John H Greinwald

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Significance of unilateral enlarged vestibular aqueduct
    John Greinwald
    Ear and Hearing Center, Division of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Laryngoscope 123:1537-46. 2013
  2. pmc A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness
    Soraya Bardien
    Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa
    BMC Med Genet 10:2. 2009
  3. ncbi request reprint Massive lymphatic malformations of the head, neck, and chest
    John Greinwald
    Division of Pediatric Otolaryngology and Head Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Otolaryngol Head Neck Surg 37:169-73. 2008
  4. ncbi request reprint Improved diagnostic effectiveness with a sequential diagnostic paradigm in idiopathic pediatric sensorineural hearing loss
    Diego A Preciado
    Center for Hearing and Deafness Research CHDR and the Division of Pediatric Otolaryngology, Cincinnati, Ohio 45229 3039, USA
    Otol Neurotol 26:610-5. 2005
  5. ncbi request reprint Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations
    Kenneth H Lee
    Hearing and Deafness Center, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, U S A
    Laryngoscope 119:554-8. 2009
  6. pmc High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays
    Prachi Kothiyal
    1Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    BMC Biotechnol 10:10. 2010
  7. ncbi request reprint Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury
    Scott A Schraff
    Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Otolaryngol Head Neck Surg 137:612-8. 2007
  8. ncbi request reprint A diagnostic paradigm for childhood idiopathic sensorineural hearing loss
    Diego A Preciado
    Center for Hearing and Deafness Research, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Otolaryngol Head Neck Surg 131:804-9. 2004
  9. doi request reprint Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss
    Theru A Sivakumaran
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Otolaryngol Head Neck Surg 148:1007-16. 2013
  10. ncbi request reprint The role of CMV inflammatory genes in hearing loss
    Scott A Schraff
    Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Otol Neurotol 28:964-9. 2007

