L J Martin

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Endocrinol Metab 90:4255-9. 2005
  2. pmc Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
  3. pmc Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach
    Lili Ding
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S10. 2011
  4. pmc Population structure analysis using rare and common functional variants
    Tesfaye M Baye
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S8. 2011
  5. pmc Quantitative criteria for improving performance of buccal DNA for high-throughput genetic analysis
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    BMC Genet 13:75. 2012
  6. pmc Family- and population-based designs identify different rare causal variants
    Xue Zhang
    Divisions of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S36. 2011
  7. pmc Effect of population stratification analysis on false-positive rates for common and rare variants
    Hua He
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Proc 5:S116. 2011
  8. pmc Comparison of measures of marker informativeness for ancestry and admixture mapping
    Lili Ding
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    BMC Genomics 12:622. 2011
  9. pmc Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes
    Lisa J Martin
    Divisions of Human Genetics and Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e34614. 2012
  10. pmc The effect of minor allele frequency on the likelihood of obtaining false positives
    Meredith E Tabangin
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Mail Code 5041, Cincinnati, Ohio 45229, USA
    BMC Proc 3:S41. 2009

Collaborators

Detail Information

Publications80

  1. ncbi request reprint The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Endocrinol Metab 90:4255-9. 2005
    ..Because adiponectin is secreted by adipocytes, it may also act locally to counteract insulin resistance and dyslipidemia worsened by inflammation...
  2. pmc Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations
    Lili Ding
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Hum Genomics 7:16. 2013
    ..We performed genome-wide association studies on 859,790 SNPs genotyped in 527 affected offspring trios of European, African, and Hispanic ancestry using publically available asthma database in the Genotypes and Phenotypes database...
  3. pmc Detection of associations with rare and common SNPs for quantitative traits: a nonparametric Bayes-based approach
    Lili Ding
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S10. 2011
    ..We conclude that our method provides a novel and broadly applicable strategy for obtaining association results with a reasonably low proportion of false discovery and that it can be routinely used in resequencing studies...
  4. pmc Population structure analysis using rare and common functional variants
    Tesfaye M Baye
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S8. 2011
    ....
  5. pmc Quantitative criteria for improving performance of buccal DNA for high-throughput genetic analysis
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    BMC Genet 13:75. 2012
    ..phs.wfubmc.edu/public/index.cfm)...
  6. pmc Family- and population-based designs identify different rare causal variants
    Xue Zhang
    Divisions of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    BMC Proc 5:S36. 2011
    ..Family-based and population-based study designs can be complementary in the identification of rare causal variants and should be considered in future studies...
  7. pmc Effect of population stratification analysis on false-positive rates for common and rare variants
    Hua He
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Proc 5:S116. 2011
    ..Taken together, these results suggest that sequence-level data should be interpreted with caution, because extremely rare SNPs may exhibit sporadic association that is not controlled using PCA...
  8. pmc Comparison of measures of marker informativeness for ancestry and admixture mapping
    Lili Ding
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    BMC Genomics 12:622. 2011
    ....
  9. pmc Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes
    Lisa J Martin
    Divisions of Human Genetics and Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e34614. 2012
    ..The purpose of this study was to determine whether with a sufficient number of variants a linkage signal can be fully explained...
  10. pmc The effect of minor allele frequency on the likelihood of obtaining false positives
    Meredith E Tabangin
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Mail Code 5041, Cincinnati, Ohio 45229, USA
    BMC Proc 3:S41. 2009
    ..1]) than MAF = 25% and 50%. Similar results were seen at the other alpha values.These results suggest that removal of low MAF SNPs from analysis due to concerns about inflated false-positive results may not be appropriate...
  11. pmc Comparison of false-discovery rate for genome-wide and fine mapping regions
    Meredith E Tabangin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 5041, Cincinnati, Ohio 45229 3039, USA
    BMC Proc 1:S148. 2007
    ..However, in fine mapping, all tested methods performed poorly, producing a high proportion of significant results. Thus, caution should be used when employing FDR for fine mapping...
