Stella Davies

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Subsequent malignant neoplasms in survivors of childhood cancer: Childhood Cancer Survivor Study (CCSS) studies
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 48:727-30. 2007
  2. ncbi request reprint GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
  3. ncbi request reprint Susceptibility to cancer: why did this happen to my child?
    Stella M Davies
    Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
    Pediatr Blood Cancer 43:536-8. 2004
  4. pmc Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Stella M Davies
    Department of Pediatrics, Cincinnati Children s Hospital and Medical Center, OH 45230, USA
    Blood 111:2984-90. 2008
  5. doi request reprint Pediatric acute lymphoblastic leukemia: is there still a role for transplant?
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45230, USA
    Hematology Am Soc Hematol Educ Program 2010:363-7. 2010
  6. ncbi request reprint XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease
    Ann C Mertens
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Cancer 101:1463-72. 2004
  7. ncbi request reprint Matched sibling donor haematopoietic stem cell transplantation in Fanconi anaemia: an update of the Cincinnati Children's experience
    Azadeh Farzin
    Divisions of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Br J Haematol 136:633-40. 2007
  8. ncbi request reprint Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival
    William R Kiffmeyer
    Department of Pediatrics, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 100:411-7. 2004
  9. ncbi request reprint Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemia
    Franklin O Smith
    Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 116:716-24. 2002
  10. ncbi request reprint High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study
    Parinda Mehta
    Division of Hematology Oncology and PPRU, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 12:235-40. 2006

Research Grants

  1. THERAPY-RELATED LEUKEMIA--CLINICAL/BIOLOGIC PREDICTORS
    Stella Davies; Fiscal Year: 2002
  2. Host factors and etiology of leukemia
    Stella Davies; Fiscal Year: 2003

Detail Information

Publications63

  1. ncbi request reprint Subsequent malignant neoplasms in survivors of childhood cancer: Childhood Cancer Survivor Study (CCSS) studies
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 48:727-30. 2007
    ..The planned formation of a new CCSS cohort, treated with more modern therapy, will allow the extension of these studies to younger populations and will define their experience of subsequent malignant neoplasms...
  2. ncbi request reprint GST genotype may modify clinical phenotype in patients with Fanconi anaemia
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45329, USA
    Br J Haematol 131:118-22. 2005
    ..GSTM1 genotype significantly influenced time to bone marrow failure in complementation group FA-C, (median age 3.0 years vs. 7.0 years, P < 0.01). GSTP1 genotype did not influence FA phenotype...
  3. ncbi request reprint Susceptibility to cancer: why did this happen to my child?
    Stella M Davies
    Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
    Pediatr Blood Cancer 43:536-8. 2004
  4. pmc Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group
    Stella M Davies
    Department of Pediatrics, Cincinnati Children s Hospital and Medical Center, OH 45230, USA
    Blood 111:2984-90. 2008
    ..009, logistic regression), when comparing "best" and "worst" risk groups. These data are consistent with growing evidence that both acquired and host genetics influence response to cancer therapy...
  5. doi request reprint Pediatric acute lymphoblastic leukemia: is there still a role for transplant?
    Stella M Davies
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45230, USA
    Hematology Am Soc Hematol Educ Program 2010:363-7. 2010
    ..However, a rigorous approach must be taken in determining whether transplant does improve outcome whenever this strategy is applied...
  6. ncbi request reprint XRCC1 and glutathione-S-transferase gene polymorphisms and susceptibility to radiotherapy-related malignancies in survivors of Hodgkin disease
    Ann C Mertens
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Cancer 101:1463-72. 2004
    ..Survivors of Hodgkin disease (HD), in particular, have been shown to be at high risk of subsequent malignancy, the occurrence of which has been associated strongly with exposure to radiotherapy...
  7. ncbi request reprint Matched sibling donor haematopoietic stem cell transplantation in Fanconi anaemia: an update of the Cincinnati Children's experience
    Azadeh Farzin
    Divisions of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Br J Haematol 136:633-40. 2007
    ..These data indicate excellent long-term outcomes and serve as a reference for newer radiation-free preparative regimes that may reduce the risk of late secondary malignancy...
  8. ncbi request reprint Genetic polymorphisms in the Hmong population: implications for cancer etiology and survival
    William R Kiffmeyer
    Department of Pediatrics, University of Minnesota Cancer Center, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer 100:411-7. 2004
    ..The authors compared frequencies of common genetic polymorphisms believed to influence risk of malignancy to determine whether frequencies in the Hmong are different from those in other Asian populations and in white Minnesotans...
