T Glauser

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Management of childhood epilepsy
    Tracy A Glauser
    Hospital Medical Center, 3333 Burnet Avenue, ML2015, Cincinnati, OH 45229, USA
    Continuum (Minneap Minn) 19:656-81. 2013
  2. doi request reprint Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
    Tracy Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Epilepsia 54:551-63. 2013
  3. pmc Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months
    Tracy A Glauser
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Epilepsia 54:141-55. 2013
  4. ncbi request reprint Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty
    Tracy A Glauser
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Med Res Opin 24:3463-77. 2008
  5. ncbi request reprint Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents
    Tracy A Glauser
    Division of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 2899, USA
    J Child Neurol 22:693-9. 2007
  6. doi request reprint Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome
    T Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Avenue, MLC 2015, C 5, Cincinnati, OH 45229, USA
    Neurology 70:1950-8. 2008
  7. ncbi request reprint Pharmacokinetics of levetiracetam in infants and young children with epilepsy
    Tracy A Glauser
    Children s Hospital Medical Center, Department of Neurology, Cincinnati, Ohio 45229, USA
    Epilepsia 48:1117-22. 2007
  8. pmc Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients
    Cynthia A Prows
    Division of Patient Services, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Child Adolesc Psychopharmacol 19:385-94. 2009
  9. pmc Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy
    Tracy A Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 2015, Cincinnati, OH 45229, USA
    N Engl J Med 362:790-9. 2010
  10. ncbi request reprint Monitoring gene changes during antiepileptic drug therapy to widen the safety window and reduce pharmacoresistance
    Tracy A Glauser
    Comprehensive Epilepsy Program, Division of Neurology, Cincinnati Children s Hospital, Cincinnati, Ohio, USA
    Epilepsia 48:19-25. 2007