  12. pmc Quality assessment of buccal versus blood genomic DNA using the Affymetrix 500 K GeneChip
    Jessica G Woo
    University of Cincinnati College of Medicine, 321 Albert Sabin Way, Cincinnati, OH 45267, USA
    BMC Genet 8:79. 2007
    ..We sought to describe the genomic DNA yield and concordance between stored buccal brushes and blood samples from the same individuals in the context of Affymetrix 500 K Human GeneChip genotyping...
  13. pmc Accuracy of haplotype estimation in a region of low linkage disequilibrium
    Christy L Avery
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    BMC Genet 6:S80. 2005
    ....
  14. pmc HDL cholesterol in females in the Framingham Heart Study is linked to a region of chromosome 2q
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill 27514 USA
    BMC Genet 4:S98. 2003
    ....
  15. ncbi request reprint Bivariate linkage between acylation-stimulating protein and BMI and high-density lipoproteins
    Lisa J Martin
    Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Obes Res 12:669-78. 2004
    ..Acylation-stimulating protein (ASP), an adipose-derived protein, influences lipid metabolism, obesity, and glucose use. Therefore, our objective was to examine the genetic regulation of ASP and associated pleiotropic effects...
  16. pmc Phenotypic, genetic, and genome-wide structure in the metabolic syndrome
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, 45229, USA
    BMC Genet 4:S95. 2003
    ..We next applied factor analysis to summarize the relationship between these phenotypes...
  17. ncbi request reprint Variation in menstrual cycle length and cessation of menstruation in captive raised baboons
    L J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Mech Ageing Dev 124:865-71. 2003
    ..89 and 26.34 years, respectively. These results provide evidence that captive aging female baboons experience menstrual cycle changes similar to peri- and menopausal women...
  18. pmc Quantitative trait locus-specific genotype x alcoholism interaction on linkage for evoked electroencephalogram oscillations
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    BMC Genet 6:S123. 2005
    ..1). Further, we detected QTL-specific genotype x alcoholism interaction at these loci. This work demonstrates the importance of considering the complexity of common complex traits in our search for genes that predispose to alcoholism...
  19. ncbi request reprint A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family
    Lisa J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 2800 Winslow, Room 2110, Mail Code 5041, Cincinnati, OH 45229, USA
    Diabetes 51:3568-72. 2002
    ..Within the 1-LOD unit support interval, there are two strong candidates: PCSK1 and CAST. Furthermore, we have obtained a replication (LOD = 1.6) for a QTL for type 2 diabetes on chromosome 11 detected by Hanson and colleagues (1998)...
  20. ncbi request reprint Major quantitative trait locus for resting heart rate maps to a region on chromosome 4
    Lisa J Martin
    Department of Pediatrics, Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Mail Code 5041, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Hypertension 43:1146-51. 2004
    ..This signal is in the same region as a quantitative trait locus (QTL) for long QT syndrome 4 and a QTL for heart rate in rats. Within the 1-LOD unit support interval, there are 2 strong candidates: ankyrin-B and myozenin 2...
  21. pmc Shared genetic contributions of fruit and vegetable consumption with BMI in families 20 y after sharing a household
    Lisa J Martin
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Clin Nutr 94:1138-43. 2011
    ..Interestingly, diet also has a genetic basis. Thus, we hypothesized that the genetic underpinnings of diet may partially overlap with the genetics of obesity...
  22. pmc Improving the signal-to-noise ratio in genome-wide association studies
    Lisa J Martin
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Genet Epidemiol 33:S29-32. 2009
    ..This article reviews how Genetic Analysis Workshop 16 Group 5 investigators proposed to adjust for multiple tests while simultaneously using information about the structure of the genome to improve the detection of true positives...
  23. ncbi request reprint Multiple testing in the genomics era: findings from Genetic Analysis Workshop 15, Group 15
    Lisa J Martin
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Genet Epidemiol 31:S124-31. 2007
    ..We show that while each approach may have certain advantages, adequate error control is largely dependent upon the question under consideration and often requires the use of multiple analytic strategies...