  9. ncbi request reprint Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemia
    Franklin O Smith
    Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 116:716-24. 2002
    ..With lower relapse observed in patients with chronic GVHD, new treatment strategies that focus on enhancing the graft-versus-leukaemia effect may improve survival...
  10. ncbi request reprint High-dose weekly AmBisome antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study
    Parinda Mehta
    Division of Hematology Oncology and PPRU, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 12:235-40. 2006
    ..Our data show measurable amphotericin B plasma concentrations 7 days after high-dose infusion of AmBisome. This suggests that once-weekly dosing, as described in this study, may provide useful protection against fungal infections...
  11. ncbi request reprint XPD Lys751Gln polymorphism in the etiology and outcome of childhood acute myeloid leukemia: a Children's Oncology Group report
    Parinda A Mehta
    Cincinnati Children s Hospital and Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Blood 107:39-45. 2006
    ..These data, representing the only data in pediatric AML, suggest that XPD genotype does not affect the etiology or outcome of childhood AML...
  12. ncbi request reprint Pharmacogenetics of acute lymphoblastic leukemia
    Parinda A Mehta
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Hematol 11:434-8. 2004
    ..This review discusses literature reports in this area and describes some of the challenges facing the field as it moves forward...
  13. pmc Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia
    Parinda A Mehta
    Division of Haematology Oncology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 137:152-7. 2007
    ..We did not observe an association with IL-1alpha genotype in donor and/or recipient and transplant-outcome. These data suggest that the outcome of unrelated donor transplant for CML is not influenced by IL-1alpha genotype...
  14. ncbi request reprint Chemotherapy for myeloid malignancy in children with Fanconi anemia
    Parinda A Mehta
    Fanconi Anemia Comprehensive Care Center, Cincinnati Children s Hospital Medical Center CCHMC, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 48:668-72. 2007
    ..In this report we describe the toxicity of a chemotherapy approach for patients with FA and myeloid malignancy to achieve cytoreduction prior to SCT...
  15. ncbi request reprint Pre-transplant minimal residual disease in children with acute lymphoblastic leukemia
    Parinda A Mehta
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Pediatr Blood Cancer 48:1-2. 2007
  16. ncbi request reprint High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation
    Margaret L Macmillan
    Department of Pediatrics, University of Minnesota, MMC 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Transplantation 76:1758-62. 2003
    ..Because IL-2 is a proinflammatory cytokine, we hypothesized that recipients with high-producer genotypes would have increased frequency of GVHD after allogeneic bone marrow transplantation (BMT)...
  17. doi request reprint Alternate-day micafungin antifungal prophylaxis in pediatric patients undergoing hematopoietic stem cell transplantation: a pharmacokinetic study
    Parinda A Mehta
    Division of Bone Marrow Transplantation Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Biol Blood Marrow Transplant 16:1458-62. 2010
    ..These data suggest that alternate day micafungin dosing, as described here, may provide an attractive alternative for antifungal prophylaxis in HSCT patients and merits further evaluation...
  18. pmc Recent decrease in acute graft-versus-host disease in children with leukemia receiving unrelated donor bone marrow transplants
    Stella M Davies
    Dept of Pediatrics, Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
    Biol Blood Marrow Transplant 15:360-6. 2009
    ..93; 95% CI = 1.27 to 2.91; P = .002). We conclude that outcomes have changed significantly over time, with a reduced risk of aGVHD associated with the more recent transplantations...
  19. ncbi request reprint Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems
    Margaret L Macmillan
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:387-94. 2002
    ..More effective prophylaxis and therapy for acute GVHD is needed for mismatched unrelated donor recipients and for those with severe GVHD...
  20. ncbi request reprint Early antithymocyte globulin therapy improves survival in patients with steroid-resistant acute graft-versus-host disease
    Margaret L Macmillan
    Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:40-6. 2002
    ..These data suggest that treatment with ATG can be an active therapy, especially in patients with skin GVHD and early signs of steroid resistance...
  21. pmc FAS promoter polymorphism: outcome of childhood acute myeloid leukemia. A children's oncology group report
    Parinda A Mehta
    Division of Hematology Oncology, Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio 45229, USA
    Clin Cancer Res 14:7896-9. 2008
    ..We hypothesized that FAS genotype by altering susceptibility to apoptosis might affect outcome of childhood AML therapy...
