Rohit Kohli

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins
    Samir Softic
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e38952. 2012
  2. pmc A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery
    Rohit Kohli
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Endocrinology 154:2341-51. 2013
  3. pmc Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities
    Rohit Kohli
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010
  4. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
  5. doi request reprint Molecular insights from bariatric surgery
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, MLC 2010, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Rev Endocr Metab Disord 12:211-7. 2011
  6. ncbi request reprint FXR is a molecular target for the effects of vertical sleeve gastrectomy
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Nature 509:183-8. 2014
  7. ncbi request reprint MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet
    Vidya Gadang
    Department of Pathology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio
    Am J Physiol Endocrinol Metab 305:E549-56. 2013
  8. doi request reprint Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner
    Andriy Myronovych
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 22:390-400. 2014
  9. pmc A multidisciplinary clinical program is effective in stabilizing BMI and reducing transaminase levels in pediatric patients with NAFLD
    Stephanie DeVore
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 57:119-23. 2013
  10. pmc Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats
    Karen K Ryan
    The University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Cincinnati, OH 45237, USA
    Endocrinology 154:9-15. 2013

Collaborators

Detail Information

Publications19

  1. pmc Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins
    Samir Softic
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e38952. 2012
    ..Thus, we asked whether insulin is an independent modulator of hepatic lipid accumulation...
  2. pmc A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery
    Rohit Kohli
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Endocrinology 154:2341-51. 2013
    ..Further, our work establishes a model for focused study of bile acids in the context of bariatric surgery that may lead to the identification of therapeutics for metabolic disease. ..
  3. pmc Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities
    Rohit Kohli
    Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
    Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010
    ..Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery...
  4. pmc High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Hepatology 52:934-44. 2010
    ..001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice...
  5. doi request reprint Molecular insights from bariatric surgery
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, MLC 2010, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
    Rev Endocr Metab Disord 12:211-7. 2011
    ..We will also discuss existing literature regarding the weight-loss-independent metabolic benefits including improvement in insulin sensitivity and central nervous system integration of these signals...
  6. ncbi request reprint FXR is a molecular target for the effects of vertical sleeve gastrectomy
    Karen K Ryan
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Nature 509:183-8. 2014
    ..These results point to bile acids and FXR signalling as an important molecular underpinning for the beneficial effects of this weight-loss surgery. ..
  7. ncbi request reprint MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet
    Vidya Gadang
    Department of Pathology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio
    Am J Physiol Endocrinol Metab 305:E549-56. 2013
    ..In addition, loss of MLK3 improved insulin resistance and decreased hepatic steatosis. Together, these data demonstrate that MLK3 promotes saturated fatty acid-induced JNK activation in vivo and diet-induced metabolic dysfunction...
  8. doi request reprint Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner
    Andriy Myronovych
    Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 22:390-400. 2014
    ..Our objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG)...
  9. pmc A multidisciplinary clinical program is effective in stabilizing BMI and reducing transaminase levels in pediatric patients with NAFLD
    Stephanie DeVore
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 57:119-23. 2013
    ..We hypothesized that one can achieve success in improving NAFLD and weight-related outcomes in a structured and focused multidisciplinary clinical program feasible to implement in a gastroenterology clinic...
  10. pmc Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats
    Karen K Ryan
    The University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Cincinnati, OH 45237, USA
    Endocrinology 154:9-15. 2013
    ..Together, these findings identify the central nervous system as a potentially important target for the beneficial effects of FGF19 in the treatment of obesity and diabetes...
  11. pmc Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease
    Stavra A Xanthakos
    Steatohepatitis Center, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH Electronic address
    J Pediatr 164:186-8. 2014
    ..We demonstrate that magnetic resonance elastography is feasible and accurate in detecting significant hepatic fibrosis in a case series of 35 children with chronic liver disease, including severely obese children. ..
  12. pmc Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids
    Rohit Kohli
    Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Clin Endocrinol Metab 98:E708-12. 2013
    ....
  13. doi request reprint Fatty liver disease in children--what should one do?
    Kristin S Bramlage
    Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Indian J Pediatr 80:S109-14. 2013
    ..This review will focus on NAFLD and NASH, their definitions, epidemiology, diagnosis and treatment. The authors will also discuss NAFLD in the Indian subcontinent, and the future of NAFLD and NASH...
  14. doi request reprint Advances in the surgical treatment of morbid obesity
    Margaret A Stefater
    Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
    Mol Aspects Med 34:84-94. 2013
    ..This may position VSG as an increasingly important procedure, particularly for the treatment of pediatric obesity...
  15. pmc The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transposition
    Shrawan Gaitonde
    Department of Surgery, University Hospital University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Surg Res 178:33-9. 2012
    ..Ileal transposition involves a short segment of distal ileum being transposed to the proximal jejunum in an isoperistaltic direction, thereby avoiding any gastric resection or intestinal bypass...
  16. ncbi request reprint Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia
    Kirk M Habegger
    Division of Endocrinology, Department of Internal Medicine, Metabolic Diseases Institute, Obesity Research Center, University of Cincinnati, Cincinnati, Ohio, USA
    Gut 63:1238-46. 2014
    ..We implanted this device in Zucker Diabetic Fatty (ZDF) rats to gain greater understanding of duodenal nutrient exclusion on glucose homeostasis...
  17. pmc Isolated unilateral cytomegalovirus retinitis: a rare long-term complication after pediatric liver transplantation
    James E Squires
    Pediatric Liver Care Center, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Transplant 17:E16-9. 2013
    ..Currently, there is no standard of care regarding screening for CMV retinitis, and thus, further research is needed to define the need for potential changes in current clinical practices and post-transplant screening protocols...
  18. ncbi request reprint Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway
    Rohit Kohli
    Department of Pediatrics, Children s Memorial Hospital, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    J Biol Chem 282:21327-36. 2007
    ..Our findings suggest a common path for response to altered nutrition involving mitochondrial ROS-dependent PI 3-kinase pathway regulation, leading to steatosis...
  19. ncbi request reprint Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
    Atul Sahai
    Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Research Center, Chicago, IL 60614, USA
    Am J Physiol Gastrointest Liver Physiol 291:G55-62. 2006
    ..PI3-kinase plays a central role in signaling the MCD medium-induced steatosis and increased OPN expression, whereas OPN appears to play a role in signaling hepatocyte ALT release but not steatosis...