WILLIAM HARDIE

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Signaling pathways in the epithelial origins of pulmonary fibrosis
    William D Hardie
    Department of Pediatrics, Pulmonary Medicine, University of California, San Diego, CA, USA
    Cell Cycle 9:2769-76. 2010
  2. pmc Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis
    Satish K Madala
    Division of Pulmonary Medicine, Cincinnati, OH, USA
    Respir Res 13:51. 2012
  3. pmc MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation
    Satish K Madala
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 46:380-8. 2012
  4. pmc Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 37:309-21. 2007
  5. doi request reprint EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1217-25. 2008
  6. ncbi request reprint Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis
    William D Hardie
    Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004
  7. pmc Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
    Thomas R Korfhagen
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:562-72. 2009
  8. ncbi request reprint Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Physiol Lung Cell Mol Physiol 293:L314-27. 2007
  9. pmc Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma
    Timothy D Le Cras
    Division of Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 300:L414-21. 2011
  10. pmc Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:415-25. 2009

Collaborators

Detail Information

Publications20

  1. pmc Signaling pathways in the epithelial origins of pulmonary fibrosis
    William D Hardie
    Department of Pediatrics, Pulmonary Medicine, University of California, San Diego, CA, USA
    Cell Cycle 9:2769-76. 2010
    ..Finally, we will present data demonstrating a minimal contribution of epithelial-mesenchymal transition in the development of fibrotic lesions in the transforming growth factor-alpha transgenic model of lung fibrosis...
  2. pmc Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis
    Satish K Madala
    Division of Pulmonary Medicine, Cincinnati, OH, USA
    Respir Res 13:51. 2012
    ..However, the direct role of Fizz1 produced in the pulmonary epithelium has not been determined...
  3. pmc MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation
    Satish K Madala
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 46:380-8. 2012
    ..These findings demonstrate that MEK inhibition prevents progression of established fibrosis in the TGF-α model, and provides proof of concept of targeting the MEK pathway in fibrotic lung disease...
  4. pmc Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 37:309-21. 2007
    ..These studies support a role for epithelial cell-derived TGF-alpha in the regulation of processes that alter the airway and vascular architecture and function...
  5. doi request reprint EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis
    William D Hardie
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1217-25. 2008
    ....
  6. ncbi request reprint Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis
    William D Hardie
    Div of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L741-9. 2004
    ..Induction of pulmonary fibrosis by TGF-alpha was independent of inflammation or early activation of TGF-beta...
  7. pmc Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
    Thomas R Korfhagen
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:562-72. 2009
    ....
  8. ncbi request reprint Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Physiol Lung Cell Mol Physiol 293:L314-27. 2007
    ..Pathological changes in TGF-alpha-overexpressing mice bore similarities to premature infants born in the saccular phase who develop BPD, including remodeling of the distal lung septae and arteries...
  9. pmc Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma
    Timothy D Le Cras
    Division of Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 300:L414-21. 2011
    ..This study demonstrates that EGFR signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model...
  10. pmc Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice
    Elizabeth L Kramer
    Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Respir Cell Mol Biol 41:415-25. 2009
    ..This provides a unique model to study the processes causing pulmonary fibrosis and ASM thickening without the complicating effects of inflammation...
  11. ncbi request reprint Acute lung injury: functional genomics and genetic susceptibility
    George D Leikauf
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 121:70S-75S. 2002
    ..Thus, the functional genomic approaches of large gene set expression (complementary DNA microarray) and genome-wide analyses continue to provide novel insights into the genetic susceptibility of lung injury...
  12. ncbi request reprint Cavitary lung lesions in a 2-year-old child
    Gary L McPhail
    Division of Pulmonary Medicine, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Respiration 76:117-8. 2008
  13. ncbi request reprint TGF-alpha perturbs surfactant homeostasis in vivo
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 289:L34-43. 2005
    ..Abnormalities in surfactant function and decreased surfactant level in the airways may contribute to the pathophysiology induced by TGF-alpha in both the developing and adult lung...
  14. ncbi request reprint Dose-related protection from nickel-induced lung injury in transgenic mice expressing human transforming growth factor-alpha
    William D Hardie
    Division of Pulmonary Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 26:430-7. 2002
    ..In the TGF-alpha transgenic mouse model, TGF-alpha protects against nickel-induced acute lung injury, at least in part, by attenuating the inflammatory response, reducing pulmonary edema, and preserving levels of SP-B...
  15. pmc Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis
    Timothy D Le Cras
    Divisions of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Am J Pathol 176:679-86. 2010
    ..These data show that PI3K is activated in TGFalpha/EGFR-mediated pulmonary fibrosis and support further studies to determine the role of PI3K activation in human lung fibrotic disease, which could be amenable to targeted therapy...
  16. ncbi request reprint Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha
    Timothy D Le Cras
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1046-54. 2003
    ..Reductions in VEGF may contribute to the pathogenesis of pulmonary vascular disease in TGF-alpha mice...
  17. pmc Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production
    Hitesh S Deshmukh
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 180:834-45. 2009
    ..Previously, we reported that acrolein levels found in COPD sputum could activate matrix metalloproteinase-9 (MMP9)...
  18. pmc Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
    Hitesh S Deshmukh
    Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
    Am J Respir Cell Mol Biol 38:446-54. 2008
    ..Augmentation of hMMP9 activity, in turn, could contribute to persistent excessive mucin production...
  19. pmc Emerging concepts in the pathogenesis of lung fibrosis
    William D Hardie
    Department of Pediatrics, Cincinnati Children s Medical Center, Cincinnati, Ohio, USA
    Am J Pathol 175:3-16. 2009
    ....
  20. doi request reprint Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria
    Jeffrey S Loeb
    Department of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatr Pulmonol 43:1020-4. 2008
    ..These data demonstrate most children are able to perform acceptable/repeatable spirometry with their first effort based on revised ATS/ERS criteria...

Research Grants7

  1. TRANSFORMING GROWTH FACTOR ALPHA AND LUNG INJURY
    WILLIAM HARDIE; Fiscal Year: 2003
    ..The experiments proposed will permit the P.I. to develop an independent line of research in a division dedicated to understanding the basic pathobiology of various lung diseases. ..
  2. Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis
    WILLIAM HARDIE; Fiscal Year: 2007
    ..Completion of the proposed studies will determine a role of EGFR in lung fibrosis and suggest therapeutic targets to alter the course of human lung fibrosis. ..
  3. Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis
    WILLIAM DAVID HARDIE; Fiscal Year: 2010
    ..Completion of the proposed studies will determine a role of EGFR in lung fibrosis and suggest therapeutic targets to alter the course of human lung fibrosis. ..
  4. Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis
    WILLIAM HARDIE; Fiscal Year: 2009
    ..Completion of the proposed studies will determine a role of EGFR in lung fibrosis and suggest therapeutic targets to alter the course of human lung fibrosis. ..