Hartmut Geiger

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity
    Hartmut Geiger
    Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Med 18:1123-9. 2012
  2. ncbi request reprint Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging
    Hartmut Geiger
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 6:884-7. 2007
  3. pmc Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
    Hartmut Geiger
    Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:5102-7. 2005
  4. pmc Targeting erythroblast-specific apoptosis in experimental anemia
    Abhinav Diwan
    Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
    Apoptosis 13:1022-30. 2008
  5. doi request reprint Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization
    Marnie A Ryan
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
    Nat Med 16:1141-6. 2010
  6. pmc R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
  7. pmc Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
    Haiming Xu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Blood 114:3557-66. 2009
  8. pmc Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
    Theodosia A Kalfa
    Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
    Haematologica 95:27-35. 2010
  9. pmc Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    Linda Yang
    Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5091-6. 2007
  10. pmc RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
    Xuan Zhou
    Division of Experimental Hematology and Cancer Biology, 2 Molecular and Development Biology Graduate Program, 3 Division of Ophthalmology, and 4 Division of Developmental Biology, Cincinnati Children s Research Foundation, University of Cincinnati, Cincinnati, OH 45229
    J Exp Med 210:2371-85. 2013

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity
    Hartmut Geiger
    Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Nat Med 18:1123-9. 2012
    ..These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd or aPC might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation...
  2. ncbi request reprint Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging
    Hartmut Geiger
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Cell Cycle 6:884-7. 2007
    ....
  3. pmc Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
    Hartmut Geiger
    Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 102:5102-7. 2005
    ....
  4. pmc Targeting erythroblast-specific apoptosis in experimental anemia
    Abhinav Diwan
    Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
    Apoptosis 13:1022-30. 2008
    ..These results support the concept of targeting erythroblast apoptosis to maximize erythrocyte production in acute anemia, which may be of value in erythropoietin resistance...
  5. doi request reprint Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization
    Marnie A Ryan
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
    Nat Med 16:1141-6. 2010
    ..Our findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provide a new pharmacological approach for improving HSPC mobilization and thereby transplantation outcomes...
  6. pmc R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization
    Xun Shang
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 286:24068-78. 2011
    ..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization...
  7. pmc Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential
    Haiming Xu
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Blood 114:3557-66. 2009
    ..Our study defines p190-B as a critical transducer element of HSC self-renewal activity and long-term engraftment, thus suggesting that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype...
  8. pmc Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen
    Theodosia A Kalfa
    Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
    Haematologica 95:27-35. 2010
    ..The role of these Rac GTPases in erythropoiesis has not yet been fully elucidated...
  9. pmc Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    Linda Yang
    Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 104:5091-6. 2007
    ..Thus, Cdc42 is a critical coordinator of HSC quiescence maintenance and interaction with the BM niche...
  10. pmc RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
    Xuan Zhou
    Division of Experimental Hematology and Cancer Biology, 2 Molecular and Development Biology Graduate Program, 3 Division of Ophthalmology, and 4 Division of Developmental Biology, Cincinnati Children s Research Foundation, University of Cincinnati, Cincinnati, OH 45229
    J Exp Med 210:2371-85. 2013
    ..These results show that RhoA is a critical and specific regulator of multipotent HPCs during cytokinesis and thus essential for multilineage hematopoiesis. ..
  11. pmc Increased hematopoietic stem cell mobilization in aged mice
    Zhenlan Xing
    Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 108:2190-7. 2006
    ..These results might indicate that stroma-stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age...
  12. pmc Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation
    Amitava Sengupta
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:9957-62. 2011
    ....
  13. doi request reprint Aging in the lympho-hematopoietic stem cell compartment
    Hartmut Geiger
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Trends Immunol 30:360-5. 2009
    ..Reverting or ameliorating aging of HSCs might be a crucial step to restoring immuno-competence in the elderly...
  14. pmc Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential
    Jon P Williams
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Cell Stem Cell 3:658-69. 2008
    ..We suggest that expansion of an EGFR-expressing early glial progenitor contributes to neurofibroma formation...
  15. pmc TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells
    June Li
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 117:3283-95. 2007
    ..We conclude that TNF-alpha exposure creates an environment in which somatically mutated preleukemic stem cell clones are selected and from which unaltered TNF-alpha-hypersensitive Fancc-/- stem cells are purged...
  16. pmc The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
    Deidre Daria
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA
    Blood 111:1894-902. 2008
    ..In summary, Rb is critical for hematopoietic stem and progenitor cell function, localization, and differentiation...
