Christopher KarpSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Non-canonical alternatives: what a macrophage is 4Christopher L Karp
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
J Exp Med 209:427-31. 2012..Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors...
Biomedicine. Eosinophils in asthma: remodeling a tangled taleMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Science 305:1726-9. 2004- Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune systemChristopher L Karp
Molecular Immunology Section, Children s Hospital Research Foundation, University of Cincinnati, TCHRF 1566, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Ann N Y Acad Sci 961:337-40. 2002 - A role for immune complexes in enhanced respiratory syncytial virus diseaseFernando P Polack
Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
J Exp Med 196:859-65. 2002..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease... - The anaphylatoxins bridge innate and adaptive immune responses in allergic asthmaHeiko Hawlisch
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Mol Immunol 41:123-31. 2004..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction... - Chitin checking--novel insights into asthmaMarsha Wills-Karp
Division of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
N Engl J Med 351:1455-7. 2004 - Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 6:571-8. 2005..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses... - An adenoviral vector for probing promoter activity in primary immune cellsPulak Tripathi
Division of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Immunol Methods 311:19-30. 2006..The pSLUG system promises to be a powerful tool for the analysis of DNA regulatory regions in diverse types of primary immune cells...
Research Grants
- Role of Regulatory T cells in Leishmania major infectionChristopher Karp; Fiscal Year: 2007..major; and (2) Determine the mechanisms underlying Treg-mediated modulation of immune responses to L. major both in vitro and in vivo. ..
- Regulation of TLR Signaling and Innate Immunity by RP105Christopher Karp; Fiscal Year: 2007....
- Lipid Mediators and Dysregulated Inflammation in CFChristopher Karp; Fiscal Year: 2009....
- Regulation of TLR Signaling and Innate Immunity by RP105Christopher Karp; Fiscal Year: 2009....
- Immunobiology of IFRD1, a gene modifying CF lung diseaseChristopher Karp; Fiscal Year: 2009..The studies in this proposal will define the molecular mechanisms by which IFRD1 modifies lung disease severity in cystic fibrosis, with the long-term goal of developing novel therapeutic approaches to this devastating disease. ..
- Allergenicity resulting from functional mimicry of the TLR complexChristopher L Karp; Fiscal Year: 2010....
- Regulation of TLR Signaling and Innate Immunity by RP105Christopher L Karp; Fiscal Year: 2010....
- Regulation of Toll-like Receptor signaling by RP105Christopher Karp; Fiscal Year: 2006..The studies in this proposal aim at mechanistic definition, both in vitro and in vivo, of the role of RP105 in modulating TLR4 signaling and TLR4-driven immune responses. ..
- IFN BETA AND IMMUNOREGUALTION IN MULTIPLE SCLEROSISChristopher Karp; Fiscal Year: 2003....
- HEPATITIS C: IFN-ALPHA, IL-12 AND IMMUNOREGULATIONChristopher Karp; Fiscal Year: 2003..abstract_text> ..
- Ebola Virus: Immunopathogenesis and TherapyChristopher Karp; Fiscal Year: 2003..The studies in this application will examine these hypotheses at multiple levels, ranging from the molecular to in vivo in the rhesus macaque model of EVHF . ..
- Novel lipid -based therapies for cystic fibrosisChristopher Karp; Fiscal Year: 2004..If successful, these studies will provide the basis for pursuing preclinical and clinical studies in this area. ..
- Immunobiology of IFRD1, a gene modifying CF lung diseaseChristopher L Karp; Fiscal Year: 2010..The studies in this proposal will define the molecular mechanisms by which IFRD1 modifies lung disease severity in cystic fibrosis, with the long-term goal of developing novel therapeutic approaches to this devastating disease. ..