Claire A Chougnet

Summary

Affiliation: Cincinnati Children's Hospital Medical Center
Country: USA

Publications

  1. pmc In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells
    Pietro Presicce
    Division of Cellular and Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e42802. 2012
  2. pmc Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy
    Pietro Presicce
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e28118. 2011
  3. pmc Low-level HIV infection of hepatocytes
    Ling Kong
    Division of Digestive Diseases, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Virol J 9:157. 2012
  4. pmc A major role for Bim in regulatory T cell homeostasis
    Claire A Chougnet
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 186:156-63. 2011
  5. ncbi request reprint Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshop
    Claire A Chougnet
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    AIDS Res Hum Retroviruses 23:945-52. 2007
  6. pmc Homeostasis and function of regulatory T cells in HIV/SIV infection
    Maria E Moreno-Fernandez
    Division of Molecular and Cellular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Virol 86:10262-9. 2012
  7. pmc Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 117:5372-80. 2011
  8. pmc Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia
    Celine S Lages
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hepatology 56:219-27. 2012
  9. pmc cAMP during HIV infection: friend or foe?
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, Immunobiology Graduate Program University of Cincinnati, College of Medicine, Ohio 45229, USA
    AIDS Res Hum Retroviruses 28:49-53. 2012
  10. pmc Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia
    Pranavkumar Shivakumar
    Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 119:2281-90. 2009

