A H Jobe

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Effects of chorioamnionitis on the fetal lung
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7029, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 39:441-57. 2012
  2. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
  3. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
  4. pmc Communities, birth attendants and health facilities: a continuum of emergency maternal and newborn care (the Global Network's EmONC trial)
    Omrana Pasha
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 10:82. 2010
  5. ncbi request reprint Mechanisms to explain surfactant responses
    Alan H Jobe
    Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio, USA
    Biol Neonate 89:298-302. 2006
  6. ncbi request reprint Choice and dose of corticosteroid for antenatal treatments
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Am J Obstet Gynecol 190:878-81. 2004
  7. pmc Postnatal corticosteroids for bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 36:177-88. 2009
  8. pmc The new bronchopulmonary dysplasia
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:167-72. 2011
  9. ncbi request reprint An unanticipated benefit of the treatment of preterm infants with CuZn superoxide dismutase
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 111:680. 2003
  10. doi request reprint "Miracle" extremely low birth weight neonates: examples of developmental plasticity
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Obstet Gynecol 116:1184-90. 2010

Research Grants

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. pmc Effects of chorioamnionitis on the fetal lung
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7029, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 39:441-57. 2012
    ..In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia...
  2. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
    ..Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia...
  3. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
    ..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation...
  4. pmc Communities, birth attendants and health facilities: a continuum of emergency maternal and newborn care (the Global Network's EmONC trial)
    Omrana Pasha
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 10:82. 2010
    ..However, the effectiveness of emergency obstetric and neonatal care services has never been proven. Also unproven is the effectiveness of community mobilization and community birth attendant training to improve pregnancy outcomes...
  5. ncbi request reprint Mechanisms to explain surfactant responses
    Alan H Jobe
    Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio, USA
    Biol Neonate 89:298-302. 2006
    ..Prenatal corticosteroids complement surfactant to further enhance lung function. The magic of surfactant therapy results from the multiple interactions between surfactant and the preterm lung...
  6. ncbi request reprint Choice and dose of corticosteroid for antenatal treatments
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Am J Obstet Gynecol 190:878-81. 2004
    ..However, a change from current practice will require further randomized controlled trials...
  7. pmc Postnatal corticosteroids for bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 36:177-88. 2009
    ..An approach to minimizing risk is to use low-dose, short-duration treatments in the highest risk ventilator-dependent patients. Questions remain about which corticosteroid is the safest and how to dose that corticosteroid...
  8. pmc The new bronchopulmonary dysplasia
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:167-72. 2011
    ..Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment...
  9. ncbi request reprint An unanticipated benefit of the treatment of preterm infants with CuZn superoxide dismutase
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 111:680. 2003
  10. doi request reprint "Miracle" extremely low birth weight neonates: examples of developmental plasticity
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Obstet Gynecol 116:1184-90. 2010
    ..The adaptations that permit survival after very preterm birth may have adverse effects in later life. The biology of multiple organ system plasticities resulting from very preterm birth remains to be extensively explored...
  11. ncbi request reprint Drug pricing in pediatrics: the egregious example of indomethacin
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pediatrics 119:1197-8. 2007
  12. ncbi request reprint The cardiopulmonary system: research and training opportunities
    A H Jobe
    Division of Pulmonary Biology Cincinnati Children s Hospital, University of Cincinnati School of Medicine, OH 45229, USA
    J Perinatol 26:S5-7. 2006
    ..The research initiatives require excellently trained and motivated clinician-scientists, but there are numerous barriers to the training and support of clinician-scientists in cardiology and neonatology...
  13. ncbi request reprint Dose and time response after intraamniotic endotoxin in preterm lambs
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 164:982-8. 2001
    ..The cells in the amniotic fluid may be a source of prolonged fetal exposure to proinflammatory cytokines...
  14. ncbi request reprint Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs
    S G Kallapur
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L527-36. 2001
    ....
