Andreas W Loepke

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint The physiologic effects of isoflurane anesthesia in neonatal mice
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Anesth Analg 102:75-80. 2006
  2. doi request reprint An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, USA
    Anesth Analg 106:1681-707. 2008
  3. ncbi request reprint Injury pattern of the neonatal brain after hypothermic low-flow cardiopulmonary bypass in a piglet model
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Institute of Pediatric Anesthesia, Cincinnati Children s Hospital Research Foundation, Ohio 45229, USA
    Anesth Analg 101:340-8, table of contents. 2005
  4. doi request reprint The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesth Analg 108:90-104. 2009
  5. doi request reprint Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets
    C Dean Kurth
    Department of Anesthesiology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Anesth Analg 108:1268-77. 2009
  6. doi request reprint Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Anesth Analg 116:845-54. 2013
  7. doi request reprint Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Anesthesiology 114:578-87. 2011
  8. pmc Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis
    Brian L Murphy
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, U S A
    Epilepsia 53:908-21. 2012
  9. doi request reprint Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3036, USA
    Anesthesiology 111:533-46. 2009
  10. doi request reprint Cell age-specific vulnerability of neurons to anesthetic toxicity
    Rylon D Hofacer
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Ann Neurol 73:695-704. 2013

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The physiologic effects of isoflurane anesthesia in neonatal mice
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Anesth Analg 102:75-80. 2006
    ..Use of 0.8 MAC isoflurane for evaluation of neuroprotection during hypoxia-ischemia requires mechanical ventilation and glucose supplementation in this model...
  2. doi request reprint An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, USA
    Anesth Analg 106:1681-707. 2008
    ..In the present review, we assess the evidence for the effects of commonly used anesthetics on neuronal structure and neurocognitive function in newborn humans and animals...
  3. ncbi request reprint Injury pattern of the neonatal brain after hypothermic low-flow cardiopulmonary bypass in a piglet model
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Institute of Pediatric Anesthesia, Cincinnati Children s Hospital Research Foundation, Ohio 45229, USA
    Anesth Analg 101:340-8, table of contents. 2005
    ..Factors mitigating injury were higher arterial carbon dioxide, hematocrit, and blood glucose levels...
  4. doi request reprint The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Anesth Analg 108:90-104. 2009
    ..We examined the effects of neonatal isoflurane exposure and blood glucose on brain cell viability, spontaneous locomotor activity, as well as spatial learning and memory in mice...
  5. doi request reprint Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets
    C Dean Kurth
    Department of Anesthesiology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Anesth Analg 108:1268-77. 2009
    ..We investigated the relationship between H-I duration at Sc(O2) 35%, a viability threshold which causes neurophysiological impairment, to neurological outcome...
  6. doi request reprint Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Anesth Analg 116:845-54. 2013
    ..We conducted the present study to immunohistochemically identify the dying cells and to quantify the fraction of cells undergoing apoptotic death in neonatal mouse cortex, a substantially affected brain region...
  7. doi request reprint Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Anesthesiology 114:578-87. 2011
    ....
  8. pmc Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis
    Brian L Murphy
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, U S A
    Epilepsia 53:908-21. 2012
    ....
  9. doi request reprint Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm
    John J McAuliffe
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3036, USA
    Anesthesiology 111:533-46. 2009
    ..The authors used these agents in a delayed preconditioning model to test the hypothesis that they could provide neuroprotection against neonatal hypoxia-ischemia as assessed by a battery of behavioral tests...
  10. doi request reprint Cell age-specific vulnerability of neurons to anesthetic toxicity
    Rylon D Hofacer
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Ann Neurol 73:695-704. 2013
    ..Elucidating these questions is critical for assessing the phenomenon's applicability to humans, defining the susceptible age, predicting vulnerable neuronal populations, and devising mitigating strategies...
  11. doi request reprint Anesthetics and sedatives: toxic or protective for the developing brain?
    Christopher G Ward
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pharmacol Res 65:271-4. 2012
    ..The mechanisms and human applicability of anesthetic neurotoxicity and neuroprotection remain under intense investigation and this Perspectives article summarizes the current state of research...
  12. ncbi request reprint The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Best Pract Res Clin Anaesthesiol 24:433-49. 2010
    ..Moreover, this article outlines the putative mechanisms of anaesthetic neurotoxicity, and the phenomenon's implications for clinical practice in this rapidly emerging field...
  13. pmc Heterogeneous integration of adult-generated granule cells into the epileptic brain
    Brian L Murphy
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 31:105-17. 2011
    ..These data imply that newborn cells play complex--and potentially conflicting--roles in epilepsy...
  14. pmc Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy
    Steve C Danzer
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hippocampus 20:113-24. 2010
    ....
  15. doi request reprint Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine?
    Andreas W Loepke
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 11:217-26. 2010
    ..To evaluate the currently available evidence for the deleterious effects of sedatives and anesthetics on developing brain structure and neurocognitive function...
  16. ncbi request reprint General anesthetics and the developing brain
    George K Istaphanous
    Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Curr Opin Anaesthesiol 22:368-73. 2009
    ..This review presents recent developments in this rapidly emerging field...
  17. doi request reprint CON: The toxic effects of anesthetics in the developing brain: the clinical perspective
    Andreas W Loepke
    Anesth Analg 106:1664-9. 2008
  18. ncbi request reprint The plasma pharmacokinetics and cerebral spinal fluid penetration of intravenous topiramate in newborn pigs
    Jeffrey L Galinkin
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biopharm Drug Dispos 25:265-71. 2004
    ..The plasma pharmacokinetics, cerebrospinal fluid (CSF) penetration and pharmacodynamics of intravenous topiramate were studied in an established piglet model of hypoxia-ischemia...
  19. ncbi request reprint Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets
    Dara Ditsworth
    Brain Research Laboratory, Department of Anesthesiology and Critical Care Medicine, The Joseph Stokes Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 98:1119-27. 2003
    ..Caspases, cytochrome c, tumor necrosis factor (TNF), and Fas play a role in apoptosis in many ischemic models. This study examined the expression of these factors in a DHCA piglet model...
  20. ncbi request reprint Desflurane improves neurologic outcome after low-flow cardiopulmonary bypass in newborn pigs
    Andreas W Loepke
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Anesthesiology 97:1521-7. 2002
    ..Desflurane confers neuroprotection against ischemia at normothermia and for DHCA. This study compared neurologic outcome of a desflurane-based with a fentanyl-based anesthetic for LF-CPB...
  21. ncbi request reprint Let's not throw the baby out with the bath water: potential neurotoxicity of anesthetic drugs in infants and children
    Sulpicio G Soriano
    Department of Anaesthesia, Harvard Medical School and Children s Hospital, Boston, Massachusetts, USA
    J Neurosurg Anesthesiol 17:207-9. 2005