Xi Jiang

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particles
    Tomoyuki Tanaka
    Sakai City Institute of Public Health, Sakai, Osaka, Japan
    Microbiol Immunol 50:883-8. 2006
  2. pmc Poly-LacNAc as an age-specific ligand for rotavirus P[11] in neonates and infants
    Yang Liu
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e78113. 2013
  3. pmc Norovirus P particle efficiently elicits innate, humoral and cellular immunity
    Hao Fang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e63269. 2013
  4. pmc Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    PLoS ONE 4:e5058. 2009
  5. pmc Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
    Yutao Chen
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS Pathog 7:e1002152. 2011
  6. ncbi request reprint Human milk contains elements that block binding of noroviruses to histo-blood group antigens in saliva
    Xi Jiang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Adv Exp Med Biol 554:447-50. 2004
  7. ncbi request reprint Human milk contains elements that block binding of noroviruses to human histo-blood group antigens in saliva
    Xi Jiang
    Division of Infectious Diseases, Center for Epidemiology and Biostatistics, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 190:1850-9. 2004
  8. pmc Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 79:6714-22. 2005
  9. pmc Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Virology 379:324-34. 2008
  10. ncbi request reprint Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 188:19-31. 2003

Research Grants

  1. Novel vaccine against Norovirus
    Xi Jiang; Fiscal Year: 2010
  2. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 1999
  3. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2007
  4. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2003
  5. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2005
  6. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2009
  7. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2009
  8. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2004
  9. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2002
  10. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2010

Collaborators

Detail Information

Publications86

  1. ncbi request reprint High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particles
    Tomoyuki Tanaka
    Sakai City Institute of Public Health, Sakai, Osaka, Japan
    Microbiol Immunol 50:883-8. 2006
    ..These results suggest that an immunization route that mimics the natural route of viral infection pathway may facilitate MAb technology by increasing the yields of antibody secreting hybridoma cells...
  2. pmc Poly-LacNAc as an age-specific ligand for rotavirus P[11] in neonates and infants
    Yang Liu
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e78113. 2013
    ..Overall, our results suggested that the poly-LacNAc could serve as an age-specific receptor for P[11] RVs and well explained the epidemiology that P[11] RVs mainly infect neonates and young children. ..
  3. pmc Norovirus P particle efficiently elicits innate, humoral and cellular immunity
    Hao Fang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e63269. 2013
    ..Since the P particle is highly effective for both humoral and cellular immune responses and easily produced in Escherichia coli (E. coli), it is a good choice of vaccine against NoVs and a vaccine platform against other diseases...
  4. pmc Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    PLoS ONE 4:e5058. 2009
    ..Our hypothesis is that, if HBGAs are the viral receptors necessary for norovirus infection and spread, their binding interfaces should be under a selection pressure in the evolution of noroviruses...
  5. pmc Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
    Yutao Chen
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    PLoS Pathog 7:e1002152. 2011
    ..The results provide insight into the complex interaction between the diverse noroviruses and the polymorphic HBGAs and highlight the role of human HBGA as a critical factor in norovirus evolution...
  6. ncbi request reprint Human milk contains elements that block binding of noroviruses to histo-blood group antigens in saliva
    Xi Jiang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Adv Exp Med Biol 554:447-50. 2004
  7. ncbi request reprint Human milk contains elements that block binding of noroviruses to human histo-blood group antigens in saliva
    Xi Jiang
    Division of Infectious Diseases, Center for Epidemiology and Biostatistics, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 190:1850-9. 2004
    ..Secretor and Lewis, but not A or B antigens, were present in human milk and were responsible for blocking NV binding to receptors and therefore are likely to be decoy receptors that protect breast-fed infants from NV infection...
  8. pmc Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patterns
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 79:6714-22. 2005
    ..The high polymorphism of the human HBGA system, the involvement of multiple epitopes, and the typical protein/carbohydrate interaction between norovirus VLPs and HBGAs provide an explanation for the virus-ligand binding diversities...
  9. pmc Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis study
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Virology 379:324-34. 2008
    ..Taken together, our study provides new insights into the carbohydrate/capsid interactions which are a valuable complement to the atomic structures in understanding the virus/host interaction and in the future design of antiviral agents...
