Theodosia A Kalfa

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Pelger-Huët anomaly in a child with 1q42.3-44 deletion
    Theodosia A Kalfa
    Hematology Oncology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 46:645-8. 2006
  2. pmc Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
    Theodosia A Kalfa
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH 45229, USA
    Blood 108:3637-45. 2006
  3. pmc Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
    Theodosia A Kalfa
    Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
    Haematologica 95:27-35. 2010
  4. pmc Targeting erythroblast-specific apoptosis in experimental anemia
    Abhinav Diwan
    Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
    Apoptosis 13:1022-30. 2008
  5. pmc Signaling and cytoskeletal requirements in erythroblast enucleation
    Diamantis G Konstantinidis
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 119:6118-27. 2012
  6. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
  7. pmc Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species
    Alex George
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Blood Cells Mol Dis 45:41-5. 2010
  8. pmc K-Cl cotransporter gene expression during human and murine erythroid differentiation
    Dao Pan
    Molecular and Cell Therapy Program, Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:30492-503. 2011
  9. pmc Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis
    Abhinav Diwan
    Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:6794-9. 2007
  10. pmc Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome
    Daren Wang
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:19958-63. 2009

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Pelger-Huët anomaly in a child with 1q42.3-44 deletion
    Theodosia A Kalfa
    Hematology Oncology, Cincinnati Children s Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 46:645-8. 2006
    ..Additional features in this child included failure to thrive, developmental delay, cleft palate, seizure disorder, and dysmorphic facial features...
  2. pmc Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
    Theodosia A Kalfa
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH 45229, USA
    Blood 108:3637-45. 2006
    ..Thus, deficiency of Rac1 and Rac2 GTPases in mice alters actin assembly in RBCs and causes microcytic anemia with reticulocytosis, implicating Rac GTPases as dynamic regulators of the erythrocyte cytoskeleton organization...
  3. pmc Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
    Theodosia A Kalfa
    Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
    Haematologica 95:27-35. 2010
    ..The role of these Rac GTPases in erythropoiesis has not yet been fully elucidated...
  4. pmc Targeting erythroblast-specific apoptosis in experimental anemia
    Abhinav Diwan
    Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
    Apoptosis 13:1022-30. 2008
    ..These results support the concept of targeting erythroblast apoptosis to maximize erythrocyte production in acute anemia, which may be of value in erythropoietin resistance...
  5. pmc Signaling and cytoskeletal requirements in erythroblast enucleation
    Diamantis G Konstantinidis
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 119:6118-27. 2012
    ....
  6. pmc Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis
    Linda Yang
    Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 110:3853-61. 2007
    ..Thus, Cdc42 is an essential regulator of the balance between myelopoiesis and erythropoiesis...
  7. pmc Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: the role of protein kinase C, Rac GTPases, and reactive oxygen species
    Alex George
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Blood Cells Mol Dis 45:41-5. 2010
    ..We discuss in particular the known and potential roles of protein kinase C and the Rac GTPases in these two processes...
  8. pmc K-Cl cotransporter gene expression during human and murine erythroid differentiation
    Dao Pan
    Molecular and Cell Therapy Program, Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:30492-503. 2011
    ..The results suggest that KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 among individuals that could result in modulation of KCC activity...
  9. pmc Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis
    Abhinav Diwan
    Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:6794-9. 2007
    ..These results suggest that physiological codependence and coordinated regulation of pro- and antiapoptotic Bcl2 family members may represent a general regulatory paradigm in hematopoiesis...
  10. pmc Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome
    Daren Wang
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:19958-63. 2009
    ..This approach provides a paradigm for the utilization of RBC precursors as a depot for efficient and potentially safer systemic delivery of nonsecreted proteins by ex vivo HSC gene transfer...
  11. pmc Cooperating G6PD mutations associated with severe neonatal hyperbilirubinemia and cholestasis
    Benjamin Mizukawa
    Department of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 56:840-2. 2011
    ..The G6PD Cincinnati mutation may have aggravated the clinical picture of G6PD Gastonia with the result of severe perinatal hemolysis causing cholestasis and associated liver injury...
  12. doi request reprint The impact of the 2009 H1N1 influenza pandemic on pediatric patients with sickle cell disease
    Alex George
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 57:648-53. 2011
    ..Respiratory infections are associated with clinically significant illness in patients with sickle cell disease (SCD). The 2009 H1N1 pandemic was perceived as a significant threat to this population...
  13. pmc Rho GTPases in hematopoiesis and hemopathies
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 115:936-47. 2010
    ..In this review we discuss recent genetic studies of Rho GTPases in hematopoiesis and several blood lineages and the implications of Rho GTPase signaling in hematologic malignancies, immune pathology. and anemia...