Wei Du

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc)
    Wei Du
    Division of Experimental Hematology and Cancer Biology, The Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 285:37436-44. 2010
  2. pmc TNF-α signaling in Fanconi anemia
    Wei Du
    Division of Experimental Hematology and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA Electronic address
    Blood Cells Mol Dis 52:2-11. 2014
  3. pmc Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 117:4243-52. 2011
  4. pmc Oxidative stress in Fanconi anemia hematopoiesis and disease progression
    Wei Du
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Antioxid Redox Signal 10:1909-21. 2008
  5. pmc The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
    Wei Du
    Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 119:4142-51. 2012
  6. pmc Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance
    Xue Li
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 119:4162-73. 2012
  7. pmc Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 191:2806-17. 2013
  8. pmc NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in mice
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Carcinogenesis 31:302-10. 2010
  9. pmc TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice
    Yun Zhou
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 112:2474-83. 2008
  10. pmc Oxidative stress-specific interaction between FANCD2 and FOXO3a
    Jie Li
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 115:1545-8. 2010

Collaborators

Detail Information

Publications11

  1. pmc Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc)
    Wei Du
    Division of Experimental Hematology and Cancer Biology, The Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 285:37436-44. 2010
    ..Our findings not only reveal the molecular mechanism involving cytoplasmic retention of NPMc but also suggest cytoplasmic function of FANCA and FANCC in NPMc-related leukemogenesis...
  2. pmc TNF-α signaling in Fanconi anemia
    Wei Du
    Division of Experimental Hematology and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA Electronic address
    Blood Cells Mol Dis 52:2-11. 2014
    ..In this brief review, we discuss the link between TNF-α signaling and FA pathway with emphasis on the implication of inflammation in the pathophysiology and abnormal hematopoiesis in FA. ..
  3. pmc Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 117:4243-52. 2011
    ..These results demonstrate that IL-3Rα is a cell-surface marker present on FA-AML leukemia-initiating cells and may be a valuable therapeutic target...
  4. pmc Oxidative stress in Fanconi anemia hematopoiesis and disease progression
    Wei Du
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Antioxid Redox Signal 10:1909-21. 2008
    ..In this brief review, we discuss the functional link between FA proteins and oxidative DNA damage response/repair, with emphasis on the implication of oxidative stress in the pathophysiology and abnormal hematopoiesis in FA...
  5. pmc The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
    Wei Du
    Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 119:4142-51. 2012
    ..In addition, oxidative stress-induced FANCD2 ubiquitination is required for the formation of a FA-BRG1-promoter complex. Taken together, these data identify a role for the FA pathway in cellular antioxidant defense...
  6. pmc Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenance
    Xue Li
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 119:4162-73. 2012
    ..Together, these findings suggest that activation of PARP-1 by salidroside could affect the homeostasis and function of HSCs and contribute to the antioxidant effects of salidroside...
  7. pmc Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 191:2806-17. 2013
    ..These results suggest a functional crosstalk between Notch signaling and NF-κB pathway in regulation of HSC differentiation. ..
  8. pmc NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in mice
    Wei Du
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Carcinogenesis 31:302-10. 2010
    ..Thus, these findings reveal a novel function of NPM on regulation of cell cycle progression, in which phosphorylation of NPM controls cell cycle progression at G(2)/M transition through modulation of Cdk1 and Cdc25C activities...
  9. pmc TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice
    Yun Zhou
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Blood 112:2474-83. 2008
    ..Thus, TAT-delivered NPM peptide may provide a novel therapy for inflammation-associated tumors that require NF-kappaB signaling for survival...
  10. pmc Oxidative stress-specific interaction between FANCD2 and FOXO3a
    Jie Li
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 115:1545-8. 2010
    ..The novel oxidative stress response pathway identified in this study, in which FANCD2 and FOXO3a converge, probably contributes to cellular antioxidant defense...
  11. pmc Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress
    Xue Li
    1 Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Antioxid Redox Signal 20:1853-65. 2014
    ..The aim of this study was to investigate the mechanism by which PARP1 activation by Salidroside maintains HSCs under oxidative stress...