  10. ncbi request reprint Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patterns
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 188:19-31. 2003
    ..Oligosaccharides containing the Lewis and ABH antigenic epitopes were involved in binding. Our findings suggest that different strains of NORs may recognize different human HBGAs on intestinal epithelial cells as receptors for infection...
  11. pmc Rotavirus VP8*: phylogeny, host range, and interaction with histo-blood group antigens
    Yang Liu
    Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Virol 86:9899-910. 2012
    ..Our study suggests that HBGAs play an important role in RV infection and evolution...
  12. pmc Genetic and phenotypic characterization of GII-4 noroviruses that circulated during 1987 to 2008
    Yang Yang
    State Key Laboratory of Agro Biotechnology, China Agricultural University, Beijing, China
    J Virol 84:9595-607. 2010
    ..A potential outcome of such counterselection between theses two factors in NV evolution is discussed...
  13. pmc Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Virol 86:4833-43. 2012
    ..Our results suggest that the spike protein VP8* of RVs is involved in the recognition of human HBGAs that may function as ligands or receptors for RV attachment to host cells...
  14. pmc Noroviral P particle: structure, function and applications in virus-host interaction
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Virology 382:115-23. 2008
    ..The P particles are easily produced in E. coli and yeast and are stable, which are potentially useful for a broad application including vaccine development against noroviruses...
  15. pmc Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques
    Xiling Liu
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 200031 Shanghai, China
    Genome Res 22:611-22. 2012
    ..Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages...
  16. pmc Structural basis for the receptor binding specificity of Norwalk virus
    Weiming Bu
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Virol 82:5340-7. 2008
    ..The A-trisaccharide binding mode seen in the NV P domain complex cannot be sterically accommodated in the VA387 P domain...
  17. pmc C-terminal arginine cluster is essential for receptor binding of norovirus capsid protein
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 80:7322-31. 2006
    ..3 kDa (Norwalk virus) or 34.3 kDa (VA387), similar to the soluble P protein found in vivo. Our findings imply that the proteolytic process could be a necessary step for norovirus replication in the host...
  18. pmc Polyvalent complexes for vaccine development
    Leyi Wang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Biomaterials 34:4480-92. 2013
    ..Therefore, our polyvalent complex system provides a new strategy for novel vaccine development and may find various applications throughout biomedicine...
  19. pmc Inhibition of histo-blood group antigen binding as a novel strategy to block norovirus infections
    Xu Fu Zhang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 8:e69379. 2013
    ..Interestingly, 4 of the top-5 compounds shared the basic structure of cyclopenta [a] dimethyl phenanthren, indicating a promising structural template for further improvement by rational design. ..
  20. pmc Structural basis for the recognition of blood group trisaccharides by norovirus
    Sheng Cao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    J Virol 81:5949-57. 2007
    ..The extensive interface between the two protomers in a P dimer also plays a crucial role in the formation of the receptor binding interface...
  21. doi request reprint Emergence of the GII4/2006b variant and recombinant noroviruses in China
    Miao Jin
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
    J Med Virol 80:1997-2004. 2008
    ..This study suggests that continual surveillance focusing on strain variation and dynamic change is important for understanding the epidemiology and development of a strategy for disease control and prevention...
  22. doi request reprint Predicting susceptibility to norovirus GII.4 by use of a challenge model involving humans
    Robert Frenck
    Division Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
    J Infect Dis 206:1386-93. 2012
    ..We performed the first GII.4 challenge study involving humans and prospectively evaluated the relationship between HBGAs and norovirus infection and associated illness...
  23. pmc Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Nanomedicine (Lond) 7:889-97. 2012
    ..This article summarizes the discovery, structure, development and applications of the P particles as a vaccine against NoVs, as well as a vaccine platform against rotavirus, influenza virus and possibly other pathogens in the future...
  24. pmc Norovirus-host interaction: multi-selections by human histo-blood group antigens
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
    Trends Microbiol 19:382-8. 2011
    ..A model of this multi-selection of NoVs by HBGAs is proposed...
  25. pmc Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particles
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Virology 410:345-52. 2011
    ..The small P particles may also be a useful alternative in study of norovirus-host interaction and vaccine development for noroviruses...
