Alexei A Grom

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Joyce Villanueva
    1Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R30-7. 2005
  2. pmc Algorithm development for corticosteroid management in systemic juvenile idiopathic arthritis trial using consensus methodology
    Norman T Ilowite
    Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA
    Pediatr Rheumatol Online J 10:31. 2012
  3. ncbi request reprint Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?
    Alexei A Grom
    Cincinnati Children s Hospital Medical Center, OH 45215, USA
    Curr Opin Rheumatol 15:587-90. 2003
  4. ncbi request reprint Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
    Alexei A Grom
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45215, USA
    Arthritis Rheum 50:689-98. 2004
  5. pmc Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
  6. ncbi request reprint Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Alexei A Grom
    William S Rowe Division of Rheumatology, and the Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 142:292-6. 2003
  7. pmc Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
  8. pmc Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis
    Janos Sumegi
    Divisions of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH 45229, USA
    Blood 121:e14-24. 2013
  9. pmc The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness
    Keith A Sikora
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:3799-808. 2012
  10. pmc Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010

Collaborators

Detail Information

Publications25

  1. pmc Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Joyce Villanueva
    1Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R30-7. 2005
    ..This phenomenon was particularly common in the systemic form of JRA, a clinical entity strongly associated with MAS...
  2. pmc Algorithm development for corticosteroid management in systemic juvenile idiopathic arthritis trial using consensus methodology
    Norman T Ilowite
    Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA
    Pediatr Rheumatol Online J 10:31. 2012
    ..abstract:..
  3. ncbi request reprint Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?
    Alexei A Grom
    Cincinnati Children s Hospital Medical Center, OH 45215, USA
    Curr Opin Rheumatol 15:587-90. 2003
    ..The main purpose of the review is to summarize current understanding of the relation between macrophage activation syndrome and other clinically similar hemophagocytic disorders...
  4. ncbi request reprint Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
    Alexei A Grom
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45215, USA
    Arthritis Rheum 50:689-98. 2004
  5. pmc Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
    ....
  6. ncbi request reprint Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Alexei A Grom
    William S Rowe Division of Rheumatology, and the Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 142:292-6. 2003
    ..To assess natural killer (NK) and cytotoxic functions in patients with systemic-onset juvenile rheumatoid arthrithis (soJRA) complicated by macrophage activation syndrome (MAS)...
  7. pmc Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
    ..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
  8. pmc Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis
    Janos Sumegi
    Divisions of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH 45229, USA
    Blood 121:e14-24. 2013
    ..These differentially expressed genes may represent biomarkers that can be used as predictors of disease progression...
  9. pmc The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness
    Keith A Sikora
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:3799-808. 2012
    ..This study sought to characterize the status of an IFN-induced signature within affected tissue and to gauge the integrity of IFN signaling pathways within peripheral monocytes from patients with systemic JIA...
  10. pmc Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
    ..To explore biologic correlates to age at onset in patients with juvenile idiopathic arthritis (JIA) using peripheral blood mononuclear cell (PBMC) gene expression analysis...
  11. pmc Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
    ..To determine whether peripheral blood mononuclear cells (PBMCs) from children with recent-onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures...
  12. ncbi request reprint Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    Ndate Fall
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:3793-804. 2007
    ..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...
  13. pmc Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    Kejian Zhang
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 58:2892-6. 2008
    ..The development of familial HLH has been recently associated with mutations in MUNC13-4. The purpose of this study was to assess for possible sequence alterations in MUNC13-4 in patients with systemic JIA/macrophage activation syndrome...
  14. pmc Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
    Janos Sumegi
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH, USA
    Blood 117:e151-60. 2011
    ..This first study of genome-wide expression profiling in children with FHL demonstrates the complexity of gene expression patterns, which underlie the immunobiology of FHL...
  15. ncbi request reprint The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    Jack Bleesing
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:965-71. 2007
    ..This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA)...
  16. ncbi request reprint Association between lack of angiogenic response in muscle tissue and high expression of angiostatic ELR-negative CXC chemokines in patients with juvenile dermatomyositis: possible link to vasculopathy
    Ndate Fall
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 52:3175-80. 2005
    ..To investigate the relationship between the vasculopathy of juvenile dermatomyositis (juvenile DM) and the balance between the angiostatic ELR- and angiogenic ELR+ CXC chemokines in the muscle of patients with the disease...
  17. pmc Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis
    Mark Gorelik
    Division of Rheumatology, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center UPMC, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    J Rheumatol 40:1191-9. 2013
    ..Our objective was to correlate FSTL-1 levels with gene expression, known biomarkers, and measures of disease activity in systemic juvenile idiopathic arthritis (sJIA), including macrophage activation syndrome (MAS)...
  18. pmc Macrophage activation syndrome: advances towards understanding pathogenesis
    Alexei A Grom
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Curr Opin Rheumatol 22:561-6. 2010
    ..There are no validated diagnostic criteria and early diagnosis is difficult. This review summarizes the progress in understanding of MAS pathophysiology that may help define specific diagnostic biomarkers...
  19. ncbi request reprint Feasibility and construct validity of the parent willingness-to-pay technique for children with juvenile idiopathic arthritis
    Andrea C Barron
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 51:899-908. 2004
    ..To assess the feasibility and construct validity of the willingness-to-pay (WTP) technique for measuring health care preferences in families of children with juvenile idiopathic arthritis (JIA)...
  20. ncbi request reprint Interleukin-15 inhibits sodium nitroprusside-induced apoptosis of synovial fibroblasts and vascular endothelial cells
    Lin Yang
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 46:3010-4. 2002
    ..Since synovial vascular endothelial cells (VECs) expressed IL-15 receptors, the present study was undertaken to investigate the hypothesis that IL-15 might play a role in neovascularization of the pannus...
  21. pmc Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis
    Kenneth M Kaufman
    Cincinnati Children s Hospital Medical Center and Cincinnati VA Medical Center, Cincinnati, Ohio
    Arthritis Rheumatol 66:3486-95. 2014
    ..We undertook this study to test our hypothesis that MAS predisposition in systemic JIA could be attributed to rare gene sequence variants affecting the cytotolytic pathway...
  22. pmc Update on the pathogenesis and treatment of systemic idiopathic arthritis
    Keith A Sikora
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Opin Pediatr 23:640-6. 2011
    ..In this review, we describe the recent immunological reclassification of SJIA as an autoinflammatory disorder as well as detailing the dramatic changes in its treatment...
  23. doi request reprint Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies
    Grant S Schulert
    Division of Pediatric Rheumatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 email
    Annu Rev Med 66:145-59. 2015
    ..The mainstay of treatment remains corticosteroids; other medications, including cyclosporine, are used in patients who fail to respond. ..
  24. pmc Macrophage activation syndrome and cytokine-directed therapies
    Grant S Schulert
    Division of Pediatric Rheumatology, Children s Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Electronic address
    Best Pract Res Clin Rheumatol 28:277-92. 2014
    ..Finally, we will review current treatment options for MAS and examine how cytokine-directed therapy could serve as novel treatment modalities...
  25. ncbi request reprint Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue
    Michael P Scola
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Rheumatol 29:369-78. 2002
    ..To compare synovial tissue cytokine mRNA expression between patients with juvenile rheumatoid arthritis (JRA) and a heterogeneous group of non-autoimmune arthropathies (controls) with respect to type 1/type 2 balance...