Timothy Crombleholme

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. doi request reprint Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation
    Timothy M Crombleholme
    The Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 203:397.e1-9. 2010
  2. pmc A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome
    Timothy M Crombleholme
    Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, MLC 2023, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Obstet Gynecol 197:396.e1-9. 2007
  3. doi request reprint Fetal cervical teratoma: What is the role of fetal MRI in predicting pulmonary hypoplasia?
    Katherine Wolfe
    University of Cincinnati College of Medicine, Cincinnati, Ohio 80045, USA
    Fetal Diagn Ther 33:252-6. 2013
  4. doi request reprint Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience
    Mounira Habli
    The Fetal Care Center of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:417.e1-7. 2009
  5. doi request reprint The outcome of twin-twin transfusion syndrome complicated with placental insufficiency
    Mounira Habli
    Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 199:424.e1-6. 2008
  6. doi request reprint Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome
    Mounira Habli
    Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 199:412.e1-6. 2008
  7. ncbi request reprint The EXIT procedure: experience and outcome in 31 cases
    Sarah Bouchard
    Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Surg 37:418-26. 2002
  8. doi request reprint Twin-to-twin transfusion syndrome: a comprehensive update
    Mounira Habli
    The Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 36:391-416, x. 2009
  9. pmc Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia
    Jose F Vuletin
    Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 45:703-8. 2010
  10. doi request reprint Characterization of diastolic dysfunction in twin-twin transfusion syndrome: association between Doppler findings and ventricular hypertrophy
    Allison Divanovic
    Fetal Heart Program, Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Am Soc Echocardiogr 24:834-40. 2011

Research Grants

  1. Endothelial Progenitor Cell Biology in Type 1 Diabetes
    Timothy Crombleholme; Fiscal Year: 2007
  2. Endothelial Progenitor Cell Recruitment in Diabetic Mice
    Timothy Crombleholme; Fiscal Year: 2007
  3. Twin-Twin Transfusion Syndrome Trial
    Timothy Crombleholme; Fiscal Year: 2004
  4. DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALING
    Timothy Crombleholme; Fiscal Year: 2004

