Thomas Inge

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Bariatric surgery in hypothalamic obesity
    Nathan C Bingham
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati, OH, USA
    Front Endocrinol (Lausanne) 3:23. 2012
  2. pmc The effect of obesity in adolescence on adult health status
    Thomas H Inge
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2023, Cincinnati, OH 45229 3039
    Pediatrics 132:1098-104. 2013
  3. ncbi request reprint WP744 is a novel anthracycline with enhanced activity against neuroblastoma
    Thomas H Inge
    Children s Hospital Research Foundation, Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Surg Res 121:187-96. 2004
  4. ncbi request reprint Bariatric surgery for pediatric extreme obesity: now or later?
    T H Inge
    Division of Pediatric and Thoracic Surgery, Comprehensive Weight Management Program, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Int J Obes (Lond) 31:1-14. 2007
  5. doi request reprint Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen
    Thomas Inge
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Laparoendosc Adv Surg Tech A 18:157-69. 2008
  6. ncbi request reprint Childhood obesity--a problem of surgical proportions?
    Thomas H Inge
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2023, Cincinnati, OH 45229 3039, USA
    Nat Clin Pract Gastroenterol Hepatol 5:180-1. 2008
  7. ncbi request reprint Bariatric surgery for morbidly obese adolescents: is there a rationale for early intervention?
    Thomas H Inge
    Division of Pediatric General and Thoracic Surgery, Comprehensive Weight Management Center, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OSB 3320, Cincinnati, OH 45229 3039, USA
    Growth Horm IGF Res 16:S15-9. 2006
  8. doi request reprint Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents
    Thomas H Inge
    Division of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 123:214-22. 2009
  9. ncbi request reprint Managing bariatric patients in a children's hospital: radiologic considerations and limitations
    Thomas H Inge
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr Surg 40:609-17. 2005
  10. ncbi request reprint Surgical approach to adolescent obesity
    Thomas H Inge
    Department of Surgery, Division of Pediatric Surgery, University of Cincinnati, Cincinnati, OH, USA
    Adolesc Med Clin 15:429-53. 2004

Research Grants

Detail Information

Publications48

  1. pmc Bariatric surgery in hypothalamic obesity
    Nathan C Bingham
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine Cincinnati, OH, USA
    Front Endocrinol (Lausanne) 3:23. 2012
    ..There continues to be a need for more robust, controlled, prospective studies with long term follow-up in order to better define the role of bariatric surgery in the treatment of HyOb...
  2. pmc The effect of obesity in adolescence on adult health status
    Thomas H Inge
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2023, Cincinnati, OH 45229 3039
    Pediatrics 132:1098-104. 2013
    ..To test the hypothesis that adolescent obesity would be associated with greater risks of adverse health in severely obese adults...
  3. ncbi request reprint WP744 is a novel anthracycline with enhanced activity against neuroblastoma
    Thomas H Inge
    Children s Hospital Research Foundation, Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Surg Res 121:187-96. 2004
    ..Two analogs, WP744 and WP769, were selected and their biological properties were compared with Dox and the daunorubicin-based bisintercalator WP631. These novel Dox analogs may have antitumor activity beyond MDR evasion...
  4. ncbi request reprint Bariatric surgery for pediatric extreme obesity: now or later?
    T H Inge
    Division of Pediatric and Thoracic Surgery, Comprehensive Weight Management Program, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Int J Obes (Lond) 31:1-14. 2007
    ....
  5. doi request reprint Challenges of adolescent bariatric surgery: tips for managing the extremely obese teen
    Thomas Inge
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Laparoendosc Adv Surg Tech A 18:157-69. 2008
    ..Finally, the views and opinions expressed in this paper reflect the balanced examination of various issues related to pediatric bariatric surgery by the presenters but do not necessarily represent the opinions of the IPEG organization...
  6. ncbi request reprint Childhood obesity--a problem of surgical proportions?
    Thomas H Inge
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2023, Cincinnati, OH 45229 3039, USA
    Nat Clin Pract Gastroenterol Hepatol 5:180-1. 2008
  7. ncbi request reprint Bariatric surgery for morbidly obese adolescents: is there a rationale for early intervention?
    Thomas H Inge
    Division of Pediatric General and Thoracic Surgery, Comprehensive Weight Management Center, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OSB 3320, Cincinnati, OH 45229 3039, USA
    Growth Horm IGF Res 16:S15-9. 2006
    ..In this paper, the indications, contraindications, and early surgical outcomes of gastric bypass surgery for morbidly obese adolescents are reviewed, and important directions for future research are discussed...
