Prasad Devarajan

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
  2. ncbi Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis
    Lindsey E Romick-Rosendale
    Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
    Arthritis Res Ther 13:R199. 2011
  3. ncbi Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
  4. ncbi Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
    Michael Zappitelli
    Texas Children s Hospital, Fannin Street, Houston, Texas 77030, USA
    Crit Care 11:R84. 2007
  5. ncbi The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
  6. ncbi Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics
    Prasad Devarajan
    Department of Nephrology, Cincinnati Children s Hospital, Medical Center and Research Foundation, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 80:365-76. 2003
  7. ncbi Cellular and molecular derangements in acute tubular necrosis
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    Curr Opin Pediatr 17:193-9. 2005
  8. ncbi Proteomic identification of early biomarkers of acute kidney injury after cardiac surgery in children
    Prasad Devarajan
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
    Am J Kidney Dis 56:632-42. 2010
  9. ncbi Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    Nephrology (Carlton) 15:419-28. 2010
  10. ncbi The use of targeted biomarkers for chronic kidney disease
    Prasad Devarajan
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Adv Chronic Kidney Dis 17:469-79. 2010

Detail Information

Publications88

  1. ncbi Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
    ..The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI...
  2. ncbi Identification of urinary metabolites that distinguish membranous lupus nephritis from proliferative lupus nephritis and focal segmental glomerulosclerosis
    Lindsey E Romick-Rosendale
    Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA
    Arthritis Res Ther 13:R199. 2011
    ....
  3. ncbi Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
    ..The purpose of this study was to test the role of serum cytokines as biomarkers for AKI and prolonged mechanical ventilation...
  4. ncbi Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
    Michael Zappitelli
    Texas Children s Hospital, Fannin Street, Houston, Texas 77030, USA
    Crit Care 11:R84. 2007
    ..It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in critically ill children...
  5. ncbi The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
    ..Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors...
  6. ncbi Gene expression in early ischemic renal injury: clues towards pathogenesis, biomarker discovery, and novel therapeutics
    Prasad Devarajan
    Department of Nephrology, Cincinnati Children s Hospital, Medical Center and Research Foundation, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 45229 3039, USA
    Mol Genet Metab 80:365-76. 2003
    ..The implications of these findings to the ability of the kidney to repair itself and potential strategies for accelerating recovery are briefly discussed...
  7. ncbi Cellular and molecular derangements in acute tubular necrosis
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229, USA
    Curr Opin Pediatr 17:193-9. 2005
    ..The purpose of this review is to summarize recent advances that have provided an improved understanding of the underlying cellular and molecular derangements, and have resulted in the design of novel therapeutic approaches...
  8. ncbi Proteomic identification of early biomarkers of acute kidney injury after cardiac surgery in children
    Prasad Devarajan
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229 3039, USA
    Am J Kidney Dis 56:632-42. 2010
    ..Serum creatinine is a delayed marker of acute kidney injury (AKI). Our purpose is to discover and validate novel early urinary biomarkers of AKI after cardiac surgery...
  9. ncbi Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    Nephrology (Carlton) 15:419-28. 2010
    ..However, given the complexity of AKI, additional biomarkers (perhaps a panel of plasma and urinary biomarkers) may eventually need to be developed and validated for optimal progress to occur...
  10. ncbi The use of targeted biomarkers for chronic kidney disease
    Prasad Devarajan
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Adv Chronic Kidney Dis 17:469-79. 2010
    ....
  11. ncbi Update on mechanisms of ischemic acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine, OH 45229-3039, USA
    J Am Soc Nephrol 17:1503-20. 2006
  12. ncbi Proteomics for biomarker discovery in acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Semin Nephrol 27:637-51. 2007
    ..Such studies will be facilitated markedly by the development of commercial tools for the reproducible measurement of biomarkers across different laboratories...
  13. ncbi Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 2029, USA
    Scand J Clin Lab Invest Suppl 241:89-94. 2008
    ..Such studies will be facilitated by the anticipated widespread availability of standardized commercial tools in the near future...