  17. doi request reprint Quantification of genomic mutations in murine hematopoietic cells
    Hartmut Geiger
    Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Methods Mol Biol 506:423-36. 2009
    ....
  18. pmc The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
    Melissa Dumble
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH, USA
    Blood 109:1736-42. 2007
    ..Thus, alteration of p53 activity affects stem-cell numbers, proliferation potential, and hematopoiesis in older organisms, supporting a model in which aging is caused in part by a decline in tissue stem cell regenerative function...
  19. doi request reprint Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells
    Michael D Milsom
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Cancer Res 68:6171-80. 2008
    ..These studies have direct translational relevance to ongoing clinical gene therapy studies using MGMT(P140K), whereas the novel mechanistic findings are relevant to the basic understanding of DNA repair by MGMT...
  20. ncbi request reprint Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11
    Hui Chen Hsu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
    Mech Ageing Dev 123:1145-58. 2002
    ..6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development...
  21. doi request reprint The ageing haematopoietic stem cell compartment
    Hartmut Geiger
    Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany
    Nat Rev Immunol 13:376-89. 2013
    ..Stem cell ageing has long been considered to be irreversible. However, recent findings indicate that several molecular pathways could be targeted to rejuvenate HSCs and thus to reverse some aspects of immunosenescence...
  22. pmc Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis
    Abhinav Diwan
    Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
    Proc Natl Acad Sci U S A 104:6794-9. 2007
    ..These results suggest that physiological codependence and coordinated regulation of pro- and antiapoptotic Bcl2 family members may represent a general regulatory paradigm in hematopoiesis...
  23. doi request reprint HSPCs get their motors running for asymmetric fate choice
    Yi Zheng
    Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA Electronic address
    Cell Stem Cell 14:1-2. 2014
    ....
  24. doi request reprint Cdc42 and aging of hematopoietic stem cells
    Hartmut Geiger
    Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany
    Curr Opin Hematol 20:295-300. 2013
    ..Identifying conditions under which aged HSCs become equivalent to young stem cells might result in treatments for age-associated imbalances in lymphopoiesis and myelopoiesis and in blood regeneration...
  25. pmc Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia
    Deepika Bhatla
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Br J Haematol 144:388-94. 2009
    ..59 +/- 12% AA and 55 +/- 14% AC; P = 0.40). These data indicate that children with a low activity CDA genotype are at increased risk of TRM with ara-C based therapy for AML...
  26. pmc p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
    Ondrej Krejci
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA
    Blood 111:2190-9. 2008
    ..It is possible that the superior outcome of t(8;21) patients is partly due to an activated p53 pathway, and that loss of the p53 response pathway is associated with disease progression...
  27. ncbi request reprint The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
    Ying Liang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Nat Genet 39:178-88. 2007
    ..Thus, promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells...
  28. pmc Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
    Olga S Kustikova
    Department of Experimental Hematology, Hannover Medical School, Germany
    Blood 109:1897-907. 2007
    ..The IDDb forms a powerful resource for the identification of genes that stimulate or transform hematopoietic stem/progenitor cells and is an important reference for vector biosafety studies in human gene therapy...
  29. ncbi request reprint Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines
    Els Henckaerts
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Blood 99:3947-54. 2002
    ....
  30. ncbi request reprint Genetic analysis of progenitor cell mobilization by granulocyte colony-stimulating factor: verification and mechanisms for loci on murine chromosomes 2 and 11
    Hartmut Geiger
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    Exp Hematol 32:60-7. 2004
    ..The aim of this study was to verify this linkage and to gain insight into the function of these loci...
  31. ncbi request reprint A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Blood 100:2056-62. 2002
    ..Our data are consistent with the hypothesis that this isolated cell cycle QTL does not result from a mutation in a single gene but rather is a consequence of variable expression of a collection of highly linked genes...
  32. ncbi request reprint Analysis of the hematopoietic potential of muscle-derived cells in mice
    Hartmut Geiger
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Blood 100:721-3. 2002
    ..Unexpectedly, the blood-forming cells were enriched in muscle relative to their frequency in peripheral blood...
  33. ncbi request reprint Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain
    Mark A Lovell
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 800 S Limestone St, 101 Sanders Brown Bldg, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurobiol Aging 27:909-17. 2006
    ..These results raise the possibility of stimulation of inherent precursor cells of aged individuals or AD patients to replace neurons lost in aging and/or neurodegeneration...
  34. ncbi request reprint Mutagenic potential of temozolomide in bone marrow cells in vivo
    Hartmut Geiger
    Blood 107:3010-1. 2006
  35. ncbi request reprint The aging of lympho-hematopoietic stem cells
    Hartmut Geiger
    Departments of Medicine and Physiology, University of Kentucky, Lexington, KY 40536 0093, USA
    Nat Immunol 3:329-33. 2002
    ..We speculate that age-related functional decline in adult tissue HSCs limits longevity in mammals...

Research Grants5

  1. Genetic Reg. of Hematopoietic Stem Cell Mobilization
    Hartmut Geiger; Fiscal Year: 2007
    ..g. to muscle tissue, or to other hematopoietic niches. ..