Sudhansu K Dey

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc A new role for muscle segment homeobox genes in mammalian embryonic diapause
    Jeeyeon Cha
    Division of Reproductive Sciences, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Open Biol 3:130035. 2013
  2. pmc Ovarian LGR5 is critical for successful pregnancy
    Xiaofei Sun
    1Cincinnati Children s Hospital Medical Center, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    FASEB J 28:2380-9. 2014
  3. pmc Loss of cannabinoid receptor CB1 induces preterm birth
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 3:e3320. 2008
  4. pmc Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
    Kristin E Burnum
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 9104, USA
    Endocrinology 153:4568-79. 2012
  5. pmc Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 153:2486-93. 2012
  6. pmc How we are born
    Sudhansu K Dey
    Cincinnati Children s Research Foundation, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Clin Invest 120:952-5. 2010
  7. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
  8. ncbi request reprint Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
  9. pmc Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
  10. pmc Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005

Collaborators

Detail Information

Publications66

  1. pmc A new role for muscle segment homeobox genes in mammalian embryonic diapause
    Jeeyeon Cha
    Division of Reproductive Sciences, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Open Biol 3:130035. 2013
    ..These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness...
  2. pmc Ovarian LGR5 is critical for successful pregnancy
    Xiaofei Sun
    1Cincinnati Children s Hospital Medical Center, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    FASEB J 28:2380-9. 2014
    ..Sun, X., Terakawa, J., Clevers, H., Barker, N., Daikoku, T., Dey, S. K. Ovarian LGR5 is critical for successful pregnancy. ..
  3. pmc Loss of cannabinoid receptor CB1 induces preterm birth
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    PLoS ONE 3:e3320. 2008
    ..Since our previous studies demonstrated that loss of CB1 defers the normal implantation window in mice, we surmised that CB1 deficiency would influence parturition events...
  4. pmc Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
    Kristin E Burnum
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 9104, USA
    Endocrinology 153:4568-79. 2012
    ..In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53...
  5. pmc Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 153:2486-93. 2012
    ..These findings suggest that uterine Gal1 is an important downstream target of P(4)-FKBP52-PR signaling in the uterus to support P(4) responsiveness during pregnancy...
  6. pmc How we are born
    Sudhansu K Dey
    Cincinnati Children s Research Foundation, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Clin Invest 120:952-5. 2010
    ....
  7. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
    ....
  8. ncbi request reprint Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
    ..This study is clinically relevant because deferral of on time implantation leads to spontaneous pregnancy loss, and defective trophoblast invasion is one cause of preeclampsia in humans...
  9. pmc Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
    ....
  10. pmc Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation...
  11. pmc Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress
    Yasushi Hirota
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:15577-82. 2010
    ..This study shows that FKBP52-PRDX6 signaling protects pregnancy from overt OS...
  12. pmc Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:16887-92. 2010
    ....
  13. ncbi request reprint Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency
    Limin Yue
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocrinology 146:2424-33. 2005
    ....
  14. ncbi request reprint Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 279:10649-58. 2004
    ..In light of this finding, the therapeutic use and efficacy of COX-2-specific inhibitors among human populations without regard for genetic and ethnic diversities should be revisited...
  15. pmc Genetic loss of Faah compromises male fertility in mice
    Xiaofei Sun
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 80:235-42. 2009
    ..Collectively, the results show that aberrant endocannabinoid signaling via CNR1 impairs normal sperm function. Besides unveiling a new regulatory mechanism of sperm function, this study has clinical significance in male fertility...
  16. ncbi request reprint Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
    ..The ability of aspirin to inhibit EOC growth in vivo is an exciting finding because of its low cost, lack of cardiovascular side effects, and availability...
  17. pmc Deficiency of immunophilin FKBP52 promotes endometriosis
    Yasushi Hirota
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Pathol 173:1747-57. 2008
    ..This investigation is highly relevant for clinical application, particularly because P(4) resistance is favorably indicated in endometriosis and other gynecological diseases...
  18. pmc CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  19. pmc Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenessee 37232, USA
    Cancer Res 68:5619-27. 2008
    ..These mouse models have the added advantage because they mimic several features of human EMC...
  20. ncbi request reprint N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation
    Yong Guo
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 280:23429-32. 2005
    ..The expression is well correlated with its activity and anandamide levels. This study is clinically relevant, since elevated anandamide levels in peripheral circulation are associated with spontaneous pregnancy failure in women...
  21. ncbi request reprint Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade
    Dingzhi Wang
    Departments of Medicine, Pediatrics, Cancer Biology, and Cell and Developmental and Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee
    Cancer Res 65:1822-9. 2005
    ..One intriguing finding is that COX-2-derived PGE2 mimics the effects of constitutively active Ras through a self-amplifying loop that allows for a distinct growth advantage...
  22. ncbi request reprint Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, TN 37232, USA
    Cancer Cell 6:285-95. 2004
    ..We demonstrate that PPARdelta is a focal point of crosstalk between the prostaglandin and Wnt signaling pathways which results in a shift from cell death to cell survival, leading to increased tumor growth...
