Pirooz Eghtesady

..Fetal interventions are now being performed, based on the presumption that they would prevent such pathogenic mechanisms...

..We examined potential maternal-fetal interactions during fetal cardiopulmonary bypass. these interactions, not previously described, may significantly influence attempts at fetal cardiac surgery...

..We discuss the unique challenges posed by HIT II complicating pediatric VAD support and in relation to the heparin coating of the device...

..Implications for other congenital heart diseases and the broader picture of global public health are discussed...

..The objective of this study was to examine seasonal and temporal patterns of hypoplastic left heart syndrome births compared with other left-sided heart defects in the United States...

..Calcium addition to the prime adversely affects fetal gas exchange worsening acidosis during fetal bypass. Bicarbonate addition to the prime is also detrimental to the fetus resulting in greater CO2 production and impaired hemodynamics...

..We set out to test its feasibility as a monitor of fetal and placental oxygenation during fetal cardiac surgery...

..VAVD can be safely applied during fetal bypass provided pressures are kept < or = -20 mm Hg. However, the achieved higher flow rates do not prevent postbypass placental dysfunction and may indeed be detrimental to the fetus...

..We set out to characterize this fetal stress response and its potential role in placental dysfunction...

..We sought to assess growth status at the time of the Fontan procedure and the effect of poor growth status on surgical outcomes...

..The placental nitric oxide (NO) pathway has been implicated in this pathophysiology. We set out to examine possible perturbations in this pathway in an ovine model of fetal bypass...

..Finally, while previous fetal experiments have used late-gestation mature fetuses, we studied more immature fetuses of mid-gestation, relevant to current clinical attempts in fetal therapy...

..The hypothesis was that fetal cardiac bypass results in myocardial dysfunction, possibly because of perturbation of calcium cycling and contractile proteins...

..These initial findings warrant further investigation of interventions to restore metabolic and hemodynamic homeostasis after fetal bypass...

..To assess growth from the time of neonatal discharge to the time of performance of the bidirectional Glenn (BDG) procedure in infants with a single ventricle and determine predictors of poor growth...

..We sought to assess the effect of nutritional status at the time of the bidirectional Glenn procedure on short-term outcomes...

..The degree or mechanisms behind these volume changes (or location) have not been defined. We characterized the preceding and correlated the findings to plasma vasopressin concentrations, the critical peptide of osmoregulation...

..The purpose of this study was to identify factors predicting risk of aortic arch recoarctation after the Norwood procedure...

..Protection and preservation of fetal myocardial function are important for successful fetal intracardiac repair. Our objective was to determine fetal biventricular cardiac performance after two cardiac-arrest techniques...

..We hypothesized that these natriuretic peptides may account for the paradoxic rise in cGMP seen with fetal bypass...

..We studied their usefulness, based on amniotic fluid concentrations, in an ovine model of fetal aortic stenosis and in response to fetal cardiac intervention...

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..This strategy of ECMO with extubation, then high-frequency oscillatory ventilation is a useful rescue therapy in patients with postoperative tracheal dehiscence...

..If proven true, the findings will have a profound impact on this disease and the lives of many mothers and their affected babies. ..