Research Grants

Detail Information

Publications46

  1. doi request reprint Management of childhood epilepsy
    Tracy A Glauser
    Hospital Medical Center, 3333 Burnet Avenue, ML2015, Cincinnati, OH 45229, USA
    Continuum (Minneap Minn) 19:656-81. 2013
    ..This article outlines a diagnostic and management approach to pediatric seizures and epilepsy syndromes, and delineates pharmacologic and nonpharmacologic treatment options...
  2. doi request reprint Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes
    Tracy Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Epilepsia 54:551-63. 2013
    ..When selecting a patient's AED, all relevant variables and not just efficacy and effectiveness should be considered...
  3. pmc Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy: initial monotherapy outcomes at 12 months
    Tracy A Glauser
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Epilepsia 54:141-55. 2013
    ..Determine the optimal initial monotherapy for children with newly diagnosed childhood absence epilepsy (CAE) based on 12 months of double-blind therapy...
  4. ncbi request reprint Core elements of epilepsy diagnosis and management: expert consensus from the Leadership in Epilepsy, Advocacy, and Development (LEAD) faculty
    Tracy A Glauser
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Med Res Opin 24:3463-77. 2008
    ....
  5. ncbi request reprint Topiramate monotherapy in newly diagnosed epilepsy in children and adolescents
    Tracy A Glauser
    Division of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 2899, USA
    J Child Neurol 22:693-9. 2007
    ..As shown in this subset analysis, topiramate is effective and well tolerated as monotherapy in children and adolescents...
  6. doi request reprint Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome
    T Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Avenue, MLC 2015, C 5, Cincinnati, OH 45229, USA
    Neurology 70:1950-8. 2008
    ..Current available treatments are inadequate, leaving patients with few treatment options and opportunities...
  7. ncbi request reprint Pharmacokinetics of levetiracetam in infants and young children with epilepsy
    Tracy A Glauser
    Children s Hospital Medical Center, Department of Neurology, Cincinnati, Ohio 45229, USA
    Epilepsia 48:1117-22. 2007
    ..To assess the single-dose pharmacokinetics of levetiracetam and its major metabolite ucb L057 in infants and young children with epilepsy...
  8. pmc Drug-metabolizing enzyme genotypes and aggressive behavior treatment response in hospitalized pediatric psychiatric patients
    Cynthia A Prows
    Division of Patient Services, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Child Adolesc Psychopharmacol 19:385-94. 2009
    ..The aim of this study was to examine the association between the CYP2D6 and CYP2C19 genotype-predicted combined phenotypes and short-term measures of psychotropic efficacy and toxicity...
  9. pmc Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy
    Tracy A Glauser
    Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital, 3333 Burnet Ave, MLC 2015, Cincinnati, OH 45229, USA
    N Engl J Med 362:790-9. 2010
    ..Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical treatment has not been defined...
  10. ncbi request reprint Monitoring gene changes during antiepileptic drug therapy to widen the safety window and reduce pharmacoresistance
    Tracy A Glauser
    Comprehensive Epilepsy Program, Division of Neurology, Cincinnati Children s Hospital, Cincinnati, Ohio, USA
    Epilepsia 48:19-25. 2007
    ....
  11. ncbi request reprint Designing practical evidence-based treatment plans for children with prolonged seizures and status epilepticus
    Tracy A Glauser
    Comprehensive Epilepsy Program, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Child Neurol 22:38S-46S. 2007
    ..Four scenarios illustrating these considerations are included and provide examples of plans that fulfill these criteria...
  12. pmc Biomarkers for antiepileptic drug response
    Tracy A Glauser
    Division of Child Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 2015, Cincinnati, OH 45229, USA
    Biomark Med 5:635-41. 2011
    ..Current methodological challenges to identifying new antiepileptic medication biomarkers can only be overcome with large-scale collaborative research efforts...
  13. ncbi request reprint Behavioral and psychiatric adverse events associated with antiepileptic drugs commonly used in pediatric patients
    Tracy A Glauser
    Children s Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, C 5, MLC 2015, Cincinnati, OH 45229 3039, USA
    J Child Neurol 19:S25-38. 2004
    ..Moreover, the overwhelming body of data on the behavioral effects of phenobarbital should convince clinicians that, whenever possible, it should not be used as the initial-or even the second-monotherapy in children with epilepsy...
  14. ncbi request reprint Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society
    J J Riviello
    Division of Epilepsy and Clinical Neurophysiology and the Critical Care Neurology Service, Department of Neurology, Children s Hospital, Boston, MA, USA
    Neurology 67:1542-50. 2006
    ..To review evidence on the assessment of the child with status epilepticus (SE)...
  15. ncbi request reprint Response to carbamazepine in children with newly diagnosed partial onset epilepsy
    Katherine D Holland
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neurology 69:596-9. 2007
    ..The purpose of this work is to characterize the effectiveness and therapeutic doses of carbamazepine (CBZ) in children with localization-related epilepsy...