  23. pmc Inactivation of nuclear Wnt-beta-catenin signaling limits blastocyst competency for implantation
    Huirong Xie
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA
    Development 135:717-27. 2008
    ..These findings constitute novel evidence that Wnt signaling is at least one pathway that determines blastocyst competency for implantation...
  24. pmc Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Hum Reprod 19:463-72. 2013
    ..In conclusion, Tsc1(PR(d/d)) and Tsc1(Amhr2(d/d)) have overlapping yet distinct phenotypes in the context of compartment-specific deletion of Tsc1. ..
  25. pmc Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Mol Endocrinol 27:1492-501. 2013
    ..These changes in uteri of deleted mice were reflected by the failure of differentiation of the luminal epithelium, which is essential for blastocyst attachment. ..
  26. pmc FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    J Clin Invest 117:1824-34. 2007
    ....
  27. pmc Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
    Huirong Xie
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 287:32288-97. 2012
    ..This study provides evidence that a tightly regulated endocannabinoid signaling is critical to normal preimplantation embryo development and migration of trophoblast stem cells...
  28. ncbi request reprint Hoxa-10 deficiency alters region-specific gene expression and perturbs differentiation of natural killer cells during decidualization
    Mohammad A Rahman
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 290:105-17. 2006
    ..Collectively, the results provide evidence that Hoxa-10 influences a host of genes and cell functions necessary for propagating normal decidual development during the post-implantation period...
  29. pmc Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prostaglandins Other Lipid Mediat 83:62-74. 2007
    ..The results suggest that aberrant functioning of these pathways impacting uterine anandamide and/or 2-AG levels would compromise pregnancy outcome...
  30. pmc Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 123:4063-75. 2013
    ....
  31. pmc Fatty acid amide hydrolase deficiency limits early pregnancy events
    Haibin Wang
    Department of Pediatrics, Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Clin Invest 116:2122-31. 2006
    ..This study uncovers what we believe to be a novel regulation of preimplantation processes, which could be clinically relevant for fertility regulation in women...
  32. pmc Loss of cannabinoid receptor 1 accelerates intestinal tumor growth
    Dingzhi Wang
    Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA
    Cancer Res 68:6468-76. 2008
    ..These results indicate that the endogenous cannabinoid system may represent a potential therapeutic target for prevention or treatment of colorectal cancer...
  33. ncbi request reprint Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus
    Takiko Daikoku
    Department of Pediatrics and Cancer Biology, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Endocrinol 19:683-97. 2005
    ..Collectively, these results and the female infertility phenotype of FKBP52 suggest that a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation...
  34. pmc Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus
    Xi Huang
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 136:2535-43. 2009
    ....
  35. ncbi request reprint Aberrant cannabinoid signaling impairs oviductal transport of embryos
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Med 10:1074-80. 2004
    ..Besides uncovering a new regulatory mechanism, this study could be clinically relevant to ectopic pregnancy...
  36. pmc In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus
    Xiaofei Sun
    Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Endocrinology 150:5065-73. 2009
    ..However, identifying definitive uterine function of LGR5 will require further investigation using conditional deletion of uterine Lgr5 because systemic deletion of this gene is neonatally lethal...
  37. pmc Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer
    Michael G Backlund
    Department of Medicine, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 68:9331-7. 2008
    ..These results also provide a cyclooxygenase-2-independent mechanism to explain increased PGE(2) levels that contribute to progression of CRC...
  38. pmc Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 65:3735-44. 2005
    ..The growth inhibitory effects of SC-560 result from reduced cell proliferation and/or accelerated apoptosis. Our results imply COX-1 as a target for the prevention and/or treatment of EOC...
  39. ncbi request reprint Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 18:1238-50. 2004
    ..Collectively, the present results provide evidence for a novel cytokine-homeotic-Wnt signaling network in implantation...
  40. ncbi request reprint Conditional gene recombination by adenovirus-driven Cre in the mouse uterus
    Haibin Wang
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Genesis 44:51-6. 2006
    ..These findings demonstrate the feasibility of achieving conditional expression or deletion of specific genes in uterine cells at desired times and physiological states...
  41. pmc Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2
    Carol A Rouzer
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Biochem J 399:91-9. 2006
    ..They also indicate that the 2-AG and AA used for PG-G and PG synthesis respectively are derived from independent pathways...
  42. ncbi request reprint Maternal pentraxin 3 deficiency compromises implantation in mice
    Susanne Tranguch
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Biol Reprod 77:425-32. 2007
    ..This study has clinical implications, since PTX3 is expressed in the receptive endometrium, and trophoblast cells influence decidual Ptx3 expression in humans...
  43. ncbi request reprint Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity
    Jiyoung Hong
    Pediatrics, Cell and Developmental Biology, Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Reproduction 133:395-403. 2007
    ..This study is clinically relevant because unraveling the role of immunophilin signaling in male fertility will help identify new targets for male contraceptives and/or alleviate male infertility...
  44. pmc Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:1145-50. 2012
    ..This is associated with the retention of the epithelium around the implantation chamber with arrested embryonic growth. These results suggest that Klf5 is indispensable for normal implantation...
