Research Topics
Genomes and Genes | Daniel ChooSummaryAffiliation: Cincinnati Children's Hospital Medical Center Country: USA Publications
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Publications
Universal newborn hearing screening in 2010Daniel Choo
Department of Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Curr Opin Otolaryngol Head Neck Surg 18:399-404. 2010....
Molecular mechanisms underlying inner ear patterning defects in kreisler mutantsDaniel Choo
Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Deafness Research, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OH 45229 3039, USA
Dev Biol 289:308-17. 2006..The data also identify Gbx2, Dlx5, Wnt2b and Otx2 as key otic genes ultimately affected by perturbation of the kr/mafB-hindbrain pathway...- The role of the hindbrain in patterning of the otocystDaniel Choo
Ear and Hearing Center, Univeristy of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Dev Biol 308:257-65. 2007 - Audiometric, clinical and educational outcomes in a pediatric symptomatic congenital cytomegalovirus (CMV) population with sensorineural hearing lossColm Madden
Center of Hearing and Deafness Research, Division of Otolaryngology-Head and Neck Surgery, Department of Pediatric Otolaryngology, OSB-3, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Int J Pediatr Otorhinolaryngol 69:1191-8. 2005.... 
Audiologic and temporal bone imaging findings in patients with sensorineural hearing loss and GJB2 mutationsKenneth H Lee
Hearing and Deafness Center, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, U S A
Laryngoscope 119:554-8. 2009....- The large vestibular aqueduct: a new definition based on audiologic and computed tomography correlationMark Boston
Ear and Hearing Center, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Otolaryngol Head Neck Surg 136:972-7. 2007..The study goal was to determine the prevalence and clinical significance of a large vestibular aqueduct (LVA) in children with sensorineural hearing loss (SNHL)... - Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutantMichele Merves
Department of Pediatric Otolaryngology, Center for Hearing and Deafness Research, Cincinnati, OH 45229, USA
J Assoc Res Otolaryngol 4:264-75. 2003..These results suggest redundant or alternative mechanisms that likely regulate water homeostasis in the developing and mature inner ear... - Auditory skills development among children with developmental delays and cochlear implantsSusan Wiley
Division of Developmental and Behavioral Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Ann Otol Rhinol Laryngol 117:711-8. 2008..We sought to understand auditory skills outcomes in young children with cochlear implants and developmental delay... - Functional magnetic resonance imaging of hearing-impaired children under sedation before cochlear implantationAnkur M Patel
Imaging Research Center, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Arch Otolaryngol Head Neck Surg 133:677-83. 2007..To investigate functional magnetic resonance imaging (fMRI) in pediatric cochlear implantation candidates with residual hearing who are under sedation for evaluation of auditory function... - Auditory Skills Checklist: clinical tool for monitoring functional auditory skill development in young children with cochlear implantsJareen Meinzen Derr
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 5041, Cincinnati, OH 45229 3039, USA
Ann Otol Rhinol Laryngol 116:812-8. 2007..We describe the development, validation, and utility of the ASC for use in young children with cochlear implants... - Co-expression of pendrin, vacuolar H+-ATPase alpha4-subunit and carbonic anhydrase II in epithelial cells of the murine endolymphatic sacHongwei Dou
Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
J Histochem Cytochem 52:1377-84. 2004.... - Mice lacking the B1 subunit of H+ -ATPase have normal hearingHongwei Dou
Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Hear Res 180:76-84. 2003.... - Macrophage inflammatory proteins in cytomegalovirus-related inner ear injuryScott A Schraff
Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Otolaryngol Head Neck Surg 137:612-8. 2007..The purpose of the study was to determine if a virally encoded macrophage inflammatory protein played a role in CMV-related hearing loss... - Pediatric hearing impairment caregiver experience: impact of duration of hearing loss on parental stressJareen Meinzen-Derr
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 5041, Cincinnati, OH 45229, United States
Int J Pediatr Otorhinolaryngol 72:1693-703. 2008..Thus, we hypothesized that stress experienced by caregivers evolves over time and is impacted by the duration since the diagnosis of hearing loss... - The role of CMV inflammatory genes in hearing lossScott A Schraff
