Noah H Hillman

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio, USA
    Pediatr Res 72:593-9. 2012
  2. pmc Inflammation and lung maturation from stretch injury in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 300:L232-41. 2011
  3. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
  4. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
  5. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
  6. pmc Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L712-20. 2011
  7. pmc Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep
    Clare A Berry
    Division of Pulmonary Biology Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Reprod Sci 18:1092-102. 2011
  8. pmc Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
  9. doi request reprint High and low body temperature during the initiation of ventilation for near-term lambs
    Molly K Ball
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Resuscitation 80:133-7. 2009
  10. doi request reprint Toll-like receptors and agonist responses in the developing fetal sheep lung
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 63:388-93. 2008

Detail Information

Publications16

  1. doi request reprint Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio, USA
    Pediatr Res 72:593-9. 2012
    ..Exposure to large tidal volumes (V(T)s) at birth causes lung inflammation, and oxygen may amplify the injury. We hypothesized that normal V(T) ventilation at birth causes lung injury that is exacerbated by 95% oxygen...
  2. pmc Inflammation and lung maturation from stretch injury in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 300:L232-41. 2011
    ..We conclude that a brief period of high V(T) ventilation causes a proinflammatory cascade, a maturation of lung monocytic cells, and an induction of surfactant protein mRNA...
  3. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
    ..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation...
  4. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
    ..Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia...
  5. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
    ..HSP70 protein decreased in the lung tissue and increased in BALF with ventilation. Initiation of ventilation induced a stress response and inflammatory cytokines in small and medium-sized airways...
  6. pmc Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L712-20. 2011
    ..The use of PEEP during initiation of ventilation at birth decreased early mediators of lung injury. Surfactant administration changed the distribution of injury and had a moderate additive protective effect...
  7. pmc Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep
    Clare A Berry
    Division of Pulmonary Biology Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Reprod Sci 18:1092-102. 2011
    ..We conclude that IL-1 and LPS both can cause chorioamnionitis, but IL-1 is not an important mediator of LPS-induced chorioamnionitis in fetal sheep...
  8. pmc Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
    ..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation...
  9. doi request reprint High and low body temperature during the initiation of ventilation for near-term lambs
    Molly K Ball
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Resuscitation 80:133-7. 2009
    ..Recent literature suggests hypothermia may protect against lung injury. We evaluated body temperature as a variable in lung inflammation due to oxygenation and mechanical ventilation following delivery of near-term lambs...
  10. doi request reprint Toll-like receptors and agonist responses in the developing fetal sheep lung
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 63:388-93. 2008
    ..We conclude that TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung...
  11. ncbi request reprint Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    ..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections...
  12. pmc Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 187:2688-95. 2011
    ..parvum. The findings increase our understanding of how chorioamnionitis-exposed preterm infants may respond to lung injury and postnatal nosocomial infections...
  13. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  14. doi request reprint Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs
    Tate Gisslen
    1Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Innate Immun 20:214-24. 2014
    ..The different compartments of exposure to LPS (i.a. vs i.v.) are unique to the fetal to newborn transition. Intra-amniotic LPS incompletely tolerized fetal lambs to postnatal i.v. LPS. ..
  15. pmc Physiology of transition from intrauterine to extrauterine life
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7029, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 39:769-83. 2012
    ..Abnormalities in adaptation are frequently found following preterm birth or cesarean delivery at term, and many of these infants need delivery room resuscitation to assist in this transition...
  16. doi request reprint An MRI system for imaging neonates in the NICU: initial feasibility study
    Jean A Tkach
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 5033, Cincinnati, OH 45229, USA
    Pediatr Radiol 42:1347-56. 2012
    ..Transporting premature infants from a neonatal intensive care unit (NICU) to a radiology department for MRI has medical risks and logistical challenges...