  16. doi request reprint One-month adherence in children with new-onset epilepsy: white-coat compliance does not occur
    Avani C Modi
    Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, MLC 3015, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Pediatrics 121:e961-6. 2008
    ....
  17. doi request reprint Even a single seizure negatively impacts pediatric health-related quality of life
    Avani C Modi
    Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Epilepsia 50:2110-6. 2009
    ....
  18. pmc Development and validation of the Pediatric Epilepsy Medication Self-Management Questionnaire
    Avani C Modi
    Cincinnati Children s Hospital Medical Center Department of Pediatrics, Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self Management, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Epilepsy Behav 18:94-9. 2010
    ..68-0.85. Significant associations were found between PEMSQ scales, adherence, and seizures. The PEMSQ represents the first self-management measure validated for caregivers of children with epilepsy, with clinical and research utility...
  19. pmc Treatment factors affecting longitudinal quality of life in new onset pediatric epilepsy
    Avani C Modi
    Division of Behavioral Medicine and Clinical Psychology, Center for the Promotion of Adherence and Self Management, MLC 7039, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Pediatr Psychol 36:466-75. 2011
    ....
  20. pmc Patterns of nonadherence to antiepileptic drug therapy in children with newly diagnosed epilepsy
    Avani C Modi
    Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    JAMA 305:1669-76. 2011
    ..The onset and evolution of antiepileptic drug nonadherence in children with newly diagnosed epilepsy remains unknown...
  21. ncbi request reprint Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
    Catherine L Dent
    Department of Pediatrics Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Thorac Cardiovasc Surg 131:190-7. 2006
    ..To evaluate the impact of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion...
  22. ncbi request reprint Efficacy and safety of levetiracetam in children with partial seizures: an open-label trial
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Epilepsia 43:518-24. 2002
    ..To assess the efficacy and safety of levetiracetam (LEV) as adjunctive therapy in children with treatment-resistant partial-onset seizures...
  23. ncbi request reprint Following catastrophic epilepsy patients from childhood to adulthood
    Tracy A Glauser
    Department of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, U S A
    Epilepsia 45:23-6. 2004
    ..Finally, a multidisciplinary care plan that incorporates resources from health-care practitioners, social service professionals, and community agencies can be valuable in optimizing treatment for patients with catastrophic epilepsies...
  24. ncbi request reprint A child with newly diagnosed symptomatic partial epilepsy
    Tracy A Glauser
    Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Epilepsy Behav 4:S2-5; discussion S6-7. 2003
  25. ncbi request reprint Effects of antiepileptic medications on psychiatric and behavioral comorbidities in children and adolescents with epilepsy
    Tracy A Glauser
    Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Epilepsy Behav 5:S25-32. 2004
    ..All of these data are then combined and formatted into a practical algorithm useful in many clinical situations...
  26. ncbi request reprint Preliminary efficacy of levetiracetam in children
    Tracy A Glauser
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, United States
    Epileptic Disord 5:S45-50. 2003
    ..Several ongoing studies will provide further information on the pharmacokinetics, efficacy, and safety of levetiracetam in this patient population...
  27. ncbi request reprint Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion
    Catherine L Dent
    Department of Pediatrics, Division of Cardiology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Thorac Cardiovasc Surg 130:1523-30. 2005
    ..To evaluate the effect of this technique on brain ischemia, we performed serial brain magnetic resonance imaging in a cohort of infants before and after the Norwood operation using regional cerebral perfusion...
  28. ncbi request reprint Improved tolerability and efficacy in epilepsy patients with extended-release carbamazepine
    D M Ficker
    Department of Neurology, University of Cincinnati Medical Center, 231 Albert B Sabin Way, Cincinnati, OH 45267, USA
    Neurology 65:593-5. 2005
    ..Using validated, epilepsy-specific measures the authors found that switching to CBZ-ERC significantly improved patients' adverse events and quality-of-life measures. Switching to CBZ-ERC also improved seizure control...
  29. pmc Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy
    Katherine D Holland
    Division of Neurology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Neurosci Lett 433:65-70. 2008
    ..This observation of a potentially pathogenic mutation of SCN3A (Nav1.3) indicates that this gene should be further evaluated for its contribution to childhood epilepsy...
  30. pmc Selecting anti-epileptic drugs: a pediatric epileptologist's view, a computer's view
    J Pestian
    Division of Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Acta Neurol Scand 127:208-15. 2013
    ..To identify which clinical characteristics are important to include in clinical decision support systems developed for Antiepileptic Drug (AEDs) selection...
  31. ncbi request reprint Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1
    Yang Tang
    Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