  15. ncbi request reprint Surfactant protein A recruits neutrophils into the lungs of ventilated preterm lambs
    B W Kramer
    Department of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    Am J Respir Crit Care Med 163:158-65. 2001
    ..The present study identifies an unanticipated role of SP-A in neutrophil recruitment in the lungs of preterm lambs...
  16. ncbi request reprint Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep
    C J Bachurski
    Division of Pulmonary Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 280:L279-85. 2001
    ..IA endotoxin caused rapid and sustained increases in SP mRNAs that preceded the increase in alveolar saturated phosphatidylcholine processing of SP-B and improved lung compliance in prematurely delivered lambs...
  17. ncbi request reprint Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs
    O Gurel
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1266-72. 2001
    ..Eighty percent of the macrophage-associated radiolabel was recovered from lung digest macrophages. We conclude that macrophages and type II cells contribute equally to saturated phosphatidylcholine and SP-A catabolism in mice...
  18. ncbi request reprint Effects of ventilation with different positive end-expiratory pressures on cytokine expression in the preterm lamb lung
    A S Naik
    Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA
    Am J Respir Crit Care Med 164:494-8. 2001
    ..Mechanical ventilation increased the expression of proinflammatory mediators in surfactant-treated preterm lungs and the use of 4 PEEP minimized this response...
  19. ncbi request reprint Injury responses to different surfactants in ventilated premature lamb lungs
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Pediatr Res 51:689-95. 2002
    ....
  20. ncbi request reprint IL-4 increases surfactant and regulates metabolism in vivo
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 278:L75-80. 2000
    ....
  21. ncbi request reprint Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 167:779-86. 2003
    ..IP-10 and MIG are potent angiostatic chemokines that may contribute to lung injury and altered pulmonary vascular development in the preterm exposed to chorioamnionitis...
  22. ncbi request reprint Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo
    T R Korfhagen
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 273:28438-43. 1998
    ..Targeting of the mouse SP-D gene caused accumulation of surfactant lipid and altered phospholipid structures, demonstrating a previously unsuspected role for SP-D in surfactant lipid homeostasis in vivo...
  23. pmc Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
    ..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation...
  24. doi request reprint High and low body temperature during the initiation of ventilation for near-term lambs
    Molly K Ball
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Resuscitation 80:133-7. 2009
    ..Recent literature suggests hypothermia may protect against lung injury. We evaluated body temperature as a variable in lung inflammation due to oxygenation and mechanical ventilation following delivery of near-term lambs...
  25. ncbi request reprint Tolerance of SP-A-deficient mice to hyperoxia or exercise
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol 89:644-8. 2000
    ..Survival rates were similar after 4 days of hyperoxia. SP-A-(-/-) mice were equally tolerant to exercise and 4 days of hyperoxia, indicating that the SP-A-dependent alterations in surfactant did not result in functional deficits...
  26. ncbi request reprint Surfactant protein metabolism in vivo
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Biochim Biophys Acta 1408:218-25. 1998
    ..The relative importance of type II cells or macrophages to the catabolism of the protein components of surfactant remains to be characterized, as do regulators of surfactant homeostasis...
  27. ncbi request reprint Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs
    A H Jobe
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Obstet Gynecol 182:401-8. 2000
    ..We hypothesized that the proinflammatory response to intra-amniotic endotoxin would induce lung maturation in preterm lambs...
  28. ncbi request reprint Postnatal lung inflammation increased by ventilation of preterm lambs exposed antenatally to Escherichia coli endotoxin
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:356-62. 2002
    ..An antenatal exposure of the fetal lung to endotoxin enhanced the subsequent inflammatory response of the ventilated preterm lung...
  29. pmc Contribution of inflammation to lung injury and development
    S G Kallapur
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, OH 45229 3039, USA
    Arch Dis Child Fetal Neonatal Ed 91:F132-5. 2006
    ..Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD...
  30. ncbi request reprint Glucocorticoids, inflammation and the perinatal lung
    A H Jobe
    Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
    Semin Neonatol 6:331-42. 2001
    ..The opportunities for the future are to develop new safer strategies to mature the preterm foetus, and the risks are potential adverse interactions of repetitive glucocorticoid exposures and unrecognized fetal exposure to inflammation...