  8. doi request reprint Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents
    Thomas H Inge
    Division of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 123:214-22. 2009
    ..We hypothesized that gastric bypass would improve parameters of metabolic dysfunction and cardiovascular risk in adolescents with type 2 diabetes mellitus...
  9. ncbi request reprint Managing bariatric patients in a children's hospital: radiologic considerations and limitations
    Thomas H Inge
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr Surg 40:609-17. 2005
    ..Herein the authors discuss these topics within the context of characteristic bariatric patient profiles and the Roux-en-Y gastric bypass procedure, currently the authors' standard operative approach...
  10. ncbi request reprint Surgical approach to adolescent obesity
    Thomas H Inge
    Department of Surgery, Division of Pediatric Surgery, University of Cincinnati, Cincinnati, OH, USA
    Adolesc Med Clin 15:429-53. 2004
    ..Indications for operation during adolescence should be conservative until appropriately designed clinical studies have demonstrated the safety and efficacy of these techniques applied to adolescents...
  11. ncbi request reprint Bariatric surgery for severely overweight adolescents: concerns and recommendations
    Thomas H Inge
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatrics 114:217-23. 2004
    ..Surgery should be performed in institutions that are equipped to meet the tertiary care needs of severely obese patients and to collect long-term data on the clinical outcomes of these patients...
  12. pmc Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass
    Thomas H Inge
    Division of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr 156:103-108.e1. 2010
    ..Surgical treatment of extreme obesity may be appropriate for some adolescents. We hypothesized that surgical weight loss outcomes may differ by preoperative level of extreme obesity (body mass index [BMI] > or=99th percentile)...
  13. ncbi request reprint Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy
    Thomas H Inge
    Division of Pediatric General and Thoracic Surgery, ML 2023, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Nat Clin Pract Endocrinol Metab 3:606-9. 2007
    ..Extreme obesity (BMI >60 kg/m(2)) and hyperinsulinemia followed tumor resection and cranial irradiation. Dietary interventions were unsuccessful, and pharmacologic intervention (i.e. octreotide) only slowed the rate of weight gain...
  14. ncbi request reprint Preferential loss of central (trunk) adiposity in adolescents and young adults after laparoscopic gastric bypass
    Thomas Inge
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Surg Obes Relat Dis 3:153-8. 2007
    ....
  15. ncbi request reprint Obesity identified by discharge ICD-9 codes underestimates the true prevalence of obesity in hospitalized children
    Jessica G Woo
    Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr 154:327-31. 2009
    ..To define inpatient care of obese children with or without an obesity diagnosis...
  16. ncbi request reprint Application of laparoscopy for bariatric surgery in adolescents
    Victor F Garcia
    University of Cincinnati College of Medicine, Ohio, USA
    Curr Opin Pediatr 15:248-55. 2003
    ....
  17. ncbi request reprint Effect of surgical weight loss on sleep architecture in adolescents with severe obesity
    M Kalra
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Obes Surg 18:675-9. 2008
    ..Weight loss results in resolution of obesity-associated morbidity. Our aim was to determine the effect of weight loss on sleep architecture in adolescents with severe obesity...
  18. ncbi request reprint Obstructive sleep apnea in extremely overweight adolescents undergoing bariatric surgery
    Maninder Kalra
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Obes Res 13:1175-9. 2005
    ..To determine the prevalence of obstructive sleep apnea (OSA) in extremely overweight adolescents and to examine the effect of significant weight loss on OSA severity...
  19. ncbi request reprint How young for bariatric surgery in children?
    Allen F Browne
    Division of Pediatric Surgery, Nationwide Children s Hospital, Columbus, Ohio 43206, USA
    Semin Pediatr Surg 18:176-85. 2009
    ..This will require the combined efforts of the pediatric health care providers from many specialties and partnerships with industry to facilitate discovery and implementation...
  20. ncbi request reprint Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents
    Stavra Xanthakos
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Clin Gastroenterol Hepatol 4:226-32. 2006
    ..We hypothesized that NAFLD would be less severe as a result of younger age and shorter duration of obesity, but portal inflammation and fibrosis would be more prevalent...
  21. pmc Weight-specific health-related quality of life in adolescents with extreme obesity
    Avani C Modi
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 16:2266-71. 2008
    ..Overall, these data suggest that HRQOL is not homogenous in adolescents with extreme obesity...