  14. ncbi Biomarkers for the early detection of acute kidney injury
    Prasad Devarajan
    Center for Acute Care Nephrology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:194-200. 2011
    ....
  15. ncbi Emerging biomarkers of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Contrib Nephrol 156:203-12. 2007
    ..Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies...
  16. ncbi Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Biomark Med 4:265-80. 2010
    ....
  17. ncbi Proteomics for the investigation of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Contrib Nephrol 160:1-16. 2008
    ..Based on the differential expression of the biomarkers, it is also likely that the AKI panels will distinguish between the various etiologies of AKI, and predict clinical outcomes...
  18. ncbi The future of pediatric acute kidney injury management--biomarkers
    Prasad Devarajan
    Departments of Pediatrics and Developmental Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Semin Nephrol 28:493-8. 2008
    ..The availability of a panel of validated biomarkers will revolutionize renal and critical care, and enable the practice of personalized and predictive medicine at an unprecedented level...
  19. ncbi Low renal toxicity of lipoplatin compared to cisplatin in animals
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Anticancer Res 24:2193-200. 2004
    ..This is proposed as one mechanism to explain the low renal toxicity of Lipoplatin...
  20. ncbi The promise of biomarkers for personalized renal cancer care
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    Kidney Int 77:755-7. 2010
    ..This Commentary reviews the current status of these biomarkers with respect to methodological issues, specificity, and biological plausibility...
  21. ncbi Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise
    Chirag R Parikh
    Clinical Epidemiology Research Center, Veterans Affairs Medical Center, West Haven, CT, USA
    Ann Clin Biochem 47:301-12. 2010
    ..Future studies will need to address these limitations in order for further progress to be made...
  22. ncbi Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  23. ncbi Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity
    Claas H Hinze
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio
    Arthritis Rheum 60:2772-81. 2009
    ..To determine whether neutrophil gelatinase-associated lipocalin (NGAL) can predict worsening of global and renal disease activity in childhood-onset systemic lupus erythematosus (SLE)...
  24. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
    Lancet 365:1231-8. 2005
    ..00, and specificity was 0.98 for a cutoff value of 50 microg/L. INTERPRETATION: Concentrations in urine and serum of NGAL represent sensitive, specific, and highly predictive early biomarkers for acute renal injury after cardiac surgery...
  25. ncbi Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort...
  26. ncbi IL-18 and urinary NGAL predict dialysis and graft recovery after kidney transplantation
    Isaac E Hall
    Department of Medicine, Yale University, West Haven, CT 06516, USA
    J Am Soc Nephrol 21:189-97. 2010
    ..In summary, urinary NGAL and IL-18 are early, noninvasive, accurate predictors of both the need for dialysis within the first week of kidney transplantation and 3-mo recovery of graft function...
  27. ncbi Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery
    Chirag R Parikh
    Section of Nephrology, Yale University and VAMC, 950 Campbell Avenue, Mail Code 151B, West Haven, CT 06516, USA
    J Am Soc Nephrol 22:1737-47. 2011
    ..In conclusion, urine IL-18 and urine NGAL, but not plasma NGAL, associate with subsequent AKI and poor outcomes among children undergoing cardiac surgery...
  28. ncbi NGAL is an early predictive biomarker of contrast-induced nephropathy in children
    Russel Hirsch
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 22:2089-95. 2007
    ..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN...
  29. ncbi Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass
    Catherine D Krawczeski
    The Heart Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Am Coll Cardiol 58:2301-9. 2011
    ....
  30. ncbi Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass
    Catherine D Krawczeski
    The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 5:1552-7. 2010
    ..Biomarkers that are sensitive and rapidly measurable could allow early intervention and improve patient outcomes. We investigated the value of serum cystatin C as an early biomarker for AKI after pediatric CPB...
  31. ncbi Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Arthritis Rheum 64:2687-97. 2012
    ....
  32. ncbi Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease
    Mark M Mitsnefes
    Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    Pediatr Nephrol 22:101-8. 2007
    ..62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR...