  31. ncbi request reprint Mechanisms initiating lung injury in the preterm
    A H Jobe
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Early Hum Dev 53:81-94. 1998
    ..However, care strategies that minimize inflammation and ventilator-induced lung injury should help decrease BPD...
  32. ncbi request reprint CCSP deficiency does not alter surfactant homeostasis during adenoviral infection
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol 277:L983-7. 1999
    ..Persistence of alveolar capillary leak in CCSP(-/-) mice after adenovirus provides further evidence for the role of CCSP in the regulation of pulmonary inflammation...
  33. ncbi request reprint Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, and the School of Women s and Infant s Health, University of Western Australia
    Am J Obstet Gynecol 188:22-8. 2003
    ..We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation...
  34. ncbi request reprint Intratracheal endotoxin causes systemic inflammation in ventilated preterm lambs
    Boris W Kramer
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 165:463-9. 2002
    ..Inflammation in the lungs was more severe in preterm animals. Mechanical ventilation of the endotoxin-exposed preterm lung resulted in systemic effects at a low endotoxin dose and without high tidal volume ventilation...
  35. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  36. ncbi request reprint Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs
    Teicha C Wilson
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Pulmonary Biology, OH 45229, USA
    Pediatr Res 58:1204-9. 2005
    ..Our experiments show rapid induction of an APR gene in lung in response to proinflammatory stimuli...
  37. ncbi request reprint Lung inflammatory responses to intratracheal interleukin-1alpha in ventilated preterm lambs
    Neil Mulrooney
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Res 55:682-7. 2004
    ..The i.v. IL-1alpha caused no lung inflammation or injury but did result in severe neutropenia and hypotension leading to early death. IT IL-1alpha can cause intense lung inflammation and systemic shock in ventilated preterm lungs...
  38. pmc Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis
    Fook Choe Cheah
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 296:L384-93. 2009
    ..Intra-amniotic LPS recruits leukocytes to the fetal air space that have a persistent activation. These results have implications for the pathogenesis of lung inflammatory disorders in the preterm...
  39. ncbi request reprint Monocyte function in preterm, term, and adult sheep
    Boris W Kramer
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Pediatr Res 54:52-7. 2003
    ..The reduced phagocytosis of apoptotic cells by monocytes from the preterm may contribute to prolonged inflammation in diseases such as bronchopulmonary dysplasia...
  40. pmc Betamethasone for lung maturation: testing dose and formulation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:523.e1-6. 2007
    ..We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep...
  41. ncbi request reprint Effects of high PCO2 on ventilated preterm lamb lungs
    Marya Strand
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 53:468-72. 2003
    ..Preterm lambs tolerated a very high PCO(2) without physiologic compromise for 6 h. The high PCO(2) may attenuate ventilator-induced lung injury in the preterm...
  42. ncbi request reprint Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin
    Boris W Kramer
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 283:L452-9. 2002
    ..Intra-amniotic endotoxin caused surfactant secretion, inflammation, cell death, and remodeling as indications of lung injury. The recovery phase was accompanied by maturational changes in the fetal lung...
  43. ncbi request reprint Lung development and function in preterm infants in the surfactant treatment era
    A H Jobe
    Pulmonary Biology Neonatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Annu Rev Physiol 62:825-46. 2000
    ..Mechanisms of lung injury being characterized in the adult lung may have unique characteristics in the developing lung...
  44. ncbi request reprint Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:387-92. 2002
    ..05). In this model in preterm lambs CPAP results in lower indicators of acute lung injury than does mechanical ventilation during the first 2 h of life...
  45. doi request reprint Lung maturation: the survival miracle of very low birth weight infants
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Pediatr neonatol 51:7-13. 2010
    ....
  46. ncbi request reprint Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure
    Neil Mulrooney
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati School of Medicine, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 171:488-93. 2005
    ..A small amount of endogenous Sat PC is required for preterm lambs to breathe successfully with CPAP. CPAP 8 improves early newborn respiratory transition relative to CPAP 5...