    Brain Res Mol Brain Res 132:155-67. 2004
    ....
  32. ncbi request reprint Advancing the medical management of epilepsy: disease modification and pharmacogenetics
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Child Neurol 17:S85-93. 2002
    ..Such methods of tailoring antiepilepsy drug therapy would be preferable to the trial-and-error system that is currently used...
  33. ncbi request reprint Topiramate concentration in saliva: an alternative to serum monitoring
    Michael V Miles
    Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Neurol 29:143-7. 2003
    ..8% +/- 12.1% (range 62.9% to 112.7%). The results of this study support the use of saliva as a viable alternative to serum for monitoring topiramate therapy. Topiramate concentration in saliva: an alternative to serum monitoring...
  34. ncbi request reprint Integrating clinical trial data into clinical practice
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neurology 58:S6-12. 2002
  35. ncbi request reprint Zonisamide in pediatric epilepsy: review of the Japanese experience
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Child Neurol 17:87-96. 2002
    ..Additional controlled trials in children with partial- or generalized-onset seizures, infantile spasms, and Lennox-Gastaut syndrome are warranted to further delineate zonisamide's broad spectrum of efficacy and tolerability in children...
  36. ncbi request reprint Blood gene expression profiling of neurologic diseases: a pilot microarray study
    Yang Tang
    Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
    Arch Neurol 62:210-5. 2005
    ..Tissue gene expression profiling with arrays measures the transcription of thousands of genes. However, this approach cannot be readily used to guide clinical neurologic practice...
  37. ncbi request reprint Unmet needs in pediatric epilepsy
    Tracy A Glauser
    Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Child Neurol 17:S1-3. 2002
    ..The articles are the result of a closed symposium held in January 2001...
  38. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:401-9. 2004
    ..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies...
  39. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:410-23. 2004
    ....
  40. doi request reprint Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    Philip N Patsalos
    Institute of Neurology The National Hospital for Neurology and Neurosurgery, London and The Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom
    Epilepsia 49:1239-76. 2008
    ..g., in pregnancy, or when an interacting drug is added or removed); (6) to guide dose adjustments for AEDs with dose-dependent pharmacokinetics, particularly phenytoin...
  41. ncbi request reprint Periodic lateralized epileptiform discharges in La Crosse encephalitis, a worrisome subgroup: clinical presentation, electroencephalogram (EEG) patterns, and long-term neurologic outcome
    Emily C De Los Reyes
    Department of Pediatrics, Robert C Byrd Health Sciences Center, West Virginia University, Charleston, USA
    J Child Neurol 23:167-72. 2008
    ..The implications for recognition, management, and follow-up of this worrisome subset of patients with La Crosse virus encephalitis are discussed...
  42. ncbi request reprint Oxcarbazepine in infants and young children with partial seizures
    Ralph S Northam
    Monarch Research Associates, Neuro Development, Norfolk, VA 23507, USA
    Pediatr Neurol 33:337-44. 2005
    ..Oxcarbazepine was safe and well tolerated in infants and young children. The pharmacokinetic profile of MHD was predicted by extension of a model based on older children...
  43. ncbi request reprint Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate
    Srikanth C Nallani
    College of Pharmacy, University of Cincinnati Medical Center, 3223 Eden Avenue, Cincinnati, OH 45267, U S A
    Epilepsia 44:1521-8. 2003
    ..Accordingly, we investigated whether TPM induces CYP3A4 in primary human hepatocytes and activates the human pregnane X receptor (hPXR), a nuclear receptor that serves as a regulator of CYP3A4 transcription...
  44. ncbi request reprint The future of genomic profiling of neurological diseases using blood
    Frank R Sharp
    Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Arch Neurol 63:1529-36. 2006
    ..Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans...
  45. ncbi request reprint Febrile seizures
    Shlomo Shinnar
    Montefiore Medical Center, and the Albert Einstein College of Medicine, Bronx, NY 10467, USA
    J Child Neurol 17:S44-52. 2002
    ..This has led to a changing view of how we approach the treatment of these common and largely benign seizures. This chapter will review the current understanding of the prognosis and management of febrile seizures...
  46. ncbi request reprint Genomics of brain and blood: progress and pitfalls
    Frank R Sharp
    Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
    Epilepsia 47:1603-7. 2006
    ..Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future...

Research Grants4

  1. CLINICAL PHARMACOLOGY OF CHILDHOOD EPILEPSY
    Tracy Glauser; Fiscal Year: 2003
    ....
  2. Blood Genomics of Anticonvulsant Efficacy in Children
    Tracy Glauser; Fiscal Year: 2004
    ..We will study whole blood total RNA using the new human U133 Affymetrix oligonucleotide microarrays that assess over 39,000 transcripts. ..
  3. Childhood Absence Epilepsy Rx, PK-PD-Pharmacogenetics
    Tracy Glauser; Fiscal Year: 2007
    ..Knowledge gained by this study will lead to individualized treatment for children with CAE that may in part be generalizable to other pediatric and adult seizure disorders. ..