  45. ncbi request reprint Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
    Jason R Mann
    Departments of Cell and Developmental Biology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, 2300 Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 66:6649-56. 2006
    ..These data indicate that PGDH may serve a tumor suppressor function in colorectal cancer and provide a possible COX-2-independent way to target PGE(2) to inhibit cancer progression...
  46. ncbi request reprint Lipid signaling in embryo implantation
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Prostaglandins Other Lipid Mediat 77:84-102. 2005
    ..A better understanding of these molecular signaling pathways is hoped to generate new strategies to correct implantation failure and improve pregnancy rates in women...
  47. ncbi request reprint Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Rajnish A Gupta
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Cancer Res 63:906-11. 2003
    ....
  48. ncbi request reprint Cyclooxygenase-2-derived prostaglandin E(2) directs oocyte maturation by differentially influencing multiple signaling pathways
    Toshifumi Takahashi
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 281:37117-29. 2006
    ....
  49. pmc Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:9960-5. 2005
    ....
  50. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes...
  51. pmc MicroRNA regulation of cyclooxygenase-2 during embryo implantation
    Anindita Chakrabarty
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:15144-9. 2007
    ..Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy...
  52. pmc Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
    Yasushi Hirota
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:18073-8. 2011
    ..This role of mTORC1 signaling in determining the timing of birth in mice may help us better understand the mechanism of the timing of birth in humans and develop new and improved strategies to combat the global problem of preterm birth...
  53. ncbi request reprint Mechanisms of implantation: strategies for successful pregnancy
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 18:1754-67. 2012
    ..Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization...
  54. pmc Endocannabinoid signaling directs periimplantation events
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    AAPS J 8:E425-32. 2006
    ..It is hoped that a deeper understanding will lead to potential clinical applications of the endocannabinoid system as a target for regulating female fertility...
  55. ncbi request reprint Progesterone receptor requires a co-chaperone for signalling in uterine biology and implantation
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    Reprod Biomed Online 13:651-60. 2006
    ..Future studies are likely to provide a better understanding of FKBP52-PR signalling in promoting uterine receptivity for implantation and may reveal new targets for improving infertility...
  56. ncbi request reprint Roadmap to embryo implantation: clues from mouse models
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Rev Genet 7:185-99. 2006
    ..A better understanding of periimplantation biology could alleviate female infertility and help to develop novel contraceptives...
  57. pmc Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation
    Wen ge Ma
    Division of Reproductive and Developmental Biology and Department of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:2963-8. 2003
    ..These results suggest that careful regulation of estrogen levels is one of the important factors for improvement of female fertility in IVFET programs...
  58. pmc Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
    Huirong Xie
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:18315-20. 2007
    ..Our study provides genetic evidence that HB-EGF is critical for normal implantation. This finding has high clinical relevance, because HB-EGF signaling is known to be important for human implantation...
  59. ncbi request reprint Jekyll and hyde: two faces of cannabinoid signaling in male and female fertility
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocr Rev 27:427-48. 2006
    ..It is hoped that a deeper insight would lead to potential clinical applications of the endocannabinoid signaling as a target for correcting infertility and improving reproductive health in humans...
  60. pmc Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation
    Haibin Wang
    Department of Pediatric, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 100:14914-9. 2003
    ....
  61. ncbi request reprint Canonical Wnt signaling is critical to estrogen-mediated uterine growth
    Xiaonan Hou
    Department of Pediatrics, D 4105 Medical Center North, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 18:3035-49. 2004
    ..Our present results provide evidence for a novel role of estrogen that targets early Wnt/beta-catenin signaling in an ER-independent manner to regulate the late uterine growth response that is ER dependent...
  62. doi request reprint Cannabinoid/Endocannabinoid signaling impact on early pregnancy events
    Xiaofei Sun
    Reproductive Sciences, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, 45229, USA
    Curr Top Behav Neurosci 1:255-73. 2009
    ..This review summarizes some aspects of these signaling molecules in preimplantation and implantation biology utilizing genetically engineered mouse models...
  63. pmc Endocannabinoid signaling in female reproduction
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, United States
    ACS Chem Neurosci 3:349-55. 2012
    ..This review focuses on various aspects of endocannabinoid signaling in female fertility...
  64. ncbi request reprint Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice
    Vladimir R Babaev
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
    Circulation 113:108-17. 2006
    ..Here, we examined the impact of COX-1 deficiency in bone marrow-derived cells on early atherogenesis in the mouse...
  65. pmc Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts
    Anna M Raines
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 140:2942-52. 2013
    ..These results identify novel molecular functions of Hox genes in the development of the male and female reproductive tracts. ..
  66. pmc Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    Yasushi Hirota
    The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 120:803-15. 2010
    ..Taken together, our observations underscore what we believe to be a new critical role of uterine p53 in parturition...