Department of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Otol Neurotol 28:964-9. 2007..The purpose of this study is to test the hypothesis that virally encoded immunomodulatory genes play a role in cytomegalovirus (CMV)-related hearing loss... - Language performance in children with cochlear implants and additional disabilitiesJareen Meinzen-Derr
Division of Biostatistics and Epidemiology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Laryngoscope 120:405-13. 2010..Quantify post-cochlear implant (CI) language among children with disabilities and determine the role of nonverbal cognitive quotients (NVCQ) in predicting language... - Children with cochlear implants and developmental disabilities: a language skills study with developmentally matched hearing peersJareen Meinzen-Derr
Division of Biostatistics, Cincinnati Children s Hospital Medical Center, Department of Otolaryngology, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Res Dev Disabil 32:757-67. 2011..Mechanisms behind this performance-functional gap need to be understood to deliver appropriate intervention strategies for this special population... - Enlarged vestibular aqueduct syndrome in the pediatric populationColm Madden
Departments of Pediatric Otolaryngology, Center of Hearing and Deafness Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Otol Neurotol 24:625-32. 2003..Vestibular aqueduct opercular size alone showed a direct correlation with the audiometric outcome. Borderline enlarged vestibular aqueduct measurements appear to be associated with sensorineural hearing loss... - The effect of cidofovir on cytomegalovirus-induced hearing loss in a Guinea pig modelDavid R White
Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, USA
Arch Otolaryngol Head Neck Surg 132:608-15. 2006..To evaluate the utility of therapy with the cyclic cogener of the anti-cytomegalovirus (CMV) agent cidofovir against CMV-induced hearing loss in a guinea pig model... - Perceived qualitative benefits of cochlear implants in children with multi-handicapsSusan Wiley
Division of Developmental Disabilities, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, MLC 4002, Cincinnati, OH 45229 3039, USA
Int J Pediatr Otorhinolaryngol 69:791-8. 2005..To determine families' perceived benefits of cochlear implants in children with multiple-handicaps... - Actinomycosis of the temporal bone with labyrinthine and facial nerve involvementDeepak Mehta
Department of Pediatric Otolaryngology, Cincinnati Children s Hospital and Medical Center, Cincinnati, OH 45229, USA
Laryngoscope 117:1999-2001. 2007..To demonstrate the clinical, radiologic, and pathologic findings of actinomycosis of the temporal bone... - Improved diagnostic effectiveness with a sequential diagnostic paradigm in idiopathic pediatric sensorineural hearing lossDiego A Preciado
Center for Hearing and Deafness Research (CHDR) and the Division of Pediatric Otolaryngology, Cincinnati, Ohio 45229-3039, USA
Otol Neurotol 26:610-5. 2005..Laboratory investigation should not be routine but based on clinical history... - Pediatric cochlear implantation in auditory neuropathyColm Madden
Center for Hearing and Deafness Research, Audiology Department, and Department of Pediatric Otolaryngology, Children's Hospital Medical Center, Cincinnati, Ohio, USA
Otol Neurotol 23:163-8. 2002..This implies either an inner hair cell or inner hair cell-cochlear nerve junctional pathology that can be overcome by direct electrical stimulation... - The cochlear cleftJon B Chadwell
Department of Otolaryngology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
AJNR Am J Neuroradiol 25:21-4. 2004..Incidence decreased with age. CONCLUSION: We describe a cleft in the otic capsule that is frequently seen on magnified images of temporal bone CT studies in children. The cleft may be the fissula ante fenestram... - Functional magnetic resonance imaging: contemporary and future useKaren B Zur
Department of Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Curr Opin Otolaryngol Head Neck Surg 12:374-7. 2004..Functional magnetic resonance imaging can be safely and reproducibly performed in hearing-impaired children and in the preoperative evaluation of candidates for cochlear implantation... - Refining the DFNB17 interval in consanguineous Indian familiesYingshi Guo
Center for Hearing and Deafness Research, Department of Otolaryngology, Cincinnati, Children s Hospital Cincinnati, OH, USA
Mol Biol Rep 31:97-105. 2004..Analysis of coding and splice site regions of these cochlear expressed genes did not reveal any disease causing mutations. Further study of other candidate genes is currently underway... - A diagnostic paradigm for childhood idiopathic sensorineural hearing lossDiego A Preciado