  26. pmc A candidate dual vaccine against influenza and noroviruses
    Ming Xia
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Vaccine 29:7670-7. 2011
    ..These results suggest that the P particle-M2e chimera can be used as dual vaccine against both noroviruses and influenza viruses...
  27. doi request reprint Outbreak studies of a GII-3 and a GII-4 norovirus revealed an association between HBGA phenotypes and viral infection
    Ming Tan
    Divisions of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Med Virol 80:1296-301. 2008
    ..While the nonsecretor phenotype appears naturally resistant to these two strains, additional determinants on the HBGAs also may play roles in host range of the two strains...
  28. pmc Mutations within the P2 domain of norovirus capsid affect binding to human histo-blood group antigens: evidence for a binding pocket
    Ming Tan
    Division of Infectious Diseases and Division of Pediatric Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Virol 77:12562-71. 2003
    ..Taken together, our data indicate that the binding pocket likely exists on NOR capsids. Direct evidence of this hypothesis requires crystallography studies...
  29. pmc Development of an enzyme immunoassay for detection of sapovirus-specific antibodies and its application in a study of seroprevalence in children
    Tibor Farkas
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Clin Microbiol 44:3674-9. 2006
    ..SV infection is common in the first 2 years of life. The low prevalence of maternal antibodies detected in Mexican children against SVs in this study is unique and needs to be addressed in future studies...
  30. pmc The p domain of norovirus capsid protein forms a subviral particle that binds to histo-blood group antigen receptors
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Virol 79:14017-30. 2005
    ..The easy production of the P particle and its strong binding to HBGAs suggest that the P particle is useful in studying pathogenesis and morphogenesis of norovirus and candidates for antiviral or vaccine development...
  31. pmc Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaques
    Tibor Farkas
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Gen Virol 91:734-8. 2010
    ..The high prevalence of human and rhesus CV-specific serum antibodies suggests the frequent exposure of colony macaques to enteric CVs including the possibility of CV transmission between human and non-human primate hosts...
  32. ncbi request reprint Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants
    Ardythe L Morrow
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Pediatr 145:297-303. 2004
    ..To determine the association between maternal milk levels of 2-linked fucosylated oligosaccharide and prevention of diarrhea as a result of Campylobacter, caliciviruses, and diarrhea of all causes in breast-fed infants...
  33. doi request reprint The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognition
    Pengwei Huang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Glycoconj J 26:1085-96. 2009
    ..Further studies to define the structure and genetics of the high MW milk glycans are necessary...
  34. pmc The P domain of norovirus capsid protein forms dimer and binds to histo-blood group antigen receptors
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 78:6233-42. 2004
    ..The high yield and easy production of the recombinant P protein in the Escherichia coli expression system will provide a simple approach to this goal...
  35. pmc Recovery of infectious virus by transfection of in vitro-generated RNA from tulane calicivirus cDNA
    Chao Wei
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 82:11429-36. 2008
    ..The availability of the complete genomic sequence and the reverse genetics system described herein make TV a valuable model for studying calicivirus pathogenesis and replication...
  36. pmc Library screen for inhibitors targeting norovirus binding to histo-blood group antigen receptors
    Xizhi Feng
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Antimicrob Agents Chemother 51:324-31. 2007
    ..The EIA is a high-throughput method for large-scale library screening for antivirals against NVs. Studies to further characterize the lead compounds and to screen additional compounds for other NVs are ongoing in our laboratory...
  37. ncbi request reprint Homologous versus heterologous immune responses to Norwalk-like viruses among crew members after acute gastroenteritis outbreaks on 2 US Navy vessels
    Tibor Farkas
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    J Infect Dis 187:187-93. 2003
    ..These results indicate that recombinant EIAs are useful for outbreak investigation and that the homologous antibody might be protective against reinfection...
  38. ncbi request reprint Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Trends Microbiol 13:285-93. 2005
    ..This has been shown by their genetic and structural variations, which explains why norovirus-associated diseases are so common and widespread in every population worldwide...
  39. pmc Norovirus P particle, a novel platform for vaccine development and antibody production
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol 85:753-64. 2011
    ..The P particle-VP8 chimeras may serve as a dual vaccine against both rotavirus and norovirus...
  40. pmc Substrate specificity of Tulane virus protease
    Chao Wei
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Virology 436:24-32. 2013
    ..The apparently shared substrate specificities between TV and Norwalk virus proteases suggested that the cultivable TV could be used as a model for in vivo evaluation of lead candidates of protease inhibitors for human norovirus...
