Research Topics
Genomes and GenesSpecies | Xi JiangSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particlesTomoyuki Tanaka
Sakai City Institute of Public Health, Sakai, Osaka, Japan
Microbiol Immunol 50:883-8. 2006..These results suggest that an immunization route that mimics the natural route of viral infection pathway may facilitate MAb technology by increasing the yields of antibody secreting hybridoma cells...- Human milk contains elements that block binding of noroviruses to histo-blood group antigens in salivaXi Jiang
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA
Adv Exp Med Biol 554:447-50. 2004 - Human milk contains elements that block binding of noroviruses to human histo-blood group antigens in salivaXi Jiang
Division of Infectious Diseases, Center for Epidemiology and Biostatistics, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Infect Dis 190:1850-9. 2004..Secretor and Lewis, but not A or B antigens, were present in human milk and were responsible for blocking NV binding to receptors and therefore are likely to be decoy receptors that protect breast-fed infants from NV infection... 
Norovirus and histo-blood group antigens: demonstration of a wide spectrum of strain specificities and classification of two major binding groups among multiple binding patternsPengwei Huang
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Virol 79:6714-22. 2005..The high polymorphism of the human HBGA system, the involvement of multiple epitopes, and the typical protein/carbohydrate interaction between norovirus VLPs and HBGAs provide an explanation for the virus-ligand binding diversities...- Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigens: identification of 4 distinct strain-specific patternsPengwei Huang
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
J Infect Dis 188:19-31. 2003..Oligosaccharides containing the Lewis and ABH antigenic epitopes were involved in binding. Our findings suggest that different strains of NORs may recognize different human HBGAs on intestinal epithelial cells as receptors for infection... - Elucidation of strain-specific interaction of a GII-4 norovirus with HBGA receptors by site-directed mutagenesis studyMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Virology 379:324-34. 2008..Taken together, our study provides new insights into the carbohydrate/capsid interactions which are a valuable complement to the atomic structures in understanding the virus/host interaction and in the future design of antiviral agents... - Rotavirus VP8*: phylogeny, host range, and interaction with histo-blood group antigensYang Liu
Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Virol 86:9899-910. 2012..Our study suggests that HBGAs play an important role in RV infection and evolution... - Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific mannerPengwei Huang
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
J Virol 86:4833-43. 2012..Our results suggest that the spike protein VP8* of RVs is involved in the recognition of human HBGAs that may function as ligands or receptors for RV attachment to host cells... - Noroviral P particle: structure, function and applications in virus-host interactionMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Virology 382:115-23. 2008..The P particles are easily produced in E. coli and yeast and are stable, which are potentially useful for a broad application including vaccine development against noroviruses... - Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolutionMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
PLoS ONE 4:e5058. 2009..Our hypothesis is that, if HBGAs are the viral receptors necessary for norovirus infection and spread, their binding interfaces should be under a selection pressure in the evolution of noroviruses... - C-terminal arginine cluster is essential for receptor binding of norovirus capsid proteinMing Tan
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Virol 80:7322-31. 2006..3 kDa (Norwalk virus) or 34.3 kDa (VA387), similar to the soluble P protein found in vivo. Our findings imply that the proteolytic process could be a necessary step for norovirus replication in the host... - Structural basis for the receptor binding specificity of Norwalk virusWeiming Bu
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Virol 82:5340-7. 2008..The A-trisaccharide binding mode seen in the NV P domain complex cannot be sterically accommodated in the VA387 P domain... - Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virusMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Nanomedicine (Lond) 7:889-97. 2012..This article summarizes the discovery, structure, development and applications of the P particles as a vaccine against NoVs, as well as a vaccine platform against rotavirus, influenza virus and possibly other pathogens in the future... - Norovirus-host interaction: multi-selections by human histo-blood group antigensMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Trends Microbiol 19:382-8. 2011..A model of this multi-selection of NoVs by HBGAs is proposed... - Terminal modifications of norovirus P domain resulted in a new type of subviral particles, the small P particlesMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Virology 410:345-52. 2011..The small P particles may also be a useful alternative in study of norovirus-host interaction and vaccine development for noroviruses... - Development of an enzyme immunoassay for detection of sapovirus-specific antibodies and its application in a study of seroprevalence in childrenTibor Farkas
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Clin Microbiol 44:3674-9. 2006..SV infection is common in the first 2 years of life. The low prevalence of maternal antibodies detected in Mexican children against SVs in this study is unique and needs to be addressed in future studies... - The p domain of norovirus capsid protein forms a subviral particle that binds to histo-blood group antigen receptorsMing Tan
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA
J Virol 79:14017-30. 2005..The easy production of the P particle and its strong binding to HBGAs suggest that the P particle is useful in studying pathogenesis and morphogenesis of norovirus and candidates for antiviral or vaccine development... - A candidate dual vaccine against influenza and norovirusesMing Xia
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Vaccine 29:7670-7. 2011..These results suggest that the P particle-M2e chimera can be used as dual vaccine against both noroviruses and influenza viruses... 