  22. ncbi request reprint Pregnancy after gastric bypass surgery in adolescents
    Helmut R Roehrig
    Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Obes Surg 17:873-7. 2007
    ..There is no previous research or documentation of the incidence of pregnancy or pregnancy outcomes in female adolescents after undergoing bariatric surgery...
  23. doi request reprint Reversibility of cardiac abnormalities in morbidly obese adolescents
    Holly M Ippisch
    Division of Cardiology, Cincinnati Children s Hospital, Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Am Coll Cardiol 51:1342-8. 2008
    ..The purpose of this study was to evaluate changes in cardiac geometry, systolic and diastolic function before and after weight loss in morbidly obese adolescents...
  24. ncbi request reprint Bariatric surgery and adolescent gynecology
    Rachel J Miller
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Obstet Gynecol 19:427-33. 2007
    ..This review summarizes the impact of bariatric surgery on gynecologic complications in the context of the extremely obese adolescent and reviews contraceptive considerations before and after adolescent bariatric surgery...
  25. pmc Psychosocial functioning improves following adolescent bariatric surgery
    Meg H Zeller
    Division of Behavioral Medicine and Clinical Psychology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 17:985-90. 2009
    ..Longer-term follow-up will be critical to determine adolescent weight and psychosocial trajectories, their interrelations, and what role psychosocial status plays in continued weight loss, maintenance, and regain...
  26. ncbi request reprint Nutritional consequences of bariatric surgery
    Stavra A Xanthakos
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Curr Opin Clin Nutr Metab Care 9:489-96. 2006
    ....
  27. ncbi request reprint One-year outcomes of Roux-en-Y gastric bypass for morbidly obese adolescents: a multicenter study from the Pediatric Bariatric Study Group
    M Louise Lawson
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45255, USA
    J Pediatr Surg 41:137-43; discussion 137-43. 2006
    ..Little is known about the metabolic outcomes of adolescent bariatric surgery. We report changes in weight, metabolic profile, and types of complications seen in a multicenter cohort...
  28. ncbi request reprint Bariatric surgery in adolescents: an update
    Stavra A Xanthakos
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, ML 2010, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Adolesc Med Clin 17:589-612; abstract x. 2006
    ..Data on the complications and outcomes of bariatric surgery in this special population are reviewed...
  29. ncbi request reprint A critical appraisal of evidence supporting a bariatric surgical approach to weight management for adolescents
    Thomas H Inge
    Division of Pediatric General and Thoracic Surgery, Center for Epidemiology and Biostatistics, University of Cincinnati, Cincinnati, OH, USA
    J Pediatr 147:10-9. 2005
  30. pmc Best practice updates for pediatric/adolescent weight loss surgery
    Janey S A Pratt
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:901-10. 2009
    ....
  31. ncbi request reprint Health-related quality of life and depressive symptoms in adolescents with extreme obesity presenting for bariatric surgery
    Meg H Zeller
    Division of Behavioral Medicine and Clinical Psychology, College of Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Pediatrics 117:1155-61. 2006
    ..We sought to document health-related quality of life (HRQoL) impairment and depressive symptomatology in adolescents with extreme obesity considering surgical weight loss...
  32. doi request reprint Changes in depressive symptoms among adolescent bariatric candidates from preoperative psychological evaluation to immediately before surgery
    Megan B Ratcliff
    Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children s Hospital Medical Center, Cinncinnati, Ohio 45229, USA
    Surg Obes Relat Dis 7:50-4. 2011
    ..The present study examined whether adolescent depressive symptoms among bariatric candidates change during preoperative preparation compared with adolescents with extreme obesity who were not seeking surgery...
  33. doi request reprint Intraoperative manometry during laparoscopic Heller myotomy improves outcome in pediatric achalasia
    Mubeen Jafri
    Department of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 43:66-70; discussion 70. 2008
    ..Intraoperative esophageal manometry has been used to ensure adequacy of myotomies in adults. The purpose of the present study was to review our experience in the management of children with achalasia...
  34. doi request reprint Adolescent paraplegia, morbid obesity, and pickwickian syndrome: outcome of gastric bypass surgery
    Go Miyano
    Department of Pediatric General and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr Surg 44:e41-4. 2009
    ..This case illustrates that paraplegia does not necessarily impair either weight loss efficacy or comorbidity resolution after Roux-en-Y gastric bypass surgery...