  33. ncbi Kidney NGAL is a novel early marker of acute injury following transplantation
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 21:856-63. 2006
    ..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation...
  34. ncbi Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin
    Jaya Mishra
    Division of Nephrology and Hypertension, MLC 7022, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Am Soc Nephrol 15:3073-82. 2004
    ..The results indicate that NGAL may represent a novel therapeutic intervention in ischemic acute renal failure, based at least in part on its ability to tilt the balance of tubule cell fate toward survival...
  35. ncbi Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery
    Chirag R Parikh
    Section of Nephrology, Yale University and Veterans Administration Medical Center, 950 Campbell Avenue, Mail Code 151B, West Haven, CT 06516, USA
    J Am Soc Nephrol 22:1748-57. 2011
    ..In conclusion, urine IL-18, urine NGAL, and plasma NGAL associate with subsequent AKI and poor outcomes among adults undergoing cardiac surgery...
  36. ncbi Biomarkers for the early detection of acute kidney injury
    Mai T Nguyen
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Nephrol 23:2151-7. 2008
    ..It will be important in future studies to validate the sensitivity and specificity of these biomarker panels in clinical samples from large cohorts and from multiple clinical situations...
  37. ncbi Induction of Zf9 in the kidney following early ischemia/reperfusion
    Ridwan Tarabishi
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Kidney Int 68:1511-9. 2005
    ..An improved understanding of the early cell injury mechanisms is critical for effective therapy of acute renal failure (ARF)...
  38. ncbi Induction of proapoptotic Daxx following ischemic acute kidney injury
    Qing Ma
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Kidney Int 74:310-8. 2008
    ..Antisense oligonucleotides to Daxx and specific JNK inhibitors blunted the apoptotic response to ATP depletion. These studies indicate that Daxx may play an unrecognized role in the early apoptotic response to ischemic renal injury...
  39. ncbi Urinary aprotinin as a predictor of acute kidney injury after cardiac surgery in children receiving aprotinin therapy
    Mai T Nguyen
    Department of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 23:1317-26. 2008
    ..We concluded that urinary aprotinin levels 2 h after initiation of CPB predict the development of AKI and adverse clinical outcomes...
  40. ncbi Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis
    Michiko Suzuki
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 65:530-6. 2009
    ..0001), and L-PGDS (p < 0.01) occurred, indicating that these PS proteins are biomarkers of LN activity and may help anticipate the future course of LN...
  41. ncbi Identification of a urinary proteomic signature for lupus nephritis in children
    Michiko Suzuki
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Pediatr Nephrol 22:2047-57. 2007
    ..90 for 22, 23, 44, 79, and 100 kDa biomarkers. Thus, SELDI-TOF-MS has identified a urine proteomic signature strongly associated with SLE renal involvement and active SLE nephritis...
  42. ncbi NGAL distinguishes steroid sensitivity in idiopathic nephrotic syndrome
    Michael R Bennett
    Division Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, ML 7022, Cincinnati, OH 45229, USA
    Pediatr Nephrol 27:807-12. 2012
    ..We set out to determine if urine NGAL can distinguish between patients with SRNS, SSNS, and healthy controls...
  43. ncbi Early prediction of acute renal injury using urinary proteomics
    Mai T Nguyen
    Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Am J Nephrol 25:318-26. 2005
    ..98. CONCLUSION: SELDI-TOF-MS is a novel, non-invasive, sensitive, highly predictive, reproducible, rapid method for the prediction of acute renal injury following CPB...
  44. ncbi Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA
    Am J Nephrol 24:307-15. 2004
    ..CONCLUSION: The results indicate that NGAL represents an early and quantitative urinary biomarker for cisplatin nephrotoxicity...
  45. ncbi Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  46. ncbi Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: roles of proteinuria and Fas-dependent pathways
    Elif Erkan
    Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA
    J Am Soc Nephrol 16:398-407. 2005
    ..The results indicate that an elevated tubule cell apoptosis rate at the time of initial biopsy represents an independent predictor of progression to ESRD in patients with early FSGS...
