Sudhansu K Dey

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
    Kristin E Burnum
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 9104, USA
    Endocrinology 153:4568-79. 2012
  2. pmc Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 153:2486-93. 2012
  3. pmc How we are born
    Sudhansu K Dey
    Cincinnati Children s Research Foundation, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Clin Invest 120:952-5. 2010
  4. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
  5. pmc Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:1145-50. 2012
  6. pmc A new role for muscle segment homeobox genes in mammalian embryonic diapause
    Jeeyeon Cha
    Division of Reproductive Sciences, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Open Biol 3:130035. 2013
  7. pmc Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress
    Yasushi Hirota
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:15577-82. 2010
  8. pmc Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Hum Reprod 19:463-72. 2013
  9. pmc Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 123:4063-75. 2013
  10. pmc Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
    Huirong Xie
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 287:32288-97. 2012

Collaborators

Detail Information

Publications19

  1. pmc Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
    Kristin E Burnum
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 9104, USA
    Endocrinology 153:4568-79. 2012
    ..In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53...
  2. pmc Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 153:2486-93. 2012
    ..These findings suggest that uterine Gal1 is an important downstream target of P(4)-FKBP52-PR signaling in the uterus to support P(4) responsiveness during pregnancy...
  3. pmc How we are born
    Sudhansu K Dey
    Cincinnati Children s Research Foundation, Division of Reproductive Sciences, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Clin Invest 120:952-5. 2010
    ....
  4. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
    ....
  5. pmc Kruppel-like factor 5 (KLF5) is critical for conferring uterine receptivity to implantation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:1145-50. 2012
    ..This is associated with the retention of the epithelium around the implantation chamber with arrested embryonic growth. These results suggest that Klf5 is indispensable for normal implantation...
  6. pmc A new role for muscle segment homeobox genes in mammalian embryonic diapause
    Jeeyeon Cha
    Division of Reproductive Sciences, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Open Biol 3:130035. 2013
    ..These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness...
  7. pmc Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress
    Yasushi Hirota
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:15577-82. 2010
    ..This study shows that FKBP52-PRDX6 signaling protects pregnancy from overt OS...
  8. pmc Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Hum Reprod 19:463-72. 2013
    ..In conclusion, Tsc1(PR(d/d)) and Tsc1(Amhr2(d/d)) have overlapping yet distinct phenotypes in the context of compartment-specific deletion of Tsc1. ..
  9. pmc Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 123:4063-75. 2013
    ....
  10. pmc Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration
    Huirong Xie
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 287:32288-97. 2012
    ..This study provides evidence that a tightly regulated endocannabinoid signaling is critical to normal preimplantation embryo development and migration of trophoblast stem cells...
  11. pmc Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
    Yasushi Hirota
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:18073-8. 2011
    ..This role of mTORC1 signaling in determining the timing of birth in mice may help us better understand the mechanism of the timing of birth in humans and develop new and improved strategies to combat the global problem of preterm birth...
  12. pmc Uterine deletion of Gp130 or Stat3 shows implantation failure with increased estrogenic responses
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Mol Endocrinol 27:1492-501. 2013
    ..These changes in uteri of deleted mice were reflected by the failure of differentiation of the luminal epithelium, which is essential for blastocyst attachment. ..
  13. pmc Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts
    Anna M Raines
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Development 140:2942-52. 2013
    ..These results identify novel molecular functions of Hox genes in the development of the male and female reproductive tracts. ..
  14. doi request reprint Mechanisms of implantation: strategies for successful pregnancy
    Jeeyeon Cha
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Med 18:1754-67. 2012
    ..Understanding molecular signaling networks that coordinate strategies for successful implantation and decidualization may lead to approaches to improve the outcome of natural pregnancy and pregnancy conceived from in vitro fertilization...
  15. pmc Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:16887-92. 2010
    ....
  16. pmc Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    Yasushi Hirota
    The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 120:803-15. 2010
    ..Taken together, our observations underscore what we believe to be a new critical role of uterine p53 in parturition...
  17. pmc Endocannabinoid signaling in female reproduction
    Xiaofei Sun
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, United States
    ACS Chem Neurosci 3:349-55. 2012
    ..This review focuses on various aspects of endocannabinoid signaling in female fertility...
  18. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes...
  19. doi request reprint Cannabinoid/Endocannabinoid signaling impact on early pregnancy events
    Xiaofei Sun
    Reproductive Sciences, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, 45229, USA
    Curr Top Behav Neurosci 1:255-73. 2009
    ..This review summarizes some aspects of these signaling molecules in preimplantation and implantation biology utilizing genetically engineered mouse models...