Research Topics
| Timothy CrombleholmeSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulationTimothy M Crombleholme
The Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
Am J Obstet Gynecol 203:397.e1-9. 2010..The purpose of this study was to evaluate the effect of maternal nifedipine on fetal survival when started 24-48 hours before selective fetoscopic laser photocoagulation (SFLP)...
A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndromeTimothy M Crombleholme
Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, MLC 2023, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Obstet Gynecol 197:396.e1-9. 2007..The objective of the study was to examine the effect of selective fetoscopic laser photocoagulation (SFLP) vs serial amnioreduction (AR) on perinatal mortality in severe twin-twin transfusion syndrome (TTTS)...- Incidence of complications in twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a single-center experienceMounira Habli
The Fetal Care Center of Cincinnati, Cincinnati, OH, USA
Am J Obstet Gynecol 201:417.e1-7. 2009..The purpose of this study was to evaluate the incidence of complications after selective fetoscopic laser photocoagulation for twin-twin transfusion syndrome (TTTS)... - The outcome of twin-twin transfusion syndrome complicated with placental insufficiencyMounira Habli
Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University Hospital, Cincinnati, OH 45229 3039, USA
Am J Obstet Gynecol 199:424.e1-6. 2008..The aim was to evaluate the incidence and perinatal outcomes of TTTS complicated with placental insufficiency (PI/TTTS)... - Acute effects of selective fetoscopic laser photocoagulation on recipient cardiac function in twin-twin transfusion syndromeMounira Habli
Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
Am J Obstet Gynecol 199:412.e1-6. 2008..This study evaluated the acute effects of selective fetoscopic laser photocoagulation (SFLP) on recipient cardiovascular function in a twin-twin transfusion syndrome (TTTS) pregnancy... 
The EXIT procedure: experience and outcome in 31 casesSarah Bouchard
Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr Surg 37:418-26. 2002....- Twin-to-twin transfusion syndrome: a comprehensive updateMounira Habli
The Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, OH 45229 3039, USA
Clin Perinatol 36:391-416, x. 2009.... - Prenatal pulmonary hypertension index: novel prenatal predictor of severe postnatal pulmonary artery hypertension in antenatally diagnosed congenital diaphragmatic herniaJose F Vuletin
Division of Pediatric and Thoracic Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Pediatr Surg 45:703-8. 2010..This study aim to assess the potential of prenatal predictors of postnatal severe pulmonary artery hypertension (PAH) in isolated left congenital diaphragmatic hernia (CDH) and to define a new prenatal pulmonary hypertension index (PPHI)... - Characterization of diastolic dysfunction in twin-twin transfusion syndrome: association between Doppler findings and ventricular hypertrophyAllison Divanovic
Fetal Heart Program, Division of Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Am Soc Echocardiogr 24:834-40. 2011..It was the purpose of this study to perform a detailed assessment of ventricular geometry and diastolic function between controls, donor twins (DTs), and RTs... - Prenatal MRI findings of fetuses with congenital high airway obstruction sequenceCarolina V A Guimaraes
Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Korean J Radiol 10:129-34. 2009..To define the MRI findings of congenital high airway obstruction sequence (CHAOS) in a series of fetuses... - Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgeryAnne Boat
Department of Anesthesiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Paediatr Anaesth 20:748-56. 2010..To lower the incidence and severity of fetal cardiovascular depression during maternal fetal surgery under general anesthesia... - Congenital cystic lung disease: contemporary antenatal and postnatal managementRichard G Azizkhan
Fetal Care Center of Cincinnati, Division of Thoracic and General Pediatric Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Pediatr Surg Int 24:643-57. 2008.... - The relationship between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in twin-twin transfusion syndromeMounira Habli
Fetal Care Center of Cincinnati, Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
Am J Obstet Gynecol 203:404.e1-7. 2010..We sought to evaluate amniotic fluid brain natriuretic peptide (BNP) levels as a biomarker of recipient twin (RT) cardiomyopathy (RTCM) in twin-twin transfusion syndrome... - The EXIT procedure: principles, pitfalls, and progressAhmad Marwan
Fetal Care Center of Cincinnati, Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
Semin Pediatr Surg 15:107-15. 2006..This review summarizes the underlying principles of the EXIT procedure, the expanding indications for its use, the pitfalls of management, and the progress that has been made in its successful application... - Severe micrognathia: indications for EXIT-to-AirwayLee M Morris
Fetal Care Center of Cincinnati, Divisions of Pediatric General, Thoracic, and Fetal Surgery, Otolaryngology, Genetics, and Maternal Fetal Medicine, Cincinnati Children s Hospital, University Hospital, Good Samaritan Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Fetal Diagn Ther 26:162-6. 2009..We propose indications for EXIT-to-Airway in micrognathia to include a jaw index <5%, with indirect evidence of aerodigestive tract obstruction such as polyhydramnios, glossoptosis or an absent stomach bubble... - Initial fetal cardiovascular profile score predicts recipient twin outcome in twin-twin transfusion syndromeAmy D Shah
Fetal Care Center of Cincinnati, Divisions of Pediatric Cardiology, General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Am Soc Echocardiogr 21:1105-8. 2008..The aim of this study was to assess the relationship between cardiomyopathy and recipient twin (RT) outcome in twin-twin transfusion syndrome (TTTS)... - High-risk fetal congenital pulmonary airway malformations have a variable response to steroidsLee M Morris
