Research Topics
Genomes and Genes
| Hartmut GeigerSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicityHartmut Geiger
Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Nat Med 18:1123-9. 2012..These findings suggest that pharmacologic augmentation of the activity of the Thbd-aPC pathway by recombinant Thbd or aPC might offer a rational approach to the mitigation of tissue injury and lethality caused by ionizing radiation...
Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell agingHartmut Geiger
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
Cell Cycle 6:884-7. 2007....- Regulation of hematopoietic stem cell aging in vivo by a distinct genetic elementHartmut Geiger
Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 102:5102-7. 2005.... - Targeting erythroblast-specific apoptosis in experimental anemiaAbhinav Diwan
Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA
Apoptosis 13:1022-30. 2008..These results support the concept of targeting erythroblast apoptosis to maximize erythrocyte production in acute anemia, which may be of value in erythropoietin resistance... 
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilizationMarnie A Ryan
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio, USA
Nat Med 16:1141-6. 2010..Our findings reveal a previously unknown signaling pathway regulating stem cell mobilization and provide a new pharmacological approach for improving HSPC mobilization and thereby transplantation outcomes...- Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potentialHaiming Xu
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
Blood 114:3557-66. 2009..Our study defines p190-B as a critical transducer element of HSC self-renewal activity and long-term engraftment, thus suggesting that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype... - Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleenTheodosia A Kalfa
Division of Hematology Oncology, Oncology, Cincinnati Children s Research Foundation, Cincinnati Children s Hospital Medical Center, MLC 7015 Cincinnati, OH 45229 3039, USA
Haematologica 95:27-35. 2010..The role of these Rac GTPases in erythropoiesis has not yet been fully elucidated... - Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrowLinda Yang
Division of Experimental Hematology and Pathology, Cincinnati Children s Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 104:5091-6. 2007..Thus, Cdc42 is a critical coordinator of HSC quiescence maintenance and interaction with the BM niche... - R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilizationXun Shang
Division of Experimental Hematology and Cancer Biology, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
J Biol Chem 286:24068-78. 2011..These results indicate that R-Ras is a critical regulator of Rac signaling required for HPC migration, homing, and mobilization... - Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationAmitava Sengupta
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 108:9957-62. 2011.... - Increased hematopoietic stem cell mobilization in aged miceZhenlan Xing
Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 108:2190-7. 2006..These results might indicate that stroma-stem cell interactions are dynamic over a lifetime and result in physiologically relevant changes in the biology of primitive hematopoietic cells with age... - Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potentialJon P Williams
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Cell Stem Cell 3:658-69. 2008..We suggest that expansion of an EGFR-expressing early glial progenitor contributes to neurofibroma formation... - Aging in the lympho-hematopoietic stem cell compartmentHartmut Geiger
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Trends Immunol 30:360-5. 2009..Reverting or ameliorating aging of HSCs might be a crucial step to restoring immuno-competence in the elderly... - TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cellsJune Li
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 117:3283-95. 2007..We conclude that TNF-alpha exposure creates an environment in which somatically mutated preleukemic stem cell clones are selected and from which unaltered TNF-alpha-hypersensitive Fancc-/- stem cells are purged... - The impact of altered p53 dosage on hematopoietic stem cell dynamics during agingMelissa Dumble
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH, USA
Blood 109:1736-42. 2007..Thus, alteration of p53 activity affects stem-cell numbers, proliferation potential, and hematopoiesis in older organisms, supporting a model in which aging is caused in part by a decline in tissue stem cell regenerative function... - Quantification of genomic mutations in murine hematopoietic cellsHartmut Geiger
Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
Methods Mol Biol 506:423-36. 2009.... - The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stressDeidre Daria
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA
Blood 111:1894-902. 2008..In summary, Rb is critical for hematopoietic stem and progenitor cell function, localization, and differentiation... - Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cellsMichael D Milsom
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
Cancer Res 68:6171-80. 2008..These studies have direct translational relevance to ongoing clinical gene therapy studies using MGMT(P140K), whereas the novel mechanistic findings are relevant to the basic understanding of DNA repair by MGMT... - Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11Hui Chen Hsu
Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294 0007, USA
Mech Ageing Dev 123:1145-58. 2002..6 cM, and 18.0 cM, respectively. Our results suggest that several genetic loci regulate the intra-thymic T-cell maturation process and play an important role in determining age-related decline in thymic T-cell development... - Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesisAbhinav Diwan
Center for Molecular Cardiovascular Research and Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA
Proc Natl Acad Sci U S A 104:6794-9. 2007..These results suggest that physiological codependence and coordinated regulation of pro- and antiapoptotic Bcl2 family members may represent a general regulatory paradigm in hematopoiesis... - p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced deathOndrej Krejci
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA
Blood 111:2190-9. 2008..It is possible that the superior outcome of t(8;21) patients is partly due to an activated p53 pathway, and that loss of the p53 response pathway is associated with disease progression... - Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemiaDeepika Bhatla
Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Br J Haematol 144:388-94. 2009..59 +/- 12% AA and 55 +/- 14% AC; P = 0.40). These data indicate that children with a low activity CDA genotype are at increased risk of TRM with ara-C based therapy for AML... - The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in miceYing Liang
Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
Nat Genet 39:178-88. 2007..Thus, promoter polymorphisms between the B6 and D2 alleles may affect Lxn gene expression and consequently influence the population size of hematopoietic stem cells... - Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathwaysOlga S Kustikova
Department of Experimental Hematology, Hannover Medical School, Germany
Blood 109:1897-907. 2007..The IDDb forms a powerful resource for the identification of genes that stimulate or transform hematopoietic stem/progenitor cells and is an important reference for vector biosafety studies in human gene therapy... - Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokinesEls Henckaerts
Carl C Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Blood 99:3947-54. 2002.... - Genetic analysis of progenitor cell mobilization by granulocyte colony-stimulating factor: verification and mechanisms for loci on murine chromosomes 2 and 11Hartmut Geiger
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
Exp Hematol 32:60-7. 2004..The aim of this study was to verify this linkage and to gain insight into the function of these loci... - A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnoverGerald de Haan
Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
Blood 100:2056-62. 2002..Our data are consistent with the hypothesis that this isolated cell cycle QTL does not result from a mutation in a single gene but rather is a consequence of variable expression of a collection of highly linked genes... - Analysis of the hematopoietic potential of muscle-derived cells in miceHartmut Geiger
Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA
Blood 100:721-3. 2002..Unexpectedly, the blood-forming cells were enriched in muscle relative to their frequency in peripheral blood... - Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brainMark A Lovell
Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 800 S Limestone St, 101 Sanders Brown Bldg, University of Kentucky, Lexington, KY 40536 0230, USA
Neurobiol Aging 27:909-17. 2006..These results raise the possibility of stimulation of inherent precursor cells of aged individuals or AD patients to replace neurons lost in aging and/or neurodegeneration... - Mutagenic potential of temozolomide in bone marrow cells in vivoHartmut Geiger
Blood 107:3010-1. 2006 - The aging of lympho-hematopoietic stem cellsHartmut Geiger
Departments of Medicine and Physiology, University of Kentucky, Lexington, KY 40536-0093, USA
Nat Immunol 3:329-33. 2002..We speculate that age-related functional decline in adult tissue HSCs limits longevity in mammals...
Research Grants
- Genetic Reg. of Hematopoietic Stem Cell MobilizationHartmut Geiger; Fiscal Year: 2007..g. to muscle tissue, or to other hematopoietic niches. ..