Outbreak studies of a GII-3 and a GII-4 norovirus revealed an association between HBGA phenotypes and viral infectionMing Tan
Divisions of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Med Virol 80:1296-301. 2008..While the nonsecretor phenotype appears naturally resistant to these two strains, additional determinants on the HBGAs also may play roles in host range of the two strains...- The carbohydrate moiety and high molecular weight carrier of histo-blood group antigens are both required for norovirus-receptor recognitionPengwei Huang
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Glycoconj J 26:1085-96. 2009..Further studies to define the structure and genetics of the high MW milk glycans are necessary... - Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infantsArdythe L Morrow
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Pediatr 145:297-303. 2004..To determine the association between maternal milk levels of 2-linked fucosylated oligosaccharide and prevention of diarrhea as a result of Campylobacter, caliciviruses, and diarrhea of all causes in breast-fed infants... - Detection of norovirus-, sapovirus- and rhesus enteric calicivirus-specific antibodies in captive juvenile macaquesTibor Farkas
Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Gen Virol 91:734-8. 2010..The high prevalence of human and rhesus CV-specific serum antibodies suggests the frequent exposure of colony macaques to enteric CVs including the possibility of CV transmission between human and non-human primate hosts... - Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzleMing Tan
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Trends Microbiol 13:285-93. 2005..This has been shown by their genetic and structural variations, which explains why norovirus-associated diseases are so common and widespread in every population worldwide... - Norovirus P particle, a novel platform for vaccine development and antibody productionMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Virol 85:753-64. 2011..The P particle-VP8 chimeras may serve as a dual vaccine against both rotavirus and norovirus... - Homologous versus heterologous immune responses to Norwalk-like viruses among crew members after acute gastroenteritis outbreaks on 2 US Navy vesselsTibor Farkas
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Ohio 45229, USA
J Infect Dis 187:187-93. 2003..These results indicate that recombinant EIAs are useful for outbreak investigation and that the homologous antibody might be protective against reinfection... - Library screen for inhibitors targeting norovirus binding to histo-blood group antigen receptorsXizhi Feng
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Antimicrob Agents Chemother 51:324-31. 2007..The EIA is a high-throughput method for large-scale library screening for antivirals against NVs. Studies to further characterize the lead compounds and to screen additional compounds for other NVs are ongoing in our laboratory... - Mutations within the P2 domain of norovirus capsid affect binding to human histo-blood group antigens: evidence for a binding pocketMing Tan
Division of Infectious Diseases and Division of Pediatric Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Virol 77:12562-71. 2003..Taken together, our data indicate that the binding pocket likely exists on NOR capsids. Direct evidence of this hypothesis requires crystallography studies... - Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrheaArdythe L Morrow
Center for Epidemiology and Biostatistics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, OH, USA
J Nutr 135:1304-7. 2005..These novel data open the potential for translational research to develop the human-milk glycans as a new class of antimicrobial agents that prevent infection by acting as pathogen anti-adhesion agents... - Seroprevalence of noroviruses in swineTibor Farkas
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Clin Microbiol 43:657-61. 2005.... - Norovirus-host interaction: implications for disease control and preventionMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Expert Rev Mol Med 9:1-22. 2007..This review summarises and discusses recent advances and highlights implications for future studies in the control and prevention of NV gastroenteritis... - The P domain of norovirus capsid protein forms dimer and binds to histo-blood group antigen receptorsMing Tan
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
J Virol 78:6233-42. 2004..The high yield and easy production of the recombinant P protein in the Escherichia coli expression system will provide a simple approach to this goal... - Recovery of infectious virus by transfection of in vitro-generated RNA from tulane calicivirus cDNAChao Wei
