Research Topics
| SIMON PATRICK HOGANSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Eosinophils in infection and intestinal immunitySimon P Hogan
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Curr Opin Gastroenterol 29:7-14. 2013..The observed link between eosinophil levels and severity and remission rates in IBD has led to speculation that eosinophils may contribute to the antimicrobial inflammatory response in IBD...- Food-induced anaphylaxis: mast cells as modulators of anaphylactic severitySimon P Hogan
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Semin Immunopathol 34:643-53. 2012.... 
Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxisMuthuvel Arumugam
Division of Biochemistry, National Institute of Siddha, Chennai, India
BMC Immunol 12:14. 2011..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...- Functional role of eosinophils in gastrointestinal inflammationSimon P Hogan
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Immunol Allergy Clin North Am 29:129-40, xi. 2009..This article describes eosinophil immunoregulatory and effector function and discusses the possible involvement of these pathways in EGIDs... 
Recent advances in eosinophil biologySimon P Hogan
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Int Arch Allergy Immunol 143:3-14. 2007..In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases...- Eosinophil Function in Eosinophil-associated Gastrointestinal DisordersSimon P Hogan
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Curr Allergy Asthma Rep 6:65-71. 2006..We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases... - Review article: The eosinophil as a therapeutic target in gastrointestinal diseaseS P Hogan
Cincinnati Children s Hospital Medical Center, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Aliment Pharmacol Ther 20:1231-40. 2004.... - A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergyS P Hogan
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 97:6681-6. 2000..Furthermore, eotaxin is identified as a critical regulator of antigen-induced eosinophilic inflammation in the gastrointestinal tract... - Gastrointestinal eosinophilsM E Rothenberg
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Immunol Rev 179:139-55. 2001..We propose that eosinophils are integral members of the gastrointestinal immune system and are likely to be important in innate, regulatory and inflammatory immune responses... - A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammationS P Hogan
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Nat Immunol 2:353-60. 2001..These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity... - Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpressionN Zimmermann
Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
J Immunol 165:5839-46. 2000..Thus, murine eotaxin-2 is a constitutively expressed eosinophil chemokine likely to be involved in homeostatic, allergen-induced, and IL-4-associated immune responses... - IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanismS M Pope
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 108:594-601. 2001..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown... - The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestineE B Brandt
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Clin Exp Allergy 36:543-53. 2006..CONCLUSION: Taken together, these results identify differential expression of the alpha4beta7-integrin on eosinophils and its critical role in regulating eosinophil responses in the intestine... - An etiological role for aeroallergens and eosinophils in experimental esophagitisA Mishra
Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA
J Clin Invest 107:83-90. 2001..These results establish a pathophysiological connection between allergic hypersensitivity responses in the lung and esophagus and demonstrate an etiologic role for inhaled allergens and eosinophils in gastrointestinal inflammation... - Summary of the First International Gastrointestinal Eosinophil Research SymposiumChris A Liacouras
J Pediatr Gastroenterol Nutr 45:370-91. 2007 - Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitisJennifer Z Bullock
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
J Pediatr Gastroenterol Nutr 45:22-31. 2007..Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little is known about the systemic immunological phenotypes of children with EE... - Eosinophils: biological properties and role in health and diseaseSimon P Hogan
Clin Exp Allergy 38:709-50. 2008..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... - Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lungNikolaos M Nikolaidis
Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Exp Lung Res 32:483-97. 2006..Thus, TFF2 is an allergen-induced gene, which is expressed in mucus-positive airways, but is not a major contributor to allergen-induced goblet cell metaplasia, mucus production, or inflammatory responses in the lung... - A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammationPatricia C Fulkerson
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
Proc Natl Acad Sci U S A 103:16418-23. 2006..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease... - Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsivenessMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 177:5595-603. 2006.... - Mechanistic analysis of experimental food allergen-induced cutaneous reactionsVanessa E Prescott
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:258-66. 2006..Collectively, these studies demonstrate that food allergy can predispose to cutaneous inflammatory reactions, and these processes are critically regulated by Th2 immune factors... - Interleukin-5 and eosinophils as therapeutic targets for asthmaPaul S Foster
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
Trends Mol Med 8:162-7. 2002..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes... - ICAM-1-dependent pathways regulate colonic eosinophilic inflammationElizabeth Forbes
Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Leukoc Biol 80:330-41. 2006..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury... - The eosinophilMarc E Rothenberg
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Annu Rev Immunol 24:147-74. 2006..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized... 
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthmaJoerg Mattes
Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
J Exp Med 195:1433-44. 2002....- Experimental analysis of eosinophil-associated gastrointestinal diseasesSimon P Hogan
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
Curr Opin Allergy Clin Immunol 2:239-48. 2002.... - Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivityMing Yang
Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
J Allergy Clin Immunol 112:935-43. 2003..CONCLUSION: These investigations demonstrate important cooperativity between eotaxin-2, IL-5, and IL-13 signaling systems and eosinophils for the development of hallmark features of allergic disease of the lung... - Chemokines in eosinophil-associated gastrointestinal disordersSimon P Hogan
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
Curr Allergy Asthma Rep 4:74-82. 2004..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases... - Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidaseElizabeth Forbes
Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
J Immunol 172:5664-75. 2004..These findings provide direct evidence of a central role for eosinophils and EPO in GI dysfunction and potentially the immunopathogenesis of UC... - T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in miceElizabeth Forbes
Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
Gastroenterology 127:105-18. 2004.... - IL-5 promotes eosinophil trafficking to the esophagusAnil Mishra
Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 168:2464-9. 2002..In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus... - Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil traffickingAnil Mishra
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 277:4406-12. 2002.... - IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivityElizabeth E Forbes
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
J Exp Med 205:897-913. 2008..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy... - Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicityVanessa E Prescott
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
J Agric Food Chem 53:9023-30. 2005..Thus, transgenic expression of non-native proteins in plants may lead to the synthesis of structural variants possessing altered immunogenicity... - A latex-induced allergic airway inflammation model in miceParvaneh Farzaneh
Immunology Department, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
Basic Clin Pharmacol Toxicol 99:405-11. 2006..These studies demonstrate that sensitization and subsequent aerosol inhalational challenge of latex allergen extract promotes allergic airway inflammation characterized by elevated IL-5 and IL-13 and eosinophils... - Genetically modified plants and food hypersensitivity diseases: usage and implications of experimental models for risk assessmentVanessa E Prescott
Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Pharmacol Ther 111:374-83. 2006.... - Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitisCarine Blanchard
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 116:536-47. 2006..Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis...
Research Grants
- Interleukin-9 In Experimental Intestinal AnaphylaxisSIMON PATRICK HOGAN; Fiscal Year: 2010....