Research Topics
| Maryam FouladiSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium studyMaryam Fouladi
Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 7015, Cincinnati, OH 45229, USA
J Clin Oncol 29:3529-34. 2011..To estimate the maximum-tolerated dose (MTD), describe dose-limiting toxicities (DLTs), and characterize pharmacokinetic properties of MK-0752, a gamma secretase inhibitor, in children with refractory or recurrent CNS malignancies...- Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium studyMaryam Fouladi
St Jude Children s Research Hospital, Memphis, TN, USA
J Clin Oncol 28:4221-7. 2010.... - Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium reportMaryam Fouladi
St Jude Children s Research Hospital, Memphis, TN, USA
J Clin Oncol 28:3623-9. 2010.... 
Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in childrenAlberto Broniscer
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN, USA
J Neurooncol 76:313-9. 2006..Although the heterogeneity of prognostic factors in our patients made assessment of treatment outcome more difficult, the addition of 6 cycles of temozolomide after radiotherapy did not seem to alter the poor outcome of these patients...- Amifostine protects against cisplatin-induced ototoxicity in children with average-risk medulloblastomaMaryam Fouladi
Department of Oncology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105 2794, USA
J Clin Oncol 26:3749-55. 2008.... - Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trialAmar Gajjar
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Lancet Oncol 7:813-20. 2006..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma... - Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem gliomaAlberto Broniscer
Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
Cancer 106:1364-71. 2006..In the current study, the authors assessed the characteristics and estimated the cumulative incidence of IH among children with BSG... 
High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumorsChie Schin Shih
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Cancer 112:1345-53. 2008..High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies...- Phase 1 study of an oxaliplatin and etoposide regimen in pediatric patients with recurrent solid tumorsLisa M McGregor
Department of Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 115:655-64. 2009..The combination of a platinating agent and etoposide has induced responses in various pediatric tumors. The study estimated the maximum tolerated dose (MTD) of an oxaliplatin and etoposide regimen in children with recurrent solid tumors... - Survival and late mortality in long-term survivors of pediatric CNS tumorsE Brannon Morris
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Clin Oncol 25:1532-8. 2007..To describe the pattern of survival and late mortality among contemporary long-term survivors of pediatric CNS tumor... - Carboplatin-based primary chemotherapy for infants and young children with CNS tumorsMaryam Fouladi
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Cancer 115:3243-53. 2009..A carboplatin-based chemotherapy regimen was used as primary postoperative therapy in infants with central nervous system (CNS) tumors to limit renal and ototoxicity and to target systemic exposure... - Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettesChristine Fuller
Department of Pathology, St Jude Children's, Research Hospital, Memphis, TN, USA
Am J Clin Pathol 126:277-83. 2006..No deletions of INI1 or amplifications of MYC or MYCN were detected. This report adds 2 cases to our experience of PNTANTR and is the first to demonstrate isochromosome 17q, a molecular alteration typical of medulloblastomas... - Phase I study of everolimus in pediatric patients with refractory solid tumorsMaryam Fouladi
Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
J Clin Oncol 25:4806-12. 2007.... - Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS)Feng Bai
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Chromatogr B Analyt Technol Biomed Life Sci 878:2348-52. 2010..Within-day and between-day precisions were<8.6%, and accuracies were 0.7 and 7.1%. This method was applied to the measurement of plasma MK-0752 levels in a Phase I study of pediatric patients with recurrent or refractory brain tumors... - Phase II study of oxaliplatin in children with recurrent or refractory medulloblastoma, supratentorial primitive neuroectodermal tumors, and atypical teratoid rhabdoid tumors: a pediatric brain tumor consortium studyMaryam Fouladi
St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 107:2291-7. 2006.... - Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a Children's Oncology Group reportMaryam Fouladi
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
J Clin Oncol 24:3678-85. 2006..The recommended phase II dose in children with solid tumors is 17 mg/m2... - Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98)Alberto Broniscer
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 103:133-9. 2005..The role of chemotherapy in the treatment of children with newly diagnosed diffuse brainstem glioma is uncertain. In the current study, the authors tested the efficacy of temozolomide treatment after radiotherapy (RT) in this setting... - Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumorClinton F Stewart
Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 N Lauderdale, Memphis, TN 38105-2794, USA
J Clin Oncol 22:3357-65. 2004..This drug warrants testing as part of standard postradiation chemotherapeutic regimens. Furthermore, these results emphasize the importance of translational research in drug development, which in this case identified an effective drug... - Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastomaTrevor McKibbin
