Jennifer M Kaplan

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:1995-2002. 2012
  2. pmc Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
    Jennifer M Kaplan
    Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 36:123-30. 2010
  3. pmc Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    Mol Med 16:491-7. 2010
  4. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 24:59-65. 2005
  5. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
  6. pmc Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 38:1955-61. 2010

Detail Information

Publications6

  1. pmc Short-term high fat feeding increases organ injury and mortality after polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 20:1995-2002. 2012
    ..CD-fed mice. Short duration high fat feeding increases mortality and organ injury following polymicrobial sepsis. These effects correspond to changes in NF-κB...
  2. pmc Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
    Jennifer M Kaplan
    Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 2005, Cincinnati, OH 45229 3039, USA
    Intensive Care Med 36:123-30. 2010
    ..Additionally, to investigate the effects of sepsis on the endogenous activator of PPARgamma, 15-deoxy-(12,14)-PGJ(2) (15d-PGJ(2)), and the downstream targets of PPARgamma activity, adiponectin and resistin...
  3. pmc Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    Mol Med 16:491-7. 2010
    ..The inflammatory effects of sepsis cause changes in PPARγ expression and activation, in part, because of phosphorylation of PPARγ by ERK1/2. This phosphorylation can be reversed by ERK1/2 inhibition, thereby improving lung injury...
  4. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and the College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Shock 24:59-65. 2005
    ..Our data demonstrate that 15d-PGJ2 ameliorates endotoxic shock most likely through repressing the proinflammatory pathway of NF-kappaB and enhancement of the cytoprotective heat shock response...
  5. pmc Biomarker discovery and development in pediatric critical care medicine
    Jennifer M Kaplan
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:165-73. 2011
    ..To frame the general process of biomarker discovery and development; and to describe a proposal for the development of a multibiomarker-based risk model for pediatric septic shock...
  6. pmc Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept
    Hector R Wong
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Crit Care Med 38:1955-61. 2010
    ..To develop a clinically feasible stratification strategy for pediatric septic shock, using gene expression mosaics and a 100-gene signature representing the first 24 hrs of admission to the pediatric intensive care unit...