Lee Denson

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi How does knowledge from translational research impact our clinical care of pediatric inflammatory bowel disease patients?
    Lee A Denson
    Pediatric Gastroenterology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Gastroenterol Rep 14:275-81. 2012
  2. ncbi Growth hormone therapy in children and adolescents: pharmacokinetic/pharmacodynamic considerations and emerging indications
    Lee A Denson
    University of Cincinnati College of Medicine, The Cincinnati Children s Hospital Medical Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, MLC 2010, 3333 Burnet Avenue, 45229, Cincinnati, Ohio, USA
    Expert Opin Drug Metab Toxicol 4:1569-80. 2008
  3. ncbi A randomized controlled trial of growth hormone in active pediatric Crohn disease
    Lee A Denson
    Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Pediatr Gastroenterol Nutr 51:130-9. 2010
  4. ncbi Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
  5. ncbi Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
  6. ncbi Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis
    Richard Ahrens
    Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine, CCHMC, Cincinnati, OH 45229, USA
    J Immunol 181:7390-9. 2008

Research Grants

  1. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
  2. Cytokine Regulation of Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2007
  3. Biomarkers for Inflammatory Bowel Disease Behavior and Treatment Response
    Lee Denson; Fiscal Year: 2009
  4. Cytokine Regulation of Growth Hormone Signaling
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
  5. Biomarkers for Inflammatory Bowel Disease Behavior and Treatment Response
    LEE ARMISTEAD DENSON; Fiscal Year: 2010

Collaborators

  • Ariel Munitz
  • Xiaonan Han
  • Richard Moriggl
  • Maria Lampinen
  • Nancy Lee
  • Shila Gilbert
  • Richard Ahrens
  • Kris Steinbrecher
  • Rongli Zhang
  • NOAH SHROYER
  • James Lin
  • Keith Stringer
  • Luqman Seidu
  • Edgar Ballard
  • Huan Xu
  • Simon P Hogan
  • Tara Wilson
  • James J Lee
  • Elizabeth Forbes
  • Carine Blanchard
  • Elizabeth Cohen
  • Amanda Waddell
  • Rebecca Carey
  • Marc E Rothenberg

Detail Information

Publications6

  1. ncbi How does knowledge from translational research impact our clinical care of pediatric inflammatory bowel disease patients?
    Lee A Denson
    Pediatric Gastroenterology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Gastroenterol Rep 14:275-81. 2012
    ..More recently, clinical and genetic models have been developed that, if validated, could be used to predict treatment responses...
  2. ncbi Growth hormone therapy in children and adolescents: pharmacokinetic/pharmacodynamic considerations and emerging indications
    Lee A Denson
    University of Cincinnati College of Medicine, The Cincinnati Children s Hospital Medical Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, MLC 2010, 3333 Burnet Avenue, 45229, Cincinnati, Ohio, USA
    Expert Opin Drug Metab Toxicol 4:1569-80. 2008
    ..However, given the high cost and potential for rare side effects, controversy remains about the optimal indications, dose and duration of hGH therapy for both the approved and investigational conditions...
  3. ncbi A randomized controlled trial of growth hormone in active pediatric Crohn disease
    Lee A Denson
    Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Pediatr Gastroenterol Nutr 51:130-9. 2010
    ..The effect on mucosal inflammation is not known. We hypothesized that GH would improve both clinical and mucosal disease activity and stimulate linear growth in pediatric CD...
  4. ncbi Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
    Shila Gilbert
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, OH, USA
    EMBO Mol Med 4:109-24. 2012
    ..Targeting IEC STAT5 signalling may be a novel therapeutic approach for treating intestinal barrier dysfunction in IBD...
  5. ncbi Paired immunoglobulin-like receptor B (PIR-B) negatively regulates macrophage activation in experimental colitis
    Ariel Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Gastroenterology 139:530-41. 2010
    ..We examined the role of the inhibitory receptor paired immunoglobulin-like receptor B (PIR-B) in the regulation of macrophage function in innate intestinal immunity...
  6. ncbi Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis
    Richard Ahrens
    Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine, CCHMC, Cincinnati, OH 45229, USA
    J Immunol 181:7390-9. 2008
    ....

Research Grants8

  1. Cytokine Regulation of Liver Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2004
    ..These findings will have implications for therapeutic strategies to ameliorate acquired GH resistance in diseases complicated by liver inflammation, including chronic cholestatic liver diseases ..
  2. Cytokine Regulation of Growth Hormone Signaling
    Lee Denson; Fiscal Year: 2007
    ..If the proposed studies support the utility of TNF blockade in reversing GH resistance in colitis, these findings should translate into improved clinical therapies for children with IBD. ..
  3. Biomarkers for Inflammatory Bowel Disease Behavior and Treatment Response
    Lee Denson; Fiscal Year: 2009
    ..These studies will advance the care of IBD patients by providing for the first time a biomarker which will both predict risk for complicated disease, and guide targeted biologic therapy more likely to modify the disease course. ..
  4. Cytokine Regulation of Growth Hormone Signaling
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
    ..If the proposed studies support the utility of TNF blockade in reversing GH resistance in colitis, these findings should translate into improved clinical therapies for children with IBD. ..
  5. Biomarkers for Inflammatory Bowel Disease Behavior and Treatment Response
    LEE ARMISTEAD DENSON; Fiscal Year: 2010
    ..These studies will advance the care of IBD patients by providing for the first time a biomarker which will both predict risk for complicated disease, and guide targeted biologic therapy more likely to modify the disease course. ..