  24. ncbi request reprint Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis
    F J Northington
    Eudowood Neonatal Pulmonary Division, Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 21:1931-8. 2001
    ..We conclude that the delayed neurodegeneration in neonatal rat ventral basal thalamus after hypoxic-ischemic injury is apoptosis mediated by death receptor activation...
  25. ncbi request reprint A quantitative trait locus influencing activin-to-estrogen ratio in pedigreed baboons maps to a region homologous to human chromosome 19
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Hum Biol 73:787-800. 2001
    ..This is the first evidence of a quantitative trait locus with a significant effect on the activin-to-estrogen ratio...
  26. ncbi request reprint Distribution of lod scores in oligogenic linkage analysis
    J T Williams
    Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S805-10. 2001
    ..We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic...
  27. pmc Insulin resistance and arterial stiffness in healthy adolescents and young adults
    E M Urbina
    Department of Pediatrics, Preventive Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, 3333 Burnet Avenue, MLC 7002, Cincinnati, OH 45229, USA
    Diabetologia 55:625-31. 2012
    ..Whether stiffness is increased in obesity/IR in youth is not known. We sought to determine if IR was a determinant of arterial stiffness in youth, independent of obesity and cardiovascular risk factors...
  28. ncbi request reprint The utility of Bayesian model averaging for detecting known oligogenic effects
    L J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, P.O. Box 760549, San Antonio, TX 78245-0549, USA
    Genet Epidemiol 21:S789-93. 2001
    ..The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2...
  29. ncbi request reprint Searching for genes underlying normal variation in human adiposity
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    J Mol Med (Berl) 79:57-70. 2001
    ..of obesity and its related phenotypes, which must be considered in designing analyses to identify the genes involved as well as reviewing what these approaches have provided in the search for genes influencing adiposity in humans..
  30. ncbi request reprint Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death
    F J Northington
    Eudowood Neonatal Pulmonary Division, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Dev Neurosci 23:186-91. 2001
    ....
  31. ncbi request reprint A quantitative trait locus on chromosome 22 for serum leptin levels adjusted for serum testosterone
    Lisa J Martin
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Obes Res 10:602-7. 2002
    ..Because interactions such as genotype x sex can confound the detection of quantitative trait loci (QTLs), we wanted to determine if there are QTLs associated with the expression of leptin adjusted for testosterone...
  32. ncbi request reprint Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 N Wolfe Street, CMSC 6 104, Baltimore, MD 21287, USA
    Neuroscience 219:192-203. 2012
    ..We conclude that Nec-1 immediately after HI, is strongly mitoprotective and prevents secondary energy failure by blocking early NO• accumulation, glutathione oxidation and attenuating mitochondrial dysfunction...
  33. ncbi request reprint The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    A G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    J Clin Endocrinol Metab 86:4321-5. 2001
    ....
  34. ncbi request reprint Genetics of leptin expression in baboons
    S A Cole
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Int J Obes Relat Metab Disord 27:778-83. 2003
    ..We have investigated leptin (LEP) gene express-ion, to determine whether it is heritable, and whether the difference in LEP expression between males and females has a genetic component...
  35. ncbi request reprint Genetic control of coordinated changes in HDL and LDL size phenotypes
    D L Rainwater
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
    Arterioscler Thromb Vasc Biol 21:1829-33. 2001
    ..Thus, our study demonstrates that the phenotypic correlation of HDL and LDL sizes results in part from the pleiotropic actions of a set of genes, some of which also influence TG levels and some of which do not...
  36. ncbi request reprint Genotype-by-smoking interaction for leptin levels in the Metabolic Risk Complications of Obesity Genes project
    L J Martin
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Int J Obes Relat Metab Disord 27:334-40. 2003
    ..Recently, we identified a genotype-by-smoking status interaction with serum leptin levels in a sample of Mexican Americans. However, it is unknown whether this phenomenon occurs in other populations as well...
  37. ncbi request reprint Adiponectin is present in human milk and is associated with maternal factors
    Lisa J Martin
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Am J Clin Nutr 83:1106-11. 2006
    ..If present in milk, adiponectin would be a promising candidate for influencing infant development, given its metabolic functions...
