Research Topics
Species | T GlauserSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromesTracy Glauser
Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Epilepsia 54:551-63. 2013..When selecting a patient's AED, all relevant variables and not just efficacy and effectiveness should be considered...
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: Initial monotherapy outcomes at 12 monthsTracy A Glauser
Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, U S A Children s National Medical Center, Washington, District of Columbia, U S A Montefiore Medical Center, Albert Einstein College of Medicine, New York, New York, U S A National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, U S A The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, U S A
Epilepsia 54:141-55. 2013..This is the first randomized controlled trial meeting International League Against Epilepsy (ILAE) criteria for class I evidence for CAE (or for any type of generalized seizure in adults or children). (NCT00088452.)...
Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) facultyTracy A Glauser
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Curr Med Res Opin 24:3463-77. 2008....- Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patientsTracy A Glauser
Children s Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, C 5, MLC 2015, Cincinnati, OH 45229 3039, USA
J Child Neurol 19:S25-38. 2004..Moreover, the overwhelming body of data on the behavioral effects of phenobarbital should convince clinicians that, whenever possible, it should not be used as the initial-or even the second-monotherapy in children with epilepsy... - Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patientsCynthia A Prows
Division of Patient Services, University of Cincinnati College of Medicine, Cincinnati, OH, USA
J Child Adolesc Psychopharmacol 19:385-94. 2009..The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotype-predicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity... - Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsyTracy A Glauser
Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 2015, Cincinnati, OH 45229, USA
N Engl J Med 362:790-9. 2010..Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined... - Pharmacokinetics of levetiracetam in infants and young children with epilepsyTracy A Glauser
Children s Hospital Medical Center, Department of Neurology, Cincinnati, Ohio 45229, USA
Epilepsia 48:1117-22. 2007..To assess the single-dose pharmacokinetics of levetiracetam and its major metabolite ucb L057 in infants and young children with epilepsy... - Designing practical evidence-based treatment plans for children with prolonged seizures and status epilepticusTracy A Glauser
Comprehensive Epilepsy Program, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
J Child Neurol 22:38S-46S. 2007..Four scenarios illustrating these considerations are included and provide examples of plans that fulfill these criteria... - Topiramate monotherapy in newly diagnosed epilepsy in children and adolescentsTracy A Glauser
Division of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 2899, USA
J Child Neurol 22:693-9. 2007..As shown in this subset analysis, topiramate is effective and well tolerated as monotherapy in children and adolescents... - Rufinamide for generalized seizures associated with Lennox-Gastaut syndromeT Glauser
Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Avenue, MLC 2015, C 5, Cincinnati, OH 45229, USA
Neurology 70:1950-8. 2008..Current available treatments are inadequate, leaving patients with few treatment options and opportunities... - Monitoring gene changes during antiepileptic drug therapy to widen the safety window and reduce pharmacoresistanceTracy A Glauser
Comprehensive Epilepsy Program, Division of Neurology, Cincinnati Children s Hospital, Cincinnati, Ohio, USA
Epilepsia 48:19-25. 2007.... - Biomarkers for antiepileptic drug responseTracy A Glauser
Division of Child Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH 45229, USA
Biomark Med 5:635-41. 2011..Current methodological challenges to identifying new antiepileptic medication biomarkers can only be overcome with large-scale collaborative research efforts... - Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology SocietyJ J Riviello
Division of Epilepsy and Clinical Neurophysiology and the Critical Care Neurology Service, Department of Neurology, Children's Hospital, Boston, MA, USA
Neurology 67:1542-50. 2006..There is insufficient evidence to support or refute routine neuroimaging in a child presenting with SE (Level U)... - Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusionCatherine L Dent
Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Thorac Cardiovasc Surg 130:1523-30. 2005..To evaluate the effect of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion... - One-month adherence in children with new-onset epilepsy: white-coat compliance does not occurAvani C Modi
Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, MLC 3015, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Pediatrics 121:e961-6. 2008.... - Response to carbamazepine in children with newly diagnosed partial onset epilepsyKatherine D Holland
Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Neurology 69:596-9. 2007..The purpose of this work is to characterize the effectiveness and therapeutic doses of carbamazepine (CBZ) in children with localization-related epilepsy... - Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusionCatherine L Dent
Department of Pediatrics Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Thorac Cardiovasc Surg 131:190-7. 2006..To evaluate the impact of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion... - Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsyTracy A Glauser
Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Epilepsy Behav 5:S25-32. 2004..All of these data are then combined and formatted into a practical algorithm useful in many clinical situations... - Following catastrophic epilepsy patients from childhood to adulthoodTracy A Glauser
Department of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, U S A
Epilepsia 45:23-6. 2004..Finally, a multidisciplinary care plan that incorporates resources from health-care practitioners, social service professionals, and community agencies can be valuable in optimizing treatment for patients with catastrophic epilepsies... - Even a single seizure negatively impacts pediatric health-related quality of lifeAvani C Modi
Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Epilepsia 50:2110-6. 2009.... - Treatment factors affecting longitudinal quality of life in new onset pediatric epilepsyAvani C Modi
Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, MLC 7039, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Pediatr Psychol 36:466-75. 2011.... - Preliminary efficacy of levetiracetam in childrenTracy A Glauser
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, United States
