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Genomes and GenesSpecies | D L GilbertSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Factors affecting the yield of pediatric EEGs in clinical practiceDonald L Gilbert
Department of Neurology, Children's Hospital Medical Center, University of Cincinnati, Ohio 45229-3039, USA
Clin Pediatr (Phila) 41:25-32. 2002..001). In practice most electroencephalograms ordered for seizure are actually for non-seizure. In routine pediatric practice, electroencephalography has a low yield and appears to be over-used...- Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndromeDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Mov Disord 19:416-25. 2004..53; P = 0.003) than with tic severity (r = 0.42; P = 0.02), suggesting that in TS, the association between SICI and ADHD symptoms may be more consistent or direct than the association between SICI and tics... - Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortexDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
Neuropsychopharmacology 31:442-9. 2006..Cortical inhibition, shown previously to be abnormal in ADHD, may play a key role producing behavioral pathology... - Assessment of scientific and ethical issues in two randomized clinical trial designs for patients with Tourette's syndrome: a model for studies of multiple neuropsychiatric diagnosesDonald L Gilbert
Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Neuropsychiatry Clin Neurosci 17:324-32. 2005.... - Does sleep or sleep deprivation increase epileptiform discharges in pediatric electroencephalograms?Donald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Pediatrics 114:658-62. 2004..The objective of this study was to compare the effects of sleep, standard sleep deprivation, partial sleep deprivation, and no sleep deprivation on the odds of an epileptiform abnormality in outpatient pediatric EEGs... - Should transcranial magnetic stimulation research in children be considered minimal risk?Donald L Gilbert
Division of Pediatric Neurology, Movement Disorders Clinics, Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Neurophysiol 115:1730-9. 2004..The purpose of this study is to provide concise information for investigators and IRBs about the safety of single and paired pulse TMS research in children... - Altered mesolimbocortical and thalamic dopamine in Tourette syndromeD L Gilbert
Movement Disorder Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neurology 67:1695-7. 2006..Altered dopaminergic function in mesolimbocortical systems and thalamus may contribute to increased motivational salience of tics... 
Atomoxetine treatment of ADHD in Tourette syndrome: reduction in motor cortex inhibition correlates with clinical improvementDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, and The University of Cincinnati, Department of Neurology, School of Medicine, OH 45229 3039, USA
Clin Neurophysiol 118:1835-41. 2007..We sought to determine in children with Tourette Syndrome (TS) whether clinical responses correlate with changes in short interval cortical inhibition (SICI)...- Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trialDonald L Gilbert
Department of Neurology, Cincinnati Children s Hospital Medical Center, Division of Developmental and Behavioral Sciences Children s Mercy Hospital, Kansas City, KS, USA
J Am Acad Child Adolesc Psychiatry 43:206-14. 2004..To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders... - Dopamine transporter genotype influences the physiological response to medication in ADHDDonald L Gilbert
Division of Neurology Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Brain 129:2038-46. 2006..In conclusion, MPH and ATX have similar effects on SICI in children with ADHD. A genetic variation in DAT1, previously linked to ADHD risk and MPH behavioural responses, influences the neurophysiological effects of both MPH and ATX... 
