Research Topics
| David Neal FranzSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Everolimus: an mTOR inhibitor for the treatment of tuberous sclerosisDavid Neal Franz
Departments of Pediatrics and Neurology, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
Expert Rev Anticancer Ther 11:1181-92. 2011..In time, the use of mTOR inhibitors in patients with TSC will likely be very well established...
Rapamycin causes regression of astrocytomas in tuberous sclerosis complexDavid Neal Franz
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Ann Neurol 59:490-8. 2006..We sought to see whether therapy with oral rapamycin could affect growth or induce regression in astrocytomas associated with TSC...- Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosisDarcy A Krueger
Department of Pediatrics, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
N Engl J Med 363:1801-11. 2010..An alternative may be the use of everolimus, which inhibits the mammalian target of rapamycin, a protein regulated by gene products involved in the tuberous sclerosis complex... - Vigabatrin for childhood partial-onset epilepsiesHansel M Greiner
Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Pediatr Neurol 46:83-8. 2012..In our clinical judgment, no cases of clinically relevant vigabatrin-associated visual impairment occurred. Vigabatrin was effective for refractory childhood partial-onset epilepsy, and was not associated with symptomatic vision loss... - Everolimus alters white matter diffusion in tuberous sclerosis complexJan Mendelt Tillema
Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Neurology 78:526-31. 2012.... - Psychiatric comorbidity and treatment response in patients with tuberous sclerosis complexThomas K Chung
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Ann Clin Psychiatry 23:263-9. 2011..Behavioral and psychiatric comorbidity are common in tuberous sclerosis complex (TSC), but information regarding psychopharmacologic management is lacking... - Levetiracetam as adjunctive antiepileptic therapy for patients with tuberous sclerosis complex: a retrospective open-label trialJames J Collins
Department of Neurology, Division of Pediatric Neurology, Cincinnati Children's Hospital Medical Center, OH 45229, USA
J Child Neurol 21:53-7. 2006..Based on these results, the use of levetiracetam as adjunctive antiepileptic therapy can reduce seizure frequency in patients with tuberous sclerosis complex. (J Child Neurol 2006;21:53-57)... - Molecular therapies for tuberous sclerosis and neurofibromatosisDavid Neal Franz
Departments of Pediatrics and Neurology, Tuberous Sclerosis Clinic, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Curr Neurol Neurosci Rep 12:294-301. 2012..This article reviews the use of mTOR inhibitors in these diseases, which have the potential to be a disease-modifying therapy in these and other conditions... - Non-neurologic manifestations of tuberous sclerosis complexDavid Neal Franz
Tuberous Sclerosis Clinic, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Child Neurol 19:690-8. 2004..Although chiefly recognized for its cerebral manifestations, understanding of the non-neurologic aspects of the disorder has advanced greatly in recent years, and they are reviewed here... - Supratentorial tuber location and autism in tuberous sclerosis complexNicolay Chertkoff Walz
Department of Pediatrics, Division of Psychology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
J Child Neurol 17:830-2. 2002..In the largest sample to date, these results fail to support the hypothesis that supratentorial tuber location is a marker for autism...