Suhas Kallapur

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    PLoS ONE 8:e63355. 2013
  2. pmc Ureaplasma and BPD
    Suhas G Kallapur
    Divisions of Neonatology and Pulmonary Biology, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, University of Cincinnati, OH 45229, USA
    Semin Perinatol 37:94-101. 2013
  3. pmc Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs
    Elke Kuypers
    Department of Pediatrics, School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 302:L380-9. 2012
  4. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
  5. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
  6. ncbi request reprint Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
  7. pmc Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 187:2688-95. 2011
  8. pmc Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Univ of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L285-95. 2011
  9. pmc IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 179:955-61. 2009
  10. pmc IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L512-9. 2009

Collaborators

Detail Information

Publications39

  1. pmc Selective exposure of the fetal lung and skin/amnion (but not gastro-intestinal tract) to LPS elicits acute systemic inflammation in fetal sheep
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    PLoS ONE 8:e63355. 2013
    ..These novel findings reveal differential fetal organ responses to pro-inflammatory stimulation and shed light on the pathogenesis of fetal systemic inflammation after exposure to chorioamnionitis...
  2. pmc Ureaplasma and BPD
    Suhas G Kallapur
    Divisions of Neonatology and Pulmonary Biology, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, University of Cincinnati, OH 45229, USA
    Semin Perinatol 37:94-101. 2013
    ..We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD...
  3. pmc Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs
    Elke Kuypers
    Department of Pediatrics, School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 302:L380-9. 2012
    ..We conclude that the order of exposures of intra-amniotic LPS or maternal betamethasone had large effects on fetal lung inflammation and maturation...
  4. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
    ..Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia...
  5. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
    ..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation...
  6. ncbi request reprint Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    ..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections...
  7. pmc Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 187:2688-95. 2011
    ..parvum. The findings increase our understanding of how chorioamnionitis-exposed preterm infants may respond to lung injury and postnatal nosocomial infections...
  8. pmc Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Univ of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L285-95. 2011
    ..IL-1α is a potent mediator of the fetal inflammatory response syndrome...
  9. pmc IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 179:955-61. 2009
    ..However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants...
  10. pmc IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L512-9. 2009
    ..Inhibition of CXCR2 did not change IA LPS-induced lung maturation. IL-8 signaling does not mediate LPS-induced lung inflammation and lung maturation...
  11. ncbi request reprint Physiological consequences of intrauterine insults
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Paediatr Respir Rev 7:110-6. 2006
    ..The information derived from clinical studies is juxtaposed with data from animal experiments to discuss the physiological consequences of intrauterine insults on fetal lung growth...
  12. pmc Contribution of inflammation to lung injury and development
    S G Kallapur
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
    Arch Dis Child Fetal Neonatal Ed 91:F132-5. 2006
    ..Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD...
  13. ncbi request reprint Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003
    ..These results have implications for lung inflammation and bronchopulmonary dysplasia in preterm infants exposed to chorioamnionitis and maternal glucocorticoids...
  14. pmc Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1315-21. 2005
    ..In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation...
  15. ncbi request reprint Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L966-74. 2005
    ..Contrary to our hypothesis, a prolonged fetal exposure to intra-amniotic endotoxin caused mild persistent inflammation but did not lead to progressive structural abnormalities in lungs of near-term gestation lambs...
  16. ncbi request reprint Vascular changes after intra-amniotic endotoxin in preterm lamb lungs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1178-85. 2004
    ..Exposure to antenatal inflammation may cause vascular remodeling and contribute to the development of BPD...
  17. pmc Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone
    Katherine B Wolfe
    1Division of Maternal Fetal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Reprod Sci 20:1447-54. 2013
    ..We tested the hypothesis that the order of exposure to maternal betamethasone and intra-amniotic (IA) lipopolysaccharide (LPS) will differentially modulate inflammation in the chorioamnion...
  18. ncbi request reprint Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 167:779-86. 2003
    ..IP-10 and MIG are potent angiostatic chemokines that may contribute to lung injury and altered pulmonary vascular development in the preterm exposed to chorioamnionitis...
  19. pmc Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
    ..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation...
  20. doi request reprint High and low body temperature during the initiation of ventilation for near-term lambs
    Molly K Ball
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Resuscitation 80:133-7. 2009
    ..Recent literature suggests hypothermia may protect against lung injury. We evaluated body temperature as a variable in lung inflammation due to oxygenation and mechanical ventilation following delivery of near-term lambs...