  38. doi request reprint Evidence of shared genetic effects between pre- and postobesity epidemic BMI levels
    Lisa J Martin
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 18:1378-82. 2010
    ..Furthermore, shared genetic effects survive the period of the transition from adolescence to adulthood...
  39. ncbi request reprint Bicuspid aortic valve is heritable
    Linda Cripe
    Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital, Ohio 45229, USA
    J Am Coll Cardiol 44:138-43. 2004
    ..Our objective was to statistically test whether the segregation pattern of BAV is consistent with genetic inheritance and to obtain an estimate of the size of the genetic effect (heritability)...
  40. ncbi request reprint Leptin's sexual dimorphism results from genotype by sex interactions mediated by testosterone
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Obes Res 10:14-21. 2002
    ..As we have shown for other measures of adiposity, such sexual dimorphism can arise from a special case of genotype by environment interaction, that of genotype by sex interaction...
  41. pmc Gender differences in the relationships among obesity, adiponectin and brachial artery distensibility in adolescents and young adults
    E M Urbina
    Division of Preventive Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Int J Obes (Lond) 33:1118-25. 2009
    ..Obesity-related cardiovascular diseases (CVDs) are a major cause of cardiovascular (CV) mortality. Obesity-related reduction in vascular protective adipose-derived proteins, such as adiponectin (APN), has an important role...
  42. ncbi request reprint Stability of adolescent body mass index during three years of follow-up
    Nancy A Crimmins
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 151:383-7. 2007
    ..A 4-year longitudinal study was conducted to determine the prevalence of overweight, detect shifts in body mass index (BMI) distribution, and determine which adolescents were at risk for pathologic weight gain...
  43. ncbi request reprint Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans
    Nancy A Crimmins
    Department of Pediatrics, MLC 7012, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Obesity (Silver Spring) 15:1903-7. 2007
    ..Our findings suggest not only that ADIPOR1 variants influence insulin resistance in the presence of adiposity, but also that these variants and haplotypes are protective in African Americans...
  44. ncbi request reprint Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Diabetes 55:523-9. 2006
    ..Interactions between noncontiguous ACDC haplotypes strongly influence adiponectin levels, suggesting nonadditive and potentially cis relationships between these regions...
  45. ncbi request reprint Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Obes Res 13:2095-101. 2005
    ..In this study, we hypothesized that sex differences in adiponectin would develop during puberty and would be influenced by level of adiposity...
  46. ncbi request reprint Failure to sustain recovery of Na,K-ATPase function is a possible mechanism for striatal neurodegeneration in hypoxic-ischemic newborn piglets
    W C Golden
    Department of Pediatrics, Eudowood Neonatal Pulmonary Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Brain Res Mol Brain Res 88:94-102. 2001
    ..We conclude that early inactivation of Na,K-ATPase function participates in the pathogenesis of striatal neuron necrosis, but that loss of enzyme function early after HI is not caused by depletion of composite alpha/beta subunits...
  47. ncbi request reprint Genotype by smoking interaction for leptin levels in the San Antonio Family Heart Study
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245 0549, USA
    Genet Epidemiol 22:105-15. 2002
    ..04). Given these results, we hypothesize that a quantitative trait locus in this vicinity of chromosome 8 may have a differential effect on the expression of leptin in smokers versus non-smokers...
  48. ncbi request reprint The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart study
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
    Hum Biol 75:635-46. 2003
    ..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
  49. pmc Hypoplastic left heart syndrome links to chromosomes 10q and 6q and is genetically related to bicuspid aortic valve
    Robert B Hinton
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Am Coll Cardiol 53:1065-71. 2009
    ..This study was designed to identify disease loci for hypoplastic left heart syndrome (HLHS) and evaluate the genetic relationship between HLHS and bicuspid aortic valve (BAV)...
  50. ncbi request reprint Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA
    Biol Psychiatry 55:739-44. 2004
    ..Further genetic analysis can help explain phenotypic correlations among monoamine levels and might eventually help identify genes involved in response to therapy or risk of psychopathology...
  51. pmc Human milk adiponectin is associated with infant growth in two independent cohorts
    Jessica G Woo
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Breastfeed Med 4:101-9. 2009
    ..We have previously shown that adiponectin is present in human milk. This study determined whether higher milk adiponectin is associated with infant growth and investigated milk adiponectin's oligomeric form...