  22. pmc MDM2 polymorphism increases susceptibility to childhood acute myeloid leukemia: a report from the Children's Oncology Group
    Christine L Phillips
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Pediatr Blood Cancer 55:248-53. 2010
    ..In addition, cells homozygous (G/G) for SNP 309 were found to have 10-fold increase resistance to topoisomerase II inhibitors in vitro...
  23. doi request reprint Reduced-intensity conditioning significantly improves survival of patients with hemophagocytic lymphohistiocytosis undergoing allogeneic hematopoietic cell transplantation
    Rebecca A Marsh
    Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 116:5824-31. 2010
    ..0001). We conclude that RIC significantly improves the outcome of patients with HLH undergoing allogeneic HCT...
  24. pmc Hematopoietic stem cell transplantation for refractory or recurrent non-Hodgkin lymphoma in children and adolescents
    Thomas G Gross
    Department of Pediatrics, Nationwide Children s Hospital, Ohio State University, Columbus, Ohio 43205, USA
    Biol Blood Marrow Transplant 16:223-30. 2010
    ..These data were unable to demonstrate a difference in outcome by donor type for the other histological subtypes...
  25. pmc Cytidine deaminase genotype and toxicity of cytosine arabinoside therapy in children with acute myeloid leukemia
    Deepika Bhatla
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Br J Haematol 144:388-94. 2009
    ..59 +/- 12% AA and 55 +/- 14% AC; P = 0.40). These data indicate that children with a low activity CDA genotype are at increased risk of TRM with ara-C based therapy for AML...
  26. ncbi request reprint Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group
    Logan G Spector
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:651-5. 2005
    ..We hypothesized that maternal consumption of dietary DNAt2 inhibitors during pregnancy would increase the risk of infant leukemia, particularly AML(MLL+)...
  27. ncbi request reprint Trends in leukemia incidence and survival in the United States (1973-1998)
    Yang Xie
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer 97:2229-35. 2003
    ..Although the overall incidence of leukemia has been declining in the United States, recent reports suggest that incidence rates may be increasing for certain age and racial groups...
  28. doi request reprint Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia: a report from the Childhood Cancer Survivor Study
    Daniel A Mulrooney
    Department of Pediatrics, University of Minnesota Medical School and Cancer Center, Minneapolis, MN 55455, USA
    Cancer 112:2071-9. 2008
    ..Limited data exist on the comprehensive assessment of late medical and social effects experienced by survivors of childhood and young adult acute myeloid leukemia (AML)...
  29. pmc Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome
    Daren Wang
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 106:19958-63. 2009
    ..This approach provides a paradigm for the utilization of RBC precursors as a depot for efficient and potentially safer systemic delivery of nonsecreted proteins by ex vivo HSC gene transfer...
  30. ncbi request reprint Prescription medication use during pregnancy and risk of infant leukemia (United States)
    Julie A Ross
    Department of Pediatrics, University of Minnesota, USA
    Cancer Causes Control 14:447-51. 2003
    ..We explored whether maternal medication use during pregnancy may be an important etiologic area for investigation in studies of infant leukemia...
  31. doi request reprint Indications for hematopoietic cell transplantation in acute leukemia
    Stella M Davies
    Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
    Biol Blood Marrow Transplant 14:154-64. 2008
    ....
  32. ncbi request reprint Stem cell collection and gene transfer in Fanconi anemia
    Patrick F Kelly
    Fanconi Anemia Comprehensive Care Center, Divisions of Experimental Hematology and Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Mol Ther 15:211-9. 2007
    ..Our early experience shows that stem cell collection is well tolerated in FA patients and suggests that collection be considered as early as possible in patients who are potential candidates for future gene transfer trials...
  33. pmc Infant leukemia and congenital abnormalities: a Children's Oncology Group study
    Kimberly J Johnson
    Division of Epidemiology Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Pediatr Blood Cancer 55:95-9. 2010
    ..Differences in survival and the molecular characteristics of leukemia in infants versus older children suggest a distinct etiology, likely involving prenatal factors...
  34. ncbi request reprint Etiology of childhood cancer: recent reports
    Julie A Ross
    Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Pediatr Blood Cancer 45:239-41. 2005
  35. doi request reprint Hematopoietic stem cell transplantation for bone marrow failure syndromes in children
    Kasiani C Myers
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Biol Blood Marrow Transplant 15:279-92. 2009
    ....