The Fetal Care Center of Cincinnati, Division of Pediatric General Surgery, Cincinnati Children s Hospital, OH 45229 3039, USA
J Pediatr Surg 44:60-5. 2009..We reviewed our experience with CPAMs to determine the fetal response to steroid therapy... - Twin-twin transfusion syndrome: cerebral ischemia is not the only fetal MR imaging findingBeth M Kline Fath
Department of Radiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati Medical Center, Cincinnati, OH, USA
Pediatr Radiol 37:47-56. 2007..Although the sonographic findings of TTTS are well documented, we believe that MR imaging is a valuable adjunct... - Intrafetal radiofrequency ablation for twin reversed arterial perfusion (TRAP): a single-center experienceJeffrey C Livingston
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH 45267 0526, USA
Am J Obstet Gynecol 197:399.e1-3. 2007..The objective of the study was to review perinatal outcomes in pregnancies treated with intrafetal radiofrequency ablation (RFA) for twin reversed arterial perfusion (TRAP) sequence... - Twin-twin transfusion syndrome: where do we go from here?Ursula F Harkness
University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Semin Perinatol 29:296-304. 2005..Questions still remain as to how various treatment options affect short- and long-term cardiac and neurodevelopmental outcomes and which patients will benefit most from selective laser photocoagulation therapy... - Congenital high airway obstruction syndrome due to complete tracheal agenesis: an accident of nature with clues for tracheal development and lessons in managementSachin S Vaikunth
Division of Pediatric General, Thoracic, and Fetal Surgery, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Fetal Diagn Ther 26:93-7. 2009..The subsequent postnatal course highlights the need for early tracheal replacement in this particularly challenging form of CHAOS... - Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumorsArturo R Maldonado
Division of Pediatric General and Thoracic Surgery, The Center for Molecular Fetal Therapy, Children s Hospital Medical Center, Cincinnati, OH, USA
J Gene Med 12:613-23. 2010..In the present study, we sought to leverage its selective expression to develop a novel oncolytic herpes simplex virus (oHSV) capable of targeting developmentally primitive cancers that express MDK... - Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosisSundeep G Keswani
Center for Molecular Fetal Therapy, The Division of General, Thoracic and Fetal Surgery, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
Semin Pediatr Surg 13:44-52. 2004..Finally, we will examine the prospects for, limitations of, and regulatory challenges facing the translation of fetal gene therapy from research to clinical application... - Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formationAshley Gordon
Center for Molecular Fetal Therapy, Division of General, Thoracic and Fetal Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Wound Repair Regen 16:70-9. 2008..Therefore, overexpression of IL-10 in postnatal wounds results in a permissive environment for scarless wound repair, possibly by replicating a fetal wound environment... - Maternal pulmonary edema during fetoscopic surgeryMarnie B Robinson
Department of Anesthesiology, Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio, USA
Anesth Analg 107:1978-80. 2008..We hypothesize that the pulmonary edema resulted from irrigating fluid (totaling net 8 L) absorbed i.v. through myometrial venous channels accessed by passage of the operating trocars... - Allantoic cyst: a prenatal clue to patent urachusPaul T Bunch
Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA
Pediatr Radiol 36:1090-5. 2006..We report a case of a patent urachus with an allantoic cyst diagnosed via fetal MR imaging at 24 weeks' gestation. Early detection allowed for appropriate counseling and prompt corrective surgery after birth... - The treatment of twin-twin transfusion syndromeTimothy M Crombleholme
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:175-81. 2003.... - Chorioamniotic membrane separation following open fetal surgery: pregnancy outcomeR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
Fetal Diagn Ther 18:314-20. 2003..3) Delivery prior to 33 weeks gestation for MMC groups was 12/43 (28%) with 3 NND (7%). (4) Elective delivery at 36-37 weeks gestation was possible for 43% of the fetal surgery population... - Fetal myelomeningocele repair: short-term clinical outcomesMark P Johnson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
Am J Obstet Gynecol 189:482-7. 2003..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair... - Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformationsR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 19:413-20. 2004.... - Fetoscopic surgeryTimothy M Crombleholme
Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
Clin Obstet Gynecol 46:76-91. 2003
Research Grants
- Endothelial Progenitor Cell Biology in Type 1 DiabetesTimothy Crombleholme; Fiscal Year: 2007..3. To determine the mechanisms by which type I diabetes alters EPC gene expression and function. ..
- Endothelial Progenitor Cell Recruitment in Diabetic MiceTimothy Crombleholme; Fiscal Year: 2007..To determine the mechanisms by which EPCs orchestrate the local angiogenic response by interaction with resident cellular milieu. ..
- Twin-Twin Transfusion Syndrome TrialTimothy Crombleholme; Fiscal Year: 2004..The overall goal of the study is to improve the outcomes of twins with TTTS by determining which treatment for TTTS has a better survival as well as cardiac, neurologic, and developmental outcome. ..
- DERMAL-EPIDERMAL INTERACTIONS IN DIABETIC WOUND HEALINGTimothy Crombleholme; Fiscal Year: 2004..abstract_text> ..