  21. ncbi request reprint Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs
    Teicha C Wilson
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Pulmonary Biology, OH 45229, USA
    Pediatr Res 58:1204-9. 2005
    ..Our experiments show rapid induction of an APR gene in lung in response to proinflammatory stimuli...
  22. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  23. pmc Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis
    Fook Choe Cheah
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 296:L384-93. 2009
    ..Intra-amniotic LPS recruits leukocytes to the fetal air space that have a persistent activation. These results have implications for the pathogenesis of lung inflammatory disorders in the preterm...
  24. pmc Betamethasone for lung maturation: testing dose and formulation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:523.e1-6. 2007
    ..We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep...
  25. doi request reprint Injury and inflammation from resuscitation of the preterm infant
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Neonatology 94:190-6. 2008
    ..Ventilation strategies that minimize injury need to be developed...
  26. pmc Betamethasone dose and formulation for induced lung maturation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:611.e1-7. 2009
    ..We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically...
  27. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
    ..HSP70 protein decreased in the lung tissue and increased in BALF with ventilation. Initiation of ventilation induced a stress response and inflammatory cytokines in small and medium-sized airways...
  28. doi request reprint Toll-like receptors and agonist responses in the developing fetal sheep lung
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 63:388-93. 2008
    ..We conclude that TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung...
  29. ncbi request reprint Minimal lung and systemic responses to TNF-alpha in preterm sheep
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003
    ..Therefore, the presence of a mediator such as TNF-alpha in a developing animal does not necessarily mean that it is causing the responses anticipated from previous results in adult animals...
  30. ncbi request reprint Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L573-9. 2004
    ..After lung inflammation was induced by intra-amniotic endotoxin injection, ventilation did not increase lung injury...
  31. ncbi request reprint Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model
    Fook Choe Cheah
    Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Res 63:274-9. 2008
    ..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia...
  32. ncbi request reprint Overexpression of vascular endothelial growth factor in the germinal matrix induces neurovascular proteases and intraventricular hemorrhage
    Dianer Yang
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Sci Transl Med 5:193ra90. 2013
    ..Collectively, these results support a causative role of VEGF in perinatal cerebral hemorrhage and implicate its downstream proteases as potential therapeutic targets. ..
  33. pmc Long term consequences of oxygen therapy in the neonatal period
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Semin Fetal Neonatal Med 15:230-5. 2010
    ..Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury...
  34. doi request reprint Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep
    David G Sweet
    Department of Child Health, The Queen s University of Belfast, UK
    Neonatology 94:79-86. 2008
    ..The effectors of this antenatally-induced lung maturation are not understood. Matrix metalloproteinases (MMPs) 2 and 9 are type-IV collagenases that can degrade alveolar basement membranes...
  35. pmc Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep
    Timothy J M Moss
    School of Women s and Infants Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
    Am J Obstet Gynecol 198:122.e1-8. 2008
    ..The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6...
  36. ncbi request reprint Endotoxin-induced maturation of monocytes in preterm fetal sheep lung
    Boris W Kramer
    University Hospital Maastricht, Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 293:L345-53. 2007
    ..Intra-amniotic endotoxin induced lung monocytes to develop into functionally mature cells consistent with macrophages. These findings have implications for lung immune responses after exposure to chorioamnionitis...
  37. ncbi request reprint IL-1 alpha causes lung inflammation and maturation by direct effects on preterm fetal lamb lungs
    Ilene R S Sosenko
    Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33106, USA
    Pediatr Res 60:294-8. 2006
    ..IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes. Lung inflammation and maturation result from direct exposure of the fetal lung to a single cytokine - IL-1alpha...
  38. ncbi request reprint Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    ..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses...
  39. ncbi request reprint Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung
    Karen E Willet
    Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002
    ..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...

Research Grants3

  1. Mechanisms of Vascular Injury in the preterm lung
    Suhas Kallapur; Fiscal Year: 2006
    ..The experimental design in this proposal incorporates challenging but, particularly in this environment achievable goals that will provide important knowledge in the pathogenesis of bronchopulmonary dysplasia. ..
  2. Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis
    Suhas Kallapur; Fiscal Year: 2009
    ..This knowledge will be essential to developing treatment approaches aimed at improving preterm infant outcomes. ..
  3. Mechanisms of Fetal Inflammatory Response Syndrome Induced by Chorioamnionitis
    Suhas Kallapur; Fiscal Year: 2010
    ..This knowledge will be essential to developing treatment approaches aimed at improving preterm infant outcomes. ..