Kasper Hoebe

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Endotoxin Res 9:250-5. 2003
  2. ncbi Forward genetic analysis of TLR-signaling pathways: an evaluation
    Kasper Hoebe
    Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Division of Molecular Immunology, Room S5 421, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Adv Drug Deliv Rev 60:824-9. 2008
  3. ncbi PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development
    Sophie Rutschmann
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 176:7525-32. 2006
  4. ncbi Analysis of the MCMV resistome by ENU mutagenesis
    Karine Crozat
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Mamm Genome 17:398-406. 2006
  5. ncbi Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
    Bruce Beutler
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 24:353-89. 2006
  6. ncbi The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 175:6042-9. 2005
  7. ncbi Genetic analysis of innate immunity: identification and function of the TIR adapter proteins
    Bruce Beutler
    Scripps Research Institute, Department of Immunology, IMM 31, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Adv Exp Med Biol 560:29-39. 2005
  8. ncbi Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation
    Zuping Zhou
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Immunol 35:1918-27. 2005
  9. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
  10. ncbi The interface between innate and adaptive immunity
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 5:971-4. 2004

Research Grants

  1. Functional analysis of NK cells and their potential to generate CTL responses
    Kasper Hoebe; Fiscal Year: 2009
  2. Functional analysis of NK cells and their potential to generate CTL responses
    Kasper Hoebe; Fiscal Year: 2010

Collaborators

  • BRUCE A BEUTLER
  • S Akira
  • Xin Du
  • Philippe Georgel
  • Sophie Rutschmann
  • Karine Crozat
  • Navjiwan Mann
  • Zuping Zhou
  • Catharina W Wieland
  • Louis Shamel
  • Koichi Tabeta
  • Bassil I Dahiyat
  • Paul Steed
  • Jonathan Zalevsky
  • Tom van der Poll
  • Nico A Maris
  • Sandrine Florquin
  • Zhengfan Jiang
  • Kiyoshi Takeda
  • Lena Alexopoulou
  • Sosathya Sovath
  • Richard A Flavell
  • Suzanne Mudd
  • Edith Janssen
  • Jason Goode

Detail Information

Publications13

  1. ncbi Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Endotoxin Res 9:250-5. 2003
    ..The Lps2 mutation does not preclude signaling initiated by peptidoglycan or unmethylated DNA. Hence, genetic data suggest that there is at least one 'missing' component of the LPS receptor complex that has yet to be found...
  2. ncbi Forward genetic analysis of TLR-signaling pathways: an evaluation
    Kasper Hoebe
    Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Division of Molecular Immunology, Room S5 421, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Adv Drug Deliv Rev 60:824-9. 2008
    ..Here we review some of the more important insights developed from this approach and discuss its prospects...
  3. ncbi PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development
    Sophie Rutschmann
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 176:7525-32. 2006
    ..However, PanR1 mutant mice show normal architecture of the spleen and Peyer's patches, suggesting that TNF is not essential for the formation of these lymphoid structures...
  4. ncbi Analysis of the MCMV resistome by ENU mutagenesis
    Karine Crozat
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Mamm Genome 17:398-406. 2006
    ....
  5. ncbi Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
    Bruce Beutler
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Annu Rev Immunol 24:353-89. 2006
    ..A still broader genetic screen--one that detects all mutations that compromise survival during infection--is permitting fresh insight into the number and types of proteins that mammals use to defend themselves against microbes...
  6. ncbi The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 175:6042-9. 2005
    ..These data suggest that the MyD88-dependent pathway of TLR4 is important for an effective innate immune response to respiratory tract infection caused by NTHi...
  7. ncbi Genetic analysis of innate immunity: identification and function of the TIR adapter proteins
    Bruce Beutler
    Scripps Research Institute, Department of Immunology, IMM 31, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Adv Exp Med Biol 560:29-39. 2005
    ..Other key innate immunity genes have also been disclosed by germline mutagenesis, and are discussed in the present review...
  8. ncbi Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation
    Zuping Zhou
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Immunol 35:1918-27. 2005
    ..These data indicate that Type I IFN play a dual role in the TLR-mediated expression of B7 costimulatory family members and suggest that they may act to limit B7RP-1 expression and thus limit signals derived from B7RP-1-ICOS interaction...
  9. ncbi CD36 is a sensor of diacylglycerides
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 433:523-7. 2005
    ..Already known as a receptor for endogenous molecules, CD36 is also a selective and nonredundant sensor of microbial diacylglycerides that signal via the TLR2/6 heterodimer...
  10. ncbi The interface between innate and adaptive immunity
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 5:971-4. 2004
    ..This focus analyzes some of the ways the innate immune system influences adaptive immune responses. Here the main principles and themes that govern this intricate relationship are discussed...
  11. ncbi Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    Koichi Tabeta
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:3516-21. 2004
    ..The phenotypic effect of the Tlr9(CpG1) allele thus points to a critical role for TLR9 in viral sensing and identifies a vulnerable amino acid within the ectodomain of three TLR proteins, essential for a ligand response...
  12. ncbi Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    Kasper Hoebe
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 4:1223-9. 2003
    ..These findings show that UCM involves an autocrine or paracrine loop, and indicate that an alternative TLR3-independent, Trif-independent pathway contributes to dsRNA-induced UCM...
  13. ncbi ENU mutagenesis in mice
    Philippe Georgel
    Laboratoire d Immunogénétique Moléculaire Humaine, Centre de Recherche en Immunologie et Hématologie, Faculte de Medecine, Strasbourg Cedex, France
    Methods Mol Biol 415:1-16. 2008
    ..In this chapter, we will provide a practical guideline for performing germline mutagenesis in mice. In particular, we will focus on the application of this technology to identify genes that are essential to innate immune defense...

Research Grants2

  1. Functional analysis of NK cells and their potential to generate CTL responses
    Kasper Hoebe; Fiscal Year: 2009
    ..In addition, a better understanding of this pathway may be essential to provide insight into the development and/or control of a wide variety of diseases, including viral/bacterial infections, autoimmunity, and/or neoplastic diseases. ..
  2. Functional analysis of NK cells and their potential to generate CTL responses
    Kasper Hoebe; Fiscal Year: 2010
    ..In addition, a better understanding of this pathway may be essential to provide insight into the development and/or control of a wide variety of diseases, including viral/bacterial infections, autoimmunity, and/or neoplastic diseases. ..