Center for Hearing and Deafness Research, Division of Pediatric Otolaryngology Head and Neck Surgery, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
Otolaryngol Head Neck Surg 131:804-9. 2004..Our objective was to determine the diagnostic yield of laboratory testing, radiological imaging, and GJB2 mutation screening in a large cohort of patients with differing severities of idiopathic sensorineural hearing loss (SNHL)... - Analysis of hearing preservation after endolymphatic mastoid sac surgery for Meniere's diseaseGordon H Sun
Department of Otolaryngology Head and Neck Surgery, University of Cincinnati Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267 0528, USA
Laryngoscope 120:591-7. 2010..Comparison of audiometric outcomes between patients with definite Meniere's disease who underwent endolymphatic mastoid sac surgery (EMSS) following failed medical therapy and patients who underwent medical therapy only... - Petrous carotid canal dehiscence: an anatomic and radiographic studyMatthew J Hearst
Departments of Otolaryngology Head and Neck Surgery, University of Cincinnati, Cincinnati, Ohio, USA
Otol Neurotol 29:1001-4. 2008..Development of the osseous petrous carotid canal is frequently incomplete... - Clinical and audiological features in auditory neuropathyColm Madden
Center for Hearing and Deafness Research, Department of Pediatric Otolaryngology, Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Arch Otolaryngol Head Neck Surg 128:1026-30. 2002..To medically and audiologically characterize a population of children diagnosed as having auditory neuropathy (AN)... - Genotypic and phenotypic correlations of DFNB1-related hearing impairment in the Midwestern United StatesLynne H Y Lim
Center for Hearing and Deafness Research, Cincinnati, Ohio, USA
Arch Otolaryngol Head Neck Surg 129:836-40. 2003..To determine the genotypic and phenotypic correlations of hearing impairment (HI) in a midwestern US population related to autosomal recessive nonsyndromic hearing loss locus 1 (DFNB1)... - Hearing preservation surgery for small endolymphatic sac tumors in patients with von Hippel-Lindau syndromeCliff A Megerian
Department of Otolaryngology Head and Neck Surgery, Medical Center, University of Massachusetts Medical School, 55 Lake Avenue, Room S2 861, Worcester, MA 01655, U S A
Otol Neurotol 23:378-87. 2002.... - Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing lossZhiyuan Li
Department of Otolaryngology, The First Affiliated Hospital and Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, China
Hum Genet 117:9-15. 2005..These data strongly suggest that the mitochondrial 12S rRNA is a hot-spot for deafness-associated mutations in the Chinese population... - Temporal bone abnormalities associated with hearing loss in Waardenburg syndromeColm Madden
Center of Hearing and Deafness Research, Cincinnati Children's Hospital Medical Center, Ohio 45229, USA
Laryngoscope 113:2035-41. 2003..As shown by computed tomography, enlargement of the vestibular aqueduct and the upper vestibule, narrowing of the internal auditory canal porus, and hypoplasia of the modiolus are features of Waardenburg syndrome... - Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNASer(UCN) genes in two Chinese familiesYi Zhu
Department of Otolaryngology and Zhejiang Provincial Key Laboratory of Medical Genetics, The First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, China
Biochem Biophys Res Commun 342:843-50. 2006..Therefore, nuclear modifier gene(s) or aminoglycoside(s) may play a role in the phenotypic expression of the deafness-associated G7444A mutation in these Chinese pedigrees... - Genomic organization and expression analysis of the murine Fam3c geneValentina V Pilipenko
Center for Hearing and Deafness Research, Division of Otolaryngology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Gene 335:159-68. 2004..Further study is underway to determine the role of FAM3C in inner ear development... - Tumors of the endolymphatic sac in von Hippel-Lindau diseaseRussell R Lonser
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
N Engl J Med 350:2481-6. 2004
Research Grants
- Molecular Development of the Endolymphatic Duct and SacDaniel Choo; Fiscal Year: 2005..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2007..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel I Choo; Fiscal Year: 2010..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
- A preclinical trial of intratympanic antivirals for CMV-related hearing lossDaniel Choo; Fiscal Year: 2009..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..