  41. ncbi request reprint Norovirus-host interaction: implications for disease control and prevention
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Expert Rev Mol Med 9:1-22. 2007
    ..This review summarises and discusses recent advances and highlights implications for future studies in the control and prevention of NV gastroenteritis...
  42. ncbi request reprint E. coli-expressed recombinant norovirus capsid proteins maintain authentic antigenicity and receptor binding capability
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Med Virol 74:641-9. 2004
    ....
  43. pmc Seroprevalence of noroviruses in swine
    Tibor Farkas
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Clin Microbiol 43:657-61. 2005
    ....
  44. ncbi request reprint Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea
    Ardythe L Morrow
    Center for Epidemiology and Biostatistics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, OH, USA
    J Nutr 135:1304-7. 2005
    ..These novel data open the potential for translational research to develop the human-milk glycans as a new class of antimicrobial agents that prevent infection by acting as pathogen anti-adhesion agents...
  45. pmc Characterization of a rhesus monkey calicivirus representing a new genus of Caliciviridae
    Tibor Farkas
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Virol 82:5408-16. 2008
    ..Although the pathogenicity of TV in rhesus macaques remains to be elucidated, the likelihood of TV causing intestinal infection and the availability of a tissue culture system make this virus a valuable surrogate for human CVs...
  46. pmc Inhibition of Tulane virus replication in vitro with RNA interference
    Qiang Fan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Med Virol 85:179-86. 2013
    ..Since the TV shares many biological properties with human noroviruses (NoVs), the successful demonstration of RNAi in TV replication would provide valuable information in control of acute gastroenteritis caused by human NoVs...
  47. ncbi request reprint Norovirus gastroenteritis, increased understanding and future antiviral options
    Ming Tan
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Curr Opin Investig Drugs 9:146-51. 2008
    ..This review summarizes new developments in the treatment of norovirus gastroenteritis and discusses future research directions...
  48. ncbi request reprint Human caliciviruses and pediatric gastroenteritis
    Sarbelio Moreno-Espinosa
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Semin Pediatr Infect Dis 15:237-45. 2004
    ..Major developments in this field are expected to occur in the near future...
  49. ncbi request reprint [Bacterial diversity recovered from Qiyi Glacier and runoff, Qilian Mts]
    Jun Xie
    State Key Laboratory of Cryospheric Science, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China
    Huan Jing Ke Xue 30:2735-40. 2009
    ....
  50. pmc Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants
    Ardythe L Morrow
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45213, USA
    J Pediatr 158:745-51. 2011
    ..To investigate secretor gene fucosyltransferase 2 (FUT2) polymorphism and secretor phenotype in relation to outcomes of prematurity...
  51. ncbi request reprint Norovirus capsid protein expressed in yeast forms virus-like particles and stimulates systemic and mucosal immunity in mice following an oral administration of raw yeast extracts
    Ming Xia
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Med Virol 79:74-83. 2007
    ..The mice immunization study also indicated that the oral administration of raw yeast extracts without an adjuvant is a safe and simple way which is worth to be studied for vaccine delivery in humans...
  52. pmc High-pressure inactivation of human norovirus virus-like particles provides evidence that the capsid of human norovirus is highly pressure resistant
    Fangfei Lou
    Department of Food Science and Technology, College of Food, Agricultural and Environmental Sciences, The Ohio State University, Columbus, Ohio, USA
    Appl Environ Microbiol 78:5320-7. 2012
    ..While human NoV VLPs may not be fully representative of viable human NoV, destruction of the VLP capsid is highly suggestive of a typical response for viable human NoV...
  53. pmc The formation of P particle increased immunogenicity of norovirus P protein
    Ming Tan
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Immunology 136:28-9. 2012
    ..It emphasizes the importance of P particle formation in the immune enhancement of the vaccine and methods for production/verification of high quality P particles which may be easily neglected by researchers...
  54. pmc MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates
    Mehmet Somel
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, Shanghai, China
    PLoS Biol 9:e1001214. 2011
    ....