Collaborators

Detail Information

Publications32

  1. doi request reprint Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation
    Timothy M Crombleholme
    The Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 203:397.e1-9. 2010
    ..The purpose of this study was to evaluate the effect of maternal nifedipine on fetal survival when started 24-48 hours before selective fetoscopic laser photocoagulation (SFLP)...
  2. pmc A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome
    Timothy M Crombleholme
    Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, MLC 2023, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Obstet Gynecol 197:396.e1-9. 2007
    ..The objective of the study was to examine the effect of selective fetoscopic laser photocoagulation (SFLP) vs serial amnioreduction (AR) on perinatal mortality in severe twin-twin transfusion syndrome (TTTS)...
  3. doi request reprint Fetal cervical teratoma: What is the role of fetal MRI in predicting pulmonary hypoplasia?
    Katherine Wolfe
    University of Cincinnati College of Medicine, Cincinnati, Ohio 80045, USA
    Fetal Diagn Ther 33:252-6. 2013
    ..To determine whether total fetal lung volumes estimated by MRI could predict lethal pulmonary hypoplasia in a cohort of fetuses with cervical teratomas...
  4. doi request reprint Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experience
    Mounira Habli
    The Fetal Care Center of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:417.e1-7. 2009
    ..The purpose of this study was to evaluate the incidence of complications after selective fetoscopic laser photocoagulation for twin-twin transfusion syndrome (TTTS)...
  5. doi request reprint The outcome of twin-twin transfusion syndrome complicated with placental insufficiency
    Mounira Habli
    Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 199:424.e1-6. 2008
    ..The aim was to evaluate the incidence and perinatal outcomes of TTTS complicated with placental insufficiency (PI/TTTS)...
  6. doi request reprint Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndrome
    Mounira Habli
    Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 199:412.e1-6. 2008
    ..This study evaluated the acute effects of selective fetoscopic laser photocoagulation (SFLP) on recipient cardiovascular function in a twin-twin transfusion syndrome (TTTS) pregnancy...
  7. ncbi request reprint The EXIT procedure: experience and outcome in 31 cases
    Sarah Bouchard
    Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Surg 37:418-26. 2002
    ..The EXIT (ex utero intrapartum treatment) procedure, although initially designed for reversal of tracheal occlusion in fetuses with congenital diaphragmatic hernias (CDH), has been adapted to treat a variety of fetal conditions...
  8. doi request reprint Twin-to-twin transfusion syndrome: a comprehensive update
    Mounira Habli
    The Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 36:391-416, x. 2009
    ....
  9. pmc Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic hernia
    Jose F Vuletin
    Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr Surg 45:703-8. 2010
    ..This study aim to assess the potential of prenatal predictors of postnatal severe pulmonary artery hypertension (PAH) in isolated left congenital diaphragmatic hernia (CDH) and to define a new prenatal pulmonary hypertension index (PPHI)...
  10. doi request reprint Characterization of diastolic dysfunction in twin-twin transfusion syndrome: association between Doppler findings and ventricular hypertrophy
    Allison Divanovic
    Fetal Heart Program, Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Am Soc Echocardiogr 24:834-40. 2011
    ..It was the purpose of this study to perform a detailed assessment of ventricular geometry and diastolic function between controls, donor twins (DTs), and RTs...
  11. doi request reprint Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery
    Anne Boat
    Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Paediatr Anaesth 20:748-56. 2010
    ..To lower the incidence and severity of fetal cardiovascular depression during maternal fetal surgery under general anesthesia...
  12. doi request reprint Congenital cystic lung disease: contemporary antenatal and postnatal management
    Richard G Azizkhan
    Fetal Care Center of Cincinnati, Division of Thoracic and General Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Pediatr Surg Int 24:643-57. 2008
    ....
  13. pmc Prenatal MRI findings of fetuses with congenital high airway obstruction sequence
    Carolina V A Guimaraes
    Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Korean J Radiol 10:129-34. 2009
    ..To define the MRI findings of congenital high airway obstruction sequence (CHAOS) in a series of fetuses...
  14. doi request reprint The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndrome
    Mounira Habli
    Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    Am J Obstet Gynecol 203:404.e1-7. 2010
    ..We sought to evaluate amniotic fluid brain natriuretic peptide (BNP) levels as a biomarker of recipient twin (RT) cardiomyopathy (RTCM) in twin-twin transfusion syndrome...
  15. ncbi request reprint The EXIT procedure: principles, pitfalls, and progress
    Ahmad Marwan
    Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Semin Pediatr Surg 15:107-15. 2006
    ..This review summarizes the underlying principles of the EXIT procedure, the expanding indications for its use, the pitfalls of management, and the progress that has been made in its successful application...
  16. doi request reprint Severe micrognathia: indications for EXIT-to-Airway
    Lee M Morris
    Fetal Care Center of Cincinnati, Divisions of Pediatric General, Thoracic, and Fetal Surgery, Otolaryngology, Genetics, and Maternal Fetal Medicine, Cincinnati Children s Hospital, University Hospital, Good Samaritan Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Fetal Diagn Ther 26:162-6. 2009
    ..We propose indications for EXIT-to-Airway in micrognathia to include a jaw index <5%, with indirect evidence of aerodigestive tract obstruction such as polyhydramnios, glossoptosis or an absent stomach bubble...
  17. doi request reprint High-risk fetal congenital pulmonary airway malformations have a variable response to steroids
    Lee M Morris
    The Fetal Care Center of Cincinnati, Division of Pediatric General Surgery, Cincinnati Children s Hospital, OH 45229 3039, USA
