David Neal Franz

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    David Neal Franz
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Ann Neurol 59:490-8. 2006
  2. doi request reprint Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis
    David Neal Franz
    Departments of Pediatrics and Neurology, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Expert Rev Anticancer Ther 11:1181-92. 2011
  3. ncbi request reprint Everolimus treatment of refractory epilepsy in tuberous sclerosis complex
    Darcy A Krueger
    Departments of Pediatrics and Neurology, University of Cincinnati College of Medicine and Division of Child Neurology Cincinnati Children s Hospital Medical Center, Cincinnati, OH
    Ann Neurol 74:679-87. 2013
  4. doi request reprint Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    Darcy A Krueger
    Department of Pediatrics, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 363:1801-11. 2010
  5. doi request reprint Nursing implications for the lifelong management of tuberous sclerosis complex
    Karen Agricola
    Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Neurosci Nurs 45:226-42. 2013
  6. pmc Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
    Darcy A Krueger
    Department of Pediatrics and Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Neurology 80:574-80. 2013
  7. doi request reprint Vigabatrin for childhood partial-onset epilepsies
    Hansel M Greiner
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Neurol 46:83-8. 2012
  8. doi request reprint Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    David Neal Franz
    Department of Pediatrics and Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Child Neurol 28:602-7. 2013
  9. doi request reprint Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial
    David Neal Franz
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Lancet 381:125-32. 2013
  10. doi request reprint Everolimus alters white matter diffusion in tuberous sclerosis complex
    Jan Mendelt Tillema
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Neurology 78:526-31. 2012

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    David Neal Franz
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Ann Neurol 59:490-8. 2006
    ..We sought to see whether therapy with oral rapamycin could affect growth or induce regression in astrocytomas associated with TSC...
  2. doi request reprint Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosis
    David Neal Franz
    Departments of Pediatrics and Neurology, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Expert Rev Anticancer Ther 11:1181-92. 2011
    ..In time, the use of mTOR inhibitors in patients with TSC will likely be very well established...
  3. ncbi request reprint Everolimus treatment of refractory epilepsy in tuberous sclerosis complex
    Darcy A Krueger
    Departments of Pediatrics and Neurology, University of Cincinnati College of Medicine and Division of Child Neurology Cincinnati Children s Hospital Medical Center, Cincinnati, OH
    Ann Neurol 74:679-87. 2013
    ..We report the first prospective human clinical trial to directly assess whether everolimus will also benefit epilepsy in TSC patients...
  4. doi request reprint Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    Darcy A Krueger
    Department of Pediatrics, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    N Engl J Med 363:1801-11. 2010
    ..An alternative may be the use of everolimus, which inhibits the mammalian target of rapamycin, a protein regulated by gene products involved in the tuberous sclerosis complex...
  5. doi request reprint Nursing implications for the lifelong management of tuberous sclerosis complex
    Karen Agricola
    Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Neurosci Nurs 45:226-42. 2013
    ..This article will review the various manifestations of TSC and describe treatment strategies, recommendations for surveillance, and use of mTOR inhibitors in their management. ..
  6. pmc Everolimus long-term safety and efficacy in subependymal giant cell astrocytoma
    Darcy A Krueger
    Department of Pediatrics and Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Neurology 80:574-80. 2013
    ..To report long-term efficacy and safety data for everolimus for the treatment of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC)...
  7. doi request reprint Vigabatrin for childhood partial-onset epilepsies
    Hansel M Greiner
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Neurol 46:83-8. 2012
    ..In our clinical judgment, no cases of clinically relevant vigabatrin-associated visual impairment occurred. Vigabatrin was effective for refractory childhood partial-onset epilepsy, and was not associated with symptomatic vision loss...
  8. doi request reprint Everolimus for tumor recurrence after surgical resection for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    David Neal Franz
    Department of Pediatrics and Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Child Neurol 28:602-7. 2013
    ..Further surgery has been avoided in all cases to date. This course of treatment offers a new and welcome option for these difficult-to-treat patients...
  9. doi request reprint Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial
    David Neal Franz
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Lancet 381:125-32. 2013
    ..We assessed the efficacy and safety of everolimus in patients with subependymal giant cell astrocytomas associated with tuberous sclerosis complex...
  10. doi request reprint Everolimus alters white matter diffusion in tuberous sclerosis complex
    Jan Mendelt Tillema
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Neurology 78:526-31. 2012
    ....
  11. ncbi request reprint Psychiatric comorbidity and treatment response in patients with tuberous sclerosis complex
    Thomas K Chung
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Ann Clin Psychiatry 23:263-9. 2011
    ..Behavioral and psychiatric comorbidity are common in tuberous sclerosis complex (TSC), but information regarding psychopharmacologic management is lacking...
  12. ncbi request reprint Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trial
    James J Collins
    Department of Neurology, Division of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Child Neurol 21:53-7. 2006
    ..Based on these results, the use of levetiracetam as adjunctive antiepileptic therapy can reduce seizure frequency in patients with tuberous sclerosis complex. (J Child Neurol 2006;21:53-57)...
  13. doi request reprint Molecular therapies for tuberous sclerosis and neurofibromatosis
    David Neal Franz
    Departments of Pediatrics and Neurology, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Curr Neurol Neurosci Rep 12:294-301. 2012
    ..This article reviews the use of mTOR inhibitors in these diseases, which have the potential to be a disease-modifying therapy in these and other conditions...
  14. ncbi request reprint Non-neurologic manifestations of tuberous sclerosis complex
    David Neal Franz
    Tuberous Sclerosis Clinic, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Child Neurol 19:690-8. 2004
    ..Although chiefly recognized for its cerebral manifestations, understanding of the non-neurologic aspects of the disorder has advanced greatly in recent years, and they are reviewed here...
  15. ncbi request reprint Supratentorial tuber location and autism in tuberous sclerosis complex
    Nicolay Chertkoff Walz
    Department of Pediatrics, Division of Psychology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Child Neurol 17:830-2. 2002
    ..In the largest sample to date, these results fail to support the hypothesis that supratentorial tuber location is a marker for autism...