Department of Clinical Pharmacy and Pharmaceutical Sciences, University of Tennessee, TN, USA
Clin Cancer Res 16:1049-57. 2010.... - White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumorMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
J Clin Oncol 22:4551-60. 2004.... - Intellectual and functional outcome of children 3 years old or younger who have CNS malignanciesMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105 2794, USA
J Clin Oncol 23:7152-60. 2005.... - A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group studyMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Cancer 110:2535-41. 2007.... - Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapyTanya M Tekautz
Department of Hematology-Oncology, Mail Stop 260, St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
J Clin Oncol 23:1491-9. 2005..ATRT presenting in older patients can be cured using a combination of radiation and high-dose alkylating therapy. Older patients with relapsed ATRT can have salvage treatment using ICE chemotherapy... - Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumorsJohn C Panetta
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
Cancer Chemother Pharmacol 52:435-41. 2003..CONCLUSIONS: This study extends previous work done in adults, and identified BSA and age as covariates that account for variability in TMZ disposition in infants and children with primary CNS malignancies... - Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenograftsMarkos Leggas
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 8:3000-7. 2002.... - Histone deacetylase inhibitors in cancer therapyMaryam Fouladi
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA
Cancer Invest 24:521-7. 2006 - Ependymoma: new therapeutic approaches including radiation and chemotherapyThomas E Merchant
Division of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Neurooncol 75:287-99. 2005..Future research in the treatment of this tumor, that afflicts fewer than 200 children in the US each year, will focus on molecular biology, clarifying risk factors for tumor control and late effects, and testing novel agents... - Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tractsKathleen J Helton
Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Neurosurg Pediatr 1:270-6. 2008..The authors sought to determine whether DT imaging and white matter tractography could detect axonal degeneration in patients with brainstem tumors... - Polar spongioblastoma of the spinal cord: a case reportChristine Fuller
Department of Pathology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA
Pediatr Dev Pathol 9:75-80. 2006..Discrimination of these rare aggressive lesions from other CNS tumors with focal palisaded architecture is crucial as the treatment and prognosis of the latter may differ significantly... - Outcome of children with centrally reviewed low-grade gliomas treated with chemotherapy with or without radiotherapy on Children's Cancer Group high-grade glioma study CCG-945Maryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Cancer 98:1243-52. 2003.... - Severe allergic reactions to thiol-based cytoprotective agents mesna and amifostine in a child with a supratentorial primitive neuroectodermal tumorKathleen Dorris
Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr Hematol Oncol 33:e250-2. 2011.... - Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivoClaire Graham
Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA
Clin Cancer Res 12:223-34. 2006.... - Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literatureKathleen J Helton
Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Cancer 101:1445-54. 2004..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components... - Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patientsMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 98:2232-44. 2003..Histologically, it may mimic oligodendroglioma, central neurocytoma, hemangioblastoma, and renal cell carcinoma... - Survival and functional outcome of children with hypothalamic/chiasmatic tumorsMaryam Fouladi
Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Cancer 97:1084-92. 2003..We evaluated the impact of clinical and neuroimaging parameters and primary therapy on overall (OS) and progression-free (PFS) survival and on neuroendocrine and neurocognitive outcome in children with H and/or C tumors... - Determination of lapatinib (GW572016) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS)Feng Bai
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA
J Chromatogr B Analyt Technol Biomed Life Sci 831:169-75. 2006..This method has been used to measure plasma lapatinib concentrations in a Phase I study in children with cancer... - Medulloblastoma with melanotic differentiation: case report and review of the literatureChristine L Phillips
Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
J Neurooncol 103:759-64. 2011.... - End-of-life care preferences of pediatric patients with cancerPamela S Hinds
Division of Nursing Research and Patient Care Services, Department of Hematology Oncology, Palliative and End of Life Care Task Force, and Ethics Committee, St Jude Children s Research Hospital, Memphis, TN, USA
J Clin Oncol 23:9146-54. 2005..We identified the preferences of children and adolescents with advanced cancer about their end-of-life care and the factors that influenced their decisions... - Altered irinotecan pharmacokinetics in pediatric high-grade glioma patients receiving enzyme-inducing anticonvulsant therapyKristine R Crews
Departments of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Clin Cancer Res 8:2202-9. 2002..The purpose of this study was to determine the effect of enzyme-inducing anticonvulsants (EIAs) on the disposition of irinotecan and metabolites in pediatric patients with high-grade glioma...