Research Topics
Species | Suhas KallapurSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungsElke Kuypers
Department of Pediatrics, School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
Am J Physiol Lung Cell Mol Physiol 302:L380-9. 2012..We conclude that the order of exposures of intra-amniotic LPS or maternal betamethasone had large effects on fetal lung inflammation and maturation...- Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheepNoah H Hillman
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
Respir Res 10:124. 2009..Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia... - Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheepNoah H Hillman
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
Respir Res 11:151. 2010..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation... - IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lungSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 297:L512-9. 2009..Inhibition of CXCR2 did not change IA LPS-induced lung maturation. IL-8 signaling does not mediate LPS-induced lung inflammation and lung maturation... - IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharideSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Am J Respir Crit Care Med 179:955-61. 2009..However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants... 
Physiological consequences of intrauterine insultsSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, Ohio 45229 3039, USA
Paediatr Respir Rev 7:110-6. 2006..The information derived from clinical studies is juxtaposed with data from animal experiments to discuss the physiological consequences of intrauterine insults on fetal lung growth...- Contribution of inflammation to lung injury and developmentS G Kallapur
Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
Arch Dis Child Fetal Neonatal Ed 91:F132-5. 2006..Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD... - Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambsSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 172:1315-21. 2005..In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation... - Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungsSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, University of Cincinnati College of Medicine, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 288:L966-74. 2005..Contrary to our hypothesis, a prolonged fetal exposure to intra-amniotic endotoxin caused mild persistent inflammation but did not lead to progressive structural abnormalities in lungs of near-term gestation lambs... - Vascular changes after intra-amniotic endotoxin in preterm lamb lungsSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 287:L1178-85. 2004..Exposure to antenatal inflammation may cause vascular remodeling and contribute to the development of BPD... - Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheepSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, Univ of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 301:L285-95. 2011..IL-1α is a potent mediator of the fetal inflammatory response syndrome... - Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheepSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
J Immunol 187:2688-95. 2011..parvum. The findings increase our understanding of how chorioamnionitis-exposed preterm infants may respond to lung injury and postnatal nosocomial infections... - Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambsSuhas G Kallapur
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003..These results have implications for lung inflammation and bronchopulmonary dysplasia in preterm infants exposed to chorioamnionitis and maternal glucocorticoids... - Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitisSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
J Immunol 179:8491-9. 2007..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections... - Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lungSuhas G Kallapur
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 167:779-86. 2003..IP-10 and MIG are potent angiostatic chemokines that may contribute to lung injury and altered pulmonary vascular development in the preterm exposed to chorioamnionitis... 
High and low body temperature during the initiation of ventilation for near-term lambsMolly K Ball
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Resuscitation 80:133-7. 2009..Recent literature suggests hypothermia may protect against lung injury. We evaluated body temperature as a variable in lung inflammation due to oxygenation and mechanical ventilation following delivery of near-term lambs...- Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitisTushar A Shah
Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Res 68:210-5. 2010..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation... - Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheepNoah H Hillman
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Respir Crit Care Med 176:575-81. 2007..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support... - Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambsTeicha C Wilson
Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Division of Pulmonary Biology, OH 45229, USA
Pediatr Res 58:1204-9. 2005..Our experiments show rapid induction of an APR gene in lung in response to proinflammatory stimuli... - Betamethasone for lung maturation: testing dose and formulation in fetal sheepAlan H Jobe
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Am J Obstet Gynecol 197:523.e1-6. 2007..We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep... - Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitisFook Choe Cheah
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 296:L384-93. 2009..Intra-amniotic LPS recruits leukocytes to the fetal air space that have a persistent activation. These results have implications for the pathogenesis of lung inflammatory disorders in the preterm... - Injury and inflammation from resuscitation of the preterm infantAlan H Jobe
Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Neonatology 94:190-6. 2008..Ventilation strategies that minimize injury need to be developed... - Betamethasone dose and formulation for induced lung maturation in fetal sheepAlan H Jobe
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Am J Obstet Gynecol 201:611.e1-7. 2009..We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically... - Airway injury from initiating ventilation in preterm sheepNoah H Hillman
Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
Pediatr Res 67:60-5. 2010..HSP70 protein decreased in the lung tissue and increased in BALF with ventilation. Initiation of ventilation induced a stress response and inflammatory cytokines in small and medium-sized airways... - Toll-like receptors and agonist responses in the developing fetal sheep lungNoah H Hillman
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Pediatr Res 63:388-93. 2008..We conclude that TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung... - Minimal lung and systemic responses to TNF-alpha in preterm sheepMachiko Ikegami
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003..Therefore, the presence of a mediator such as TNF-alpha in a developing animal does not necessarily mean that it is causing the responses anticipated from previous results in adult animals... - Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before deliveryMachiko Ikegami
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 286:L573-9. 2004..After lung inflammation was induced by intra-amniotic endotoxin injection, ventilation did not increase lung injury... - Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis modelFook Choe Cheah
Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Pediatr Res 63:274-9. 2008..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia... - Long term consequences of oxygen therapy in the neonatal periodAlan H Jobe
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Semin Fetal Neonatal Med 15:230-5. 2010..Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury... - Endotoxin-induced maturation of monocytes in preterm fetal sheep lungBoris W Kramer
University Hospital Maastricht, Maastricht, The Netherlands
Am J Physiol Lung Cell Mol Physiol 293:L345-53. 2007..Intra-amniotic endotoxin induced lung monocytes to develop into functionally mature cells consistent with macrophages. These findings have implications for lung immune responses after exposure to chorioamnionitis... - IL-1 alpha causes lung inflammation and maturation by direct effects on preterm fetal lamb lungsIlene R S Sosenko
Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33106, USA
Pediatr Res 60:294-8. 2006..IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes. Lung inflammation and maturation result from direct exposure of the fetal lung to a single cytokine - IL-1alpha... - Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheepJohn P Newnham
School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
Am J Obstet Gynecol 189:1458-66. 2003..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses... - Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheepTimothy J M Moss
School of Women s and Infants Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
Am J Obstet Gynecol 198:122.e1-8. 2008..The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6... - Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheepDavid G Sweet
Department of Child Health, The Queen s University of Belfast, UK
Neonatology 94:79-86. 2008..The effectors of this antenatally-induced lung maturation are not understood. Matrix metalloproteinases (MMPs) 2 and 9 are type-IV collagenases that can degrade alveolar basement membranes... - Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lungKaren E Willet
Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...
Research Grants
- Mechanisms of Vascular Injury in the preterm lungSuhas Kallapur; Fiscal Year: 2006..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
- Mechanisms of Fetal Inflammatory Response Syndrome Induced by ChorioamnionitisSuhas Kallapur; Fiscal Year: 2010..This knowledge will be essential to developing treatment approaches aimed at improving preterm infant outcomes. ..