Research Grants

Collaborators

Detail Information

Publications29

  1. doi request reprint Significance of unilateral enlarged vestibular aqueduct
    John Greinwald
    Ear and Hearing Center, Division of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Laryngoscope 123:1537-46. 2013
    ..In view of clinical observations and previously published data, we hypothesized that patients with unilateral EVA would have a much higher rate of contralateral hearing loss than patients with unilateral hearing loss without EVA...
  2. pmc A rapid method for detection of five known mutations associated with aminoglycoside-induced deafness
    Soraya Bardien
    Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa
    BMC Med Genet 10:2. 2009
    ..The aim of the present study was to develop a rapid screening method to determine whether these mutations are present in the South African population...
  3. ncbi request reprint Massive lymphatic malformations of the head, neck, and chest
    John Greinwald
    Division of Pediatric Otolaryngology and Head Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Otolaryngol Head Neck Surg 37:169-73. 2008
    ..To provide clinicians with an overview of the complications and functional and clinical outcomes of children affected by massive lymphatic malformations affecting multiple sites in the head, neck, and/or chest...
  4. ncbi request reprint Improved diagnostic effectiveness with a sequential diagnostic paradigm in idiopathic pediatric sensorineural hearing loss
    Diego A Preciado
    Center for Hearing and Deafness Research CHDR and the Division of Pediatric Otolaryngology, Cincinnati, Ohio 45229 3039, USA
    Otol Neurotol 26:610-5. 2005
    ..To determine whether a stepwise diagnostic paradigm is more diagnostically efficient and cost-effective than a simultaneous testing approach in the evaluation of idiopathic pediatric sensorineural hearing loss (SNHL)...
  5. ncbi request reprint Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutations
    Kenneth H Lee
    Hearing and Deafness Center, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, U S A
    Laryngoscope 119:554-8. 2009
    ....
  6. pmc High-throughput detection of mutations responsible for childhood hearing loss using resequencing microarrays
    Prachi Kothiyal
    1Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    BMC Biotechnol 10:10. 2010
    ..We present results from hearing loss arrays developed in two different research facilities and highlight some of the approaches we adopted to enhance the applicability of resequencing arrays in a clinical setting...
  7. ncbi request reprint Macrophage inflammatory proteins in cytomegalovirus-related inner ear injury
    Scott A Schraff
    Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Otolaryngol Head Neck Surg 137:612-8. 2007
    ..The purpose of the study was to determine if a virally encoded macrophage inflammatory protein played a role in CMV-related hearing loss...
  8. ncbi request reprint A diagnostic paradigm for childhood idiopathic sensorineural hearing loss
    Diego A Preciado
    Center for Hearing and Deafness Research, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Otolaryngol Head Neck Surg 131:804-9. 2004
    ..Our objective was to determine the diagnostic yield of laboratory testing, radiological imaging, and GJB2 mutation screening in a large cohort of patients with differing severities of idiopathic sensorineural hearing loss (SNHL)...
  9. doi request reprint Performance evaluation of the next-generation sequencing approach for molecular diagnosis of hereditary hearing loss
    Theru A Sivakumaran
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Otolaryngol Head Neck Surg 148:1007-16. 2013
    ..To evaluate the performance of a next-generation sequencing (NGS)-based targeted resequencing genetic test, OtoSeq, to identify the sequence variants in the genes causing sensorineural hearing loss (SNHL)...
  10. ncbi request reprint The role of CMV inflammatory genes in hearing loss
    Scott A Schraff
    Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Otol Neurotol 28:964-9. 2007
    ..The purpose of this study is to test the hypothesis that virally encoded immunomodulatory genes play a role in cytomegalovirus (CMV)-related hearing loss...
  11. doi request reprint Characteristics of children diagnosed as having coagulopathies following posttonsillectomy bleeding
    Gordon H Sun
    Department of Otolaryngology Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Ohio, USA
    Arch Otolaryngol Head Neck Surg 137:65-8. 2011
    ..To determine the prevalence of coagulopathy among children presenting with posttonsillectomy bleeding (PTB) and describe risk factors that could indicate the presence of occult coagulopathy...
  12. ncbi request reprint The cochlear cleft
    Jon B Chadwell
    Department of Otolaryngology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    AJNR Am J Neuroradiol 25:21-4. 2004
    ..We noted an unfamiliar structure, which we now call the "cochlear cleft," in the otic capsule. To our knowledge, this report represents the first description of this structure in the medical imaging literature...
  13. ncbi request reprint Codeine-related adverse drug reactions in children following tonsillectomy: a prospective study
    Cynthia A Prows
    Division of Human Genetics, University of Cincinnati, Cincinnati, Ohio Division of Pharmacy, University of Cincinnati, Cincinnati, Ohio
    Laryngoscope 124:1242-50. 2014
    ..To prospectively determine factors associated with codeine's adverse drug reactions (ADRs) at home in a large homogenous population of children undergoing outpatient tonsillectomy...
  14. doi request reprint An overview of custom array sequencing
    Prachi Kothiyal
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Curr Protoc Hum Genet . 2009
    ..Critical topics in the design, implementation, and analysis of targeted sequencing arrays not previously discussed in detail are highlighted...
