Affiliation: Cincinnati Children's Hospital Medical Center
- A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgeryRohit Kohli
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Endocrinology 154:2341-51. 2013..Further, our work establishes a model for focused study of bile acids in the context of bariatric surgery that may lead to the identification of therapeutics for metabolic disease. ..
- Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbiditiesRohit Kohli
Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Ohio, USA
Am J Physiol Gastrointest Liver Physiol 299:G652-60. 2010..Changes in serum bile acids or bile acid enterohepatic recycling may mediate the metabolic benefits seen after bariatric surgery...
- High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitisRohit Kohli
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Hepatology 52:934-44. 2010....
- Molecular insights from bariatric surgeryRohit Kohli
Division of Gastroenterology, Hepatology, and Nutrition, MLC 2010, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH 45229, USA
Rev Endocr Metab Disord 12:211-7. 2011..We will also discuss existing literature regarding the weight-loss-independent metabolic benefits including improvement in insulin sensitivity and central nervous system integration of these signals...
- Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteinsSamir Softic
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS ONE 7:e38952. 2012..Thus, we asked whether insulin is an independent modulator of hepatic lipid accumulation...
- Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male ratsKaren K Ryan
The University of Cincinnati College of Medicine, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Cincinnati, OH 45237, USA
Endocrinology 154:9-15. 2013..Together, these findings identify the central nervous system as a potentially important target for the beneficial effects of FGF19 in the treatment of obesity and diabetes...
- Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile AcidsRohit Kohli
MD, Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110
J Clin Endocrinol Metab 98:E708-12. 2013..004, P = .807). Conclusions: Compared with LAGB, RYGB increases circulating BAs and TGR5 signaling, but this increase in BAs is not a significant predictor of changes in glucose homeostasis or energy metabolism...
- Advances in the surgical treatment of morbid obesityMargaret A Stefater
Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, United States
Mol Aspects Med 34:84-94. 2013..This may position VSG as an increasingly important procedure, particularly for the treatment of pediatric obesity...
- The role of the gut hormone GLP-1 in the metabolic improvements caused by ileal transpositionShrawan Gaitonde
Department of Surgery, University Hospital University of Cincinnati, Cincinnati, Ohio 45267, USA
J Surg Res 178:33-9. 2012..Ileal transposition involves a short segment of distal ileum being transposed to the proximal jejunum in an isoperistaltic direction, thereby avoiding any gastric resection or intestinal bypass...
- A multidisciplinary clinical program is effective in stabilizing BMI and reducing transaminase levels in pediatric patients with NAFLDStephanie DeVore
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr Gastroenterol Nutr 57:119-23. 2013..We hypothesized that one can achieve success in improving NAFLD and weight-related outcomes in a structured and focused multidisciplinary clinical program feasible to implement in a gastroenterology clinic...
- MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched dietVidya Gadang
Department of Pathology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio
Am J Physiol Endocrinol Metab 305:E549-56. 2013..In addition, loss of MLK3 improved insulin resistance and decreased hepatic steatosis. Together, these data demonstrate that MLK3 promotes saturated fatty acid-induced JNK activation in vivo and diet-induced metabolic dysfunction. ..
- Fatty liver disease in children--what should one do?Kristin S Bramlage
Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Indian J Pediatr 80:S109-14. 2013..This review will focus on NAFLD and NASH, their definitions, epidemiology, diagnosis and treatment. The authors will also discuss NAFLD in the Indian subcontinent, and the future of NAFLD and NASH...
- Isolated unilateral cytomegalovirus retinitis: a rare long-term complication after pediatric liver transplantationJames E Squires
Pediatric Liver Care Center, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Pediatr Transplant 17:E16-9. 2013..Currently, there is no standard of care regarding screening for CMV retinitis, and thus, further research is needed to define the need for potential changes in current clinical practices and post-transplant screening protocols...
- Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathwayRohit Kohli
Department of Pediatrics, Children s Memorial Hospital, Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
J Biol Chem 282:21327-36. 2007..Our findings suggest a common path for response to altered nutrition involving mitochondrial ROS-dependent PI 3-kinase pathway regulation, leading to steatosis...
- Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient mediumAtul Sahai
Department of Pediatrics, Northwestern University Feinberg School of Medicine and Children s Memorial Research Center, Chicago, IL 60614, USA
Am J Physiol Gastrointest Liver Physiol 291:G55-62. 2006..PI3-kinase plays a central role in signaling the MCD medium-induced steatosis and increased OPN expression, whereas OPN appears to play a role in signaling hepatocyte ALT release but not steatosis...