John B Hogenesch
Affiliation: Cincinnati Children's Hospital Medical Center
Wu G, Ruben M, Schmidt R, Francey L, Smith D, Anafi R, et al
. Population-level rhythms in human skin with implications for circadian medicine. Proc Natl Acad Sci U S A. 2018;115:12313-12318 pubmed publisher
..In summary, we show rhythms in human epidermis that persist at the population scale and describe a path to develop robust single-sample circadian biomarkers. ..
Ruben M, Wu G, Smith D, Schmidt R, Francey L, Lee Y, et al
. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine. Sci Transl Med. 2018;10: pubmed publisher
..These results provide a useful resource for studying the role of circadian rhythms in medicine and support the idea that biological time might play a role in determining drug response. ..
Krishnaiah S, Wu G, Altman B, Growe J, Rhoades S, Coldren F, et al
. Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism. Cell Metab. 2017;25:961-974.e4 pubmed publisher
..These results provide the first comprehensive views of circadian liver and cell-autonomous metabolism. ..
Ruben M, Hogenesch J. Circadian Rhythms: Move Over Neurons - Astrocytes Mediate SCN Clock Function. Curr Biol. 2017;27:R350-R352 pubmed publisher
..However, a series of recent studies demonstrate the importance of another cell type, astrocytes, for biological timekeeping. ..