  47. pmc Betamethasone dose and formulation for induced lung maturation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:611.e1-7. 2009
    ..We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically...
  48. ncbi request reprint Surfactant protein B inhibits endotoxin-induced lung inflammation
    Ralph Epaud
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 28:373-8. 2003
    ....
  49. pmc Antenatal infection/inflammation and postnatal lung maturation and injury
    A H Jobe
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Respir Res 2:27-32. 2001
    ..The mechanisms by which infection/inflammation can have both beneficial and injurious effects on the preterm lung remain to be characterized...
  50. ncbi request reprint Exogenous surfactant changes the phenotype of alveolar macrophages in mice
    B W Kramer
    Division of Pulmonary Biology, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA
    Am J Physiol Lung Cell Mol Physiol 280:L689-94. 2001
    ..Surfactant treatment in healthy mice transiently changed the phenotype of alveolar macrophages to large and foamy without indications of changes in the surface markers characteristic of activation...
  51. ncbi request reprint Biology of surfactant
    A H Jobe
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Perinatol 28:655-69, vii-viii. 2001
    ..Ventilation styles that injure the lung also result in altered surfactant function...
  52. ncbi request reprint Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L573-9. 2004
    ..After lung inflammation was induced by intra-amniotic endotoxin injection, ventilation did not increase lung injury...
  53. ncbi request reprint Antenatal associations with lung maturation and infection
    Alan H Jobe
    Division Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
    J Perinatol 25:S31-5. 2005
    ..These experimental observations contribute to explanations of why preterm infants have variable degrees of lung maturation at birth and unpredictably develop bronchopulmonary dysplasia BPD...
  54. ncbi request reprint Vascular changes after intra-amniotic endotoxin in preterm lamb lungs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1178-85. 2004
    ..Exposure to antenatal inflammation may cause vascular remodeling and contribute to the development of BPD...
  55. pmc IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 179:955-61. 2009
    ..However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants...
  56. ncbi request reprint Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L966-74. 2005
    ..Contrary to our hypothesis, a prolonged fetal exposure to intra-amniotic endotoxin caused mild persistent inflammation but did not lead to progressive structural abnormalities in lungs of near-term gestation lambs...
  57. pmc Inflammation and lung maturation from stretch injury in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 300:L232-41. 2011
    ..We conclude that a brief period of high V(T) ventilation causes a proinflammatory cascade, a maturation of lung monocytic cells, and an induction of surfactant protein mRNA...
  58. ncbi request reprint Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003
    ..These results have implications for lung inflammation and bronchopulmonary dysplasia in preterm infants exposed to chorioamnionitis and maternal glucocorticoids...
  59. ncbi request reprint Minimal lung and systemic responses to TNF-alpha in preterm sheep
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003
    ..Therefore, the presence of a mediator such as TNF-alpha in a developing animal does not necessarily mean that it is causing the responses anticipated from previous results in adult animals...
  60. ncbi request reprint Animal models of antenatal corticosteroids: clinical implications
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Ohio 45229 3039, USA
    Clin Obstet Gynecol 46:174-89. 2003
  61. doi request reprint Toll-like receptors and agonist responses in the developing fetal sheep lung
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 63:388-93. 2008
    ..We conclude that TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung...
  62. ncbi request reprint Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model
    Fook Choe Cheah
    Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Res 63:274-9. 2008
    ..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia...
  63. ncbi request reprint Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    ..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections...
  64. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
    ..HSP70 protein decreased in the lung tissue and increased in BALF with ventilation. Initiation of ventilation induced a stress response and inflammatory cytokines in small and medium-sized airways...
  65. pmc IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L512-9. 2009
    ..Inhibition of CXCR2 did not change IA LPS-induced lung maturation. IL-8 signaling does not mediate LPS-induced lung inflammation and lung maturation...
  66. pmc Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1315-21. 2005
    ..In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation...
  67. ncbi request reprint Prevention of bronchopulmonary dysplasia
    A H Jobe
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio, USA
    Curr Opin Pediatr 13:124-9. 2001
    ..More adverse effects of postnatal steroids are being recognized. New insights into the pathophysiology of BPD and a new emphasis on minimizing ventilation and ventilator-mediated injury should improve outcomes for very preterm infants...