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Virol 82:11429-36. 2008..The availability of the complete genomic sequence and the reverse genetics system described herein make TV a valuable model for studying calicivirus pathogenesis and replication... - E. coli-expressed recombinant norovirus capsid proteins maintain authentic antigenicity and receptor binding capabilityMing Tan
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Med Virol 74:641-9. 2004.... - Human caliciviruses and pediatric gastroenteritisSarbelio Moreno-Espinosa
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Semin Pediatr Infect Dis 15:237-45. 2004..Major developments in this field are expected to occur in the near future... - Norovirus gastroenteritis, increased understanding and future antiviral optionsMing Tan
Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Curr Opin Investig Drugs 9:146-51. 2008..This review summarizes new developments in the treatment of norovirus gastroenteritis and discusses future research directions... - Characterization of a rhesus monkey calicivirus representing a new genus of CaliciviridaeTibor Farkas
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Virol 82:5408-16. 2008..Although the pathogenicity of TV in rhesus macaques remains to be elucidated, the likelihood of TV causing intestinal infection and the availability of a tissue culture system make this virus a valuable surrogate for human CVs... - The formation of P particle increased immunogenicity of norovirus P proteinMing Tan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Immunology 136:28-9. 2012..It emphasizes the importance of P particle formation in the immune enhancement of the vaccine and methods for production/verification of high quality P particles which may be easily neglected by researchers... - Norovirus capsid protein expressed in yeast forms virus-like particles and stimulates systemic and mucosal immunity in mice following an oral administration of raw yeast extractsMing Xia
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Med Virol 79:74-83. 2007..The mice immunization study also indicated that the oral administration of raw yeast extracts without an adjuvant is a safe and simple way which is worth to be studied for vaccine delivery in humans... - Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infantsArdythe L Morrow
Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45213, USA
J Pediatr 158:745-51. 2011..To investigate secretor gene fucosyltransferase 2 (FUT2) polymorphism and secretor phenotype in relation to outcomes of prematurity... - Inhibition of Tulane virus replication in vitro with RNA interferenceQiang Fan
Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
J Med Virol 85:179-86. 2013..J. Med. Virol. 85:179-186, 2012. © 2012 Wiley Periodicals, Inc... - Update on caliciviruses and human acute gastroenteritisXi Jiang
Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Pediatr Infect Dis J 21:1069-70. 2002 - Emergence of the GII4/2006b variant and recombinant noroviruses in ChinaMiao Jin
National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
J Med Virol 80:1997-2004. 2008..This study suggests that continual surveillance focusing on strain variation and dynamic change is important for understanding the epidemiology and development of a strategy for disease control and prevention... - Seroepidemiology and risk factors for sporadic norovirus/Mexico strainAnne E Peasey
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom
J Infect Dis 189:2027-36. 2004..001). This study provides initial evidence of risk factors associated with sporadic NV infection. Data indicate some similarities to risk factors associated with outbreaks of NV infection... - [Noroviruses are the most common pathogens causing nosocomial gastroenteritis outbreaks in Hungarian hospitals]Gabor Reuter
Allami Népegészségügyi és Tisztiorvosi Szolgálat Baranya Megyei Intézete, Regionális Virológiai Laboratórium, Pécsi, Pecs
Orv Hetil 144:1611-6. 2003..Epidemics commonly occur in crowded community and spread by fecal-oral route through contaminated food, water and direct contact... - Human susceptibility and resistance to Norwalk virus infectionLisa Lindesmith
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Nat Med 9:548-53. 2003..Of the susceptible population that encoded a functional FUT2 gene, a portion was resistant to infection, suggesting that a memory immune response or some other unidentified factor also affords protection from Norwalk virus infection... - [Sapporo-like viruses in sporadic gastroenteritis of unknown origin]Gabor Reuter
Allami Népegészségügyi és Tisztiorvosi Szolgálat Baranya Megyei Intézete, Pecs, Regionális Virológiai Laboratórium
