Rebecca A Marsh

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:877-83. 2013
  2. doi request reprint Flow cytometric measurement of SLAM-associated protein and X-linked inhibitor of apoptosis
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Biol 979:189-97. 2013
  3. doi request reprint Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Ann N Y Acad Sci 1238:106-21. 2011
  4. pmc Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Blood Cancer 60:101-9. 2013
  5. pmc Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 154:556-63. 2011
  6. pmc A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency
    Rebecca A Marsh
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Cytometry B Clin Cytom 76:334-44. 2009
  7. doi request reprint Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 116:5824-31. 2010
  8. pmc Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    J Immunol Methods 362:1-9. 2010
  9. pmc XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 116:1079-82. 2010
  10. doi request reprint STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America
    Rebecca A Marsh
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 55:134-40. 2010

Collaborators

Detail Information

Publications15

  1. doi request reprint Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:877-83. 2013
    ..RIC regimens should be pursued with caution and, if possible, efforts should be made to ensure HLH remission before HCT in these patients...
  2. doi request reprint Flow cytometric measurement of SLAM-associated protein and X-linked inhibitor of apoptosis
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Methods Mol Biol 979:189-97. 2013
    ..Proc Natl Acad Sci U S A 95:13765-13770, 1998; Sayos et al. Nature 395:462-469, 1998; Rigaud et al. Nature 444:110-114, 2006). This procedure describes a technique that can be efficiently used to detect SAP and XIAP by flow cytometry...
  3. doi request reprint Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Ann N Y Acad Sci 1238:106-21. 2011
    ..Here, we will describe the genetic and functional bases of these diseases, highlight their clinical manifestations, and discuss current diagnostic and therapeutic strategies...
  4. pmc Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Blood Cancer 60:101-9. 2013
    ..Salvage therapies have been described only in limited case reports, and there are no large studies of second-line therapies...
  5. pmc Reduced-intensity conditioning haematopoietic cell transplantation for haemophagocytic lymphohistiocytosis: an important step forward
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 154:556-63. 2011
    ..Here we review the current state of the treatment of patients with HLH with allogeneic HCT, highlighting the important steps forward that have been made with reduced-intensity conditioning...
  6. pmc A rapid flow cytometric screening test for X-linked lymphoproliferative disease due to XIAP deficiency
    Rebecca A Marsh
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Cytometry B Clin Cytom 76:334-44. 2009
    ..Until now, a rapid screening test for XIAP deficiency has not been available...
  7. doi request reprint Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 116:5824-31. 2010
    ..0001). We conclude that RIC significantly improves the outcome of patients with HLH undergoing allogeneic HCT...
  8. pmc Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    J Immunol Methods 362:1-9. 2010
    ..This review will give a brief overview of the clinical manifestations and molecular basis of SAP deficiency and XIAP deficiency, and will focus on the use of flow cytometry for diagnosis of XLP...
  9. pmc XIAP deficiency: a unique primary immunodeficiency best classified as X-linked familial hemophagocytic lymphohistiocytosis and not as X-linked lymphoproliferative disease
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 116:1079-82. 2010
    ..We conclude that XIAP deficiency is a unique primary immunodeficiency that is more appropriately classified as X-linked familial hemophagocytic lymphohistiocytosis...
  10. doi request reprint STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America
    Rebecca A Marsh
    Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 55:134-40. 2010
    ..Mutations in STX11 are responsible for Familial Hemophagocytic Lymphohistiocytosis (FHLH) type 4, a rare primary immunodeficiency which has previously been observed only in patients of Kurdish, Turkish, and Lebanese ethnic background...
  11. pmc Patients with X-linked lymphoproliferative disease due to BIRC4 mutation have normal invariant natural killer T-cell populations
    Rebecca A Marsh
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Clin Immunol 132:116-23. 2009
    ..We conclude that XLP due to BIRC4 mutation is not associated with decreased populations of iNKT cells, and that XIAP is likely not a requirement for iNKT cell development...
  12. doi request reprint Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation
    Hilary L Haines
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 17:1512-9. 2011
    ..We conclude that the degree of BK viremia, and not viruria, may predict renal, urologic, and overall outcome in the post-HSCT population...
  13. doi request reprint High-dose methylprednisolone for veno-occlusive disease of the liver in pediatric hematopoietic stem cell transplantation recipients
    Kasiani C Myers
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229, USA
    Biol Blood Marrow Transplant 19:500-3. 2013
    ..We conclude that high-dose steroid therapy if initiated early may reverse VOD of the liver in pediatric HSCT patients, abrogating the need for defibrotide therapy with its associated toxicities and regulatory difficulties...
  14. pmc Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH
    Kejian Zhang
    Division of Human Genetics, Children s Hospital Medical Center, University of Cincinnati College of Medicie, Cincinnati, OH 45229, USA
    Blood 118:5794-8. 2011
    ..We conclude that late-onset familial HLH occurs more commonly than was suspected previously...
  15. pmc X-linked lymphoproliferative syndromes: brothers or distant cousins?
    Alexandra H Filipovich
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Blood 116:3398-408. 2010
    ..In this review, we describe the genetic, clinical, and immunopathologic features of these 2 disorders and discuss current diagnostic and therapeutic strategies...