Xiaonan Han

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Recent Pat Inflamm Allergy Drug Discov 4:159-76. 2010
  2. ncbi Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16139. 2011
  3. ncbi Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Gut 59:1066-78. 2010
  4. ncbi Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
  5. ncbi Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    Xiaonan Han
    Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 136:1261-71, e1-3. 2009
  6. ncbi Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
  7. ncbi Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice
    Charles M Samson
    Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 17:2443-55. 2011
  8. ncbi Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:22381-6. 2009
  9. ncbi Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
    Rebecca Carey
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 14:446-57. 2008
  10. ncbi Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis
    Xiaonan Han
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Pathol 169:1999-2013. 2006

Collaborators

Detail Information

Publications11

  1. ncbi Intestinal permeability as a clinical surrogate endpoint in the development of future Crohn's disease therapies
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Recent Pat Inflamm Allergy Drug Discov 4:159-76. 2010
    ..Herein, we discuss the feasibility of using intestinal permeability as an endpoint in the clinical trials of CD by current investigations and relevant patents...
  2. ncbi Loss of guanylyl cyclase C (GCC) signaling leads to dysfunctional intestinal barrier
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e16139. 2011
    ..As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regulation of intestinal barrier function...
  3. ncbi Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury
    Xiaonan Han
    Division of Gastroenterology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Gut 59:1066-78. 2010
    ..STAT5 signalling is central to GM-CSF action. It was therefore hypothesised that GM-CSF signalling in non-haematopoietic cells is required for ileal homeostasis...
  4. ncbi Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
    ..We examined the role of the inhibitory receptor paired immunoglobulin-like receptor B (PIR-B) in the regulation of macrophage function in innate intestinal immunity...
  5. ncbi Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease
    Xiaonan Han
    Department of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 136:1261-71, e1-3. 2009
    ..We investigated whether GM-CSF Ab regulates neutrophil function in CD...
  6. ncbi Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
    ..Targeting IEC STAT5 signalling may be a novel therapeutic approach for treating intestinal barrier dysfunction in IBD...
  7. ncbi Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice
    Charles M Samson
    Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 17:2443-55. 2011
    ..We hypothesized that GM-CSF neutralization promotes ileal disease by modulating expression of CCL25 by IEC and CCR9 by T lymphocytes via Nod2-dependent and independent pathways...
  8. ncbi Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism
    Katherine R Groschwitz
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:22381-6. 2009
    ..Collectively, these findings identify a mechanism by which mast cells regulate homeostatic intestinal epithelial migration and barrier function...
  9. ncbi Activation of an IL-6:STAT3-dependent transcriptome in pediatric-onset inflammatory bowel disease
    Rebecca Carey
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Inflamm Bowel Dis 14:446-57. 2008
    ..We hypothesized that a proinflammatory IL-6:STAT3-dependent biological network would be up regulated in pediatric-onset IBD patients, and would be associated with the severity of mucosal inflammation...
  10. ncbi Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis
    Xiaonan Han
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, MLC 2010, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Pathol 169:1999-2013. 2006
    ..Therapeutic activation of the GH:STAT5b axis therefore represents a novel target for restoring both normal anabolic metabolism and mucosal tolerance in CD...
  11. ncbi Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis
    Xiaonan Han
    Cincinnati Children's Hospital Medical cetner and the University of Cincinnati College of Medicine, Ohio, USA
    Gastroenterology 129:185-203. 2005
    ..Growth hormone may be a useful therapy in inflammatory bowel disease, in terms of both improving anabolic metabolism and enhancing mucosal healing...