Orv Hetil 143:351-4. 2002..The etiologic role of these viruses is evident but little is known about the incidence of acute gastroenteritis caused by them. Sapporo-like viruses have not been detected in Hungary before... - Association of histo-blood group antigens with susceptibility to norovirus infection may be strain-specific rather than genogroup dependentMing Tan
J Infect Dis 198:940-1; author reply 942-3. 2008 - Detection of Norwalk-like virus infection aboard two U.S. Navy shipsScott Thornton
Navy Environmental and Preventive Medicine Unit No. 5, San Diego, CA 92136, USA
Mil Med 167:826-30. 2002..No point source was found for either ship. The on-site laboratory investigation can provide important information for outbreak control and prevention while new cases are still presenting... - Molecular epidemiology of human calicivirus gastroenteritis outbreaks in Hungary, 1998 to 2000Gabor Reuter
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
J Med Virol 68:390-8. 2002..This is the first country-wide molecular epidemiological investigation of human calicivirus-associated, gastroenteritis outbreaks in Hungary and Central-Eastern Europe... - Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLPNoritoshi Kitamoto
School of Humanities for Environmental Policy and Technology, Himeji Institute of Technology, Hyogo 670-0092, Japan
J Clin Microbiol 40:2459-65. 2002..These strain-, genogroup-, and genus-reactive MAbs will be useful tools for further study of the antigenic and structural topography of the HuCV virion and for diagnostic assays for HuCVs... - Norwalk virus binds to histo-blood group antigens present on gastroduodenal epithelial cells of secretor individualsSeverine Marionneau
INSERM U419, Institut de Biologie, Nantes, France
Gastroenterology 122:1967-77. 2002..CONCLUSIONS: rNV VLPs use H type 1 and/or H types (3/4) as ligands on gastroduodenal epithelial cells of secretor individuals... - A Norwalk-like virus outbreak on the Appalachian TrailLucy A Peipins
Agency for Toxic Substances and Disease Registry, 1600 Clifton Rd, NE, E 31, Atlanta, GA 30333, USA
J Environ Health 64:18-23, 32. 2002..Poor sanitation, scarce water supplies, and crowding can increase the risk of gastrointestinal illness among long-distance hikers... - Sequence diversity of human caliciviruses recovered from children with diarrhea in Mendoza, Argentina, 1995-1998Norma Martinez
Virology Laboratory, Central Hospital, Mendoza, Argentina
J Med Virol 67:289-98. 2002.... - Seroprevalence of antibodies against noroviruses among students in a Chinese military medical universityYing-chun Dai
Department of Epidemiology, First Military Medical University, Guangzhou, China
J Clin Microbiol 42:4615-9. 2004..The distribution of ABO blood types did not differ among the three groups. These data suggest that NVs are prevalent in China and that both genetic and environmental factors play a role in NV infection... - Gastroenteritis in US Marines during Operation Iraqi FreedomScott A Thornton
Navy Environmental and Preventive Medicine Unit No 6, Pearl Harbor, Hawaii 96860, USA
Clin Infect Dis 40:519-25. 2005..A Navy Preventive Medicine laboratory was set up in Ad Diwaniyah, Iraq, to provide clinical diagnostic support for Marine medical units during a period of repositioning in south-central Iraq... - Binding of recombinant norovirus like particle to histo-blood group antigen on cells in the lumen of pig duodenumPeng Tian
Produce Safety and Microbiology Research Unit, Western Regional Research Center, Agricultural Research Service, United States Department of Agriculture, 800 Buchanan Street, Albany, CA 94710 1105, USA
Res Vet Sci 83:410-8. 2007..It highlights the importance of further study of human norovirus incidence and potential infection and residence in non-human animal hosts and suggests the possibility that norovirus may be a zoonotic pathogen... - Structural basis for the recognition of blood group trisaccharides by norovirusSheng Cao
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
J Virol 81:5949-57. 2007..The extensive interface between the two protomers in a P dimer also plays a crucial role in the formation of the receptor binding interface... - [Investigation of human calicivirus (HuCV) diarrhea among infantile and young children in China, 1999--2005]Zhao Yin Fang
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
Bing Du Xue Bao 23:9-15. 2007.... - Norovirus recognizes histo-blood group antigens on gastrointestinal cells of clams, mussels, and oysters: a possible mechanism of bioaccumulationPeng Tian
Produce Safety and Microbiology Research Unit, U S Department of Agriculture, Agricultural Research Service, Western Regional Research Center, 800 Buchanan Street, Albany, California 94710, USA
J Food Prot 70:2140-7. 2007..Our results also suggest that this bioaccumulation could be reversed by incubation with HBGA analogs, a possible important new strategy for depuration... - Molecular characterization of unusual human G5P[6] rotaviruses identified in ChinaDan di Li
