Research Topics
Species | Claire A ChougnetSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
A major role for Bim in regulatory T cell homeostasisClaire A Chougnet
Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
J Immunol 186:156-63. 2011..Collectively, our data suggest that chronic stimulation by IL-2 leads to preferential expansion of Treg having low expression of Bim, which favors their survival and accumulation in aged hosts...
Regulatory T cells (Treg) and HIV/AIDS: summary of the September 7-8, 2006 workshopClaire A Chougnet
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
AIDS Res Hum Retroviruses 23:945-52. 2007....- Homeostasis and function of regulatory T cells in HIV/SIV infectionMaria E Moreno-Fernandez
Division of Molecular and Cellular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
J Virol 86:10262-9. 2012..The aim of this review is thus to discuss the recent findings on Treg homeostasis and function in the setting of HIV infection... - cAMP during HIV infection: friend or foe?Maria E Moreno-Fernandez
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, Immunobiology Graduate Program University of Cincinnati, College of Medicine, Ohio 45229, USA
AIDS Res Hum Retroviruses 28:49-53. 2012.... - Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresiaPranavkumar Shivakumar
Cincinnati Children s Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Clin Invest 119:2281-90. 2009..These findings identify NK cells as key initiators of cholangiocyte injury via Nkg2d and demonstrate that injury to the duct epithelium drives the phenotype of experimental biliary atresia... - Homeostasis and function of regulatory T cells in agingJana Raynor
Division of Cellular and Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, USA
Curr Opin Immunol 24:482-7. 2012..As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging... - Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapyPietro Presicce
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 6:e28118. 2011..The most striking difference in terms of functional molecules was the high expression of CD39 by Tregs in untreated patients, which HAART only partially controlled... - Post-natal paucity of regulatory T cells and control of NK cell activation in experimental biliary atresiaAlexander G Miethke
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, MLC 2010, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Hepatol 52:718-26. 2010..Although recent studies have identified important roles for T and NK cells in the pathogenesis of biliary atresia (BA), the mechanisms by which susceptibility to bile duct injury is restricted to the neonatal period are unknown... - Regulatory T cells control the CD8 adaptive immune response at the time of ductal obstruction in experimental biliary atresiaCeline S Lages
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Hepatology 56:219-27. 2012..CONCLUSION: Activation of hepatic T-lymphocytes driving biliary obstruction in BA is regulated by mDCs by way of CD86-dependent costimulation and is susceptible to inhibition by Tregs... - In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cellsPietro Presicce
Division of Cellular and Molecular Immunology, Cincinnati Children s Hospital Research Foundation, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
PLoS ONE 7:e42802. 2012..Taken together, our data suggest that Treg induction may be defective when DCs are exposed to high levels of virus, such as during the acute phase of infection or in AIDS patients... 
Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cellsPietro Presicce
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Ohio, USA
AIDS 26:263-73. 2012..To determine whether the ability of primary myeloid dendritic cells (mDCs) to induce regulatory T cells (Treg) is affected by chronic simian immunodeficiency virus (SIV) infection...- Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infectionAlice M Nyakeriga
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
J Virol 83:1193-200. 2009..Our results suggest that the engagement of CD4 by HIV gp120 prior to T-cell receptor stimulation leads to dysregulation of early signaling events and could consequently play an important role in impaired CD4(+) T-cell function... - Highly active antiretroviral therapy in patients infected with human immunodeficiency virus increases CD40 ligand expression and IL-12 production in cells ex vivoAlice M Nyakeriga
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
Viral Immunol 24:281-9. 2011.... - Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanismMaria E Moreno-Fernandez
Division of Molecular Immunology, Department of Pediatrics, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH, USA
Blood 117:5372-80. 2011..Such a protective role of Tregs could have a profound impact on infection outcome... - Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strainMaria E Moreno-Fernandez
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
J Virol 83:12925-33. 2009..Our results suggest that the relative susceptibility of Treg to HIV infection compared to Teff varies, depending on both viral and host factors. These variations may play an important role in HIV pathogenesis... - The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patientsJan Andersson
Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
J Immunol 174:3143-7. 2005..Our data could provide a new basis for immune-based therapies that counteract in vivo Treg and thereby reinforce appropriate antiviral immunity...
Research Grants
- Role of Regulatory T Cells in HIV InfectionClaire A Chougnet; Fiscal Year: 2010....
- Homeostasis and function of regulatory T cells in agingClaire Chougnet; Fiscal Year: 2009..The proposal explores the mechanisms responsible for the accumulation of these suppressive cells and whether or not they can be manipulated to improve immune function in the aging. ..
- Role of Regulatory T Cells in HIV InfectionClaire Chougnet; Fiscal Year: 2009....
- CD40 Ligand Dysregulation and HIV PathogenesisClaire Chougnet; Fiscal Year: 2009..abstract_text> ..
- Role of Regulatory T Cells in HIV InfectionClaire Chougnet; Fiscal Year: 2007....
- Immunosuppression and regulatory T cells in agingClaire Chougnet; Fiscal Year: 2006..abstract_text> ..
- Homeostasis and function of regulatory T cells in agingDavid A Hildeman; Fiscal Year: 2010..The proposal explores the mechanisms responsible for the accumulation of these suppressive cells and whether or not they can be manipulated to improve immune function in the aging. ..