Jochen Mattner

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Liver autoimmunity triggered by microbial activation of natural killer T cells
    Jochen Mattner
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 3:304-15. 2008
  2. ncbi Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein
    Yuval Sagiv
    Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 177:26-30. 2006
  3. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
  4. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
  5. ncbi Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties
    Yang Liu
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA
    Bioorg Med Chem Lett 18:3052-5. 2008
  6. ncbi c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:308-16. 2008
  7. ncbi Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids
    Xiangtian Long
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, Utah 84602, USA
    Nat Chem Biol 3:559-64. 2007
  8. ncbi A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells
    Yang Liu
    Brigham Young University, Provo, UT 84602, USA
    J Immunol Methods 312:34-9. 2006
  9. ncbi NKT cells mediate organ-specific resistance against Leishmania major infection
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Germany
    Microbes Infect 8:354-62. 2006
  10. ncbi Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    Dirk M Zajonc
    Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:810-8. 2005

Research Grants

  1. Primary biliary cirrhosis: molecular genetics and microbial pathogenesis
    Jochen Mattner; Fiscal Year: 2009
  2. Primary biliary cirrhosis: molecular genetics and microbial pathogenesis
    Jochen Mattner; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Liver autoimmunity triggered by microbial activation of natural killer T cells
    Jochen Mattner
    Howard Hughes Medical Institute, Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 3:304-15. 2008
    ....
  2. ncbi Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein
    Yuval Sagiv
    Committee on Immunology, Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 177:26-30. 2006
    ..These findings reveal a blockade of lipid trafficking between endosome and lysosome as a consequence of NPC1 deficiency and suggest a common mechanism for the defects in lipid presentation and development of Valpha14-Jalpha18 NKT cells...
  3. ncbi Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
    Jochen Mattner
    Committee on Immunology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 434:525-9. 2005
    ..These findings identify two novel antigenic targets of NKT cells in antimicrobial defence, and show that glycosylceramides are an alternative to LPS for innate recognition of the Gram-negative, LPS-negative bacterial cell wall...
  4. ncbi Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity...
  5. ncbi Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties
    Yang Liu
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA
    Bioorg Med Chem Lett 18:3052-5. 2008
    ..We found that substitution did not significantly impact glycosidase activity or loading into CD1d...
  6. ncbi c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Infect Immun 76:308-16. 2008
    ..Collectively, these findings provide strong evidence that JNK2 is an important regulatory protein for IFN-gamma secretion upon challenge with A. phagocytophilum...
  7. ncbi Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids
    Xiangtian Long
    Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, Utah 84602, USA
    Nat Chem Biol 3:559-64. 2007
    ....
  8. ncbi A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells
    Yang Liu
    Brigham Young University, Provo, UT 84602, USA
    J Immunol Methods 312:34-9. 2006
    ..We have developed an alpha-galactosyl ceramide with improved solubility over KRN7000 that effectively stains NKT cells, both mouse and human, and stimulates cytokine release at low concentrations...
  9. ncbi NKT cells mediate organ-specific resistance against Leishmania major infection
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Germany
    Microbes Infect 8:354-62. 2006
    ..Thus, NKT cells fulfill organ-specific protective functions during infection with L. major, but are not essential for parasite control...
  10. ncbi Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
    Dirk M Zajonc
    Department of Molecular Biology and The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 6:810-8. 2005
    ....
  11. ncbi Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells
    Randal D Goff
    Brigham Young University, Provo, Utah 84602, USA
    J Am Chem Soc 126:13602-3. 2004
    ..In similar fashion, the length of the acyl chain in alpha-galactosylceramides influences cytokine release profiles...
  12. ncbi Protection against progressive leishmaniasis by IFN-beta
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:7574-82. 2004
    ..These results identify IFN-beta as a novel cytokine with a strong, dose-dependent protective effect against progressive cutaneous leishmaniasis that results from IL-12- and STAT4-dependent as well as -independent events...
  13. ncbi Control of Leishmania major in the absence of Tyk2 kinase
    Ulrike Schleicher
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 34:519-29. 2004
    ..Thus, Tyk2 is required for the IL-12 response of NK cells and CD8(+) T cells in L. major-infected mice, but not for the generation of Th1 cells and the ultimate control of the disease...

Research Grants2

  1. Primary biliary cirrhosis: molecular genetics and microbial pathogenesis
    Jochen Mattner; Fiscal Year: 2009
    ....
  2. Primary biliary cirrhosis: molecular genetics and microbial pathogenesis
    Jochen Mattner; Fiscal Year: 2010
    ....