SIMON PATRICK HOGAN

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
    Elizabeth E Forbes
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
    J Exp Med 205:897-913. 2008
  2. pmc CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis
    Maria Lampinen
    2 Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, ML7028, Cincinnati, OH, 45229 E mail, and Gastroenterology Research Group, Department of Medical Sciences, University Hospital, Uppsala 751 85 Sweden E mail
    J Leukoc Biol 94:1061-70. 2013
  3. pmc Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Am J Physiol Gastrointest Liver Physiol 304:G479-89. 2013
  4. doi request reprint Eosinophils in infection and intestinal immunity
    Simon P Hogan
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Gastroenterol 29:7-14. 2013
  5. doi request reprint Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
    Simon P Hogan
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Semin Immunopathol 34:643-53. 2012
  6. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
  7. ncbi request reprint Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Allergy Asthma Rep 6:65-71. 2006
  8. ncbi request reprint Recent advances in eosinophil biology
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Int Arch Allergy Immunol 143:3-14. 2007
  9. pmc Functional role of eosinophils in gastrointestinal inflammation
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 29:129-40, xi. 2009
  10. ncbi request reprint Review article: The eosinophil as a therapeutic target in gastrointestinal disease
    S P Hogan
    Cincinnati Children s Hospital Medical Center, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Aliment Pharmacol Ther 20:1231-40. 2004