A novel hereditary spastic paraplegia with dystonia linked to chromosome 2q24-2q31Donald L Gilbert
Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
Mov Disord 24:364-70. 2009..0. On the basis of clinical presentation and linkage results, we conclude that this disease is a novel neurological disorder. Identifying the causative gene may elucidate an important pathway for pyramidal and extrapyramidal disorders...- Transcranial magnetic stimulation-evoked cortical inhibition: a consistent marker of attention-deficit/hyperactivity disorder scores in tourette syndromeDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229 3039, USA
Biol Psychiatry 57:1597-600. 2005..We sought to validate this observation... - Tourette's syndrome improvement with pergolide in a randomized, double-blind, crossover trialD L Gilbert
Children s Hospital Medical Center, Department of Neurology, University of Cincinnati, OH 45229 3039, USA
Neurology 54:1310-5. 2000..To determine whether pergolide, a mixed D1-D2-D3 dopamine agonist, is efficacious and safe in the treatment of children with Tourette's syndrome... - Body mass index changes and chronic neuroleptic drug treatment for Tourette syndromeRoosje S Degrauw
Tourette Syndrome and Movement Disorders Clinics, Division of Neurology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
Pediatr Neurol 41:183-6. 2009..6) = 6.34, P = 0.0007), related to first-year changes only. In children and adolescents with Tourette syndrome treated for longer than 1 year with neuroleptics, weight gain is not necessarily excessive... - Motor cortex inhibition: a marker of ADHD behavior and motor development in childrenD L Gilbert
Transcranial Magnetic Stimulation Laboratory, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neurology 76:615-21. 2011.... - Tic reduction with pergolide in a randomized controlled trial in childrenD L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Neurology 60:606-11. 2003..To determine whether pergolide, a mixed D1/D2/D3 dopamine agonist, is efficacious and safe in the treatment of children with chronic tic disorders and Tourette syndrome... - Assessing quality and normalization of microarrays: case studies using neurological genomic dataA D Hershey
Department of Pediatrics, Divisions of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Acta Neurol Scand 118:29-41. 2008..The analysis of these data is complex due to the large amount of data generated. Many tools have been developed to assist with this, but standard methods of analysis of these tools have not been established... - Tic suppression: the medical modelSteve W Wu
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Child Adolesc Psychopharmacol 20:263-76. 2010..It concludes with some context for understanding this literature, relevant to treatment decisions and future treatment research in TD... - The prevalence of neuropsychiatric disorders in Sydenham's choreaKeith R Ridel
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Pediatr Neurol 42:243-8. 2010..During and after the diagnosis of Sydenham's chorea, clinicians should be vigilant for signs and symptoms of anxiety, depression, and attention deficit hyperactivity disorder... - Acute and chronic chorea in childhoodDonald L Gilbert
Movement Disorders Clinics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Semin Pediatr Neurol 16:71-6. 2009..We review the management of acute/subacute and chronic choreas, with special emphasis on Sydenham chorea and benign hereditary chorea... - Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndromeSteve W Wu
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Mov Disord 22:1813-5. 2007..His symptoms resolved on prednisone; however, his antiphospholipid antibody profile remained markedly abnormal despite being symptom-free for 26 months... - Drug-induced movement disorders in childrenDonald L Gilbert
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Ann N Y Acad Sci 1142:72-84. 2008..Many publications are small case series. This report attempts to provide useful information, with appropriate caution and discussion of the limitations of what we know... - Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysisD L Gilbert
Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Child Neurol 14:602-9. 1999.... - Motor cortex inhibitory function in Tourette syndrome, attention deficit disorder, and obsessive compulsive disorder: studies using transcranial magnetic stimulationDonald L Gilbert
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
Adv Neurol 99:107-14. 2006 - Dyskinesias associated with atomoxetine in combination with other psychoactive drugsG Randall Bond
Drug and Poison Information Center, and Division of Emergency Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio USA
Clin Toxicol (Phila) 45:182-5. 2007..Serotonin syndrome is a possibility in the second case, but not the first. Clinicians should be aware of emergent dyskinesias when combining atomoxetine with dopaminergic, noradrenergic, or serotonergic medications... - Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adultsA Dinopoulos
