Affiliation: Cincinnati Children's Hospital Medical Center
- Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injuryStephan W Glasser
Cincinnati Children s Hospital Medical Center, Perinatal Institute, Division of Neonatology, Perinatal and Pulmonary Biology, MLC7029, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Respir Res 14:19. 2013..SP-C gene targeted mice (Sftpc -/-) lack SP-C, develop an ILD-like disease and are susceptible to infection with RSV...
- Use of transgenic mouse models to understand the origins of familial pulmonary fibrosisStephan W Glasser
Department of Pediatrics, Perinatal Institute, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine Cincinnati, Ohio 45229, USA
Curr Pharm Biotechnol 12:1447-54. 2011..Determining the mechanisms for genetically defined examples of IPF should be informative for investigating the larger segment of IPF where the underlying cause remains obscure...
- The murine SP-C promoter directs type II cell-specific expression in transgenic miceStephan W Glasser
Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 288:L625-32. 2005..8-kb SP-C promoter construct is highly dependent on its chromatin environment...
- Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient miceStephan W Glasser
Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
J Immunol 181:621-8. 2008..SP-C plays an important role in innate host defense of the lung, enhancing macrophage-mediated Pseudomonas phagocytosis, clearance and limiting pulmonary inflammatory responses...
- Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infectionStephan W Glasser
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009..Preparations of purified SP-C and synthetic phospholipids blocked poly(I:C)-induced TLR3 signaling in vitro. SP-C deficiency increases the severity of RSV-induced pulmonary inflammation through regulation of TLR3 signaling...
- Deficiency of SP-B reveals protective role of SP-C during oxygen lung injuryMachiko Ikegami
Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
J Appl Physiol (1985) 92:519-26. 2002..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo...
- Pneumonitis and emphysema in sp-C gene targeted miceStephan W Glasser
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
J Biol Chem 278:14291-8. 2003..Absence of SP-C caused a severe progressive pulmonary disorder with histologic features consistent with interstitial pneumonitis...
- Signaling pathways in the epithelial origins of pulmonary fibrosisWilliam D Hardie
Department of Pediatrics, Pulmonary Medicine, University of California, San Diego, CA, USA
Cell Cycle 9:2769-76. 2010..Finally, we will present data demonstrating a minimal contribution of epithelial-mesenchymal transition in the development of fibrotic lesions in the transforming growth factor-alpha transgenic model of lung fibrosis...
- Genetically engineered mice in understanding the basis of neonatal lung diseaseStephan W Glasser
Division of Pulmonary Biology, Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Semin Perinatol 30:341-9. 2006..This review will discuss the creation of such animals and illustrate their utility in understanding human disease...
- GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expressionCong Liu
Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 277:4519-25. 2002..GATA-6 influenced the activity of the sp-C promoter, binding and acting synergistically with TTF-1...
- Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycinWilliam E Lawson
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care, Vanderbilt University School of Medicine, T 1218 MCN, Nashville, TN 37232 2650, USA
Am J Pathol 167:1267-77. 2005..Thus, SP-C functions to limit lung inflammation, inhibit collagen accumulation, and restore normal lung structure after bleomycin...
- Role of Pulmonary Surfactant C in Familial Interstitial Lung DiseaseStephan Glasser; Fiscal Year: 2007..The SP-C-/- mice provide a novel model of human interstitial disease where the inductive sequences of events remain undefined. ..
- REGULATION OF THE LUNG SURFACTANT PROTEIN C GENEStephan Glasser; Fiscal Year: 2003..The results of these studies will provide insight into Type II cell specific gene transcription and greatly facilitate the design of an appropriate therapy for surfactant deficiencies. ..
- Role of Surfactant Protein-C and Innate Lung DefenseStephan W Glasser; Fiscal Year: 2010..These studies should be useful in designing therapies for treatment of RSV infection in patients that have SP-C deficiency. ..