  68. ncbi request reprint Adrenal and thyroid axis function in preterm ventilated baboons
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Biol Neonate 83:208-16. 2003
    ..The hypothalamic-pituitary-adrenal (HPA) axis was unresponsive to standard dose stimulation tests until 11 days of age in preterm baboons, indicating HPA immaturity...
  69. ncbi request reprint Antenatal factors and the development of bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, 3333 Burnet Avenue, 45229 3039, Cincinnati, OH, USA
    Semin Neonatol 8:9-17. 2003
    ..In this article, the hypothesis developed is that bronchopulmonary dysplasia occurs because of repetitive adverse lung exposures, or hits, and that the initial hits may be antenatal glucocorticoid exposure and/or antenatal inflammation...
  70. ncbi request reprint Characteristics of surfactant from SP-A-deficient mice
    M Ikegami
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol 275:L247-54. 1998
    ..Although the absence of SP-A changed the structure and in vitro properties of surfactant, the in vivo function of surfactant in SP-A(-/-) mice was not changed under the conditions of these experiments...
  71. doi request reprint Injury and inflammation from resuscitation of the preterm infant
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Neonatology 94:190-6. 2008
    ..Ventilation strategies that minimize injury need to be developed...
  72. ncbi request reprint Indications for and questions about antenatal steroids
    Alan H Jobe
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Adv Pediatr 49:227-43. 2002
    ..Antenatal glucocorticoid therapy is very effective, and no adverse effects of a single treatment course have been identified...
  73. pmc Long term consequences of oxygen therapy in the neonatal period
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Semin Fetal Neonatal Med 15:230-5. 2010
    ..Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury...
  74. ncbi request reprint Early bubble CPAP and outcomes in ELBW preterm infants
    Vivek Narendran
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0541, USA
    J Perinatol 23:195-9. 2003
    ..To test whether the introduction of early bubble continuous positive airway pressure (CPAP) results in improved respiratory outcomes in extremely low birth-weight infants...
  75. ncbi request reprint Fetal surgery for myelomeningocele
    Alan H Jobe
    Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:230-1. 2002
  76. ncbi request reprint Recruitment and development of academic pediatricians: departmental commitments to promote success
    Alan H Jobe
    Division of Pulmonary Biology, Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 51:662-4. 2002
  77. ncbi request reprint The multiple negative randomized controlled trials in perinatology--why?
    Marya Strand
    Division of Pulmonary Biology Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Semin Perinatol 27:343-50. 2003
    ....
  78. ncbi request reprint Chorioamnionitis induced by subchorionic endotoxin infusion in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, WA 6009, Australia
    Am J Obstet Gynecol 189:1771-6. 2003
    ..This study was undertaken to determine whether subchorionic endotoxin infusion causes chorioamnionitis and preterm lung maturation, as occurs after intra-amniotic endotoxin...
  79. ncbi request reprint Intraamniotic endotoxin increases lung antioxidant enzyme activity in preterm lambs
    Ilene R S Sosenko
    Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Florida 33101, USA
    Pediatr Res 53:679-83. 2003
    ..Thus, mechanisms involving proinflammatory stimulation, unrelated to glucocorticoid hormones, can induce maturation of the AOE system of the fetal lung...
  80. ncbi request reprint Single and multiple prenatal glucocorticoid exposures improve preterm newborn lamb cardiovascular and renal function similarly
    Lynne M Smith
    Department of Pediatrics, University of California, Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90502, USA
    Am J Obstet Gynecol 188:444-53. 2003
    ..Renal and cardiovascular function improves in preterm newborn lambs after a single prenatal betamethasone treatment. We hypothesized that multiple betamethasone exposures would further improve renal and cardiovascular adaptation...