  55. pmc Novel human rotavirus of genotype G5P[6] identified in a stool specimen from a Chinese girl with diarrhea
    Zhao Jun Duan
    National Institute for Viral Disease Control and Prevention, Beijing, China
    J Clin Microbiol 45:1614-7. 2007
    ..5% homologous to those of the porcine P[6] strains 134/04-10, 134/04-11, 221/04-7, and 221/04-13. Our findings indicate a dynamic interaction between human and porcine rotaviruses...
  56. pmc A dual vaccine candidate against norovirus and hepatitis E virus
    Leyi Wang
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, United States
    Vaccine 32:445-52. 2014
    ..Thus, GST-NoV P(-)-HEV P and NoV P(-)-HEV P complexes are promising dual vaccine candidates against both NoV and HEV. ..
  57. ncbi request reprint Update on caliciviruses and human acute gastroenteritis
    Xi Jiang
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Infect Dis J 21:1069-70. 2002
  58. ncbi request reprint Histo-blood group antigens: a common niche for norovirus and rotavirus
    Ming Tan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Expert Rev Mol Med 16:e5. 2014
    ..Thus, exploratory research into whether such diverse recognitions also occur for other viral and bacterial pathogens that recognise HBGAs is warranted. ..
  59. ncbi request reprint [Hydrochemical characteristics and evolution of runoff at Qiyi glacier, Qilian Mts]
    Xiao Bo Wu
    State Key Laboratory of Cryospheric Sciences, Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China
    Huan Jing Ke Xue 29:613-8. 2008
    ..The spatial characteristic of ions concentration is controlled by the process of water-rock and temporal change is hydrological factors...
  60. pmc Widespread expression of piRNA-like molecules in somatic tissues
    Zheng Yan
    Key laboratory of Computational Biology, CAS MPG Partner Institute for Computational Biology, Chinese Academy of Sciences, 320 Yueyang Road, 200031, Shanghai, China
    Nucleic Acids Res 39:6596-607. 2011
    ..Further, using western blot, we have shown the expression of Miwi protein in mouse pancreas. These findings indicate that piRNA-like molecules might play important roles outside of the germline...
  61. ncbi request reprint Human susceptibility and resistance to Norwalk virus infection
    Lisa Lindesmith
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Nat Med 9:548-53. 2003
    ..Of the susceptible population that encoded a functional FUT2 gene, a portion was resistant to infection, suggesting that a memory immune response or some other unidentified factor also affords protection from Norwalk virus infection...
  62. ncbi request reprint Sequence diversity of human caliciviruses recovered from children with diarrhea in Mendoza, Argentina, 1995-1998
    Norma Martinez
    Virology Laboratory, Central Hospital, Mendoza, Argentina
    J Med Virol 67:289-98. 2002
    ....
  63. ncbi request reprint [Sapporo-like viruses in sporadic gastroenteritis of unknown origin]
    Gabor Reuter
    Allami Népegészségügyi és Tisztiorvosi Szolgálat Baranya Megyei Intézete, Pecs, Regionális Virológiai Laboratórium
    Orv Hetil 143:351-4. 2002
    ..The etiologic role of these viruses is evident but little is known about the incidence of acute gastroenteritis caused by them. Sapporo-like viruses have not been detected in Hungary before...
  64. pmc Seroprevalence of antibodies against noroviruses among students in a Chinese military medical university
    Ying chun Dai
    Department of Epidemiology, First Military Medical University, Guangzhou, China
    J Clin Microbiol 42:4615-9. 2004
    ..The distribution of ABO blood types did not differ among the three groups. These data suggest that NVs are prevalent in China and that both genetic and environmental factors play a role in NV infection...
  65. ncbi request reprint Seroepidemiology and risk factors for sporadic norovirus/Mexico strain
    Anne E Peasey
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
    J Infect Dis 189:2027-36. 2004
    ..001). This study provides initial evidence of risk factors associated with sporadic NV infection. Data indicate some similarities to risk factors associated with outbreaks of NV infection...
  66. ncbi request reprint [Noroviruses are the most common pathogens causing nosocomial gastroenteritis outbreaks in Hungarian hospitals]
    Gabor Reuter
    Allami Népegészségügyi és Tisztiorvosi Szolgálat Baranya Megyei Intézete, Regionális Virológiai Laboratórium, Pécsi, Pecs
    Orv Hetil 144:1611-6. 2003
    ..Epidemics commonly occur in crowded community and spread by fecal-oral route through contaminated food, water and direct contact...