    J Pediatr Surg 44:60-5. 2009
    ..We reviewed our experience with CPAMs to determine the fetal response to steroid therapy...
  18. ncbi request reprint Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experience
    Jeffrey C Livingston
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH 45267 0526, USA
    Am J Obstet Gynecol 197:399.e1-3. 2007
    ..The objective of the study was to review perinatal outcomes in pregnancies treated with intrafetal radiofrequency ablation (RFA) for twin reversed arterial perfusion (TRAP) sequence...
  19. ncbi request reprint Twin-twin transfusion syndrome: cerebral ischemia is not the only fetal MR imaging finding
    Beth M Kline-Fath
    Department of Radiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Pediatr Radiol 37:47-56. 2007
    ..Although the sonographic findings of TTTS are well documented, we believe that MR imaging is a valuable adjunct...
  20. ncbi request reprint Twin-twin transfusion syndrome: where do we go from here?
    Ursula F Harkness
    University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Semin Perinatol 29:296-304. 2005
    ..Questions still remain as to how various treatment options affect short- and long-term cardiac and neurodevelopmental outcomes and which patients will benefit most from selective laser photocoagulation therapy...
  21. pmc Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndrome
    Amy D Shah
    Fetal Care Center of Cincinnati, Divisions of Pediatric Cardiology, General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Am Soc Echocardiogr 21:1105-8. 2008
    ..The aim of this study was to assess the relationship between cardiomyopathy and recipient twin (RT) outcome in twin-twin transfusion syndrome (TTTS)...
  22. doi request reprint Congenital high airway obstruction syndrome due to complete tracheal agenesis: an accident of nature with clues for tracheal development and lessons in management
    Sachin S Vaikunth
    Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Fetal Diagn Ther 26:93-7. 2009
    ..The subsequent postnatal course highlights the need for early tracheal replacement in this particularly challenging form of CHAOS...
  23. ncbi request reprint Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation
    Ashley Gordon
    Center for Molecular Fetal Therapy, Division of General, Thoracic and Fetal Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Wound Repair Regen 16:70-9. 2008
    ..Therefore, overexpression of IL-10 in postnatal wounds results in a permissive environment for scarless wound repair, possibly by replicating a fetal wound environment...
  24. ncbi request reprint Allantoic cyst: a prenatal clue to patent urachus
    Paul T Bunch
    Department of Radiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pediatr Radiol 36:1090-5. 2006
    ..We report a case of a patent urachus with an allantoic cyst diagnosed via fetal MR imaging at 24 weeks' gestation. Early detection allowed for appropriate counseling and prompt corrective surgery after birth...
  25. doi request reprint Maternal pulmonary edema during fetoscopic surgery
    Marnie B Robinson
    Department of Anesthesiology, Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
    Anesth Analg 107:1978-80. 2008
    ..We hypothesize that the pulmonary edema resulted from irrigating fluid (totaling net 8 L) absorbed i.v. through myometrial venous channels accessed by passage of the operating trocars...
  26. ncbi request reprint Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosis
    Sundeep G Keswani
    Center for Molecular Fetal Therapy, The Division of General, Thoracic and Fetal Surgery, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Semin Pediatr Surg 13:44-52. 2004
    ..Finally, we will examine the prospects for, limitations of, and regulatory challenges facing the translation of fetal gene therapy from research to clinical application...
  27. doi request reprint Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors
    Arturo R Maldonado
    Division of Pediatric General and Thoracic Surgery, The Center for Molecular Fetal Therapy, Children s Hospital Medical Center, Cincinnati, OH, USA
    J Gene Med 12:613-23. 2010
    ..In the present study, we sought to leverage its selective expression to develop a novel oncolytic herpes simplex virus (oHSV) capable of targeting developmentally primitive cancers that express MDK...
  28. ncbi request reprint The treatment of twin-twin transfusion syndrome
    Timothy M Crombleholme
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Semin Pediatr Surg 12:175-81. 2003
    ....
  29. ncbi request reprint Chorioamniotic membrane separation following open fetal surgery: pregnancy outcome
    R Douglas Wilson
    Department of Surgery, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
    Fetal Diagn Ther 18:314-20. 2003
    ....
  30. ncbi request reprint Fetoscopic surgery
    Timothy M Crombleholme
    Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Clin Obstet Gynecol 46:76-91. 2003
  31. ncbi request reprint Fetal myelomeningocele repair: short-term clinical outcomes
    Mark P Johnson
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
    Am J Obstet Gynecol 189:482-7. 2003
    ..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair...
  32. ncbi request reprint Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformations
    R Douglas Wilson
    Department of Surgery, Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 19:413-20. 2004
    ....

Research Grants18

  1. Endothelial Progenitor Cell Biology in Type 1 Diabetes
    Timothy Crombleholme; Fiscal Year: 2007
    ..3. To determine the mechanisms by which type I diabetes alters EPC gene expression and function. ..
  2. Endothelial Progenitor Cell Recruitment in Diabetic Mice
    Timothy Crombleholme; Fiscal Year: 2007
    ..To determine the mechanisms by which EPCs orchestrate the local angiogenic response by interaction with resident cellular milieu. ..
  3. Twin-Twin Transfusion Syndrome Trial
    Timothy Crombleholme; Fiscal Year: 2004
    ..The overall goal of the study is to improve the outcomes of twins with TTTS by determining which treatment for TTTS has a better survival as well as cardiac, neurologic, and developmental outcome. ..
  4. DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALING
    Timothy Crombleholme; Fiscal Year: 2004
    ..abstract_text> ..