  81. ncbi request reprint Surfactant phosphatidylcholine half-life and pool size measurements in premature baboons developing bronchopulmonary dysplasia
    Daphne J M T Janssen
    Department of Pediatrics Neonatology, Sophia s Children s Hospital Erasmus University Rotterdam, Rotterdam, The Netherlands
    Pediatr Res 52:724-9. 2002
    ..Measurements with stable isotopes are comparable to measurements with radioactive tracers and measurements at autopsy...
  82. ncbi request reprint Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, 35 Stirling Highway, Crawley WA, Perth, Australia
    Am J Obstet Gynecol 187:1059-65. 2002
    ..Our purpose was to determine whether improved preterm lung function caused by intraamniotic endotoxin treatment requires endotoxin entry into the respiratory tract...
  83. ncbi request reprint The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep
    John P Newnham
    Department of Obstetrics and Gynaecology, University of Western Australia at King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 186:1062-8. 2002
    ..This study aimed to explore the mechanisms by which endotoxin matures the lungs by determining whether the route of administration influenced the maturational responses of the fetus...
  84. ncbi request reprint Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  85. ncbi request reprint Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung
    Karen E Willet
    Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002
    ..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...
  86. ncbi request reprint The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Perth, Western Australia
    Am J Obstet Gynecol 193:313-21. 2005
    ..The outcomes that were studied included the rates of fetal death and the features of inflammation and lung maturation in survivors...
  87. doi request reprint Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep
    David G Sweet
    Department of Child Health, The Queen s University of Belfast, UK
    Neonatology 94:79-86. 2008
    ..The effectors of this antenatally-induced lung maturation are not understood. Matrix metalloproteinases (MMPs) 2 and 9 are type-IV collagenases that can degrade alveolar basement membranes...
  88. ncbi request reprint Transition/adaptation in the delivery room and less RDS: "Don't just do something, stand there!"
    Alan H Jobe
    J Pediatr 147:284-6. 2005
  89. ncbi request reprint The clever fetus: responding to inflammation to minimize lung injury
    Boris W Kramer
    Universit├Ąts Kinderklinik, Wurzburg, Germany
    Biol Neonate 88:202-7. 2005
    ..Both exposures can either increase or decrease fetal inflammatory responses depending on the timing of the exposures. The immunomodulatory ability of the fetus to fetal exposures remains an unexplored research field...
  90. ncbi request reprint Experimental intrauterine Ureaplasma infection in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 192:1179-86. 2005
    ..We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development...
  91. ncbi request reprint Prenatal glucocorticoid exposure and postnatal adaptation in premature newborn baboons ventilated for six days
    Lynne M Smith
    Department of Pediatrics, Harbor UCLA Research and Education Institute, University of California, Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance, Calif, USA
    Am J Obstet Gynecol 191:1688-94. 2004
    ..Study design Pregnant baboons received saline or BETA (6 mg) 48 and 24 hours before preterm delivery at 125 days' gestation. The newborn baboons were ventilated for 6 days, and assessed for renal, cardiovascular, and endocrine function...
  92. ncbi request reprint Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep
    Boris W Kramer
    University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Am J Respir Crit Care Med 171:73-7. 2005
    ..Modulation of fetal innate immune responses by exposure to inflammation may alter subsequent immune adaptation after birth...
  93. ncbi request reprint Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry
    J Jane Pillow
    Centre for Child Health Research, The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 287:L992-8. 2004
    ..Despite the complex cascade of events initiated by antenatal endotoxin exposure, variability in lung tissue mechanics is associated primarily with changes in alveolar Sat PC pool and lung morphology...
  94. ncbi request reprint IL-1 alpha causes lung inflammation and maturation by direct effects on preterm fetal lamb lungs
    Ilene R S Sosenko
    Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33106, USA
    Pediatr Res 60:294-8. 2006
    ..IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes. Lung inflammation and maturation result from direct exposure of the fetal lung to a single cytokine - IL-1alpha...
  95. ncbi request reprint Antenatal inflammation induced TGF-beta1 but suppressed CTGF in preterm lungs
    Steffen Kunzmann
    Department of Pediatrics, Academisch Ziekenhuis Maastricht, Postbus 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L223-31. 2007
    ..These effects may contribute to the impaired alveolar and pulmonary vascular development that is the hallmark of the new form of BPD...