  35. ncbi request reprint Nuclear factor-kappa B and apoptosis inducing factor activation by doxorubicin analog WP744 in SH-SY5Y neuroblastoma cells
    Jianqiang Wu
    Department of Pediatric Surgery and Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Surg Res 122:231-9. 2004
    ..We have shown that the Dox analogue WP744 has enhanced the killing activity of NB compared to Dox, but the mechanism(s) of action is unclear...
  36. ncbi request reprint Cost analysis of ligature versus stapling techniques of laparoscopic appendectomy in children
    William E Wehrman
    Department of Pediatric General and Thoracic Surgery, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Laparoendosc Adv Surg Tech A 17:371-4. 2007
    ..In light of the pressures for cost containment, we evaluated data from both laparoscopic methods to determine which was more effective based on cost and patient outcomes...
  37. ncbi request reprint Treatment considerations for severe adolescent obesity
    Thomas H Inge
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Surg Obes Relat Dis 1:133-9. 2005
  38. ncbi request reprint A multidisciplinary approach to the adolescent bariatric surgical patient
    Thomas H Inge
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 39:442-7; discussion 446-7. 2004
    ..The purpose of this report was to describe the establishment and early experience of a multidisciplinary Comprehensive Weight Management Center (CWMC) in a free-standing children's hospital...
  39. pmc Bariatric surgery for severe obesity in two adolescents with type 1 diabetes
    Janet Chuang
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 7012, Cincinnati, OH 45229 3039
    Pediatrics 132:e1031-4. 2013
    ..Patients with T1DM have ongoing dependency on exogenous insulin, and optimal glycemic control still depends on patient compliance with diabetes care. ..
  40. ncbi request reprint Attitudes of bariatric surgeons concerning adolescent bariatric surgery (ABS)
    Steven R Allen
    Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Obes Surg 15:1192-5. 2005
    ..As the number of adolescents with clinically severe obesity has grown, so too have the number of adolescents seeking bariatric surgery...
  41. ncbi request reprint The combined effects of balloon valvuloplasty and surgical weight loss in treatment of aortic stenosis
    Christopher M Tangren
    Department of Pediatric General and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Pediatr Surg 42:1443-5. 2007
    ..She dramatically improved after the combined use of balloon valvuloplasty and Roux en Y gastric bypass. Gastric bypass surgery has promise for patients with congenital cardiac disease whose treatment is complicated by extreme obesity...
  42. ncbi request reprint Importance of Sp1 consensus motifs in the MYCN promoter
    Thomas H Inge
    Children s Hospital Research Foundation and Department of Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Surgery 132:232-8. 2002
    ..This region contains two GC-rich motifs and a CT box, regions for potential transcription factor interaction...
  43. ncbi request reprint The effect of a right-sided aortic arch on outcome in children with esophageal atresia and tracheoesophageal fistula
    Steven R Allen
    Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 41:479-83. 2006
    ..During repair of an esophageal atresia with tracheoesophageal fistula (EA/TEF), a right-sided aortic arch (RAA) presents a technical challenge. We reviewed our experience with EA/TEF focusing on the impact of RAA...
  44. ncbi request reprint A view from down under: laparoscopic look at a subrectus pacemaker
    Michael R Epstein
    Divisions of Cardiology and Pediatric Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pacing Clin Electrophysiol 25:1662-3. 2002
    ..A photograph taken within the peritoneal cavity provides a unique view of the patient's subrectus pulse generator...
  45. pmc Teen-Longitudinal Assessment of Bariatric Surgery: methodological features of the first prospective multicenter study of adolescent bariatric surgery
    Thomas H Inge
    J Pediatr Surg 42:1969-71. 2007
  46. ncbi request reprint Beriberi after gastric bypass surgery in adolescence
    Alexander Towbin
    Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Pediatr 145:263-7. 2004
    ..We report three cases of dry beriberi in adolescents who underwent gastric bypass surgery for clinically severe obesity. The key to successful treatment of this problem lies in prompt recognition and thiamine supplementation...
  47. ncbi request reprint Adolescent obesity and bariatric surgery
    Michael A Helmrath
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, Texas Children s Hospital Clinical Care Center, Suite 650, 6621 Fannin, Houston, TX 77030, USA
    Surg Clin North Am 86:441-54, x. 2006
  48. ncbi request reprint Extreme pediatric obesity: weighing the health dangers
    Stavra A Xanthakos
    J Pediatr 150:3-5. 2007

Research Grants3