Xiaonan Han

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Recent Pat Inflamm Allergy Drug Discov 4:159-76. 2010
  2. pmc Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16139. 2011
  3. pmc Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
  4. doi request reprint Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Gut 59:1066-78. 2010
  5. pmc Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
  6. doi request reprint Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    Xiaonan Han
    Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 136:1261-71, e1-3. 2009
  7. pmc Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
    Rebecca Carey
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 14:446-57. 2008
  8. pmc Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice
    Charles M Samson
    Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 17:2443-55. 2011
  9. pmc Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Pharmacy, Faculty of Chemistry, P Catholic University of Chile, Santiago, Chile
    Gastroenterology 145:808-19. 2013
  10. pmc Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:22381-6. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Recent Pat Inflamm Allergy Drug Discov 4:159-76. 2010
    ..Herein, we discuss the feasibility of using intestinal permeability as an endpoint in the clinical trials of CD by current investigations and relevant patents...
  2. pmc Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16139. 2011
    ..As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regulation of intestinal barrier function...
  3. pmc Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
    ..Targeting IEC STAT5 signalling may be a novel therapeutic approach for treating intestinal barrier dysfunction in IBD...
  4. doi request reprint Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Gut 59:1066-78. 2010
    ..STAT5 signalling is central to GM-CSF action. It was therefore hypothesised that GM-CSF signalling in non-haematopoietic cells is required for ileal homeostasis...
  5. pmc Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
    ..We examined the role of the inhibitory receptor paired immunoglobulin-like receptor B (PIR-B) in the regulation of macrophage function in innate intestinal immunity...
  6. doi request reprint Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    Xiaonan Han
    Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 136:1261-71, e1-3. 2009
    ..We investigated whether GM-CSF Ab regulates neutrophil function in CD...
  7. pmc Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
    Rebecca Carey
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 14:446-57. 2008
    ..We hypothesized that a proinflammatory IL-6:STAT3-dependent biological network would be up regulated in pediatric-onset IBD patients, and would be associated with the severity of mucosal inflammation...
  8. pmc Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice
    Charles M Samson
    Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 17:2443-55. 2011
    ..We hypothesized that GM-CSF neutralization promotes ileal disease by modulating expression of CCL25 by IEC and CCR9 by T lymphocytes via Nod2-dependent and independent pathways...
  9. pmc Cdc42 coordinates proliferation, polarity, migration, and differentiation of small intestinal epithelial cells in mice
    Jaime Melendez
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio Department of Pharmacy, Faculty of Chemistry, P Catholic University of Chile, Santiago, Chile
    Gastroenterology 145:808-19. 2013
    ..In the intestinal epithelium, a balance among these events maintains homeostasis. We used genetic techniques to investigate the role of Cdc42 in intestinal homeostasis andĀ its mechanisms...
  10. pmc Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:22381-6. 2009
    ..Collectively, these findings identify a mechanism by which mast cells regulate homeostatic intestinal epithelial migration and barrier function...
  11. pmc Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis
    Xiaonan Han
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Pathol 169:1999-2013. 2006
    ..Therapeutic activation of the GH:STAT5b axis therefore represents a novel target for restoring both normal anabolic metabolism and mucosal tolerance in CD...
  12. ncbi request reprint Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis
    Xiaonan Han
    Cincinnati Children s Hospital Medical cetner and the University of Cincinnati College of Medicine, Ohio, USA
    Gastroenterology 129:185-203. 2005
    ..SHP-2, through binding to the glycoprotein 130 signaling receptor, negatively regulates STAT3 activation. Growth hormone reduces disease activity and promotes mucosal healing in colitis and can activate SHP-2...