Research Topics
Genomes and GenesSpecies | Wei DuSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Cytoplasmic FANCA-FANCC complex interacts and stabilizes the cytoplasm-dislocalized leukemic nucleophosmin protein (NPMc)Wei Du
Division of Experimental Hematology and Cancer Biology, The Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Biol Chem 285:37436-44. 2010..Our findings not only reveal the molecular mechanism involving cytoplasmic retention of NPMc but also suggest cytoplasmic function of FANCA and FANCC in NPMc-related leukemogenesis...- Oxidative stress in Fanconi anemia hematopoiesis and disease progressionWei Du
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Antioxid Redox Signal 10:1909-21. 2008..In this brief review, we discuss the functional link between FA proteins and oxidative DNA damage response/repair, with emphasis on the implication of oxidative stress in the pathophysiology and abnormal hematopoiesis in FA... - Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AMLWei Du
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Blood 117:4243-52. 2011..These results demonstrate that IL-3Rα is a cell-surface marker present on FA-AML leukemia-initiating cells and may be a valuable therapeutic target... - The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promotersWei Du
Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 119:4142-51. 2012..In addition, oxidative stress-induced FANCD2 ubiquitination is required for the formation of a FA-BRG1-promoter complex. Taken together, these data identify a role for the FA pathway in cellular antioxidant defense... - Salidroside stimulates DNA repair enzyme Parp-1 activity in mouse HSC maintenanceXue Li
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 119:4162-73. 2012..Together, these findings suggest that activation of PARP-1 by salidroside could affect the homeostasis and function of HSCs and contribute to the antioxidant effects of salidroside... - NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in miceWei Du
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Carcinogenesis 31:302-10. 2010..Thus, these findings reveal a novel function of NPM on regulation of cell cycle progression, in which phosphorylation of NPM controls cell cycle progression at G(2)/M transition through modulation of Cdk1 and Cdc25C activities... - Oxidative stress-specific interaction between FANCD2 and FOXO3aJie Li
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Blood 115:1545-8. 2010..The novel oxidative stress response pathway identified in this study, in which FANCD2 and FOXO3a converge, probably contributes to cellular antioxidant defense... - TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in miceYun Zhou
Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
Blood 112:2474-83. 2008..Thus, TAT-delivered NPM peptide may provide a novel therapy for inflammation-associated tumors that require NF-kappaB signaling for survival...