Takiko Daikoku

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Hum Reprod 19:463-72. 2013
  2. pmc Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenessee 37232, USA
    Cancer Res 68:5619-27. 2008
  3. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
  4. pmc Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress
    Yasushi Hirota
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:15577-82. 2010
  5. pmc Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
  6. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
  7. pmc Deficiency of immunophilin FKBP52 promotes endometriosis
    Yasushi Hirota
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Pathol 173:1747-57. 2008
  8. ncbi request reprint Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
  9. ncbi request reprint Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency
    Limin Yue
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocrinology 146:2424-33. 2005
  10. pmc Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    Yasushi Hirota
    The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 120:803-15. 2010

Collaborators

Detail Information

Publications27

  1. pmc Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, MLC 7045, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Mol Hum Reprod 19:463-72. 2013
    ..In conclusion, Tsc1(PR(d/d)) and Tsc1(Amhr2(d/d)) have overlapping yet distinct phenotypes in the context of compartment-specific deletion of Tsc1. ..
  2. pmc Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tenessee 37232, USA
    Cancer Res 68:5619-27. 2008
    ..These mouse models have the added advantage because they mimic several features of human EMC...
  3. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes...
  4. pmc Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress
    Yasushi Hirota
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 107:15577-82. 2010
    ..This study shows that FKBP52-PRDX6 signaling protects pregnancy from overt OS...
  5. pmc Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
    Susanne Tranguch
    Departments of Pediatrics, Cell and Developmental Biology, Cancer Biology, and Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:14326-31. 2005
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation...
  6. pmc Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity
    Takiko Daikoku
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Dev Cell 21:1014-25. 2011
    ....
  7. pmc Deficiency of immunophilin FKBP52 promotes endometriosis
    Yasushi Hirota
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN, USA
    Am J Pathol 173:1747-57. 2008
    ..This investigation is highly relevant for clinical application, particularly because P(4) resistance is favorably indicated in endometriosis and other gynecological diseases...
  8. ncbi request reprint Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Division of Reproductive and Development Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Cancer Res 67:5285-92. 2007
    ..The ability of aspirin to inhibit EOC growth in vivo is an exciting finding because of its low cost, lack of cardiovascular side effects, and availability...
  9. ncbi request reprint Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: evidence for aberrant regulation with Hoxa-10 deficiency
    Limin Yue
    Division of Reproductive and Developmental Biology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Endocrinology 146:2424-33. 2005
    ....
  10. pmc Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
    Yasushi Hirota
    The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio, USA
    J Clin Invest 120:803-15. 2010
    ..Taken together, our observations underscore what we believe to be a new critical role of uterine p53 in parturition...
  11. pmc FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific
    Susanne Tranguch
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232 2678, USA
    J Clin Invest 117:1824-34. 2007
    ....
  12. ncbi request reprint Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus
    Takiko Daikoku
    Department of Pediatrics and Cancer Biology, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Endocrinol 19:683-97. 2005
    ..Collectively, these results and the female infertility phenotype of FKBP52 suggest that a Hoxa10-FKBP52 signaling axis is critical to uterine receptivity and implantation...
  13. pmc Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
    Yasushi Hirota
    Division of Reproductive Sciences, Perinatal Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:18073-8. 2011
    ..This role of mTORC1 signaling in determining the timing of birth in mice may help us better understand the mechanism of the timing of birth in humans and develop new and improved strategies to combat the global problem of preterm birth...
  14. pmc In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus
    Xiaofei Sun
    Division of Reproductive Sciences, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Endocrinology 150:5065-73. 2009
    ..However, identifying definitive uterine function of LGR5 will require further investigation using conditional deletion of uterine Lgr5 because systemic deletion of this gene is neonatally lethal...
  15. pmc Imaging mass spectrometry reveals unique protein profiles during embryo implantation
    Kristin E Burnum
    Department of Chemistry and Biochemistry, Mass Spectrometry Research Center, Vanderbilt University Medical Center, MCN D4100, 1161 21st Avenue South, Nashville, TN 37232, USA
    Endocrinology 149:3274-8. 2008
    ..More interestingly, the use of this approach has provided new insights regarding uterine biology of cytosolic phospholipase A(2alpha) null females that show implantation defects...
  16. pmc CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:941-51. 2006
    ..Collectively, our findings show for the first time that CXCL1 is regulated by PGE2 and indicate that CXCL1 inhibitors should be evaluated further as potential anti-angiogenic agents for treatment of CRC...
  17. ncbi request reprint Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Cancer Res 66:2527-31. 2006
    ..The results provide further evidence that Cox-1 overexpression is common in various models of EOC. Thus, Cox-1 serves as a potential marker of EOC and is a possible target for the prevention and/or treatment of this deadly disease...
  18. pmc MicroRNA regulation of cyclooxygenase-2 during embryo implantation
    Anindita Chakrabarty
    Department of Pediatrics, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:15144-9. 2007
    ..Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy...
  19. pmc A new role for muscle segment homeobox genes in mammalian embryonic diapause
    Jeeyeon Cha
    Division of Reproductive Sciences, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Open Biol 3:130035. 2013
    ..These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness...
  20. ncbi request reprint Molecular cues to implantation
    S K Dey
    Department of Pediatrics, Vanderbilt University Medical Center, MCN D4100, Nashville, Tennessee 37232, USA
    Endocr Rev 25:341-73. 2004
    ..It is hoped that the forthcoming information will generate new ideas and concepts for a process that is essential for maintaining procreation and solving major reproductive health issues in women...
  21. pmc Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua
    Kristin E Burnum
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352 9104, USA
    Endocrinology 153:4568-79. 2012
    ..In particular, down-regulation of a cluster of antioxidant enzymes in p53-deficient deciduae suggests that increased oxidative stress could be one cause of preterm birth in mice harboring uterine deletion of Trp53...
  22. pmc Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52
    Yasushi Hirota
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo 113 8655, Japan
    Endocrinology 153:2486-93. 2012
    ..These findings suggest that uterine Gal1 is an important downstream target of P(4)-FKBP52-PR signaling in the uterus to support P(4) responsiveness during pregnancy...
  23. ncbi request reprint Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: evidence for a novel cytokine-homeobox-Wnt signaling in implantation
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    Mol Endocrinol 18:1238-50. 2004
    ..Collectively, the present results provide evidence for a novel cytokine-homeotic-Wnt signaling network in implantation...
  24. ncbi request reprint Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner. Evidence for differential function of HIFs during early pregnancy
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2678, USA
    J Biol Chem 278:7683-91. 2003
    ..Using pharmacological, molecular, and genetic approaches, we also observed that although progesterone primarily up-regulates uterine HIF-1alpha expression, estrogen transiently stimulates that of HIF-2alpha...
  25. pmc Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer
    Takiko Daikoku
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cancer Res 65:3735-44. 2005
    ..The growth inhibitory effects of SC-560 result from reduced cell proliferation and/or accelerated apoptosis. Our results imply COX-1 as a target for the prevention and/or treatment of EOC...
  26. ncbi request reprint Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation
    Hiromichi Matsumoto
    Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biol Reprod 70:729-36. 2004
    ....
  27. ncbi request reprint Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice
    Hiromichi Matsumoto
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7336, USA
    J Biol Chem 277:29260-7. 2002
    ..The attenuation of uterine angiogenesis in these mice is primarily due to defective VEGF signaling and not due to the defective angiopoietin system...