  96. pmc Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs
    J Jane Pillow
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 176:63-9. 2007
    ..The technique used to provide continuous positive airway pressure (CPAP) to the newborn may influence lung function and breathing efficiency...
  97. pmc Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep
    Timothy J M Moss
    School of Women s and Infants Health, Faculty of Medicine, Dentistry, and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
    Am J Obstet Gynecol 198:122.e1-8. 2008
    ..The objective of the study was to determine the effects in late gestation of Ureaplasma parvum serovar 3 colonization and the effects, preterm, of U. parvum serovar 6...
  98. ncbi request reprint Intra-amniotic corticosteroids for preterm lung maturation in sheep
    Timothy J M Moss
    Lotteries Commission Perinatal Research Laboratories, School of Women s and Infants Health, University of Western Australia, Box M094, 35 Stirling Highway, Crawley, Perth, WA 6009, Australia
    Am J Obstet Gynecol 189:1389-95. 2003
    ..The purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone...
  99. ncbi request reprint Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    ..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses...
  100. ncbi request reprint Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, 6009, Australia
    Pediatr Res 62:32-6. 2007
    ..Similar structural changes induced by intra-amniotic corticosteroids and maternal intramuscular betamethasone were associated with improvements in lung function at 2 and 7 d...
  101. ncbi request reprint Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm lambs
    Boris W Kramer
    University Children s Hospital, 97080 Wurzburg, Germany
    Pediatr Res 55:764-8. 2004
    ..The time-dependent changes in maternal betamethasone modulation of the responses of fetal monocytes may influence immune function of the preterm lamb after delivery...

Research Grants25

  1. Postnatal Consequences of Fetal Inflammation
    Alan Jobe; Fiscal Year: 2007
    ..This research will use clinically relevant prenatal exposures and postnatal sensitization to establish under controlled conditions any link between antenatal inflammation and the hygiene hypothesis. ..
  2. Neonatal Resuscitation and Preterm Lung Injury
    Alan Jobe; Fiscal Year: 2007
    ..This translational research should result in changes in resuscitation procedures for preterm infants. ..
  3. NEW MEDIATORS OF CLINICAL LUNG MATURATION
    Alan Jobe; Fiscal Year: 2007
    ..A goal is to identify a mediator with potential for clinical use to induce lung maturation. ..
  4. Neonatal Resuscitation and Preterm Lung Injury
    Alan H Jobe; Fiscal Year: 2010
    ..This translational research should result in changes in resuscitation procedures for preterm infants. ..
  5. NEONATAL TRAINING GRANT
    Alan Jobe; Fiscal Year: 2005
    ..The goal for this training grant is to support only research training for Neonatologists who have the potential and motivation to become successful research oriented academic neonatologists. ..
  6. ANTECEDENTS TO LUNG INJURY IN THE PRETERM
    Alan Jobe; Fiscal Year: 2005
    ..Finally, the ventilation and surfactant strategies that are found to cause the least injury will be tested to see if the arrest in lung development can be prevented. ..
  7. DEVELOPMENTAL LUNG PHOSPHOLIPID METABOLISM
    Alan Jobe; Fiscal Year: 1999
    ..This information combined with the measurements of surfactant function from samples collected from the SP-B and SP-C metabolism studies will provide a uniquely integrated evaluation of surfactant within the preterm lung with RDS. ..
  8. LUNG PHOSPHOLIPID APPEARANCE AND STABILITY
    Alan Jobe; Fiscal Year: 2002
    ....
  9. NEW MEDIATORS OF CLINICAL LUNG MATURATION
    Alan Jobe; Fiscal Year: 2003
    ..Candidate mediators, identified by evaluating the fetal responses to endotoxin, will be tested for their ability to induce fetal responses and lung maturation. ..
  10. Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
    Suhas Kallapur; Fiscal Year: 2010
    ..The results will provide the information to identify infants at risk and to develop preventative and treatment strategies. (End of Abstract) ..