  36. ncbi request reprint Genetic variation in the leptin receptor gene and obesity in survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study
    Julie A Ross
    Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 22:3558-62. 2004
    ....
  37. ncbi request reprint Recent report in the etiology of childhood cancer: 'greatest hits'
    Julie A Ross
    Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 42:3-7. 2004
  38. ncbi request reprint Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group
    Logan G Spector
    Division of Epidemiology Clinical Research, Department of Pediatrics, University of Minnesota, 420 Delaware Street Southeast, MMC 715, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 16:128-34. 2007
    ..Other variables of interest were not notably associated with infant leukemia regardless of MLL status. This investigation further supports the contention that molecularly defined subtypes of infant leukemia have separate etiologies...
  39. doi request reprint Individual physician practice variation in hematopoietic cell transplantation
    Stephanie J Lee
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D5 290, Seattle, WA 98109, USA
    J Clin Oncol 26:2162-70. 2008
    ..Previous studies have evaluated practice variation in hematopoietic cell transplantation (HCT) among transplant centers and countries. There are no studies investigating individual physician practice variation in HCT...
  40. doi request reprint Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
    Javier G Blanco
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    Cancer 112:2789-95. 2008
    ....
  41. doi request reprint Twenty years of unrelated donor bone marrow transplantation for pediatric acute leukemia facilitated by the National Marrow Donor Program
    Margaret L Macmillan
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:16-22. 2008
    ..Notably, this improvement over time was not observed in unmodified peripheral blood stem cell (PBSC) recipients, suggesting unmodified PBSC may not be the optimal stem cell source for children...
  42. pmc HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation
    Judith A Wade
    Department of Surgery, University of Toronto, Ontario, Canada
    Blood 109:4064-70. 2007
    ..001). For patients without an HLA match, the selection of a CREG-compatible donor as tested does not improve outcome...
  43. ncbi request reprint Chronic graft-versus-host disease: a prospective cohort study
    Mukta Arora
    Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 9:38-45. 2003
    ..Recognition of a high-risk group should facilitate assignment of more intensified regimens. Better treatment regimens need to be identified to improve survival and limit toxicity of prolonged immunosuppression...
  44. ncbi request reprint Interleukin-1 genotype and outcome of unrelated donor bone marrow transplantation
    Margaret L Macmillan
    Pediatrics Department, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Br J Haematol 121:597-604. 2003
    ..2, P < 0.01) and decreased TRM (RR 0.1, P < 0.01). These data suggest that donor polymorphism in IL-1alpha and IL-1beta might influence survival after unrelated donor BMT, but does not alter risk of GVHD...
  45. ncbi request reprint Interleukin-10 and tumor necrosis factor alpha region haplotypes predict transplant-related mortality after unrelated donor stem cell transplantation
    Leigh J Keen
    Molecular Immunogenetics Laboratory, Department of Pathology and Microbiology, University of Bristol, United Kingdom
    Blood 103:3599-602. 2004
    ..01. No independent associations of cytokine polymorphisms with acute graft-versus-host disease were shown...
  46. ncbi request reprint Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor
    Stella M Davies
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
    Blood 100:3825-7. 2002
    ..It is possible that there will be a benefit of NK cell alloreactivity if strategies of haploidentical transplantation are used: high stem cell doses, extensive T-cell depletion, and no postgrafting immune suppression...
  47. ncbi request reprint Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  48. ncbi request reprint Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months
    Mary Eapen
    Center for Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Oncol 24:145-51. 2006
    ..To describe outcomes after unrelated donor stem cell transplantation (HCT) in children (< 18 months at diagnosis) with acute leukemia and compare these with outcomes after human leukocyte antigen (HLA)-matched sibling donor HCT...
  49. ncbi request reprint Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia
    Jorge Sierra
    International Bone Marrow Transplant Registry IBMTR, Health Policy Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Blood 100:1997-2004. 2002
    ..Best candidates are younger patients with a low percentage of blasts and preserved platelet counts...
  50. pmc Outcomes after HLA-matched sibling transplantation or chemotherapy in children with B-precursor acute lymphoblastic leukemia in a second remission: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Tr
    Mary Eapen
    Statistical Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Blood 107:4961-7. 2006
    ..92; 95% CI, 0.49-1.70, P = .78). These data support HLA-matched sibling donor transplantation using a TBI-containing regimen in second CR for children with ALL and early relapse...