  15. ncbi request reprint Refining the DFNB17 interval in consanguineous Indian families
    Yingshi Guo
    Center for Hearing and Deafness Research, Department of Otolaryngology, Cincinnati, Children s Hospital Cincinnati, OH, USA
    Mol Biol Rep 31:97-105. 2004
    ..Analysis of coding and splice site regions of these cochlear expressed genes did not reveal any disease causing mutations. Further study of other candidate genes is currently underway...
  16. ncbi request reprint Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sac
    Hongwei Dou
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Histochem Cytochem 52:1377-84. 2004
    ....
  17. doi request reprint H1N1 influenza A presenting as bacterial tracheitis
    Brandon S Hopkins
    Department of Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0528, USA
    Otolaryngol Head Neck Surg 142:612-4. 2010
    ..In hospitalized patients with presumed BT, consideration should be given to routine H1N1 testing and the addition of antiviral medication when indicated as this entity is further investigated...
  18. ncbi request reprint Genomic organization and expression analysis of the murine Fam3c gene
    Valentina V Pilipenko
    Center for Hearing and Deafness Research, Division of Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Gene 335:159-68. 2004
    ..Further study is underway to determine the role of FAM3C in inner ear development...
  19. ncbi request reprint Bacterial tracheitis reexamined: is there a less severe manifestation?
    Frank N Salamone
    Division of Otolaryngology and Maxillofacial Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    Otolaryngol Head Neck Surg 131:871-6. 2004
    ..Bacterial tracheitis (BT) is a condition that can cause fatal airway obstruction. We evaluated our experience with BT over a 10-year period...
  20. ncbi request reprint Temporal bone abnormalities associated with hearing loss in Waardenburg syndrome
    Colm Madden
    Center of Hearing and Deafness Research, Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
    Laryngoscope 113:2035-41. 2003
    ..The objectives were to correlate audiometric thresholds with radiological findings and to determine the prevalence of inner ear radiological abnormalities in patients with hearing loss and Waardenburg syndrome...
  21. doi request reprint Neuroanatomic differences in children with unilateral sensorineural hearing loss detected using functional magnetic resonance imaging
    Evan J Propst
    Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, MLC 2018, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Arch Otolaryngol Head Neck Surg 136:22-6. 2010
    ..This study used fMRI to compare neuroanatomic activation patterns in children with unilateral sensorineural hearing loss (USNHL) with the neuroanatomic activation patterns in normally hearing individuals...
  22. ncbi request reprint A multicenter study of the frequency and distribution of GJB2 and GJB6 mutations in a large North American cohort
    Girish V Putcha
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Genet Med 9:413-26. 2007
    ....
  23. ncbi request reprint Prevalence and etiology of hearing loss in rural Nicaraguan children
    James E Saunders
    Department of ORL, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Laryngoscope 117:387-98. 2007
    ..The intent of this study is to investigate the prevalence and etiology of HL in children living in a remote, impoverished region of northern Nicaragua...
  24. pmc Cosegregation of the G7444A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes with the 12S rRNA A1555G mutation in a Chinese family with aminoglycoside-induced and nonsyndromic hearing loss
    Huijun Yuan
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
    Am J Med Genet A 138:133-40. 2005
    ..These data also imply that nuclear background plays a role in the aminoglycoside ototoxicity associated with the A1555G mutation in this Chinese pedigree...
  25. ncbi request reprint Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation
    Wie yen Young
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
    Biochem Biophys Res Commun 328:1244-51. 2005
    ..However, aminoglycoside appears to be a major modifier factor for the phenotypic manifestation of the A1555G mutation in these Chinese families...
  26. pmc Clinical and molecular characterization of a Chinese patient with auditory neuropathy associated with mitochondrial 12S rRNA T1095C mutation
    Qiuju Wang
    Institute of Otolaryngology, Chinese PLA General Hospital, Beijing, China
    Am J Med Genet A 133:27-30. 2005
    ..These data suggest that the T1095C mutation may be associated with auditory neuropathy in this subject, and two novel variants I175V and V112M may play a role in the phenotypic expression of the T1095C mutation...
  27. ncbi request reprint Genotypic and phenotypic correlations of DFNB1-related hearing impairment in the Midwestern United States
    Lynne H Y Lim
    Center for Hearing and Deafness Research, Cincinnati, Ohio, USA
    Arch Otolaryngol Head Neck Surg 129:836-40. 2003
    ..To determine the genotypic and phenotypic correlations of hearing impairment (HI) in a midwestern US population related to autosomal recessive nonsyndromic hearing loss locus 1 (DFNB1)...
  28. ncbi request reprint Clinical and audiological features in auditory neuropathy
    Colm Madden
    Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Arch Otolaryngol Head Neck Surg 128:1026-30. 2002
    ..To medically and audiologically characterize a population of children diagnosed as having auditory neuropathy (AN)...
  29. ncbi request reprint The evaluation of children with sensorineural hearing loss
    John H Greinwald
    Department of Otolaryngology Maxillofacial Surgery, Center for Hearing and Deafness Research, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Arch Otolaryngol Head Neck Surg 128:84-7. 2002

Research Grants1

  1. Identification and characterization of the DFNB17 gene
    John Greinwald; Fiscal Year: 2006
    ....