Research Grants

  1. Homeostasis and function of regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2009
  2. Homeostasis and function of regulatory T cells in aging
    David A Hildeman; Fiscal Year: 2010
  3. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
  4. Role of Regulatory T Cells in HIV Infection
    Claire Chougnet; Fiscal Year: 2007
  5. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
  6. Role of Regulatory T Cells in HIV Infection
    Claire Chougnet; Fiscal Year: 2009
  7. Role of Regulatory T Cells in HIV Infection
    Claire A Chougnet; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. pmc In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells
    Pietro Presicce
    Division of Cellular and Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e42802. 2012
    ..Taken together, our data suggest that Treg induction may be defective when DCs are exposed to high levels of virus, such as during the acute phase of infection or in AIDS patients...
  2. pmc Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy
    Pietro Presicce
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 6:e28118. 2011
    ..The most striking difference in terms of functional molecules was the high expression of CD39 by Tregs in untreated patients, which HAART only partially controlled...
  3. pmc Low-level HIV infection of hepatocytes
    Ling Kong
    Division of Digestive Diseases, University of Cincinnati College of Medicine, and Cincinnati Children s Hospital Medical Center, ML 0595, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Virol J 9:157. 2012
    ..There are only limited data on whether HIV infection occurs within the liver; therefore, we explored early and late stages of the HIV life cycle in two hepatocyte cell lines--Huh7.5 and Huh7.5JFH1--as well as in primary human hepatocytes...
  4. pmc A major role for Bim in regulatory T cell homeostasis
    Claire A Chougnet
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Immunol 186:156-63. 2011
    ..Collectively, our data suggest that chronic stimulation by IL-2 leads to preferential expansion of Treg having low expression of Bim, which favors their survival and accumulation in aged hosts...
  5. ncbi request reprint Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshop
    Claire A Chougnet
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    AIDS Res Hum Retroviruses 23:945-52. 2007
    ....
  6. pmc Homeostasis and function of regulatory T cells in HIV/SIV infection
    Maria E Moreno-Fernandez
    Division of Molecular and Cellular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Virol 86:10262-9. 2012
    ..The aim of this review is thus to discuss the recent findings on Treg homeostasis and function in the setting of HIV infection...
  7. pmc Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 117:5372-80. 2011
    ..Such a protective role of Tregs could have a profound impact on infection outcome...
  8. pmc Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresia
    Celine S Lages
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Hepatology 56:219-27. 2012
    ..Increased susceptibility to hepatobiliary injury in Treg-depleted mice was linked to hepatic CD8 expansion and enhanced stimulatory capacity of hepatic DCs...
  9. pmc cAMP during HIV infection: friend or foe?
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, Immunobiology Graduate Program University of Cincinnati, College of Medicine, Ohio 45229, USA
    AIDS Res Hum Retroviruses 28:49-53. 2012
    ....
  10. pmc Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia
    Pranavkumar Shivakumar
    Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 119:2281-90. 2009
    ..These findings identify NK cells as key initiators of cholangiocyte injury via Nkg2d and demonstrate that injury to the duct epithelium drives the phenotype of experimental biliary atresia...
  11. pmc Highly active antiretroviral therapy in patients infected with human immunodeficiency virus increases CD40 ligand expression and IL-12 production in cells ex vivo
    Alice M Nyakeriga
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Viral Immunol 24:281-9. 2011
    ....
  12. pmc Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresia
    Alexander G Miethke
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, MLC 2010, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Hepatol 52:718-26. 2010
    ..Although recent studies have identified important roles for T and NK cells in the pathogenesis of biliary atresia (BA), the mechanisms by which susceptibility to bile duct injury is restricted to the neonatal period are unknown...
  13. pmc Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells
    Pietro Presicce
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Ohio, USA
    AIDS 26:263-73. 2012
    ..To determine whether the ability of primary myeloid dendritic cells (mDCs) to induce regulatory T cells (Treg) is affected by chronic simian immunodeficiency virus (SIV) infection...
  14. pmc Homeostasis and function of regulatory T cells in aging
    Jana Raynor
    Division of Cellular and Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA
    Curr Opin Immunol 24:482-7. 2012
    ..As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging...
  15. pmc Association of two clones allows for optimal detection of human FOXP3
    Pietro Presicce
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH45229, USA
    Cytometry A 77:571-9. 2010
    ..A more consistent identification of these cells will improve the knowledge of their biology, particularly during disease processes...
  16. pmc IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels
    Jana Raynor
    Division of Cellular and Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Front Immunol 4:161. 2013
    ..These data have implications for manipulating Treg to improve immune responses in the elderly. ..
  17. pmc Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain
    Maria E Moreno-Fernandez
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Virol 83:12925-33. 2009
    ..Our results suggest that the relative susceptibility of Treg to HIV infection compared to Teff varies, depending on both viral and host factors. These variations may play an important role in HIV pathogenesis...
  18. pmc Intra-amniotic IL-1β induces fetal inflammation in rhesus monkeys and alters the regulatory T cell/IL-17 balance
    Suhas G Kallapur
    Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 191:1102-9. 2013
    ..Boosting regulatory T cells and/or controlling IL-17 may provide a means to ameliorate these abnormalities...
  19. pmc Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infection
    Alice M Nyakeriga
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Virol 83:1193-200. 2009
    ..Our results suggest that the engagement of CD4 by HIV gp120 prior to T-cell receptor stimulation leads to dysregulation of early signaling events and could consequently play an important role in impaired CD4(+) T-cell function...
  20. ncbi request reprint The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients
    Jan Andersson
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Immunol 174:3143-7. 2005
    ..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity...

Research Grants13

  1. Homeostasis and function of regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2009
    ..The proposal explores the mechanisms responsible for the accumulation of these suppressive cells and whether or not they can be manipulated to improve immune function in the aging. ..
  2. Homeostasis and function of regulatory T cells in aging
    David A Hildeman; Fiscal Year: 2010
    ..The proposal explores the mechanisms responsible for the accumulation of these suppressive cells and whether or not they can be manipulated to improve immune function in the aging. ..
  3. CD40 Ligand Dysregulation and HIV Pathogenesis
    Claire Chougnet; Fiscal Year: 2009
    ..abstract_text> ..
  4. Role of Regulatory T Cells in HIV Infection
    Claire Chougnet; Fiscal Year: 2007
    ....
  5. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
    ..abstract_text> ..
  6. Role of Regulatory T Cells in HIV Infection
    Claire Chougnet; Fiscal Year: 2009
    ....
  7. Role of Regulatory T Cells in HIV Infection
    Claire A Chougnet; Fiscal Year: 2010
    ....