Ah Filipovich

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Diagnosis and manifestations of chronic graft-versus-host disease
    Alexandra H Filipovich
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Best Pract Res Clin Haematol 21:251-7. 2008
  2. doi request reprint The expanding spectrum of hemophagocytic lymphohistiocytosis
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Curr Opin Allergy Clin Immunol 11:512-6. 2011
  3. doi request reprint Hematopoietic cell transplantation for correction of primary immunodeficiencies
    Ah Filipovich
    Immunodeficiency and Histiocytosis Program, Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bone Marrow Transplant 42:S49-S52. 2008
  4. doi request reprint Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders
    Alexandra H Filipovich
    Division of Hematology Oncology, Immunodeficiency and Histiocytosis Program, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 28:293-313, viii. 2008
  5. ncbi request reprint Hemophagocytic lymphohistiocytosis and related disorders
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, ML 7015, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Opin Allergy Clin Immunol 6:410-5. 2006
  6. ncbi request reprint National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 11:945-56. 2005
  7. ncbi request reprint Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working
    Daniel Couriel
    University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Biol Blood Marrow Transplant 12:375-96. 2006
  8. ncbi request reprint National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report
    Paul J Martin
    Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 98109 1024, USA, and Hopital St Louis, Paris, France
    Biol Blood Marrow Transplant 12:491-505. 2006
  9. ncbi request reprint Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation
    Susan Molleran Lee
    Divisions of Hematology Oncology and Human Genetics, Cincinnati Children s Hospital Medical Center and the Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
    J Pediatr 149:134-7. 2006
  10. ncbi request reprint Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report
    Kirk R Schultz
    British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Blood Marrow Transplant 12:126-37. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Diagnosis and manifestations of chronic graft-versus-host disease
    Alexandra H Filipovich
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Best Pract Res Clin Haematol 21:251-7. 2008
    ..The expectation is that the provisional guidelines described here will be widely used and refined with additional observer experience...
  2. doi request reprint The expanding spectrum of hemophagocytic lymphohistiocytosis
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Curr Opin Allergy Clin Immunol 11:512-6. 2011
    ....
  3. doi request reprint Hematopoietic cell transplantation for correction of primary immunodeficiencies
    Ah Filipovich
    Immunodeficiency and Histiocytosis Program, Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bone Marrow Transplant 42:S49-S52. 2008
    ..While ultimate success rates are similar, transplant-related management of children receiving unrelated grafts is considerably more complicated and prolonged than following matched sibling HCT...
  4. doi request reprint Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders
    Alexandra H Filipovich
    Division of Hematology Oncology, Immunodeficiency and Histiocytosis Program, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Immunol Allergy Clin North Am 28:293-313, viii. 2008
    ....
  5. ncbi request reprint Hemophagocytic lymphohistiocytosis and related disorders
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, ML 7015, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Curr Opin Allergy Clin Immunol 6:410-5. 2006
    ..Awareness has grown through the Histiocyte Society and the publication of newly-recognized genetic causes. I summarize current knowledge regarding the pathophysiology, diagnosis and treatment of hemophagocytic lymphohistiocytosis...
  6. ncbi request reprint National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report
    Alexandra H Filipovich
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 11:945-56. 2005
    ..It is currently recommended that systemic therapy be considered for patients who meet criteria for chronic GVHD of moderate to severe global severity...
  7. ncbi request reprint Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working
    Daniel Couriel
    University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Biol Blood Marrow Transplant 12:375-96. 2006
    ..Optimal care of patients with chronic GVHD often requires a multidisciplinary approach...
  8. ncbi request reprint National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group report
    Paul J Martin
    Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, Washington 98109 1024, USA, and Hopital St Louis, Paris, France
    Biol Blood Marrow Transplant 12:491-505. 2006
    ..The use of consistent standards in clinical trial designs to evaluate agents that have activity in pathogenic pathways could facilitate advances in the treatment of chronic GVHD...
  9. ncbi request reprint Patients of African ancestry with hemophagocytic lymphohistiocytosis share a common haplotype of PRF1 with a 50delT mutation
    Susan Molleran Lee
    Divisions of Hematology Oncology and Human Genetics, Cincinnati Children s Hospital Medical Center and the Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
    J Pediatr 149:134-7. 2006
    ..Extent of haplotype sharing and variability of microsatellite alleles in 50delT-PRF1 chromosomes suggest that this mutation arose approximately 1000 to 4000 years ago and is restricted to patients of African descent...
  10. ncbi request reprint Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report
    Kirk R Schultz
    British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Blood Marrow Transplant 12:126-37. 2006
    ..Both approaches have merit and should be pursued. The consistent treatment and standardized documentation needed to support biomarker studies are most likely to be satisfied in prospective clinical trials...
  11. ncbi request reprint Perforin expression in cytotoxic lymphocytes from patients with hemophagocytic lymphohistiocytosis and their family members
    Kazuhiro Kogawa
    Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Blood 99:61-6. 2002
    ....