  51. pmc Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group
    Richard Aplenc
    Pediatric Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 108:74-80. 2006
    ..Fewer black children than expected had an available family marrow donor...
  52. ncbi request reprint The effect of KIR ligand incompatibility on the outcome of unrelated donor transplantation: a report from the center for international blood and marrow transplant research, the European blood and marrow transplant registry, and the Dutch registry
    Sherif S Farag
    The Ohio State University, Columbus, Ohio 43210, USA
    Biol Blood Marrow Transplant 12:876-84. 2006
    ..There were no differences in leukemia recurrence between the 4 groups. These results do not support the choice of an unrelated donor on the basis of KIR ligand mismatch determined from HLA typing...
  53. ncbi request reprint Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adults
    Juliet N Barker
    The University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
    Br J Haematol 118:101-7. 2002
    ..Future efforts should focus on improving the outcome for older BMT recipients, especially those with diagnoses other than CML...
  54. ncbi request reprint Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia
    Stella M Davies
    Children s Oncology Group, Arcadia, CA 91066 6012, USA
    Blood 100:67-71. 2002
    ..These data, representing a larger series than any reported previously, suggest that GST genotype does not affect etiology or outcome of childhood ALL...
  55. ncbi request reprint Childhood cancer etiology: recent reports
    Stella M Davies
    Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis 55455, USA
    Med Pediatr Oncol 40:35-8. 2003
  56. ncbi request reprint Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?
    Satkiran S Grewal
    University of Minnesota, 420 Delaware St SE, MMC 477, Minneapolis, MN 55455, USA
    Blood 101:4233-44. 2003
  57. ncbi request reprint Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Res
    J Douglas Rizzo
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Biol Blood Marrow Transplant 12:138-51. 2006
    ....
  58. ncbi request reprint Treating children with chronic myeloid leukemia in the imatinib era: a therapeutic dilemma?
    Ian Thornley
    Med Pediatr Oncol 41:115-7. 2003
  59. ncbi request reprint Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation
    Satkiran S Grewal
    Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    J Pediatr 144:569-73. 2004
    ..To study the efficacy of hematopoietic stem cell transplantation (HCT) for ameliorating the clinical manifestations of alpha-mannosidosis...
  60. ncbi request reprint Tissue typing for hematopoietic cell transplantation: newer techniques and newer antigens for which cross-matching is helpful
    Robert Iannone
    Children s Hospital of Philadelphia and University of Pennsyvania, Philadelphia, PA, USA
    Pediatr Transplant 9:76-80. 2005
    ..This article reviews the current state of the art for HCT donor selection based on both HLA and NK cell typing...
  61. ncbi request reprint Social support, optimism, and self-efficacy predict physical and emotional well-being after bone marrow transplantation
    Nicole Hochhausen
    The University of Iowa, Iowa City, IA 52242, USA
    J Psychosoc Oncol 25:87-101. 2007
    ..Attention to psychosocial factors prior to BMT and during recovery appears critical for physical and mental well-being, especially considering the influence of psychosocial variables independent of medical risk factors...
  62. ncbi request reprint Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning
    Aarati Rao
    Washington University School of Medicine, St Louis Children s Hospital, Box 8116, SLCH, 1 Children s Pl, St Louis, MO 63110, USA
    Blood 109:383-5. 2007
    ....
  63. ncbi request reprint Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow
    Juliet N Barker
    Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
    Biol Blood Marrow Transplant 8:257-60. 2002
    ..These unique features of UCB transplantation must be considered in comparisons of the outcomes of UCB versus BM transplant recipients and in the design of prospective trials comparing URD sources...

Research Grants11

  1. THERAPY-RELATED LEUKEMIA--CLINICAL/BIOLOGIC PREDICTORS
    Stella Davies; Fiscal Year: 2002
    ..The identification of markers of early progression to t-MDS/AML during or after therapy will also allow modification of therapy and/or the development of treatment with chemopreventive agents such as retinoids. ..
  2. Host factors and etiology of leukemia
    Stella Davies; Fiscal Year: 2003
    ..Lastly, the DNA collected will serve as a resource for studies of polymorphisms which influence complications of therapy such as second cancers, avascular necrosis of bone and thrombotic events. ..