Elizabeth A Mann

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Prevalence of mutations in hepatitis C virus core protein associated with alteration of NF-kappaB activation
    Elizabeth A Mann
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati, 231 Albert B Sabin Way, OH 55267 0595, USA
    Virus Res 121:51-7. 2006
  2. pmc Lack of guanylate cyclase C results in increased mortality in mice following liver injury
    Elizabeth A Mann
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, USA
    BMC Gastroenterol 10:86. 2010
  3. doi request reprint Gastrointestinal infection as a trigger for inflammatory bowel disease
    Elizabeth A Mann
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Opin Gastroenterol 28:24-9. 2012
  4. ncbi request reprint Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
    Stephen L Carrithers
    Department of Internal Medicine, Division of Infectious Diseases, Lexington VA Medical Center and University of Kentucky, Lexington, Kentucky 40506, USA
    Kidney Int 65:40-53. 2004
  5. pmc Murine guanylate cyclase C regulates colonic injury and inflammation
    Kris A Steinbrecher
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:7205-14. 2011
  6. ncbi request reprint Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
    Elizabeth A Mann
    Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Cancer 116:500-5. 2005
  7. pmc Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
    Elizabeth A Mann
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Gastroenterol 13:135. 2013
  8. pmc Clostridium difficile infection and treatment in the pediatric inflammatory bowel disease population
    Ethan Mezoff
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 52:437-41. 2011
  9. pmc Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis
    Eleana Harmel-Laws
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e79180. 2013
  10. pmc E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions
    Ralph A Giannella
    Division of Digestive Diseases, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0595, USA
    Trans Am Clin Climatol Assoc 114:67-85; discussion 85-6. 2003

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Prevalence of mutations in hepatitis C virus core protein associated with alteration of NF-kappaB activation
    Elizabeth A Mann
    Department of Internal Medicine, Division of Digestive Diseases, University of Cincinnati, 231 Albert B Sabin Way, OH 55267 0595, USA
    Virus Res 121:51-7. 2006
    ..Further studies are needed to assess potential associations between specific amino acid substitutions at positions 9-11 and liver disease progression and/or response to treatment in individual patients...
  2. pmc Lack of guanylate cyclase C results in increased mortality in mice following liver injury
    Elizabeth A Mann
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, USA
    BMC Gastroenterol 10:86. 2010
    ..In the adult rat liver, GC-C expression is increased in response to injury. We hypothesized that GC-C is required for repair/recovery from liver injury...
  3. doi request reprint Gastrointestinal infection as a trigger for inflammatory bowel disease
    Elizabeth A Mann
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Opin Gastroenterol 28:24-9. 2012
    ..This review focuses on the current findings on the role of gastrointestinal pathogens in the cause of chronic inflammatory bowel disease...
  4. ncbi request reprint Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor
    Stephen L Carrithers
    Department of Internal Medicine, Division of Infectious Diseases, Lexington VA Medical Center and University of Kentucky, Lexington, Kentucky 40506, USA
    Kidney Int 65:40-53. 2004
    ..However, the in vivo consequences of GN, UGN, and STa on renal function and their mechanism of action have yet to be rigorously tested...
  5. pmc Murine guanylate cyclase C regulates colonic injury and inflammation
    Kris A Steinbrecher
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 186:7205-14. 2011
    ..These findings demonstrate a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMĪ² production...
  6. ncbi request reprint Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
    Elizabeth A Mann
    Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Cancer 116:500-5. 2005
    ..We propose that these alterations are a possible compensatory mechanism by which loss of GC-C signaling also affects tumorigenesis...
  7. pmc Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
    Elizabeth A Mann
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Gastroenterol 13:135. 2013
    ..Our aim was to determine if GC-C is required for host defense during infection by the murine enteric pathogen Citrobacter rodentium of the family Enterobacteriacea...
  8. pmc Clostridium difficile infection and treatment in the pediatric inflammatory bowel disease population
    Ethan Mezoff
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 52:437-41. 2011
    ..In addition, the effectiveness of antimicrobial therapies has been questioned. Our aim was to estimate the incidence of CDAD in a pediatric IBD population and review treatment efficacy...
  9. pmc Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitis
    Eleana Harmel-Laws
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e79180. 2013
    ..Familial mutations in GC-C cause chronic diarrheal disease or constipation and are associated with intestinal inflammation and infection. Here, we investigated the impact of GC-C activity on mucosal immune responses...
  10. pmc E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions
    Ralph A Giannella
    Division of Digestive Diseases, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0595, USA
    Trans Am Clin Climatol Assoc 114:67-85; discussion 85-6. 2003
    ..Study of GC-C "knock-out" mice reveal that GC-C is important to intestinal salt and water secretion, duodenal bicarbonate secretion, recovery from CCl4-induced liver injury, and to intestinal polyp formation in Min mice lacking GC-C...