Research Topics
Genomes and Genes | TIMOTHY DAVID contact LE CRASSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthmaTimothy D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
Am J Physiol Lung Cell Mol Physiol 300:L414-21. 2011..This study demonstrates that EGFR signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model...
VEGF causes pulmonary hemorrhage, hemosiderosis, and air space enlargement in neonatal miceT D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 287:L134-42. 2004..Overexpression of VEGF in the neonatal lung increased infant mortality and caused pulmonary hemorrhage, hemosiderosis, alveolar remodeling, and inflammation...- Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthoodT D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
Am J Physiol Lung Cell Mol Physiol 287:L718-29. 2004..Transient induction of TGF-alpha during early alveologenesis permanently disrupted lung structure and function and caused chronic lung disease... - Vascular growth and remodeling in compensatory lung growth following right lobectomyTimothy D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Appl Physiol 98:1140-8. 2005.... - Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthmaElizabeth M Mushaben
Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Immunol 187:5756-63. 2011..These findings highlight the importance of the mTOR pathway in allergic airway disease... - Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung diseaseElizabeth L Kramer
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Appl Physiol 111:1760-7. 2011..Thus rapamycin reduced airway remodeling and AHR, demonstrating an important role for mTOR signaling in TGF-α-induced/EGF receptor-mediated reactive airway disease... - Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosisThomas R Korfhagen
Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 41:562-72. 2009.... - Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysisElizabeth L Kramer
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Am J Physiol Lung Cell Mol Physiol 293:L314-27. 2007..Pathological changes in TGF-alpha-overexpressing mice bore similarities to premature infants born in the saccular phase who develop BPD, including remodeling of the distal lung septae and arteries... - Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in miceElizabeth L Kramer
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Respir Cell Mol Biol 41:415-25. 2009..This provides a unique model to study the processes causing pulmonary fibrosis and ASM thickening without the complicating effects of inflammation... - Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alphaTimothy D Le Cras
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Physiol Lung Cell Mol Physiol 285:L1046-54. 2003..Reductions in VEGF may contribute to the pathogenesis of pulmonary vascular disease in TGF-alpha mice... - Midkine is regulated by hypoxia and causes pulmonary vascular remodelingPaul R Reynolds
Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Biol Chem 279:37124-32. 2004..These data provide a model wherein the respiratory epithelium responds to hypoxia via HIF-1alpha-dependent regulation of MK, enhancing myocardin expression to influence pulmonary vascular gene expression... 
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosisWilliam D Hardie
Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Physiol Lung Cell Mol Physiol 294:L1217-25. 2008....- Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosisWilliam D Hardie
Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
Am J Respir Cell Mol Biol 37:309-21. 2007..These studies support a role for epithelial cell-derived TGF-alpha in the regulation of processes that alter the airway and vascular architecture and function... - TGF-alpha perturbs surfactant homeostasis in vivoMachiko Ikegami
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 289:L34-43. 2005..Abnormalities in surfactant function and decreased surfactant level in the airways may contribute to the pathophysiology induced by TGF-alpha in both the developing and adult lung... - Vascular endothelial growth factor-A induces prenatal neovascularization and alters bronchial development in miceAnn L Akeson
Division of Pulmonary Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Res 57:82-8. 2005..Bronchial expression of VEGF-A alters late-stage morphogenesis of conducting airways and primary bronchial arteries and causes respiratory failure at birth... - Vascular changes after intra-amniotic endotoxin in preterm lamb lungsSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 287:L1178-85. 2004..Exposure to antenatal inflammation may cause vascular remodeling and contribute to the development of BPD... - Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosisWilliam D Hardie
Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004..Induction of pulmonary fibrosis by TGF-alpha was independent of inflammation or early activation of TGF-beta... - GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epitheliumHiroshi Kida
Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Pathol 172:1542-54. 2008..In the present study, we show that GP130-STAT3 signaling functions in a cell-autonomous manner to restore cell shape and numbers required for repair of the bronchiolar epithelium following injury... - Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosisTimothy D Le Cras
Divisions of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Am J Pathol 176:679-86. 2010..These data show that PI3K is activated in TGFalpha/EGFR-mediated pulmonary fibrosis and support further studies to determine the role of PI3K activation in human lung fibrotic disease, which could be amenable to targeted therapy... - Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationMarnie A Ryan
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
Nat Med 16:1141-6. 2010..Our findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provide a new pharmacological approach for improving HSPC mobilization and thereby transplantation outcomes... - Differential vascular growth in postpneumonectomy compensatory lung growthLucas G Fernandez
Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
J Thorac Cardiovasc Surg 133:309-16. 2007..The aim of our study was to characterize vascular growth among individual lobes of the lung after pneumonectomy and determine whether changes in relative blood flow correlate with growth... - Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetusVivek Balasubramaniam
Pediatric Heart Lung Center and Section of Pediatric Pulmonary Medicine, University of Colorado School of Medicine and The Children s Hospital, Denver, Colorado 80218, USA
Am J Physiol Lung Cell Mol Physiol 284:L826-33. 2003..We speculate that PDGF signaling contributes to structural vascular remodeling in perinatal PH and that selective PDGF inhibition may provide a novel therapeutic strategy for the treatment of chronic PH... - Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structureTimothy D Le Cras
Departments of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
Am J Physiol Lung Cell Mol Physiol 283:L555-62. 2002....
Research Grants
- Role of TGF-Alpha in Pulmonary Vascular DiseaseTIMOTHY LE CRAS; Fiscal Year: 2006..This information will serve as a basis for developing therapeutic strategies aimed at improving lung growth and preventing pulmonary hypertension in premature babies and adults. ..
- Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure/FuncTIMOTHY LE CRAS; Fiscal Year: 2009..End of Abstract) ..
- Impact of Early Life Diesel Exposure on Immune Patterning and Lung Structure/FuncTIMOTHY DAVID contact LE CRAS; Fiscal Year: 2010..End of Abstract) ..