Research Grants

  1. Interleukin-9 In Experimental Intestinal Anaphylaxis
    SIMON PATRICK HOGAN; Fiscal Year: 2010

Collaborators

Detail Information

Publications39

  1. pmc IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
    Elizabeth E Forbes
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, USA
    J Exp Med 205:897-913. 2008
    ..These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy...
  2. pmc CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis
    Maria Lampinen
    2 Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, ML7028, Cincinnati, OH, 45229 E mail, and Gastroenterology Research Group, Department of Medical Sciences, University Hospital, Uppsala 751 85 Sweden E mail
    J Leukoc Biol 94:1061-70. 2013
    ..In conclusion, there is a link among CD14(+)CD33(+) myeloid cells, CCL11, and eosinophils in adult UC...
  3. pmc Chymase-mediated intestinal epithelial permeability is regulated by a protease-activating receptor/matrix metalloproteinase-2-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Am J Physiol Gastrointest Liver Physiol 304:G479-89. 2013
    ..Collectively, these results suggest that mast cell/chymase-mediated intestinal epithelial barrier function is mediated by PAR-2/MMP-2-dependent pathways...
  4. doi request reprint Eosinophils in infection and intestinal immunity
    Simon P Hogan
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Gastroenterol 29:7-14. 2013
    ..The observed link between eosinophil levels and severity and remission rates in IBD has led to speculation that eosinophils may contribute to the antimicrobial inflammatory response in IBD...
  5. doi request reprint Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity
    Simon P Hogan
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Semin Immunopathol 34:643-53. 2012
    ....
  6. pmc Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis
    Muthuvel Arumugam
    Division of Biochemistry, National Institute of Siddha, Chennai, India
    BMC Immunol 12:14. 2011
    ..v infusion were assessed. Bone marrow mast cell (BMMC)s were examined for FcεRI, c-kit, degranulation efficiency, proliferation, apoptosis and cytokine profile...
  7. ncbi request reprint Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Curr Allergy Asthma Rep 6:65-71. 2006
    ..We summarize recent experimental analysis examining the underlying contribution of eosinophils to disease pathogenesis and discuss possible therapeutic approaches for the treatment of these diverse diseases...
  8. ncbi request reprint Recent advances in eosinophil biology
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Int Arch Allergy Immunol 143:3-14. 2007
    ..In this review, these studies are summarized, focusing on the implications of these findings in the understanding the role of eosinophils in diseases...
  9. pmc Functional role of eosinophils in gastrointestinal inflammation
    Simon P Hogan
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 29:129-40, xi. 2009
    ..This article describes eosinophil immunoregulatory and effector function and discusses the possible involvement of these pathways in EGIDs...
  10. ncbi request reprint Review article: The eosinophil as a therapeutic target in gastrointestinal disease
    S P Hogan
    Cincinnati Children s Hospital Medical Center, Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Aliment Pharmacol Ther 20:1231-40. 2004
    ....
  11. pmc A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 97:6681-6. 2000
    ..Furthermore, eotaxin is identified as a critical regulator of antigen-induced eosinophilic inflammation in the gastrointestinal tract...
  12. ncbi request reprint A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation
    S P Hogan
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Nat Immunol 2:353-60. 2001
    ..These results establish a critical pathological function for eotaxin and eosinophils in gastrointestinal allergic hypersensitivity...
  13. ncbi request reprint Gastrointestinal eosinophils
    M E Rothenberg
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Immunol Rev 179:139-55. 2001
    ..We propose that eosinophils are integral members of the gastrointestinal immune system and are likely to be important in innate, regulatory and inflammatory immune responses...
  14. ncbi request reprint Murine eotaxin-2: a constitutive eosinophil chemokine induced by allergen challenge and IL-4 overexpression
    N Zimmermann
    Division of Pulmonary Medicine, Allergy, and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
    J Immunol 165:5839-46. 2000
    ..Thus, murine eotaxin-2 is a constitutively expressed eosinophil chemokine likely to be involved in homeostatic, allergen-induced, and IL-4-associated immune responses...
  15. pmc An etiological role for aeroallergens and eosinophils in experimental esophagitis
    A Mishra
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio, USA
    J Clin Invest 107:83-90. 2001
    ..These results establish a pathophysiological connection between allergic hypersensitivity responses in the lung and esophagus and demonstrate an etiologic role for inhaled allergens and eosinophils in gastrointestinal inflammation...
  16. ncbi request reprint IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    S M Pope
    Division of Pulmonary Medicine, Allergy and Clinical Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 108:594-601. 2001
    ..IL-13 induces several characteristic features of asthma, including airway eosinophilia, airway hyperresponsiveness, and mucus overproduction; however, the mechanisms involved are largely unknown...
  17. ncbi request reprint The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine
    E B Brandt
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Clin Exp Allergy 36:543-53. 2006
    ..Most studies have focused on the role of the alpha4beta1-adhesion complex, but eosinophils also express the alpha4beta7-integrin complex...
  18. ncbi request reprint Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung
    Nikolaos M Nikolaidis
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Exp Lung Res 32:483-97. 2006
    ..Thus, TFF2 is an allergen-induced gene, which is expressed in mucus-positive airways, but is not a major contributor to allergen-induced goblet cell metaplasia, mucus production, or inflammatory responses in the lung...
  19. ncbi request reprint IL-5 promotes eosinophil trafficking to the esophagus
    Anil Mishra
    Division of Allergy and Immunology, Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 168:2464-9. 2002
    ..In conclusion, these studies demonstrate a central role for IL-5 in inducing eosinophil trafficking to the esophagus...
  20. ncbi request reprint Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis
    Jennifer Z Bullock
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Pediatr Gastroenterol Nutr 45:22-31. 2007
    ..Although studies of esophageal tissue suggest that Th2 cytokines and eotaxin-3 may be crucial in disease pathogenesis, little is known about the systemic immunological phenotypes of children with EE...
  21. ncbi request reprint Summary of the First International Gastrointestinal Eosinophil Research Symposium
    Chris A Liacouras
    J Pediatr Gastroenterol Nutr 45:370-91. 2007
  22. ncbi request reprint Enterocyte expression of the eotaxin and interleukin-5 transgenes induces compartmentalized dysregulation of eosinophil trafficking
    Anil Mishra
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 277:4406-12. 2002
    ....
  23. doi request reprint Eosinophils: biological properties and role in health and disease
    Simon P Hogan
    Clin Exp Allergy 38:709-50. 2008
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  24. pmc A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    Patricia C Fulkerson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45257 0524, USA
    Proc Natl Acad Sci U S A 103:16418-23. 2006
    ..In summary, we present multiple lines of independent evidence that eosinophils via CCR3 have a central role in chronic allergic airway disease...
  25. ncbi request reprint Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 177:5595-603. 2006
    ....
  26. ncbi request reprint Mechanistic analysis of experimental food allergen-induced cutaneous reactions
    Vanessa E Prescott
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:258-66. 2006
    ..Collectively, these studies demonstrate that food allergy can predispose to cutaneous inflammatory reactions, and these processes are critically regulated by Th2 immune factors...
  27. ncbi request reprint Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity
    Ming Yang
    Division of Molecular Biosciences, The John Curtin School of Medical Research, Australian National University, Canberra, ACT
    J Allergy Clin Immunol 112:935-43. 2003
    ..However, the contribution of eotaxin-2 to the development of defined pathogenic features of allergic disease remains to be defined...
  28. ncbi request reprint Chemokines in eosinophil-associated gastrointestinal disorders
    Simon P Hogan
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200
    Curr Allergy Asthma Rep 4:74-82. 2004
    ..In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases...
  29. ncbi request reprint Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Immunol 172:5664-75. 2004
    ..These findings provide direct evidence of a central role for eosinophils and EPO in GI dysfunction and potentially the immunopathogenesis of UC...
  30. ncbi request reprint T helper-2 immunity regulates bronchial hyperresponsiveness in eosinophil-associated gastrointestinal disease in mice
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    Gastroenterology 127:105-18. 2004
    ....
  31. pmc Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
    Joerg Mattes
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Exp Med 195:1433-44. 2002
    ....
  32. ncbi request reprint Experimental analysis of eosinophil-associated gastrointestinal diseases
    Simon P Hogan
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Curr Opin Allergy Clin Immunol 2:239-48. 2002
    ....
  33. ncbi request reprint Interleukin-5 and eosinophils as therapeutic targets for asthma
    Paul S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    Trends Mol Med 8:162-7. 2002
    ..The contribution of these IL-5-independent pathways should be considered when assessing the role of eosinophils in disease processes...
  34. ncbi request reprint The eosinophil
    Marc E Rothenberg
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Annu Rev Immunol 24:147-74. 2006
    ..Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized...
  35. ncbi request reprint ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  36. ncbi request reprint Genetically modified plants and food hypersensitivity diseases: usage and implications of experimental models for risk assessment
    Vanessa E Prescott
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    Pharmacol Ther 111:374-83. 2006
    ....
  37. pmc Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:536-47. 2006
    ..Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis...
  38. ncbi request reprint A latex-induced allergic airway inflammation model in mice
    Parvaneh Farzaneh
    Immunology Department, School of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
    Basic Clin Pharmacol Toxicol 99:405-11. 2006
    ..These studies demonstrate that sensitization and subsequent aerosol inhalational challenge of latex allergen extract promotes allergic airway inflammation characterized by elevated IL-5 and IL-13 and eosinophils...
  39. ncbi request reprint Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity
    Vanessa E Prescott
    Division of Molecular Bioscience, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Agric Food Chem 53:9023-30. 2005
    ..Thus, transgenic expression of non-native proteins in plants may lead to the synthesis of structural variants possessing altered immunogenicity...

Research Grants3

  1. Interleukin-9 In Experimental Intestinal Anaphylaxis
    SIMON PATRICK HOGAN; Fiscal Year: 2010
    ....