  52. doi request reprint MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome
    T X Lu
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Mucosal Immunol 5:388-96. 2012
    ..Taken together, our results support a key role of miRNAs, particularly miR-375, in regulating and fine-tuning IL-13-mediated responses...
  53. ncbi request reprint Nitric oxide synthase 1 and nitric oxide synthase 3 protein expression is regionally and temporally regulated in fetal brain
    F J Northington
    Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Brain Res Dev Brain Res 95:1-14. 1996
    ....
  54. ncbi request reprint Evidence for linkage on 21q and 7q in a subset of autism characterized by developmental regression
    C A Molloy
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH 45229 3039, USA
    Mol Psychiatry 10:741-6. 2005
    ..9 x 10(-5)) were observed. Genetic elements in these regions of 21q and 7q are likely to confer susceptibility to autism or modify the disease presentation in a subgroup of children characterized by a history of developmental regression...
  55. pmc Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 184:4033-41. 2010
    ..These results establish that the epithelial response in EE involves a cooperative interaction between IL-13 and expression of EDC genes...
  56. ncbi request reprint The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes
    Anthony G Comuzzie
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Hum Biol 79:191-200. 2007
    ....
  57. ncbi request reprint Hypoplastic left heart syndrome is heritable
    Robert B Hinton
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Coll Cardiol 50:1590-5. 2007
    ..This study sought to determine the size of the genetic effect (heritability) in families identified by a hypoplastic left heart syndrome (HLHS) proband...
  58. ncbi request reprint Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance
    N A Crimmins
    Division of Endocrinology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Obes Rev 8:419-23. 2007
    ..In addition, these polymorphism studies are used to illustrate some of the potential pitfalls and reasons for poor reproducibility of findings in genetic association studies...
  59. ncbi request reprint Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain
    F J Northington
    Department of Pediatrics, CMSC 6 104, The Johns Hopkins University School of Medicine, Johns Hopkins Hospital, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Neuroscience 149:822-33. 2007
    ..The presence of a "continuum" phenotype of cell death that varies on a cell-by-cell basis suggests that the phenotype of cell death is dependent on the energy available to drive the apoptotic pathways to completion...
  60. ncbi request reprint Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations
    Lisa J Martin
    Center for Epidemiology and Biostatistics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hum Genet 121:275-84. 2007
    ..These regions likely contain genes whose mutation results in BAV and/or associated CVM indicating their important role in valvulogenesis and cardiac development...
  61. pmc Common variants at 5q22 associate with pediatric eosinophilic esophagitis
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Genet 42:289-91. 2010
    ..These data implicate the 5q22 locus in the pathogenesis of EoE and identify TSLP as the most likely candidate gene in the region...
  62. pmc Application of genetic/genomic approaches to allergic disorders
    Tesfaye M Baye
    Division of Asthma Research, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 126:425-36; quiz 437-8. 2010
    ..We will discuss genetic and phenotypic variation, statistical approaches for gene discovery, public databases, functional genomics, clinical implications, and the challenges that remain...
  63. pmc Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis
    Joseph D Sherrill
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 126:160-5.e3. 2010
    ..In addition, the genetic contributions of other allergy-associated genes to EE risk have not been explored...
  64. doi request reprint Retrospective comparison of patient outcomes after in-person and telephone results disclosure counseling for BRCA1/2 genetic testing
    Courtney Doughty Rice
    Genetic Counseling Graduate Program, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA
    Fam Cancer 9:203-12. 2010
    ..This study suggests that telephone results disclosure is clinically appropriate when counselors utilize their clinical judgment to determine which patients are appropriate candidates...
  65. ncbi request reprint Lifespan in captive baboons is heritable
    Lisa J Martin
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Mech Ageing Dev 123:1461-7. 2002
    ..This research demonstrates that lifespan is under partial genetic control. Given these findings, we believe that the baboon has potential as a model of human aging...