  47. ncbi Urinary NGAL in premature infants
    Adrian P Lavery
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Res 64:423-8. 2008
    ..We conclude that urine NGAL is easily obtained in premature infants and that it correlates significantly with both BW and gestational age. The use of urinary NGAL as a biomarker of AKI in premature infants warrants further investigation...
  48. ncbi Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass
    Catherine D Krawczeski
    Heart Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Pediatr 158:1009-1015.e1. 2011
    ..To investigate neutrophil gelatinase-associated lipocalin (NGAL) as an early acute kidney injury (AKI) biomarker after neonatal and pediatric cardiopulmonary bypass (CPB)...
  49. ncbi The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia
    Marcela Del Rio
    Department of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 15:41-51. 2004
    ..The results identify a novel tethering interaction between ankyrin and Fas in kidney epithelia and suggest that AnkG190 may play a role as an adapter molecule in renal tubule cell death...
  50. ncbi Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: a prospective multicenter study
    Simon Li
    Division of Pediatric Critical Care, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Crit Care Med 39:1493-9. 2011
    ..To determine the incidence, severity, and risk factors of acute kidney injury in children undergoing cardiac surgery for congenital heart defects...
  51. ncbi Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  52. ncbi New biomarkers of acute kidney injury
    Chirag R Parikh
    Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA
    Crit Care Med 36:S159-65. 2008
    ....
  53. ncbi Discovery and initial validation of α 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome
    Nuntawan Piyaphanee
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Proteomics Clin Appl 5:334-42. 2011
    ..In this cross-sectional pilot study we set out to discover a non-invasive biomarker that could distinguish steroid-resistant nephrotic syndrome (SRNS) from steroid-sensitive nephrotic syndrome (SSNS)...
  54. ncbi Biomarkers for early detection of sickle nephropathy
    Nambirajan Sundaram
    Division of Experimental Hematology and Cancer Biology, University of Cincinnati, Ohio, USA
    Am J Hematol 86:559-66. 2011
    ..Our study identifies potential biomarkers for SN, and suggests longitudinal validation of these biomarkers for early detection of SN, so that therapeutic interventions can be applied before renal damage becomes irreversible...
  55. ncbi Serum cystatin C and left ventricular diastolic dysfunction in children with chronic kidney disease
    Mark Mitsnefes
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    Pediatr Nephrol 21:1293-8. 2006
    ..0173, P=0.01). We conclude that, in contrast to measured GFR or serum creatinine level, elevated serum cystatin C might be associated with diastolic dysfunction in children with CKD...
  56. ncbi Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis
    Kimberly A Czech
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital and Medical Center, 3333 Burnet Ave, MLC 7022, Cincinnati, OH 45229, USA
    Pediatr Nephrol 26:2179-84. 2011
    ..In addition, they may represent therapeutic targets for preventing chronic kidney disease progression in FSGS...
  57. ncbi Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 54:2577-84. 2006
    ..We undertook this study to determine the relationship between urinary NGAL excretion and SLE disease activity or damage, with a focus on nephritis...
  58. ncbi Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis
    Michiko Suzuki
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Nephrol 23:403-12. 2008
    ..3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p = not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE...
  59. ncbi Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli
    Michael R Bennett
    Division of Nephrology and Hypertension, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Nephron Exp Nephrol 107:e30-40. 2007
    ..These results confirm old findings, and indicate the involvement of new genetic pathways in the cause and progression of FSGS...
  60. ncbi Preterm labor biomarker discovery in serum using 3 proteomic profiling methodologies
    Caroline L Stella
    Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:387.e1-13. 2009
    ..The aim of this study was to identify changes in protein expression in normal pregnancy compared with preterm labor by using 3 proteomic methods...
  61. ncbi Biomarkers of acute kidney injury: early diagnosis, pathogenesis, and recovery
    Chirag R Parikh
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Investig Med 55:333-40. 2007
    ..The final talk discussed the role of circulating stem cells in renal tubule regeneration after ischemic injury and if they have potential for biomarkers of recovery or therapeutic intervention...