  67. ncbi request reprint Detection of Norwalk-like virus infection aboard two U.S. Navy ships
    Scott Thornton
    Navy Environmental and Preventive Medicine Unit No 5, San Diego, CA 92136, USA
    Mil Med 167:826-30. 2002
    ..No point source was found for either ship. The on-site laboratory investigation can provide important information for outbreak control and prevention while new cases are still presenting...
  68. ncbi request reprint Molecular epidemiology of human calicivirus gastroenteritis outbreaks in Hungary, 1998 to 2000
    Gabor Reuter
    Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
    J Med Virol 68:390-8. 2002
    ..This is the first country-wide molecular epidemiological investigation of human calicivirus-associated, gastroenteritis outbreaks in Hungary and Central-Eastern Europe...
  69. pmc Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP
    Noritoshi Kitamoto
    School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology, Hyogo 670 0092, Japan
    J Clin Microbiol 40:2459-65. 2002
    ..These strain-, genogroup-, and genus-reactive MAbs will be useful tools for further study of the antigenic and structural topography of the HuCV virion and for diagnostic assays for HuCVs...
  70. ncbi request reprint Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individuals
    Severine Marionneau
    INSERM U419, Institut de Biologie, Nantes, France
    Gastroenterology 122:1967-77. 2002
    ..Our aim was to test if, by analogy, recombinant NV-like particles (rNV VLPs) use carbohydrates present on human gastroduodenal epithelial cells as ligands...
  71. ncbi request reprint A Norwalk-like virus outbreak on the Appalachian Trail
    Lucy A Peipins
    Agency for Toxic Substances and Disease Registry, 1600 Clifton Rd, NE, E 31, Atlanta, GA 30333, USA
    J Environ Health 64:18-23, 32. 2002
    ..Poor sanitation, scarce water supplies, and crowding can increase the risk of gastrointestinal illness among long-distance hikers...
  72. ncbi request reprint Gastroenteritis in US Marines during Operation Iraqi Freedom
    Scott A Thornton
    Navy Environmental and Preventive Medicine Unit No 6, Pearl Harbor, Hawaii 96860, USA
    Clin Infect Dis 40:519-25. 2005
    ..A Navy Preventive Medicine laboratory was set up in Ad Diwaniyah, Iraq, to provide clinical diagnostic support for Marine medical units during a period of repositioning in south-central Iraq...
  73. ncbi request reprint Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United States
    Carmelann Zintz
    Center for Pediatric Research, Children s Hospital of the King s Daughters, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Infect Genet Evol 5:281-90. 2005
    ..In conclusion, NV and SV were frequent causes of hospitalization for acute gastroenteritis in young children and infecting strains were highly diverse, including newly recognized genogroups and genetic clusters within known genogroups...
  74. pmc Caliciviruses and foodborne gastroenteritis, Chile
    Roberto Vidal
    Microbiology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
    Emerg Infect Dis 11:1134-7. 2005
    ..Outbreaks affected ?99 persons, occurred most commonly in the home, and were associated with seafood consumption. Thirteen outbreak strains sequenced were noroviruses, including 8 GII, 2 GI, and 3 belonging to a novel genogroup...
  75. pmc Novel recombinant norovirus causing outbreaks of gastroenteritis in Santiago, Chile
    Roberto Vidal
    Programa de Microbiologia, Instituto de Ciencias Biomedicas ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    J Clin Microbiol 44:2271-5. 2006
    ..These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies...
  76. doi request reprint Molecular characterization of unusual human G5P[6] rotaviruses identified in China
    Dan di Li
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
    J Clin Virol 42:141-8. 2008
    ..We found an unusual human rotavirus, LL36755 of G5P[6] genotype, in a stool sample collected in Lulong County, Hebei Province, China. This is the first detection of rotavirus serotype G5 in Asia...
  77. ncbi request reprint Norovirus recognizes histo-blood group antigens on gastrointestinal cells of clams, mussels, and oysters: a possible mechanism of bioaccumulation
    Peng Tian
    Produce Safety and Microbiology Research Unit, U S Department of Agriculture, Agricultural Research Service, Western Regional Research Center, 800 Buchanan Street, Albany, California 94710, USA
    J Food Prot 70:2140-7. 2007
    ..Our results also suggest that this bioaccumulation could be reversed by incubation with HBGA analogs, a possible important new strategy for depuration...
