Genomes and Genes
Elizabeth A Mann
Affiliation: Cincinnati Children's Hospital Medical Center
- Prevalence of mutations in hepatitis C virus core protein associated with alteration of NF-kappaB activationElizabeth A Mann
Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati, 231 Albert B Sabin Way, OH 55267 0595, USA
Virus Res 121:51-7. 2006..Further studies are needed to assess potential associations between specific amino acid substitutions at positions 9-11 and liver disease progression and/or response to treatment in individual patients...
- Lack of guanylate cyclase C results in increased mortality in mice following liver injuryElizabeth A Mann
Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, USA
BMC Gastroenterol 10:86. 2010..In the adult rat liver, GC-C expression is increased in response to injury. We hypothesized that GC-C is required for repair/recovery from liver injury...
- Gastrointestinal infection as a trigger for inflammatory bowel diseaseElizabeth A Mann
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Curr Opin Gastroenterol 28:24-9. 2012..This review focuses on the current findings on the role of gastrointestinal pathogens in the cause of chronic inflammatory bowel disease...
- Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptorStephen L Carrithers
Department of Internal Medicine, Division of Infectious Diseases, Lexington VA Medical Center and University of Kentucky, Lexington, Kentucky 40506, USA
Kidney Int 65:40-53. 2004..However, the in vivo consequences of GN, UGN, and STa on renal function and their mechanism of action have yet to be rigorously tested...
- Murine guanylate cyclase C regulates colonic injury and inflammationKris A Steinbrecher
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 186:7205-14. 2011..These findings demonstrate a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMβ production...
- Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitisEleana Harmel-Laws
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS ONE 8:e79180. 2013..Familial mutations in GC-C cause chronic diarrheal disease or constipation and are associated with intestinal inflammation and infection. Here, we investigated the impact of GC-C activity on mucosal immune responses...
- Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse modelElizabeth A Mann
Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
Int J Cancer 116:500-5. 2005..We propose that these alterations are a possible compensatory mechanism by which loss of GC-C signaling also affects tumorigenesis...
- Guanylate cyclase C limits systemic dissemination of a murine enteric pathogenElizabeth A Mann
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
BMC Gastroenterol 13:135. 2013..Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea...
- Clostridium difficile infection and treatment in the pediatric inflammatory bowel disease populationEthan Mezoff
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr Gastroenterol Nutr 52:437-41. 2011..In addition, the effectiveness of antimicrobial therapies has been questioned. Our aim was to estimate the incidence of CDAD in a pediatric IBD population and review treatment efficacy...
- E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actionsRalph A Giannella
Division of Digestive Diseases, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0595, USA
Trans Am Clin Climatol Assoc 114:67-85; discussion 85-6. 2003..Study of GC-C "knock-out" mice reveal that GC-C is important to intestinal salt and water secretion, duodenal bicarbonate secretion, recovery from CCl4-induced liver injury, and to intestinal polyp formation in Min mice lacking GC-C...