Fukun Guo

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
  2. ncbi Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:18505-10. 2010
  3. ncbi Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, OH, USA
    Blood 112:1767-75. 2008
  4. ncbi Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
  5. ncbi Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion
    Fukun Guo
    Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, OH 45229, USA
    Oncogene 23:5577-85. 2004
  6. ncbi R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
  7. ncbi Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 281:18652-9. 2006
  8. ncbi Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
  9. ncbi Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant
    Balazs Debreceni
    Division of Experimental Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 279:3777-86. 2004
  10. ncbi RhoA of the Rho family small GTPases is essential for B lymphocyte development
    Shuangmin Zhang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e33773. 2012

Collaborators

Detail Information

Publications17

  1. ncbi Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e18002. 2011
    ..Collectively, these data establish that Cdc42 is critically involved in thymopoiesis and plays a restrictive role in effector and memory T cell differentiation and autoimmunity...
  2. ncbi Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:18505-10. 2010
    ..Thus, T-cell homeostasis is maintained through a concerted regulation of Gfi-1-IL-7R-controlled cytokine responsiveness and ERK-mediated TCR signaling strength by the Cdc42-PAK1 signaling axis...
  3. ncbi Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development
    Fukun Guo
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, OH, USA
    Blood 112:1767-75. 2008
    ..Thus, Rac1 and Rac2 have unique roles in CLP production and share a redundant but essential role in later stages of T-cell development by regulating survival and proliferation signals...
  4. ncbi Rho GTPase Cdc42 is essential for B-lymphocyte development and activation
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, OH 45229, USA
    Blood 114:2909-16. 2009
    ..These results reveal multifaceted roles of Cdc42 in B-cell development and activation...
  5. ncbi Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion
    Fukun Guo
    Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, OH 45229, USA
    Oncogene 23:5577-85. 2004
    ....
  6. ncbi R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
    ..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization...
  7. ncbi Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 281:18652-9. 2006
    ....
  8. ncbi Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
    ..Our study reveals a new function for WASp in the control of neutrophil polarity via crosstalk between CD11b and microtubules...
  9. ncbi Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant
    Balazs Debreceni
    Division of Experimental Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 279:3777-86. 2004
    ....
  10. ncbi RhoA of the Rho family small GTPases is essential for B lymphocyte development
    Shuangmin Zhang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Research Foundation, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e33773. 2012
    ..Taken together, our results uncover an important role for RhoA at multiple stages of B cell development...
  11. ncbi Cdc42 regulates extracellular matrix remodeling in three dimensions
    Nisha S Sipes
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:36469-77. 2011
    ..Thus, in addition to the previously implicated roles in intracellular regulation of actin organization, proliferation, and vesicle trafficking, Cdc42 is essential in ECM remodeling in three dimensions...
  12. ncbi Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A
    Xiaoling Zhang
    Division of Experimental Hematology, Cincinnati Children s Research Foundation and Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 112:1683-6. 2008
    ..These results provide the first evidence that FA proteins influence human BM progenitor homing and adhesion via the small GTPase Cdc42-regulated signaling pathway...
  13. ncbi Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis
    Emily E Bosco
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, OH, USA
    Blood 115:3320-8. 2010
    ..Because the Rac1 signaling axis is a critical determinant of apoptosis and tumorigenesis, it may represent an important basis for therapy in the treatment of p53-deficient lymphomas...
  14. ncbi Rho GTPases in hematopoiesis and hemopathies
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 115:936-47. 2010
    ..In this review we discuss recent genetic studies of Rho GTPases in hematopoiesis and several blood lineages and the implications of Rho GTPase signaling in hematologic malignancies, immune pathology. and anemia...
  15. ncbi Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    Yuan Gao
    Division of Experimental Hematology, Children's Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 101:7618-23. 2004
    ..Thus, NSC23766 constitutes a Rac-specific small-molecule inhibitor that could be useful to study the role of Rac in various cellular functions and to reverse tumor cell phenotypes associated with Rac deregulation...
  16. ncbi Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts
    Fukun Guo
    Division of Experimental Hematology, Children's Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Mol Cell Biol 24:1426-38. 2004
    ....
  17. ncbi p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities
    Fukun Guo
    Division of Experimental Hematology, Children s Hospital Research Foundation, University of Cincinnati, Ohio 45229, USA
    J Biol Chem 278:14414-9. 2003
    ....