Research Topics
Genomes and GenesSpecies | D L GilbertSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Views of recently first-certified US child neurologists on their residency trainingDonald L Gilbert
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45230, USA
J Child Neurol 28:332-9. 2013....
Training the next generation of child neurologists: a child health-based approachDonald L Gilbert
Child Neurology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
J Child Neurol 27:270-2. 2012..quot; This article reviews the rationale for an overdue transformation of Child Neurology training...
Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patientsWynn L Walker
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California, USA
BMC Genomics 9:494. 2008..Existing methods can correct for batch effects only when samples from all biological groups are represented in every batch...
Motor cortex inhibition: a marker of ADHD behavior and motor development in childrenD L Gilbert
Transcranial Magnetic Stimulation Laboratory, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neurology 76:615-21. 2011....
Acute and chronic chorea in childhoodDonald L Gilbert
Movement Disorders Clinics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Semin Pediatr Neurol 16:71-6. 2009..We review the management of acute/subacute and chronic choreas, with special emphasis on Sydenham chorea and benign hereditary chorea...
Drug-induced movement disorders in childrenDonald L Gilbert
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Ann N Y Acad Sci 1142:72-84. 2008..Many publications are small case series. This report attempts to provide useful information, with appropriate caution and discussion of the limitations of what we know...
Body mass index changes and chronic neuroleptic drug treatment for Tourette syndromeRoosje S Degrauw
Tourette Syndrome and Movement Disorders Clinics, Division of Neurology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
Pediatr Neurol 41:183-6. 2009..6) = 6.34, P = 0.0007), related to first-year changes only. In children and adolescents with Tourette syndrome treated for longer than 1 year with neuroleptics, weight gain is not necessarily excessive...
Tourette's syndrome improvement with pergolide in a randomized, double-blind, crossover trialD L Gilbert
Children s Hospital Medical Center, Department of Neurology, University of Cincinnati, OH 45229 3039, USA
Neurology 54:1310-5. 2000..To determine whether pergolide, a mixed D1-D2-D3 dopamine agonist, is efficacious and safe in the treatment of children with Tourette's syndrome...
Does sleep or sleep deprivation increase epileptiform discharges in pediatric electroencephalograms?Donald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Pediatrics 114:658-62. 2004..The objective of this study was to compare the effects of sleep, standard sleep deprivation, partial sleep deprivation, and no sleep deprivation on the odds of an epileptiform abnormality in outpatient pediatric EEGs...
A novel hereditary spastic paraplegia with dystonia linked to chromosome 2q24-2q31Donald L Gilbert
Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
Mov Disord 24:364-70. 2009..0. On the basis of clinical presentation and linkage results, we conclude that this disease is a novel neurological disorder. Identifying the causative gene may elucidate an important pathway for pyramidal and extrapyramidal disorders...
Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndromeDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Mov Disord 19:416-25. 2004..53; P = 0.003) than with tic severity (r = 0.42; P = 0.02), suggesting that in TS, the association between SICI and ADHD symptoms may be more consistent or direct than the association between SICI and tics...
Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndromeSteve W Wu
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Mov Disord 22:1813-5. 2007..His symptoms resolved on prednisone; however, his antiphospholipid antibody profile remained markedly abnormal despite being symptom-free for 26 months...
Atomoxetine treatment of ADHD in Tourette syndrome: reduction in motor cortex inhibition correlates with clinical improvementDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, and The University of Cincinnati, Department of Neurology, School of Medicine, OH 45229 3039, USA
Clin Neurophysiol 118:1835-41. 2007..We sought to determine in children with Tourette Syndrome (TS) whether clinical responses correlate with changes in short interval cortical inhibition (SICI)...
Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trialDonald L Gilbert
Department of Neurology, Cincinnati Children s Hospital Medical Center, Division of Developmental and Behavioral Sciences Children s Mercy Hospital, Kansas City, KS, USA
J Am Acad Child Adolesc Psychiatry 43:206-14. 2004..To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders...
Dopamine transporter genotype influences the physiological response to medication in ADHDDonald L Gilbert
Division of Neurology Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Brain 129:2038-46. 2006..In conclusion, MPH and ATX have similar effects on SICI in children with ADHD. A genetic variation in DAT1, previously linked to ADHD risk and MPH behavioural responses, influences the neurophysiological effects of both MPH and ATX...