Epileptic Disord 5:S45-50. 2003..Several ongoing studies will provide further information on the pharmacokinetics, efficacy, and safety of levetiracetam in this patient population... - A child with newly diagnosed symptomatic partial epilepsyTracy A Glauser
Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
Epilepsy Behav 4:S2-5; discussion S6-7. 2003 - Efficacy and safety of levetiracetam in children with partial seizures: an open-label trialTracy A Glauser
Department of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Epilepsia 43:518-24. 2002..To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures... - Patterns of nonadherence to antiepileptic drug therapy in children with newly diagnosed epilepsyAvani C Modi
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
JAMA 305:1669-76. 2011..The onset and evolution of antiepileptic drug nonadherence in children with newly diagnosed epilepsy remains unknown... - Development and validation of the Pediatric Epilepsy Medication Self-Management QuestionnaireAvani C Modi
Cincinnati Children s Hospital Medical Center Department of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self Management, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Epilepsy Behav 18:94-9. 2010..68-0.85. Significant associations were found between PEMSQ scales, adherence, and seizures. The PEMSQ represents the first self-management measure validated for caregivers of children with epilepsy, with clinical and research utility... - Improved tolerability and efficacy in epilepsy patients with extended-release carbamazepineD M Ficker
Department of Neurology, University of Cincinnati Medical Center, 231 Albert B Sabin Way, Cincinnati, OH 45267, USA
Neurology 65:593-5. 2005..Using validated, epilepsy-specific measures the authors found that switching to CBZ-ERC significantly improved patients' adverse events and quality-of-life measures. Switching to CBZ-ERC also improved seizure control... - Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsyKatherine D Holland
Division of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Neurosci Lett 433:65-70. 2008..This observation of a potentially pathogenic mutation of SCN3A (Nav1.3) indicates that this gene should be further evaluated for its contribution to childhood epilepsy... - Advancing the medical management of epilepsy: disease modification and pharmacogeneticsTracy A Glauser
Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Child Neurol 17:S85-93. 2002..Such methods of tailoring antiepilepsy drug therapy would be preferable to the trial-and-error system that is currently used... - Topiramate concentration in saliva: an alternative to serum monitoringMichael V Miles
Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Pediatr Neurol 29:143-7. 2003..8% +/- 12.1% (range 62.9% to 112.7%). The results of this study support the use of saliva as a viable alternative to serum for monitoring topiramate therapy. Topiramate concentration in saliva: an alternative to serum monitoring... - Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1Yang Tang
Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Brain Res Mol Brain Res 132:155-67. 2004.... - Zonisamide in pediatric epilepsy: review of the Japanese experienceTracy A Glauser
Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Child Neurol 17:87-96. 2002..Additional controlled trials in children with partial- or generalized-onset seizures, infantile spasms, and Lennox-Gastaut syndrome are warranted to further delineate zonisamide's broad spectrum of efficacy and tolerability in children... - Integrating clinical trial data into clinical practiceTracy A Glauser
Department of Neurology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA
Neurology 58:S6-12. 2002 - Unmet needs in pediatric epilepsyTracy A Glauser
Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Child Neurol 17:S1-3. 2002..The articles are the result of a closed symposium held in January 2001... - Blood gene expression profiling of neurologic diseases: a pilot microarray studyYang Tang
Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
Arch Neurol 62:210-5. 2005..In 1 cluster, 6 genes-all associated with immune cell function-were overexpressed. CONCLUSION: Blood gene expression profiling can provide surrogate markers for neurologic diseases without obvious blood phenotypes... - Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcomeEmily C De Los Reyes
Department of Pediatrics, Robert C Byrd Health Sciences Center, West Virginia University, Charleston, USA
J Child Neurol 23:167-72. 2008..The implications for recognition, management, and follow-up of this worrisome subset of patients with La Crosse virus encephalitis are discussed... - Oxcarbazepine in infants and young children with partial seizuresRalph S Northam
Monarch Research Associates, Neuro-Development, Norfolk, VA 23507, USA
Pediatr Neurol 33:337-44. 2005..Oxcarbazepine was safe and well tolerated in infants and young children. The pharmacokinetic profile of MHD was predicted by extension of a model based on older children... - Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies... - Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic StrategiesPhilip N Patsalos
Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
Epilepsia 49:1239-76. 2008..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin... - Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004.... - Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramateSrikanth C Nallani
College of Pharmacy, University of Cincinnati Medical Center, 3223 Eden Avenue, Cincinnati, OH 45267, U.S.A
Epilepsia 44:1521-8. 2003..It also is suggestive of other potential interactions when high-dose TPM therapy is used... - Genomics of brain and blood: progress and pitfallsFrank R Sharp
Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
Epilepsia 47:1603-7. 2006..Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future... - The future of genomic profiling of neurological diseases using bloodFrank R Sharp
Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
Arch Neurol 63:1529-36. 2006..Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans... - Febrile seizuresShlomo Shinnar
Montefiore Medical Center, and the Albert Einstein College of Medicine, Bronx, NY 10467, USA
J Child Neurol 17:S44-52. 2002..This has led to a changing view of how we approach the treatment of these common and largely benign seizures. This chapter will review the current understanding of the prognosis and management of febrile seizures...
Research Grants
- CLINICAL PHARMACOLOGY OF CHILDHOOD EPILEPSYTracy Glauser; Fiscal Year: 2003....
- Blood Genomics of Anticonvulsant Efficacy in ChildrenTracy Glauser; Fiscal Year: 2004..We will study whole blood total RNA using the new human U133 Affymetrix oligonucleotide microarrays that assess over 39,000 transcripts. ..
- Childhood Absence Epilepsy Rx, PK-PD-PharmacogeneticsTracy Glauser; Fiscal Year: 2007..Knowledge gained by this study will lead to individualized treatment for children with CAE that may in part be generalizable to other pediatric and adult seizure disorders. ..