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
J Clin Virol 42:141-8. 2008..We found an unusual human rotavirus, LL36755 of G5P[6] genotype, in a stool sample collected in Lulong County, Hebei Province, China. This is the first detection of rotavirus serotype G5 in Asia... - Novel recombinant norovirus causing outbreaks of gastroenteritis in Santiago, ChileRoberto Vidal
, , Facultad de Medicina, Universidad de Chile, Santiago, Chile
J Clin Microbiol 44:2271-5. 2006..These strains belonged to a novel genogroup by RdRp sequence and to genogroup GII/3 by capsid sequence. Determining the clinical and epidemiological impact of human calicivirus recombination will require future studies... - Caliciviruses and foodborne gastroenteritis, ChileRoberto Vidal
Microbiology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile
Emerg Infect Dis 11:1134-7. 2005..Outbreaks affected ?99 persons, occurred most commonly in the home, and were associated with seafood consumption. Thirteen outbreak strains sequenced were noroviruses, including 8 GII, 2 GI, and 3 belonging to a novel genogroup... - Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United StatesCarmelann Zintz
Center for Pediatric Research, Children's Hospital of The King's Daughters, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Infect Genet Evol 5:281-90. 2005..In conclusion, NV and SV were frequent causes of hospitalization for acute gastroenteritis in young children and infecting strains were highly diverse, including newly recognized genogroups and genetic clusters within known genogroups... - Enhanced tissue plasminogen activator synthesis by the sympathetic neurons that innervate aging vesselsXi Jiang
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut, USA
J Neurosci Res 71:567-74. 2003..The possibility that increased sympathetic nervous system plasminogenesis influences the aging process in nonvascular tissues also deserves further investigation... - Deletion-targeted multiplex PCR (DTM-PCR) for identification of Beijing/W genotypes of Mycobacterium tuberculosisJing Chen
Key Laboratory of Medical Molecular Virology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
Tuberculosis (Edinb) 87:446-9. 2007..Using this Deletion-Targeted Multiplex PCR (DTM-PCR) method for detecting these strains, we obtained 100% sensitivity and specificity... - Trapping norovirus by glycosylated hydrogels: a potential oral antiviral drugYalong Zhang
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA
ChemMedChem 1:1361-6. 2006 - Detection of viral agents in fecal specimens of monkeys with diarrheaYuhuan Wang
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Emory University, Atlanta, GA, USA
J Med Primatol 36:101-7. 2007.... - [Identification of two new strains of norovirus in Guangzhou]Ying chun Dai
Department of Epidemiology, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 24:1016-8, 1022. 2004..To identify the molecular biological characteristics of human caliciviruses (HuCVs) and new strains of norovirus (NV) detected in Guangdong Province... - Novel human rotavirus of genotype G5P[6] identified in a stool specimen from a Chinese girl with diarrheaZhao Jun Duan
National Institute for Viral Disease Control and Prevention, Beijing, China
J Clin Microbiol 45:1614-7. 2007..5% homologous to those of the porcine P[6] strains 134/04-10, 134/04-11, 221/04-7, and 221/04-13. Our findings indicate a dynamic interaction between human and porcine rotaviruses...
Research Grants
- Novel vaccine against NorovirusXi Jiang; Fiscal Year: 2010....
- Characterization of Human CalicivirusesXi Jiang; Fiscal Year: 2006..Specific aim 4. To characterize primate CV (PrCV) replication and attempt to cultivate HuCVs in cell culture using novel approaches learned from animal CVs. ..
- Norwalk-like Viruses and Their ReceptorsXi Jiang; Fiscal Year: 2007..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
- Third International Calicivirus ConferenceXi Jiang; Fiscal Year: 2007..We will publish a proceeding of the meeting as a supplement of the Journal of Infectious Diseases after the meeting. ..
- Norwalk-like Viruses and Their ReceptorsXi Jiang; Fiscal Year: 2009..Specific aim 3. To determine the crystal structure of NLV capsid and sub-capsid units in the presence and absence of human histo-blood group antigens. ..
- Characterization of Human CalicivirusesXi Jiang; Fiscal Year: 2010..abstract_text> ..
- CHARACTERIZATION OF HUMAN CALICIVIRUSXi Jiang; Fiscal Year: 2001..Specific aim 3. To characterize the natural history of infection in children and experimentally infected volunteers and to correlate immunity with protection against HuCV infection and illness. ..