  66. doi request reprint Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocol
    Yuri A Zarate
    Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Am J Med Genet A 149:1691-7. 2009
    ..Very high AFP values did seem to be correlated with risk for identifiable liver lesions. Determination of the natural changes in AFP levels over time will allow more appropriate comparison...
  67. ncbi request reprint A comprehensive linkage analysis for myocardial infarction and its related risk factors
    Ulrich Broeckel
    Department of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Nat Genet 30:210-4. 2002
    ..Although some of these risk factors overlap with previously identified loci, none overlaps with the newly identified susceptibility locus for myocardial infarction and coronary artery disease...
  68. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  69. ncbi request reprint Analysis of metabolic syndrome phenotypes in Framingham Heart Study families from Genetic Analysis Workshop 13
    Lynn R Goldin
    Genetic Epidemiology Branch, DCEG, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 7236, USA
    Genet Epidemiol 25:S78-89. 2003
    ..Over 40 genome-wide linkage analyses were conducted. Despite the broad range of approaches, several regions of the genome were repeatedly identified across multiple analyses...
  70. pmc Genetic determinants of obesity-related lipid traits
    Gabriele E Sonnenberg
    Division of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine and Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 45:610-5. 2004
    ..These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity...
  71. ncbi request reprint Meta-analysis of genome-wide linkage studies in BMI and obesity
    Catherine L Saunders
    King s College London, Guy s, King s and St Thomas School of Medicine, London, United Kingdom
    Obesity (Silver Spring) 15:2263-75. 2007
    ..The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis...
  72. ncbi request reprint Intervention with a low-fat, high-carbohydrate diet does not influence the timing of menopause
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada
    Am J Clin Nutr 84:920-8. 2006
    ..Later age at menopause is associated with a greater risk of breast cancer. Dietary factors may at least partially influence breast cancer risk through an effect on the age at menopause...
  73. ncbi request reprint Linkage analysis for complex diseases using variance component analysis: SOLAR
    Ulrich Broeckel
    Department of Medicine, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA
    Methods Mol Med 128:91-100. 2006
    ..In this chapter, we present as an introduction the statistical background of variance component analysis as implemented in the genetic analysis package SOLAR...
  74. ncbi request reprint Body size, mammographic density, and breast cancer risk
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2K9
    Cancer Epidemiol Biomarkers Prev 15:2086-92. 2006
    ..We have examined the associations of body size and mammographic density on breast cancer risk...
  75. ncbi request reprint A locus on chromosome 10 influences C-reactive protein levels in two independent populations
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, Milwaukee 53226, USA
    Hum Genet 122:95-102. 2007
    ..This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke...
  76. pmc Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence
    Lisa J Martin
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Avenue, Toronto, Canada M5G 2M9
    Breast Cancer Res 10:201. 2008
    ....
  77. ncbi request reprint Genetic contributions to social impulsivity and aggressiveness in vervet monkeys
    Lynn A Fairbanks
    Neuropsychiatric Institute, University of California Los Angeles, California 90024, USA
    Biol Psychiatry 55:642-7. 2004
    ..This study assessed the genetic contribution to impulsivity and aggressiveness in a social context using a nonhuman primate model...
  78. ncbi request reprint Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse
    Lisa J Martin
    Department of Environmental Health Sciences, Interdepartmental Program in Molecular Toxicology, UCLA School of Public Health, Los Angeles, California 90095 1772, USA
    Birth Defects Res A Clin Mol Teratol 67:231-9. 2003
    ....
  79. ncbi request reprint Mammographic density and the risk and detection of breast cancer
    Norman F Boyd
    Campbell Family Institute for Breast Cancer Research, Toronto, ON, Canada
    N Engl J Med 356:227-36. 2007
    ..Extensive mammographic density is associated with an increased risk of breast cancer and makes the detection of cancer by mammography difficult, but the influence of density on risk according to method of cancer detection is unknown...
  80. ncbi request reprint Mammographic density: a hormonally responsive risk factor for breast cancer
    Norman F Boyd
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Br Menopause Soc 12:186-93. 2006
    ..A better understanding of the factors that influence the response of breast tissue to these hormonal exposures may lead to an improved understanding of the aetiology of mammographic density and of breast cancer...