary concentrations of lamotrigine in pediatric and adult epilepsy populations...
  24. ncbi request reprint Correlation of levetiracetam concentrations between serum and saliva
    Shellee A Grim
    University of Kentucky Chandler Medical Center, Lexington, USA
    Ther Drug Monit 25:61-6. 2003
    ..No published data exist for levetiracetam (LEV) to the authors' knowledge. This study's objective is to determine the correlation between LEV serum and saliva concentrations...
  25. ncbi request reprint Stability of salivary concentrations of the newer antiepileptic drugs in the postal system
    Mikael D Jones
    University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536, USA
    Ther Drug Monit 27:576-9. 2005
    ..90, and ZNS rs = 1). Saliva samples mailed by patients maintain stability and can be returned in a reasonable length of time. Further studies are needed to assess patient/caretaker capability of obtaining an adequate sample...
  26. ncbi request reprint Clinical laboratory monitoring of coenzyme Q10 use in neurologic and muscular diseases
    Paul E Steele
    Department of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center and University of Cincinnati 45229 3039, USA
    Am J Clin Pathol 121:S113-20. 2004
    ..Defining patient subpopulations and characteristics that predict benefit from exogenous Q10 and defining therapeutic ranges for those particular applications are major challenges in this field...