  62. ncbi Antecedent acute kidney injury worsens subsequent endotoxin-induced lung inflammation in a two-hit mouse model
    Rajit K Basu
    Divisions of Critical Care, Cincinnati Children s Hospital and Medical Center, Ohio, USA
    Am J Physiol Renal Physiol 301:F597-604. 2011
    ..The model holds clinical relevance for patients at risk of lung injury after ischemic injury to the kidney...
  63. ncbi Proteomic analysis of acute kidney injury: biomarkers to mechanisms
    Michael R Bennett
    Cincinnati Children s Hospital Medical Center, Division of Nephrology and Hypertension, and University of Cincinnati College of Medicine, Department of Pediatrics, Cincinnati, OH 45229, USA
    Proteomics Clin Appl 5:67-77. 2011
    ..This review concludes with a discussion of the future of proteomics and personalized medicine in AKI and the challenges presented in translating these exciting proteomic results to the clinic...
  64. ncbi Microarray analysis of focal segmental glomerulosclerosis
    Kristopher Schwab
    Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Nephrol 24:438-47. 2004
    ..The genes and genetic pathways identified in this study can be compared to results of similar studies of other diseases to examine specificity and used to study the pathogenesis of FSGS...
  65. ncbi An update and review of acute kidney injury in pediatrics
    Rajit K Basu
    Division of Critical Care, Department of Pediatrics, Cincinnati Children s Hospital and Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Pediatr Crit Care Med 12:339-47. 2011
    ..To inform the pediatric intensivist of recent advancements in acute kidney injury diagnosis and management...
  66. ncbi Acute kidney injury in childhood: should we be worried about progression to CKD?
    Stuart L Goldstein
    Center for Acute Care Nephrology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, MLC 7022, Cincinnati, OH 54229 3039, USA
    Pediatr Nephrol 26:509-22. 2011
    ....
  67. ncbi Neonatal renovascular hypertension due to prenatal traumatic retroperitoneal hematoma
    Bradley P Dixon
    Department of Pediatrics, Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Nephrol 20:670-2. 2005
    ..Likewise, attention must be drawn to the classic presentation of congestive heart failure in a child with severe hypertension...
  68. ncbi NGAL in acute kidney injury: from serendipity to utility
    Prasad Devarajan
    Am J Kidney Dis 52:395-9. 2008
  69. ncbi Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways
    Moon Soo Park
    Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, New York, NY, USA
    J Am Soc Nephrol 13:858-65. 2002
    ..Inhibition of this specific pathway may provide a strategy to minimize cisplatin-induced nephrotoxicity...
  70. ncbi Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  71. ncbi Human PRMT5 expression is enhanced during in vitro tubule formation and after in vivo ischemic injury in renal epithelial cells
    Michael C Braun
    Division of Pediatric Nephrology and Hypertension, Institute for Molecular Medicine, Houston, TX, USA
    Am J Nephrol 24:250-7. 2004
    ....
  72. ncbi Differential gene expression following early renal ischemia/reperfusion
    Suroj Supavekin
    Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    Kidney Int 63:1714-24. 2003
    ....
  73. ncbi Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways
    Prasad Devarajan
    Division of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Hear Res 174:45-54. 2002
    ..Our results indicate the involvement of both the death receptor mechanisms as well as mitochondrial pathways in cisplatin-induced apoptosis of auditory cells in an in vitro model system...
  74. ncbi Dissociation of spectrin-ankyrin complex as a basis for loss of Na-K-ATPase polarity after ischemia
    Robert Woroniecki
    Division of Pediatric Nephrology, Albert Einstein College of Medicine, New York, New York 10467, USA
    Am J Physiol Renal Physiol 284:F358-64. 2003
    ....
  75. ncbi Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury
    Howard Trachtman
    Department of Pediatrics Division of Nephrology, Schneider Children s Hospital of the North Shore Long Island Jewish Medical Center, New Hyde Park, New York, NY, USA
    Pediatr Nephrol 21:989-94. 2006
    ..Diarrhea-associated hemolytic uremic syndrome (D+HUS) causes acute renal failure. Neutrophil gelatinase-associated lipocalcin (NGAL) is an early indicator of kidney injury...
