Stephan Glasser

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice
    Satish K Madala
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Pulm Med 2011:653524. 2011
  2. pmc Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury
    Stephan W Glasser
    Cincinnati Children s Hospital Medical Center, Perinatal Institute, Division of Neonatology, Perinatal and Pulmonary Biology, MLC7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Respir Res 14:19. 2013
  3. ncbi Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis
    Stephan W Glasser
    Department of Pediatrics, Perinatal Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati, Ohio 45229, USA
    Curr Pharm Biotechnol 12:1447-54. 2011
  4. pmc Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009
  5. ncbi Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
  6. ncbi The murine SP-C promoter directs type II cell-specific expression in transgenic mice
    Stephan W Glasser
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L625-32. 2005
  7. ncbi Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 92:519-26. 2002
  8. ncbi Pneumonitis and emphysema in sp-C gene targeted mice
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Biol Chem 278:14291-8. 2003
  9. pmc Signaling pathways in the epithelial origins of pulmonary fibrosis
    William D Hardie
    Department of Pediatrics, Pulmonary Medicine, University of California, San Diego, CA, USA
    Cell Cycle 9:2769-76. 2010
  10. ncbi Genetically engineered mice in understanding the basis of neonatal lung disease
    Stephan W Glasser
    Division of Pulmonary Biology, Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Semin Perinatol 30:341-9. 2006

Research Grants

  1. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 1999
  2. Role of Surfactant Protein-C and Innate Lung Defense
    Stephan Glasser; Fiscal Year: 2009
  3. Role of Pulmonary Surfactant C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2007
  4. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2006
  5. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2005
  6. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2004
  7. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2003
  8. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2002
  9. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2001
  10. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2000

Detail Information

Publications12

  1. pmc Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice
    Satish K Madala
    Division of Pulmonary Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Pulm Med 2011:653524. 2011
    ..These findings indicate that novel therapeutics will be required to treat individuals with SP-C deficient ILD/IPF...
  2. pmc Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury
    Stephan W Glasser
    Cincinnati Children s Hospital Medical Center, Perinatal Institute, Division of Neonatology, Perinatal and Pulmonary Biology, MLC7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Respir Res 14:19. 2013
    ..SP-C gene targeted mice (Sftpc -/-) lack SP-C, develop an ILD-like disease and are susceptible to infection with RSV...
  3. ncbi Use of transgenic mouse models to understand the origins of familial pulmonary fibrosis
    Stephan W Glasser
    Department of Pediatrics, Perinatal Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati, Ohio 45229, USA
    Curr Pharm Biotechnol 12:1447-54. 2011
    ..Determining the mechanisms for genetically defined examples of IPF should be informative for investigating the larger segment of IPF where the underlying cause remains obscure...
  4. pmc Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009
    ..Preparations of purified SP-C and synthetic phospholipids blocked poly(I:C)-induced TLR3 signaling in vitro. SP-C deficiency increases the severity of RSV-induced pulmonary inflammation through regulation of TLR3 signaling...
  5. ncbi Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    ..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
  6. ncbi The murine SP-C promoter directs type II cell-specific expression in transgenic mice
    Stephan W Glasser
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L625-32. 2005
    ..8-kb SP-C promoter construct is highly dependent on its chromatin environment...
  7. ncbi Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 92:519-26. 2002
    ..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo...
  8. ncbi Pneumonitis and emphysema in sp-C gene targeted mice
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Biol Chem 278:14291-8. 2003
    ..Absence of SP-C caused a severe progressive pulmonary disorder with histologic features consistent with interstitial pneumonitis...
  9. pmc Signaling pathways in the epithelial origins of pulmonary fibrosis
    William D Hardie
    Department of Pediatrics, Pulmonary Medicine, University of California, San Diego, CA, USA
    Cell Cycle 9:2769-76. 2010
    ..Finally, we will present data demonstrating a minimal contribution of epithelial-mesenchymal transition in the development of fibrotic lesions in the transforming growth factor-alpha transgenic model of lung fibrosis...
  10. ncbi Genetically engineered mice in understanding the basis of neonatal lung disease
    Stephan W Glasser
    Division of Pulmonary Biology, Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Semin Perinatol 30:341-9. 2006
    ..This review will discuss the creation of such animals and illustrate their utility in understanding human disease...
  11. ncbi GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression
    Cong Liu
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:4519-25. 2002
    ..GATA-6 influenced the activity of the sp-C promoter, binding and acting synergistically with TTF-1...
  12. pmc Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin
    William E Lawson
    Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
    Am J Pathol 167:1267-77. 2005
    ..Thus, SP-C functions to limit lung inflammation, inhibit collagen accumulation, and restore normal lung structure after bleomycin...

Research Grants11

  1. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 1999
    ..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
  2. Role of Surfactant Protein-C and Innate Lung Defense
    Stephan Glasser; Fiscal Year: 2009
    ..These studies should be useful in designing therapies for treatment of RSV infection in patients that have SP-C deficiency. ..
  3. Role of Pulmonary Surfactant C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2007
    ..The SP-C-/- mice provide a novel model of human interstitial disease where the inductive sequences of events remain undefined. ..
  4. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2006
    ..The SP-C-/- mice provide a novel model of human interstitial disease where the inductive sequences of events remain undefined. ..
  5. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2005
    ..The SP-C-/- mice provide a novel model of human interstitial disease where the inductive sequences of events remain undefined. ..
  6. Role of SP-C in Familial Interstitial Lung Disease
    Stephan Glasser; Fiscal Year: 2004
    ..The SP-C-/- mice provide a novel model of human interstitial disease where the inductive sequences of events remain undefined. ..
  7. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2003
    ..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
  8. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2002
    ..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
  9. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2001
    ..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
  10. REGULATION OF THE LUNG SURFACTANT PROTEIN C GENE
    Stephan Glasser; Fiscal Year: 2000
    ..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
  11. Role of Surfactant Protein-C and Innate Lung Defense
    Stephan W Glasser; Fiscal Year: 2010
    ..These studies should be useful in designing therapies for treatment of RSV infection in patients that have SP-C deficiency. ..