The prevalence of neuropsychiatric disorders in Sydenham's choreaKeith R Ridel
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Pediatr Neurol 42:243-8. 2010..During and after the diagnosis of Sydenham's chorea, clinicians should be vigilant for signs and symptoms of anxiety, depression, and attention deficit hyperactivity disorder...
Assessment of scientific and ethical issues in two randomized clinical trial designs for patients with Tourette's syndrome: a model for studies of multiple neuropsychiatric diagnosesDonald L Gilbert
Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
J Neuropsychiatry Clin Neurosci 17:324-32. 2005....
Comparison of the inhibitory and excitatory effects of ADHD medications methylphenidate and atomoxetine on motor cortexDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229, USA
Neuropsychopharmacology 31:442-9. 2006..Cortical inhibition, shown previously to be abnormal in ADHD, may play a key role producing behavioral pathology...
Transcranial magnetic stimulation-evoked cortical inhibition: a consistent marker of attention-deficit/hyperactivity disorder scores in tourette syndromeDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center and University of Cincinnati, OH 45229 3039, USA
Biol Psychiatry 57:1597-600. 2005..We sought to validate this observation...
Tic suppression: the medical modelSteve W Wu
Division of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Child Adolesc Psychopharmacol 20:263-76. 2010..It concludes with some context for understanding this literature, relevant to treatment decisions and future treatment research in TD...
Should transcranial magnetic stimulation research in children be considered minimal risk?Donald L Gilbert
Division of Pediatric Neurology, Movement Disorders Clinics, Cincinnati Children s Hospital Medical Center, ML 2015, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Clin Neurophysiol 115:1730-9. 2004..The purpose of this study is to provide concise information for investigators and IRBs about the safety of single and paired pulse TMS research in children...
Altered mesolimbocortical and thalamic dopamine in Tourette syndromeD L Gilbert
Movement Disorder Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Neurology 67:1695-7. 2006..Altered dopaminergic function in mesolimbocortical systems and thalamus may contribute to increased motivational salience of tics...
Motor cortex inhibitory function in Tourette syndrome, attention deficit disorder, and obsessive compulsive disorder: studies using transcranial magnetic stimulationDonald L Gilbert
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
Adv Neurol 99:107-14. 2006
Tic reduction with pergolide in a randomized controlled trial in childrenD L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Neurology 60:606-11. 2003..To determine whether pergolide, a mixed D1/D2/D3 dopamine agonist, is efficacious and safe in the treatment of children with chronic tic disorders and Tourette syndrome...
Cerebellar ataxia in youths at risk for bipolar disorderLisa L Giles
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Bipolar Disord 10:733-7. 2008..The present study examined cerebellar function in youths who were at familial risk for BD by comparing ataxia battery scores of youths with a bipolar parent to those of healthy youths...
Blood gene expression profiling of neurologic diseases: a pilot microarray studyYang Tang
Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
Arch Neurol 62:210-5. 2005..In 1 cluster, 6 genes-all associated with immune cell function-were overexpressed. CONCLUSION: Blood gene expression profiling can provide surrogate markers for neurologic diseases without obvious blood phenotypes...
Meta-analysis of EEG test performance shows wide variation among studiesDonald L Gilbert
Division of Neurology, Cincinnati Children s Hospital Medical Center, OH 45229 3039, USA
Neurology 60:564-70. 2003..EEG results are used for counseling patients with seizures about prognosis and deciding on medications. Published sensitivities of interictal EEG vary widely...
Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalitiesAndrew D Hershey
Children's Hospital Medical Center, Department of Neurology, Cincinnati, OH, USA
Headache 44:994-1004. 2004..Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis...
Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine diseaseSarah E Hopkins
Divisions of Neurology, Cincinnati Children s Hospital Medical Center, and Pathology University of Cincinnati, Ohio, USA
J Child Neurol 25:752-6. 2010..We discuss novel aspects of their presentation and implications for practice...
Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1Yang Tang
Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Brain Res Mol Brain Res 132:155-67. 2004....