  76. ncbi Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Opin Nephrol Hypertens 15:442-9. 2006
    ..The data have implications for the diagnosis and treatment of acute renal injury...
  77. ncbi Metabonomics of acute kidney injury in children after cardiac surgery
    Richard D Beger
    Division of Systems Toxicology, United States Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Pediatr Nephrol 23:977-84. 2008
    ..90 and specificity was 0.95 for a cut-off value of 24 ng/microl for HVA-SO4 at 12 h after surgery. We concluded that urinary HVA-SO4 represents a novel, sensitive, and predictive early biomarker of AKI after pediatric cardiac surgery...
  78. ncbi Dual action of neutrophil gelatinase-associated lipocalin
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Am Soc Nephrol 18:407-13. 2007
    ..This review summarizes the current knowledge about the dual effects of NGAL as a siderophore:iron-binding protein and as a growth factor and examines the role of these effects in renal injury...
  79. ncbi Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    ..A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia...
  80. ncbi Biomarkers in acute and chronic kidney disease
    Thomas L Nickolas
    Renal Division, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
    Curr Opin Nephrol Hypertens 17:127-32. 2008
    ..The paucity of early, predictive, noninvasive biomarkers has impaired our ability to institute potentially effective therapies for acute kidney injury and chronic kidney disease in a timely manner...
  81. ncbi Improving outcomes from acute kidney injury: report of an initiative
    Arvind Bagga
    Pediatr Nephrol 22:1655-8. 2007
    ..The vital role of multi-disciplinary conferences for disseminating knowledge and clarifying issues in clinical practice was recognized...
  82. ncbi Progression from acute kidney injury to chronic kidney disease: a pediatric perspective
    Stuart L Goldstein
    Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, TX, USA
    Adv Chronic Kidney Dis 15:278-83. 2008
    ....
  83. ncbi Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injury
    M Patricia Castaneda
    Division of Nephrology, Children's Hospital at Montefiore, Bronx, New York, USA
    Transplantation 76:50-4. 2003
    ..CONCLUSIONS: Ischemia-reperfusion injury in CAD kidney transplants is associated with a duration-dependent increase in tubular cell apoptosis, mediated at least in part by activation of mitochondrial pathways...
  84. ncbi A framework and key research questions in AKI diagnosis and staging in different environments
    Patrick T Murray
    Department of Medicine, Section of Nephrology, MC 5100, Room S 511, University of Chicago Hospitals, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Clin J Am Soc Nephrol 3:864-8. 2008
    ....
  85. ncbi Case 31-2007: a man with abdominal pain and elevated creatinine
    Prasad Devarajan
    N Engl J Med 358:312; author reply 313. 2008
  86. ncbi Apoptotic response to albumin overload: proximal vs. distal/collecting tubule cells
    Elif Erkan
    Golisano Children s Hospital at Strong, University of Rochester, Rochester, NY 14642, USA
    Am J Nephrol 25:121-31. 2005
    ....
  87. ncbi Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells
    Elif Erkan
    Department of Pediatrics, University of Rochester, School of Medicine, Rochester, New York, USA
    J Am Soc Nephrol 18:1199-208. 2007
    ..It is concluded that albumin induces apoptosis in human proximal tubule cells by stimulating mitochondrial apoptotic pathway independent of ROS production...
  88. ncbi Role of nitric oxide, endothelin-1, and inflammatory cytokines in blood pressure regulation in hemodialysis patients
    Elif Erkan
    Albert Einstein College of Medicine, Division of Pediatric Nephrology, Montefiore Medical Center, Bronx, NY, USA
    Am J Kidney Dis 40:76-81. 2002
    ..The purpose of this study is to investigate the relationship between cytokine-mediated activation of the NO and ET-1 systems and BP regulation in hemodialysis patients...