Alexei A Grom

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Macrophage activation syndrome: advances towards understanding pathogenesis
    Alexei A Grom
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Curr Opin Rheumatol 22:561-6. 2010
  2. ncbi Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
  3. ncbi Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
  4. ncbi The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness
    Keith A Sikora
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:3799-808. 2012
  5. ncbi Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
  6. ncbi Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    Ndate Fall
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:3793-804. 2007
  7. ncbi Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
  8. ncbi Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
    Janos Sumegi
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH, USA
    Blood 117:e151-60. 2011
  9. ncbi The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    Jack Bleesing
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:965-71. 2007
  10. ncbi Update on the pathogenesis and treatment of systemic idiopathic arthritis
    Keith A Sikora
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Opin Pediatr 23:640-6. 2011

Research Grants

  1. Pathogenic Mechanisms of the Vasculopathy of JDM
    Alexei Grom; Fiscal Year: 2004

Collaborators

Detail Information

Publications18

  1. ncbi Macrophage activation syndrome: advances towards understanding pathogenesis
    Alexei A Grom
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Curr Opin Rheumatol 22:561-6. 2010
    ..There are no validated diagnostic criteria and early diagnosis is difficult. This review summarizes the progress in understanding of MAS pathophysiology that may help define specific diagnostic biomarkers...
  2. ncbi Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis
    Claas H Hinze
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Arthritis Res Ther 12:R123. 2010
    ..The aim of this study was to determine the association of this signature with peripheral blood mononuclear cell (PBMC) subpopulations and its specificity for sJIA as compared with related conditions...
  3. ncbi Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    Michael G Barnes
    Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2102-12. 2009
    ....
  4. ncbi The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness
    Keith A Sikora
    Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Rheum 64:3799-808. 2012
    ..This study sought to characterize the status of an IFN-induced signature within affected tissue and to gauge the integrity of IFN signaling pathways within peripheral monocytes from patients with systemic JIA...
  5. ncbi Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis
    Michael G Barnes
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 62:3249-58. 2010
    ..To explore biologic correlates to age at onset in patients with juvenile idiopathic arthritis (JIA) using peripheral blood mononuclear cell (PBMC) gene expression analysis...
  6. ncbi Gene expression profiling of peripheral blood from patients with untreated new-onset systemic juvenile idiopathic arthritis reveals molecular heterogeneity that may predict macrophage activation syndrome
    Ndate Fall
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:3793-804. 2007
    ..This study was undertaken to better understand the relationship between systemic JIA and macrophage activation syndrome...
  7. ncbi Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets
    Thomas A Griffin
    William S Rowe Division of Pediatric Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 60:2113-23. 2009
    ..To determine whether peripheral blood mononuclear cells (PBMCs) from children with recent-onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures...
  8. ncbi Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
    Janos Sumegi
    Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH, USA
    Blood 117:e151-60. 2011
    ..This first study of genome-wide expression profiling in children with FHL demonstrates the complexity of gene expression patterns, which underlie the immunobiology of FHL...
  9. ncbi The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis
    Jack Bleesing
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 56:965-71. 2007
    ..This study was undertaken to assess the value of serum sIL-2Ralpha and sCD163 in diagnosing acute macrophage activation syndrome complicating systemic juvenile idiopathic arthritis (JIA)...
  10. ncbi Update on the pathogenesis and treatment of systemic idiopathic arthritis
    Keith A Sikora
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Opin Pediatr 23:640-6. 2011
    ..In this review, we describe the recent immunological reclassification of SJIA as an autoinflammatory disorder as well as detailing the dramatic changes in its treatment...
  11. ncbi Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    Kejian Zhang
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 58:2892-6. 2008
    ..The development of familial HLH has been recently associated with mutations in MUNC13-4. The purpose of this study was to assess for possible sequence alterations in MUNC13-4 in patients with systemic JIA/macrophage activation syndrome...
  12. ncbi Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Joyce Villanueva
    1Division of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio, USA
    Arthritis Res Ther 7:R30-7. 2005
    ..This phenomenon was particularly common in the systemic form of JRA, a clinical entity strongly associated with MAS...
  13. ncbi Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
    Alexei A Grom
    Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45215, USA
    Arthritis Rheum 50:689-98. 2004
  14. ncbi Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?
    Alexei A Grom
    Cincinnati Children s Hospital Medical Center, OH 45215, USA
    Curr Opin Rheumatol 15:587-90. 2003
    ....
  15. ncbi Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    Alexei A Grom
    William S Rowe Division of Rheumatology, and the Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Pediatr 142:292-6. 2003
    ..To assess natural killer (NK) and cytotoxic functions in patients with systemic-onset juvenile rheumatoid arthrithis (soJRA) complicated by macrophage activation syndrome (MAS)...
  16. ncbi Feasibility and construct validity of the parent willingness-to-pay technique for children with juvenile idiopathic arthritis
    Andrea C Barron
    Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA
    Arthritis Rheum 51:899-908. 2004
    ..Relatively large WTP estimates support a possible important negative impact of the disease on families of children with JIA...
  17. ncbi Interleukin-15 inhibits sodium nitroprusside-induced apoptosis of synovial fibroblasts and vascular endothelial cells
    Lin Yang
    Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Arthritis Rheum 46:3010-4. 2002
    ..CONCLUSION: IL-15 promotes survival of VECs on Matrigel and inhibits SNP-induced apoptosis of endothelial cells. We hypothesize that this mechanism may be relevant to the stabilization of newly formed vascular structures in JRA synovium...
  18. ncbi Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue
    Michael P Scola
    Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Rheumatol 29:369-78. 2002
    ..The strong correlation between IFN-gamma and IL-12 in JRA suggests a prominent role for IL-12 in promoting the type I bias, while IL-15 and IL-18 may also indirectly increase IFN-gamma expression and further bias the immune response...

Research Grants1

  1. Pathogenic Mechanisms of the Vasculopathy of JDM
    Alexei Grom; Fiscal Year: 2004
    ..The long-term goal of this proposal is to understand the molecular mechanisms underlying vasculopathy and to define potential targets for therapeutic intervention. ..