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neurology 64:1255-7. 2005..Both mutations had a 6 to 8% of normal GLDC activities when expressed in COS7 cells... - Complications and costs of treatment of refractory generalized convulsive status epilepticus in childrenD L Gilbert
Department of Neurology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
J Child Neurol 14:597-601. 1999..Benzodiazepines appear to have higher drug costs but lower complications and overall costs than barbiturates... - A subgroup of Tourette's patients overexpress specific natural killer cell genes in blood: a preliminary reportLisa Lit
Genetics Graduate Group, Department of Neurology, M I N D Institute, University of California at Davis, Sacramento, CA 95817, USA
Am J Med Genet B Neuropsychiatr Genet 144:958-63. 2007.... - Valproic acid blood genomic expression patterns in children with epilepsy - a pilot studyY Tang
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA
Acta Neurol Scand 109:159-68. 2004..These expression patterns provide new insight into previously undetected mechanisms of VPA anticonvulsant activity... - Blood gene expression profiling of neurologic diseases: a pilot microarray studyYang Tang
Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
Arch Neurol 62:210-5. 2005..In 1 cluster, 6 genes-all associated with immune cell function-were overexpressed. CONCLUSION: Blood gene expression profiling can provide surrogate markers for neurologic diseases without obvious blood phenotypes... - Meta-analysis of EEG test performance shows wide variation among studiesDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Neurology 60:564-70. 2003..EEG results are used for counseling patients with seizures about prognosis and deciding on medications. Published sensitivities of interictal EEG vary widely... - Cerebellar ataxia in youths at risk for bipolar disorderLisa L Giles
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Bipolar Disord 10:733-7. 2008..The present study examined cerebellar function in youths who were at familial risk for BD by comparing ataxia battery scores of youths with a bipolar parent to those of healthy youths... - Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1Yang Tang
Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Brain Res Mol Brain Res 132:155-67. 2004.... - Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine diseaseSarah E Hopkins
Divisions of Neurology, Cincinnati Children s Hospital Medical Center, and Pathology University of Cincinnati, Ohio, USA
J Child Neurol 25:752-6. 2010..We discuss novel aspects of their presentation and implications for practice... - Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalitiesAndrew D Hershey
Children's Hospital Medical Center, Department of Neurology, Cincinnati, OH, USA
Headache 44:994-1004. 2004..Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis... - Atomoxetine treatment of ADHD in children with comorbid Tourette syndromeThomas J Spencer
Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
J Atten Disord 11:470-81. 2008..This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS)... - Pharmacodynamics of ziprasidone in children and adolescents: impact on dopamine transmissionFloyd R Sallee
Pharmacology Research Center, Children s Hospital Medical Center, USA
J Am Acad Child Adolesc Psychiatry 42:902-7. 2003..It is also an agonist at 5-HT(1A), which has been shown in rats to increase dopamine in prefrontal cortex. The objective of this study was to probe the dopamine agonist and antagonist pharmacodynamic properties of ziprasidone in youth... - Epileptiform discharges and the behavior of children with epilepsyDonald L Gilbert
J Pediatr 149:283; author reply 284. 2006 - Sequence variants in SLITRK1 are associated with Tourette's syndromeJesse F Abelson
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Science 310:317-20. 2005..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS... - Genomics of brain and blood: progress and pitfallsFrank R Sharp
Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
Epilepsia 47:1603-7. 2006..Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future... - Transcranial magnetic stimulation in childrenMarjorie A Garvey
Pediatric Movement Disorders Unit, Human Motor Control Section, MNB, NINDS, 10 Center Drive, Room 5N226, MSC 1428, Bethesda, MD 20892 1428, USA
Eur J Paediatr Neurol 8:7-19. 2004..It will also briefly touch on the potential of TMS as a diagnostic tool in neurological disorders. It will not address the use of repetitive TMS in children... - Low and high-frequency repetitive transcranial magnetic stimulation for the treatment of spasticityDonald L Gilbert
Dev Med Child Neurol 49:486. 2007 - Interobserver reliability of visual interpretation of electroencephalograms in children with newly diagnosed seizuresDonald L Gilbert
Dev Med Child Neurol 48:1009-10; author reply 1010-1. 2006 - Regarding "omega-3 fatty acids supplementation in children with autism: a double-blind randomized, placebo-controlled pilot study"Donald L Gilbert
Biol Psychiatry 63:e13; author reply e15. 2008