Christopher Karp

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Non-canonical alternatives: what a macrophage is 4
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Exp Med 209:427-31. 2012
  2. ncbi request reprint Biomedicine. Eosinophils in asthma: remodeling a tangled tale
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 305:1726-9. 2004
  3. ncbi request reprint Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune system
    Christopher L Karp
    Molecular Immunology Section, Children s Hospital Research Foundation, University of Cincinnati, TCHRF 1566, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Ann N Y Acad Sci 961:337-40. 2002
  4. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
  5. ncbi request reprint The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
  6. ncbi request reprint Chitin checking--novel insights into asthma
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
    N Engl J Med 351:1455-7. 2004
  7. pmc Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
    Senad Divanovic
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 6:571-8. 2005
  8. pmc An adenoviral vector for probing promoter activity in primary immune cells
    Pulak Tripathi
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol Methods 311:19-30. 2006

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc Non-canonical alternatives: what a macrophage is 4
    Christopher L Karp
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    J Exp Med 209:427-31. 2012
    ..Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors...
  2. ncbi request reprint Biomedicine. Eosinophils in asthma: remodeling a tangled tale
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Science 305:1726-9. 2004
  3. ncbi request reprint Immunological barriers (opportunities?) to the use of bioengineered tissue: taking note of the innate immune system
    Christopher L Karp
    Molecular Immunology Section, Children s Hospital Research Foundation, University of Cincinnati, TCHRF 1566, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Ann N Y Acad Sci 961:337-40. 2002
  4. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
    ..Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease...
  5. ncbi request reprint The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
    ..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction...
  6. ncbi request reprint Chitin checking--novel insights into asthma
    Marsha Wills-Karp
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, USA
    N Engl J Med 351:1455-7. 2004
  7. pmc Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105
    Senad Divanovic
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Nat Immunol 6:571-8. 2005
    ..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses...
  8. pmc An adenoviral vector for probing promoter activity in primary immune cells
    Pulak Tripathi
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol Methods 311:19-30. 2006
    ..The pSLUG system promises to be a powerful tool for the analysis of DNA regulatory regions in diverse types of primary immune cells...

Research Grants28

  1. Role of Regulatory T cells in Leishmania major infection
    Christopher Karp; Fiscal Year: 2007
    ..major; and (2) Determine the mechanisms underlying Treg-mediated modulation of immune responses to L. major both in vitro and in vivo. ..
  2. Regulation of TLR Signaling and Innate Immunity by RP105
    Christopher Karp; Fiscal Year: 2007
    ....
  3. Lipid Mediators and Dysregulated Inflammation in CF
    Christopher Karp; Fiscal Year: 2009
    ....
  4. Regulation of TLR Signaling and Innate Immunity by RP105
    Christopher Karp; Fiscal Year: 2009
    ....
  5. Immunobiology of IFRD1, a gene modifying CF lung disease
    Christopher Karp; Fiscal Year: 2009
    ..The studies in this proposal will define the molecular mechanisms by which IFRD1 modifies lung disease severity in cystic fibrosis, with the long-term goal of developing novel therapeutic approaches to this devastating disease. ..
  6. Allergenicity resulting from functional mimicry of the TLR complex
    Christopher L Karp; Fiscal Year: 2010
    ....
  7. Regulation of TLR Signaling and Innate Immunity by RP105
    Christopher L Karp; Fiscal Year: 2010
    ....
  8. Regulation of Toll-like Receptor signaling by RP105
    Christopher Karp; Fiscal Year: 2006
    ..The studies in this proposal aim at mechanistic definition, both in vitro and in vivo, of the role of RP105 in modulating TLR4 signaling and TLR4-driven immune responses. ..
  9. IFN BETA AND IMMUNOREGUALTION IN MULTIPLE SCLEROSIS
    Christopher Karp; Fiscal Year: 2003
    ....
  10. HEPATITIS C: IFN-ALPHA, IL-12 AND IMMUNOREGULATION
    Christopher Karp; Fiscal Year: 2003
    ..abstract_text> ..
  11. Ebola Virus: Immunopathogenesis and Therapy
    Christopher Karp; Fiscal Year: 2003
    ..The studies in this application will examine these hypotheses at multiple levels, ranging from the molecular to in vivo in the rhesus macaque model of EVHF . ..
  12. Novel lipid -based therapies for cystic fibrosis
    Christopher Karp; Fiscal Year: 2004
    ..If successful, these studies will provide the basis for pursuing preclinical and clinical studies in this area. ..
  13. Immunobiology of IFRD1, a gene modifying CF lung disease
    Christopher L Karp; Fiscal Year: 2010
    ..The studies in this proposal will define the molecular mechanisms by which IFRD1 modifies lung disease severity in cystic fibrosis, with the long-term goal of developing novel therapeutic approaches to this devastating disease. ..