  78. ncbi request reprint Binding of recombinant norovirus like particle to histo-blood group antigen on cells in the lumen of pig duodenum
    Peng Tian
    Produce Safety and Microbiology Research Unit, Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 800 Buchanan Street, Albany, CA 94710 1105, USA
    Res Vet Sci 83:410-8. 2007
    ..It highlights the importance of further study of human norovirus incidence and potential infection and residence in non-human animal hosts and suggests the possibility that norovirus may be a zoonotic pathogen...
  79. ncbi request reprint [Investigation of human calicivirus (HuCV) diarrhea among infantile and young children in China, 1999--2005]
    Zhao Yin Fang
    National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
    Bing Du Xue Bao 23:9-15. 2007
    ....
  80. doi request reprint Association of histo-blood group antigens with susceptibility to norovirus infection may be strain-specific rather than genogroup dependent
    Ming Tan
    J Infect Dis 198:940-1; author reply 942-3. 2008
  81. ncbi request reprint Detection of viral agents in fecal specimens of monkeys with diarrhea
    Yuhuan Wang
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Emory University, Atlanta, GA, USA
    J Med Primatol 36:101-7. 2007
    ....
  82. ncbi request reprint Enhanced tissue plasminogen activator synthesis by the sympathetic neurons that innervate aging vessels
    Xi Jiang
    Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Neurosci Res 71:567-74. 2003
    ..The possibility that increased sympathetic nervous system plasminogenesis influences the aging process in nonvascular tissues also deserves further investigation...
  83. ncbi request reprint [Identification of two new strains of norovirus in Guangzhou]
    Ying chun Dai
    Department of Epidemiology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:1016-8, 1022. 2004
    ..To identify the molecular biological characteristics of human caliciviruses (HuCVs) and new strains of norovirus (NV) detected in Guangdong Province...
  84. ncbi request reprint Trapping norovirus by glycosylated hydrogels: a potential oral antiviral drug
    Yalong Zhang
    Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    ChemMedChem 1:1361-6. 2006
  85. ncbi request reprint Deletion-targeted multiplex PCR (DTM-PCR) for identification of Beijing/W genotypes of Mycobacterium tuberculosis
    Jing Chen
    Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Tuberculosis (Edinb) 87:446-9. 2007
    ..Using this Deletion-Targeted Multiplex PCR (DTM-PCR) method for detecting these strains, we obtained 100% sensitivity and specificity...

Research Grants20

  1. Novel vaccine against Norovirus
    Xi Jiang; Fiscal Year: 2010
    ....
  2. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 1999
    ..Specific aim 3. To characterize the natural history of infection in children and experimentally infected volunteers and to correlate immunity with protection against HuCV infection and illness. ..
  3. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2007
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  4. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2003
    ..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..
  5. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2005
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  6. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2009
    ..abstract_text> ..
  7. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2009
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  8. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2004
    ..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..
  9. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2002
    ..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..
  10. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2010
    ..abstract_text> ..
  11. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2000
    ..Specific aim 3. To characterize the natural history of infection in children and experimentally infected volunteers and to correlate immunity with protection against HuCV infection and illness. ..
  12. Third International Calicivirus Conference
    Xi Jiang; Fiscal Year: 2007
    ..We will publish a proceeding of the meeting as a supplement of the Journal of Infectious Diseases after the meeting. ..
  13. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
    ..Specific aim 3. To characterize the natural history of infection in children and experimentally infected volunteers and to correlate immunity with protection against HuCV infection and illness. ..
  14. Norwalk-like Viruses and Their Receptors
    Xi Jiang; Fiscal Year: 2006
    ..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
  15. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2006
    ..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..
  16. CHARACTERIZATION OF HUMAN CALICIVIRUS
    Xi Jiang; Fiscal Year: 2001
    ..Specific aim 3. To characterize the natural history of infection in children and experimentally infected volunteers and to correlate immunity with protection against HuCV infection and illness. ..
  17. Characterization of Human Caliciviruses
    Xi Jiang; Fiscal Year: 2005
    ..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..