  12. ncbi request reprint Life-threatening hemophagocytic syndromes: current outcomes with hematopoietic stem cell transplantation
    Alexandra H Filipovich
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Transplant 9:87-91. 2005
    ..Over the past 25 yr, through collaborative worldwide efforts, survival of children with HLH and related disorders has improved from 5% at 1 yr after diagnosis to greater than 50% 3-5 yr after diagnosis...
  13. ncbi request reprint Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis
    Annacarin Horne
    Childhood Cancer Research Unit, Institution for Woman and Child Health, Karolinska Institutet, Department of Paediatric Haematology and Oncology, Karolinska Hospital, Stockholm, Sweden
    Br J Haematol 129:622-30. 2005
    ..Patients that responded well to initial pretransplant-induction therapy fared best, but some persisting HLH activity should not automatically preclude performing SCT...
  14. ncbi request reprint Rapid detection of intracellular SH2D1A protein in cytotoxic lymphocytes from patients with X-linked lymphoproliferative disease and their family members
    Yasuhiro Tabata
    Division of Hematology Oncology and Division of Human Genetics, Children s Hospital Medical Center, MLC 7015, Cincinnati, OH 45229 3039, USA
    Blood 105:3066-71. 2005
    ..Four-color flow cytometry provides diagnostic information that may speed the identification of this fatal disease, differentiating it from other causes of EBV-HLH...
  15. ncbi request reprint Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation
    Jan Inge Henter
    Childhood Cancer Research Unit, Karolinska Institutet, Department of Pediatric Hematology and Oncology, Karolinska Hospital, Stockholm, Sweden
    Blood 100:2367-73. 2002
    ..The 3-year probability of survival after BMT was 62% (+/- 12%). HLH-94 is very effective, allowing BMT in most patients. Survival of children with HLH has been greatly improved...
  16. doi request reprint Tumor immune surveillance defect of X-linked severe combined immunodeficiency is not Epstein-Barr virus specific
    Peter Mustillo
    Division of Infectious Diseases, Nationwide Children s Hospital, Columbus, Ohio, USA
    Pediatr Blood Cancer 51:706-9. 2008
    ....
  17. ncbi request reprint Emergence and compartmentalization of fatal multi-drug-resistant cytomegalovirus infection in a patient with autosomal-recessive severe combined immune deficiency
    Samuel C Blackman
    Pediatric Residency Training Program, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Pediatr Hematol Oncol 26:601-5. 2004
    ..Serial genotypic analyses revealed multiple UL97 and UL54 (DNA polymerase) mutations that conferred phenotypic resistance to all currently licensed systemic CMV antivirals...
  18. doi request reprint Adolescent presentation of x-linked lymphoproliferative disease
    Samuel L Friedlander
    Ann Allergy Asthma Immunol 100:398-400. 2008
  19. pmc Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
    Miguel L Stein
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 121:1473-83, 1483.e1-4. 2008
    ..Anti-IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized...
  20. doi request reprint Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis
    Melissa M Hazen
    Children s Hospital Boston, Boston, Massachusetts, USA
    Arthritis Rheum 58:567-70. 2008
    ..This case broadens the range of clinical phenotypes attributable to UNC13D mutations and offers new insights into the etiology and pathogenesis of systemic JIA...
  21. ncbi request reprint Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis
    Annacarin Horne
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Br J Haematol 140:327-35. 2008
    ..Prompt treatment of HLH at onset or relapse may reduce these complications...
  22. pmc Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus
    Stella A Nicolaou
    Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Immunol 179:346-56. 2007
    ..3 constitutes the dominant K conductance. The defective temporal and spatial Kv1.3 distribution that we observed may contribute to the abnormal functions of SLE T cells...
  23. ncbi request reprint Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit
    Matthew Mischler
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pediatrics 119:e1212-8. 2007
    ....
  24. ncbi request reprint Two novel CHS1 (LYST) mutations: clinical correlations in an infant with Chediak-Higashi syndrome
    Wafika Zarzour
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Genet Metab 85:125-32. 2005
    ..These two newly described mutations are expected to give rise to a severe phenotype and, indeed, the patient had absolutely no cytotoxicity by natural killer cells or cytotoxic lymphocytes prior to his allogeneic SCT...
  25. ncbi request reprint HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis
    Jan Inge Henter
    Childhood Cancer Research Unit, Department of Woman and Child Health, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Pediatr Blood Cancer 48:124-31. 2007
    ..In order to hopefully further improve diagnosis, therapy and biological understanding, participation in HLH studies is encouraged...
  26. ncbi request reprint Healing hemophagocytosis
    Alexandra H Filipovich
    Center for Heritable Immune Deficiencies, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Immunol 117:121-4. 2005
  27. pmc Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis
    Kimberly A Risma
    Division of Allergy Immunology and Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:182-92. 2006
    ..Thus, the pathologic mechanism of perforin missense mutation likely involves a protein dosage effect of the mature protein...